-
1
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Outstanding review critically describing the experiences of Glaxo with 70 target-based high-throughput screening campaigns.
-
Payne D.J., Gwynn M.N., Holmes D.J., and Pompliano D.L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6 (2007) 29-40. Outstanding review critically describing the experiences of Glaxo with 70 target-based high-throughput screening campaigns.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
2
-
-
33845894155
-
Multi-targeting by monotherapeutic antibacterials
-
Highly instructive review supporting the concept of multiplicity of action for antibiotic therapy.
-
Silver L.L. Multi-targeting by monotherapeutic antibacterials. Nat Rev Drug Discov 6 (2007) 41-55. Highly instructive review supporting the concept of multiplicity of action for antibiotic therapy.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 41-55
-
-
Silver, L.L.1
-
3
-
-
36248994803
-
The targets of currently used antibacterial agents: lessons for drug discovery
-
Comprehensive analysis of the mechanisms of action of established antibiotics in the light of the recent literature.
-
Lange R.P., Locher H.H., Wyss P.C., and Then R.L. The targets of currently used antibacterial agents: lessons for drug discovery. Curr Pharm Des 13 (2007) 3140-3154. Comprehensive analysis of the mechanisms of action of established antibiotics in the light of the recent literature.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 3140-3154
-
-
Lange, R.P.1
Locher, H.H.2
Wyss, P.C.3
Then, R.L.4
-
4
-
-
33644544089
-
Empirical antibacterial drug discovery - foundation in natural products
-
Singh S.B., and Barrett J.F. Empirical antibacterial drug discovery - foundation in natural products. Biochem Pharmacol 71 (2006) 1006-1015
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1006-1015
-
-
Singh, S.B.1
Barrett, J.F.2
-
5
-
-
29144477176
-
Bacterial cell wall synthesis: new insights from localization studies
-
Scheffers D.J., and Pinho M.G. Bacterial cell wall synthesis: new insights from localization studies. Microbiol Mol Biol Rev 69 (2005) 585-607
-
(2005)
Microbiol Mol Biol Rev
, vol.69
, pp. 585-607
-
-
Scheffers, D.J.1
Pinho, M.G.2
-
6
-
-
38649088911
-
Quinolone-mediated bacterial death
-
Expert review compiles the current understanding and remaining questions of the complex antibacterial mechanism of quinolones.
-
Drlica K., Malik M., Kerns R.J., and Zhao X. Quinolone-mediated bacterial death. Antimicrob Agents Chemother 52 (2008) 385-392. Expert review compiles the current understanding and remaining questions of the complex antibacterial mechanism of quinolones.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 385-392
-
-
Drlica, K.1
Malik, M.2
Kerns, R.J.3
Zhao, X.4
-
7
-
-
14844339524
-
Glycopeptide and lipoglycopeptide antibiotics
-
Kahne D., Leimkuhler C., Lu W., and Walsh C. Glycopeptide and lipoglycopeptide antibiotics. Chem Rev 105 (2005) 425-448
-
(2005)
Chem Rev
, vol.105
, pp. 425-448
-
-
Kahne, D.1
Leimkuhler, C.2
Lu, W.3
Walsh, C.4
-
8
-
-
0033797686
-
Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action
-
Xiong L., Kloss P., Douthwaite S., Andersen N.M., Swaney S., Shinabarger D.L., and Mankin A.S. Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action. J Bacteriol 182 (2000) 5325-5331
-
(2000)
J Bacteriol
, vol.182
, pp. 5325-5331
-
-
Xiong, L.1
Kloss, P.2
Douthwaite, S.3
Andersen, N.M.4
Swaney, S.5
Shinabarger, D.L.6
Mankin, A.S.7
-
9
-
-
0035950132
-
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
-
Schlunzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., and Franceschi F. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413 (2001) 814-821
-
(2001)
Nature
, vol.413
, pp. 814-821
-
-
Schlunzen, F.1
Zarivach, R.2
Harms, J.3
Bashan, A.4
Tocilj, A.5
Albrecht, R.6
Yonath, A.7
Franceschi, F.8
-
11
-
-
31944443056
-
Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity
-
Kaul M., Barbieri C.M., and Pilch D.S. Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity. J Am Chem Soc 128 (2006) 1261-1271
-
(2006)
J Am Chem Soc
, vol.128
, pp. 1261-1271
-
-
Kaul, M.1
Barbieri, C.M.2
Pilch, D.S.3
-
13
-
-
0035160878
-
Macrolide resistance conferred by base substitutions in 23S rRNA
-
Vester B., and Douthwaite S. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother 45 (2001) 1-12
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1-12
-
-
Vester, B.1
Douthwaite, S.2
-
14
-
-
0033939999
-
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria
-
Du W., Brown J.R., Sylvester D.R., Huang J., Chalker A.F., So C.Y., Holmes D.J., Payne D.J., and Wallis N.G. Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria. J Bacteriol 182 (2000) 4146-4152
-
(2000)
J Bacteriol
, vol.182
, pp. 4146-4152
-
-
Du, W.1
Brown, J.R.2
Sylvester, D.R.3
Huang, J.4
Chalker, A.F.5
So, C.Y.6
Holmes, D.J.7
Payne, D.J.8
Wallis, N.G.9
-
15
-
-
8544274525
-
Self-protection mechanism in d-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and d-alanyl-d-alanine ligase, which are target enzymes of d-cycloserine
-
Noda M., Kawahara Y., Ichikawa A., Matoba Y., Matsuo H., Lee D.G., Kumagai T., and Sugiyama M. Self-protection mechanism in d-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and d-alanyl-d-alanine ligase, which are target enzymes of d-cycloserine. J Biol Chem 279 (2004) 46143-46152
-
(2004)
J Biol Chem
, vol.279
, pp. 46143-46152
-
-
Noda, M.1
Kawahara, Y.2
Ichikawa, A.3
Matoba, Y.4
Matsuo, H.5
Lee, D.G.6
Kumagai, T.7
Sugiyama, M.8
-
16
-
-
34547638220
-
Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents
-
Chopra I. Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents. Curr Opin Investig Drugs 8 (2007) 600-607
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 600-607
-
-
Chopra, I.1
-
17
-
-
0033853659
-
Sulfonamide resistance: mechanisms and trends
-
Skold O. Sulfonamide resistance: mechanisms and trends. Drug Resist Updat 3 (2000) 155-160
-
(2000)
Drug Resist Updat
, vol.3
, pp. 155-160
-
-
Skold, O.1
-
18
-
-
33644508373
-
Dihydrofolate reductase inhibitors as antibacterial agents
-
Hawser S., Lociuro S., and Islam K. Dihydrofolate reductase inhibitors as antibacterial agents. Biochem Pharmacol 71 (2006) 941-948
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 941-948
-
-
Hawser, S.1
Lociuro, S.2
Islam, K.3
-
19
-
-
17444373920
-
Structural insights into fusidic acid resistance and sensitivity in EF-G
-
Hansson S., Singh R., Gudkov A.T., Liljas A., and Logan D.T. Structural insights into fusidic acid resistance and sensitivity in EF-G. J Mol Biol 348 (2005) 939-949
-
(2005)
J Mol Biol
, vol.348
, pp. 939-949
-
-
Hansson, S.1
Singh, R.2
Gudkov, A.T.3
Liljas, A.4
Logan, D.T.5
-
20
-
-
0012684806
-
The ATP-binding site of type II topoisomerases as a target for antibacterial drugs
-
Maxwell A., and Lawson D.M. The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr Top Med Chem 3 (2003) 283-303
-
(2003)
Curr Top Med Chem
, vol.3
, pp. 283-303
-
-
Maxwell, A.1
Lawson, D.M.2
-
21
-
-
33947260230
-
Molecular mechanisms of antibacterial multidrug resistance
-
Alekshun M.N., and Levy S.B. Molecular mechanisms of antibacterial multidrug resistance. Cell 128 (2007) 1037-1050
-
(2007)
Cell
, vol.128
, pp. 1037-1050
-
-
Alekshun, M.N.1
Levy, S.B.2
-
22
-
-
33746001269
-
Antibacterial natural products in medicinal chemistry - exodus or revival?
-
Recent summary of chemical approaches to improve the pharmacological profile of antibacterial natural products.
-
von Nussbaum F., Brands M., Hinzen B., Weigand S., and Habich D. Antibacterial natural products in medicinal chemistry - exodus or revival?. Angew Chem Int Ed Engl 45 (2006) 5072-5129. Recent summary of chemical approaches to improve the pharmacological profile of antibacterial natural products.
