Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours

Clinical Endocrinology

Volumn 68, Issue 2, 2008, Pages 271-277

  Lindberg, Daniel ^a   Åkerström, Göran ^a   Westin, Gunnar ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; MESSENGER RNA;

ARTICLE; CHROMOSOME 11Q; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DNA METHYLATION; DNA SEQUENCE; ENDOCRINE TUMOR; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INSULINOMA; MULTIPLE ENDOCRINE NEOPLASIA; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P18; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA METHYLATION; HUMANS; MUTATION; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EID: 38049153551     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.03034.x     Document Type: Article

References (40)

1. Åkerström, G., Hellman, P., Hessman, O. Osmak, L. (2004) Surgical treatment of endocrine pancreatic tumours. Neuroendocrinology, 80, 62 66.
2. Öberg, K. Eriksson, B. (2005) Endocrine tumours of the pancreas. Best Practice and Research Clinical Gastroenterology, 19, 753 781.
3. House, M.G. Schulick, R.D. (2006) Endocrine tumors of the pancreas. Current Opinion in Oncology, 18, 23 29.
4. Agarwal, S.K., Kennedy, P.A., Scacheri, P.C., Novotny, E.A., Hickman, A.B., Cerrato, A., Rice, T.S., Moore, J.B., Rao, S., Ji, Y., Mateo, C., Libutti, S.K., Oliver, B., Chandrasekharappa, S.C., Burns, A.L., Collins, F.S., Spiegel, A.M. Marx, S.J. (2005) Menin molecular interactions: insights into normal functions and tumorigenesis. Hormone and Metabolic Research, 37, 369 374.
5. Åkerström, G., Hessman, O., Hellman, P. Skogseid, B. (2005) Pancreatic tumours as part of the MEN-1 syndrome. Best Practice and Research Clinical Gastroenterology, 19, 819 830.
6. Zhuang, Z., Vortmeyer, A.O., Pack, S., Huang, S., Pham, T.A., Wang, C., Park, W.S., Agarwal, S.K., Debelenko, L.V., Kester, M., Guru, S.C., Manickam, P. Olufemi, S.E., Yu, F., Heppner, C., Crabtree, J.S., Skarulis, M.C., Venzon, D.J., Emmert-Buck, M.R., Spiegel, A.M., Chandrasekharappa, S.C., Collins, F.S., Burns, A.L., Marx, S.J. Lubensky, I.A. (1997) Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Research, 57, 4682 4686.
7. Hessman, O., Lindberg, D., Skogseid, B., Carling, T., Hellman, P., Rastad, J., Akerstrom, G. Westin, G. (1998) Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Research, 58, 377 379.
8. Wang, E.H., Ebrahimi, S.A., Wu, A.Y., Kashefi, C., Passaro, E. Jr. Sawicki, M.P. (1998) Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Research, 58, 4417 4420.
9. Hessman, O., Lindberg, D., Einarsson, A., Lillhager, P., Carling, T., Grimelius, L., Eriksson, B., Akerstrom, G., Westin, G. Skogseid, B. (1999) Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN1-associated pancreatic endocrine tumors. Genes, Chromosomes and Cancer, 26, 258 264.
10. Karnik, S.K., Hughes, C.M., Gu, X., Rozenblatt-Rosen, O., McLean, G.W., Xiong, Y., Meyerson, M. Kim, S.K. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proceedings of the National Academy of Sciences of the USA, 102, 14659 14664.
11. Milne, T.A., Hughes, C.M., Lloyd, R., Yang, Z., Rozenblatt-Rosen, O., Dou, Y., Schnepp, R.W., Krankel, C., Livolsi, V.A., Gibbs, D., Hua, X., Roeder, R.G., Meyerson, M. Hess, J.L. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proceedings of the National Academy of Sciences of the USA, 102, 749 754.
12. Scacheri, P.C., Davis, S., Odom, D.T., Crawford, G.E., Perkins, S., Halawi, M.J., Agarwal, S.K., Marx, S.J., Spiegel, A.M., Meltzer, P.S. Collins, F.S. (2006) Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genetics, 2, 406 419.
13. Sherr, C.J. Roberts, J.M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes and Development, 13, 1501 1512.
14. Kim, W.Y. Sharpless, N.E. (2006) The regulation of INK4/ARF in cancer and aging. Cell, 127, 265 275.
15. Sjöblom, T., Jones, S., Wood, L.D., Parsons, D.W., Lin, J., Barber, T.D., Mandelker, D., Leary, R.J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S.D., Willis, J., Dawson, D., Willson, J.K., Gazdar, A.F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B.H., Bachman, K.E., Papadopoulos, N., Vogelstein, B., Kinzler, K.W. Velculescu, V.E. (2006) The consensus coding sequences of human breast and colorectal cancers. Science, 314, 268 274.
16. Deroanne, C.F., Bonjean, K., Servotte, S., Devy, L., Colige, A., Clausse, N., Blacher, S., Verdin, E., Foidart, J.M., Nusgens, B.V. Castronovo, V. (2002) Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene, 21, 427 436.
17. Clark, S.J., Harrison, J., Paul, C.L. Frommer, M. (1994) High sensitivity mapping of methylated cytosines. Nucleic Acids Research, 22, 2990 2997.
