Oritavancin Exhibits Dual Mode of Action to Inhibit Cell-Wall Biosynthesis in Staphylococcus aureus

Journal of Molecular Biology

Volumn 377, Issue 1, 2008, Pages 281-293

  Kim, Sung Joon ^a   Cegelski, Lynette ^a   Stueber, Dirk ^a   Singh, Manmilan ^a   Dietrich, Evelyne ^b   Tanaka, Kelly S E ^b   Parr Jr , Thomas R ^b   Far, Adel Rafai ^b   Schaefer, Jacob ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b Targanta Therapeutics Inc ^*  (Canada)

Author keywords

glycopeptide antibiotic; peptidoglycan; solid state NMR; transglycosylase; transpeptidase

Indexed keywords

DES N METHYLLEUCYL ORITAVANCIN F 19; ORITAVANCIN; PENICILLIN G; UNCLASSIFIED DRUG; VANCOMYCIN;

ARTICLE; BIOSYNTHESIS; CELL WALL; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SOLID STATE; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

EID: 39749162750     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.01.031     Document Type: Article

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