-
(2006)
Angew Chem Int Ed Engl
, vol.45
, pp. 5072-5129
-
-
von Nussbaum, F.1
Brands, M.2
Hinzen, B.3
Weigand, S.4
Habich, D.5
-
23
-
-
0035115180
-
In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci
-
Hebeisen P., Heinze-Krauss I., Angehrn P., Hohl P., Page M.G., and Then R.L. In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci. Antimicrob Agents Chemother 45 (2001) 825-836
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 825-836
-
-
Hebeisen, P.1
Heinze-Krauss, I.2
Angehrn, P.3
Hohl, P.4
Page, M.G.5
Then, R.L.6
-
24
-
-
34447254695
-
Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
-
Davies T.A., Page M.G., Shang W., Andrew T., Kania M., and Bush K. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother 51 (2007) 2621-2624
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 2621-2624
-
-
Davies, T.A.1
Page, M.G.2
Shang, W.3
Andrew, T.4
Kania, M.5
Bush, K.6
-
26
-
-
0037303518
-
Macrolide antibiotic interaction and resistance on the bacterial ribosome
-
Poehlsgaard J., and Douthwaite S. Macrolide antibiotic interaction and resistance on the bacterial ribosome. Curr Opin Investig Drugs 4 (2003) 140-148
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 140-148
-
-
Poehlsgaard, J.1
Douthwaite, S.2
-
27
-
-
4544361918
-
Macrolide resistance based on the Erm-mediated rRNA methylation
-
Maravic G. Macrolide resistance based on the Erm-mediated rRNA methylation. Curr Drug Targets Infect Disord 4 (2004) 193-202
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 193-202
-
-
Maravic, G.1
-
28
-
-
0038492422
-
Structural insight into the antibiotic action of telithromycin against resistant mutants
-
Berisio R., Harms J., Schluenzen F., Zarivach R., Hansen H.A., Fucini P., and Yonath A. Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol 185 (2003) 4276-4279
-
(2003)
J Bacteriol
, vol.185
, pp. 4276-4279
-
-
Berisio, R.1
Harms, J.2
Schluenzen, F.3
Zarivach, R.4
Hansen, H.A.5
Fucini, P.6
Yonath, A.7
-
29
-
-
33744458965
-
Functional, biophysical, and structural bases for antibacterial activity of tigecycline
-
Olson M.W., Ruzin A., Feyfant E., Rush III T.S., O'Connell J., and Bradford P.A. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother 50 (2006) 2156-2166
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 2156-2166
-
-
Olson, M.W.1
Ruzin, A.2
Feyfant, E.3
Rush III, T.S.4
O'Connell, J.5
Bradford, P.A.6
-
30
-
-
0032918653
-
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
-
Petersen P.J., Jacobus N.V., Weiss W.J., Sum P.E., and Testa R.T. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 43 (1999) 738-744
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 738-744
-
-
Petersen, P.J.1
Jacobus, N.V.2
Weiss, W.J.3
Sum, P.E.4
Testa, R.T.5
-
31
-
-
0242569143
-
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria
-
Schneider P., Hawser S., and Islam K. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett 13 (2003) 4217-4221
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4217-4221
-
-
Schneider, P.1
Hawser, S.2
Islam, K.3
-
32
-
-
20044363986
-
Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus
-
Higgins D.L., Chang R., Debabov D.V., Leung J., Wu T., Krause K.M., Sandvik E., Hubbard J.M., Kaniga K., Schmidt Jr. D.E., et al. Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 49 (2005) 1127-1134
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1127-1134
-
-
Higgins, D.L.1
Chang, R.2
Debabov, D.V.3
Leung, J.4
Wu, T.5
Krause, K.M.6
Sandvik, E.7
Hubbard, J.M.8
Kaniga, K.9
Schmidt Jr., D.E.10
-
33
-
-
0037266399
-
Mechanism of action of oritavancin and related glycopeptide antibiotics
-
Allen N.E., and Nicas T.I. Mechanism of action of oritavancin and related glycopeptide antibiotics. FEMS Microbiol Rev 26 (2003) 511-532
-
(2003)
FEMS Microbiol Rev
, vol.26
, pp. 511-532
-
-
Allen, N.E.1
Nicas, T.I.2
-
34
-
-
39749162750
-
Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus
-
Kim S.J., Cegelski L., Stueber D., Singh M., Dietrich E., Tanaka K.S., Parr Jr. T.R., Far A.R., and Schaefer J. Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. J Mol Biol 377 (2008) 281-293
-
(2008)
J Mol Biol
, vol.377
, pp. 281-293
-
-
Kim, S.J.1
Cegelski, L.2
Stueber, D.3
Singh, M.4
Dietrich, E.5
Tanaka, K.S.6
Parr Jr., T.R.7
Far, A.R.8
Schaefer, J.9
-
35
-
-
0017138982
-
Dual-action cephalosporin utilizing a novel therapeutic principle
-
Greenwood D., and O'Grady F. Dual-action cephalosporin utilizing a novel therapeutic principle. Antimicrob Agents Chemother 10 (1976) 249-252
-
(1976)
Antimicrob Agents Chemother
, vol.10
, pp. 249-252
-
-
Greenwood, D.1
O'Grady, F.2
-
36
-
-
34250160226
-
Dual action-based approaches to antibacterial agents
-
Comprehensive introduction into the chemical and pharmacological concepts of hybrid molecules.