18. Raizis, A.M., Schmitt, F. Jost, J.P. (1995) A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Analytical Biochemistry, 226, 161 166.
19. Ronaghi, M., Uhlen, M. Nyren, P. (1998) A sequencing method based on real-time pyrophosphate. Science, 281, 363 365.
20. Colella, S., Shen, L., Baggerly, K.A., Issa, J.P. Krahe, R. (2003) Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. Biotechniques, 35, 146 150.
21. Tost, J., Dunker, J. Gut, I.G. (2003) Analysis and quantification of multiple methylation variable positions in CpG islands by pyrosequencing. Biotechniques, 35, 152 156.
22. Herman, J.G., Jen, J., Merlo, A. Baylin, S.B. (1996) Hypermethylation- associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Research, 56, 722 727.
23. Worm, J., Bartkova, J., Kirkin, A.F., Straten, P., Zeuthen, J., Bartek, J. Guldberg, P. (2000) Aberrant p27Kip1 promoter methylation in malignant melanoma. Oncogene, 19, 5111 5115.
24. Sanchez-Aguilera, A., Delgado, J., Camacho, F.I., Sanchez-Beato, M., Sanchez, L., Montalban, C., Fresno, M.F., Martin, C., Piris, M.A. Garcia, J.F. (2004) Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood, 103, 2351 2357.
25. Schnepp, R.W., Chen, Y.X., Wang, H., Cash, T., Silva, A., Diehl, J.A., Brown, E. Hua, X. (2006) Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Research, 66, 5707 5715.
26. Fontaniere, S., Casse, H., Bertolino, P. Zhang, C.X. (2006) Analysis of p27 (Kip1) expression in insulinomas developed in pancreatic β-cell specific Men1 mutant mice. Familial Cancer, 5, 49 54.
27. Chang, H.J., Batts, K.P., Lloyd, R.V., Sebo, T.J., Thompson, G.B., Lohse, C.M. Pankratz, S.V. (2000) Prognostic significance of p27, Ki-67, and topoisomerase lla expression in clinically nonfunctioning pancreatic endocrine tumors. Endocrine Pathology, 11, 229 241.
28. Canavese, G., Azzoni, C., Pizzi, S., Corleto, V.D., Pasquali, C., Davoli, C., Crafa, P., Delle Fave, G. Bordi, C. (2001) p27: a potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior. Human Pathology, 32, 1094 1101.
29. Guo, S.S., Wu, X., Shimoide, A.T., Wong, J. Sawicki, M.P. (2001) Anomalous overexpression of p27 (Kip1) in sporadic pancreatic endocrine tumors. Journal of Surgical Research, 96, 284 288.
30. Rahman, A., Maitra, A., Ashfaq, R., Yeo, C.J., Cameron, J.L. Hansel, D.E. (2003) Loss of p27 nuclear expression in a prognostically favorable subset of well differentiated pancreatic endocrine neoplasms. American Journal of Clinical Pathology, 120, 685 690.
31. Baldassarre, G., Belletti, B., Nicoloso, M.S., Schiappacassi, M., Vecchione, A., Spessotto, P., Morrione, A., Canzonieri, V. Colombatti, A. (2005) p27 (Kip1) stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell, 7, 51 63.
32. Franklin, D.S., Godfrey, V.L., O'Brien, D.A., Deng, C. Xiong, Y. (2000) Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Molecular Cell Biology, 20, 6147 6158.
33. Bai, F., Pei, X.H., Nishikawa, T., Smith, M.D. Xiong, Y. (2007) p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress neuroendocrine organ tumors. Molecular Cell Biology, 27, 1495 1504.
34. Muscarella, P., Melvin, W.S., Fisher, W.E., Foor, J., Ellison, E.C., Herman, J.G., Schirmer, W.J., Hitchcock, C.L., DeYoung, B.R. Weghorst, C.M. (1998) Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation. Cancer Research, 58, 237 240.
35. Bartsch, D.K., Kersting, M., Wild, A., Ramaswamy, A., Gerdes, B., Schuermann, M., Simon, B. Rothmund, M. (2000) Low frequency of p16 (INK4a) alterations in insulinomas. Digestion, 62, 171 177.
36. Serrano, J., Goebel, S.U., Peghini, P.L., Lubensky, I.A., Gibril, F. Jensen, R.T. (2000) Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas. Journal of Clinical Endocrinology and Metabolism, 85, 4146 4156.
37. Lubomierski, N., Kersting, M., Bert, T., Muench, K., Wulbrand, U., Schuermann, M., Bartsch, D. Simon, B. (1991) Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors. Cancer Research, 61, 5905 5910.
38. Latres, E., Malumbres, M., Sotillo, R., Martin, J., Ortega, S., Martin-Caballero, J., Flores, J.M., Cordon-Cardo, C. Barbacid, M. (2000) Limited overlapping roles of P15 (INK4b) and P18 (INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO Journal, 19, 3496 3506.
39. Nguyen, C.T., Weisenberger, D.J., Velicescu, M., Gonzales, F.A., Lin, J.C., Liang, G. Jones, P.A. (2002) Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Research, 62, 6456 6461.
40. Frigola, J., Song, J., Stirzaker, C., Hinshelwood, R.A., Peinado, M.A. Clark, S.J. (2006) Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nature Genetics, 5, 540 549.