-
Bremner J.B., Ambrus J.I., and Samosorn S. Dual action-based approaches to antibacterial agents. Curr Med Chem 14 (2007) 1459-1477. Comprehensive introduction into the chemical and pharmacological concepts of hybrid molecules.
-
(2007)
Curr Med Chem
, vol.14
, pp. 1459-1477
-
-
Bremner, J.B.1
Ambrus, J.I.2
Samosorn, S.3
-
37
-
-
0030879493
-
Dual beta-lactam-fluoroquinolone compounds: a novel approach to antibacterial treatment
-
Multifarious analysis of prospects and pitfalls of fluoroquinolone-β-lactam hybrids.
-
Bryskier A. Dual beta-lactam-fluoroquinolone compounds: a novel approach to antibacterial treatment. Expert Opin Investig Drugs 6 (1997) 1479-1499. Multifarious analysis of prospects and pitfalls of fluoroquinolone-β-lactam hybrids.
-
(1997)
Expert Opin Investig Drugs
, vol.6
, pp. 1479-1499
-
-
Bryskier, A.1
-
38
-
-
0025754851
-
Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424
-
Pace J., Bertasso A., and Georgopapadakou N.H. Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424. Antimicrob Agents Chemother 35 (1991) 910-915
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 910-915
-
-
Pace, J.1
Bertasso, A.2
Georgopapadakou, N.H.3
-
39
-
-
33845995869
-
Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound
-
Butler M.M., Lamarr W.A., Foster K.A., Barnes M.H., Skow D.J., Lyden P.T., Kustigian L.M., Zhi C., Brown N.C., Wright G.E., and Bowlin T.L. Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother 51 (2007) 119-127
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 119-127
-
-
Butler, M.M.1
Lamarr, W.A.2
Foster, K.A.3
Barnes, M.H.4
Skow, D.J.5
Lyden, P.T.6
Kustigian, L.M.7
Zhi, C.8
Brown, N.C.9
Wright, G.E.10
Bowlin, T.L.11
-
40
-
-
22844433306
-
3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin
-
Hanessian S., and Kothakonda K.K. 3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin. Bioorg Med Chem 13 (2005) 5283-5288
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 5283-5288
-
-
Hanessian, S.1
Kothakonda, K.K.2
-
41
-
-
9144256610
-
Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamases
-
Stone G.W., Zhang Q., Castillo R., Doppalapudi V.R., Bueno A.R., Lee J.Y., Li Q., Sergeeva M., Khambatta G., and Georgopapadakou N.H. Mechanism of action of NB2001 and NB2030, novel antibacterial agents activated by beta-lactamases. Antimicrob Agents Chemother 48 (2004) 477-483
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 477-483
-
-
Stone, G.W.1
Zhang, Q.2
Castillo, R.3
Doppalapudi, V.R.4
Bueno, A.R.5
Lee, J.Y.6
Li, Q.7
Sergeeva, M.8
Khambatta, G.9
Georgopapadakou, N.H.10
-
42
-
-
0242416198
-
Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action
-
Hubschwerlen C., Specklin J.L., Baeschlin D.K., Borer Y., Haefeli S., Sigwalt C., Schroeder S., and Locher H.H. Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. Bioorg Med Chem Lett 13 (2003) 4229-4233
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4229-4233
-
-
Hubschwerlen, C.1
Specklin, J.L.2
Baeschlin, D.K.3
Borer, Y.4
Haefeli, S.5
Sigwalt, C.6
Schroeder, S.7
Locher, H.H.8
-
43
-
-
54849440839
-
Characterization of MCB 3681, a dual-action antibiotic
-
Gray C., Moes L., Locher H., and Dale G. Characterization of MCB 3681, a dual-action antibiotic. Intersci Conf Antimicrob Agents Chemother 45 (2005) F512
-
(2005)
Intersci Conf Antimicrob Agents Chemother
, vol.45
-
-
Gray, C.1
Moes, L.2
Locher, H.3
Dale, G.4
-
44
-
-
54849414275
-
In vitro activity of the novel antibacterial MCB 3681 against selected Gram-positive and -negative bacteria compared to established antibiotics
-
Kresken M., and Brauers J. In vitro activity of the novel antibacterial MCB 3681 against selected Gram-positive and -negative bacteria compared to established antibiotics. Intersci Conf Antimicrob Agents Chemother 46 (2006) F1-1967
-
(2006)
Intersci Conf Antimicrob Agents Chemother
, vol.46
-
-
Kresken, M.1
Brauers, J.2
-
45
-
-
46249112774
-
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies undertaken in Staphylococci and Streptococci
-
Robertson G.T., Bonventre E.J., Doyle T.B., Du Q., Duncan L., Morris T.W., Roche E.D., Yan D., and Lynch A.S. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies undertaken in Staphylococci and Streptococci. Antimicrob Agents Chemother 52 (2008) 2324-2334
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2324-2334
-
-
Robertson, G.T.1
Bonventre, E.J.2
Doyle, T.B.3
Du, Q.4
Duncan, L.5
Morris, T.W.6
Roche, E.D.7
Yan, D.8
Lynch, A.S.9
-
46
-
-
46249084681
-
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus
-
Robertson G.T., Bonventre E.J., Doyle T.B., Du Q., Duncan L., Morris T.W., Roche E.D., Yan D., and Lynch A.S. In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Antimicrob Agents Chemother 52 (2008) 2313-2323
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2313-2323
-
-
Robertson, G.T.1
Bonventre, E.J.2
Doyle, T.B.3
Du, Q.4
Duncan, L.5
Morris, T.W.6
Roche, E.D.7
Yan, D.8
Lynch, A.S.9
-
47
-
-
76649099997
-
TD-1792, a new antibiotic with improved in vitro activity
-
Krause K.M., Difuntorum S., Blais J., Turner S.D., and Marquess D. TD-1792, a new antibiotic with improved in vitro activity. Intersci Conf Antimicrob Agents Chemother 47 (2007) E-1626
-
(2007)
Intersci Conf Antimicrob Agents Chemother
, vol.47
-
-
Krause, K.M.1
Difuntorum, S.2
Blais, J.3
Turner, S.D.4
Marquess, D.5
-
48
-
-
84858637782
-
In vitro and in vivo evidence for a multivalent mode of action of TD-1792 against Staphylococcus aureus
-
Difuntorum S., Blais J., Hedge S.S., Skinner R., Reyes N., Trumbull J., Turner S.D., and Marquess D. In vitro and in vivo evidence for a multivalent mode of action of TD-1792 against Staphylococcus aureus. Intersci Conf Antimicrob Agents Chemother 47 (2007) F1-2110
-
(2007)
Intersci Conf Antimicrob Agents Chemother
, vol.47
-
-
Difuntorum, S.1
Blais, J.2
Hedge, S.S.3
Skinner, R.4
Reyes, N.5
Trumbull, J.6
Turner, S.D.7
Marquess, D.8
-
49
-
-
43949129098
-
Physicochemical properties of antibacterial compounds: implications for drug discovery
-
First analysis of the physicochemical requirements of antibiotics separated by Gram-positives, Gram-negatives, and Pseudomonas-active compounds.
-
O'Shea R., and Moser H.E. Physicochemical properties of antibacterial compounds: implications for drug discovery. J Med Chem 51 (2008) 2871-2878. First analysis of the physicochemical requirements of antibiotics separated by Gram-positives, Gram-negatives, and Pseudomonas-active compounds.
-
(2008)
J Med Chem
, vol.51
, pp. 2871-2878
-
-
O'Shea, R.1
Moser, H.E.2
-
50
-
-
4644245934
-
The impact of transcriptome and proteome analyses on antibiotic drug discovery
-
Freiberg C., Brotz-Oesterhelt H., and Labischinski H. The impact of transcriptome and proteome analyses on antibiotic drug discovery. Curr Opin Microbiol 7 (2004) 451-459
-
(2004)
Curr Opin Microbiol
, vol.7
, pp. 451-459
-
-
Freiberg, C.1
Brotz-Oesterhelt, H.2
Labischinski, H.3
|