Mechanism of Action of NB2001 and NB2030, Novel Antibacterial Agents Activated by β-Lactamases

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 2, 2004, Pages 477-483

  Stone, Geoffrey W ^a,b   Zhang, Qin ^a   Castillo, Rosario ^a   Doppalapudi, V Ramana ^a   Bueno, Analia R ^a   Lee, Jean Y ^a   Li, Qing ^a   Sergeeva, Maria ^a   Khambatta, Gody ^a   Georgopapadakou, Nafsika H ^a  

^a NewBiotics Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; BETA LACTAMASE; BETA LACTAMASE AMPC; CARBOXYPEPTIDASE TRANSPEPTIDASE; CARRIER PROTEIN; CEFALOTIN; CEPHALOSPORIN DERIVATIVE; DRUG DERIVATIVE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); ENOYL REDUCTASE; GLYCOSYLTRANSFERASE; NB 2001; NB 2030; NB2001; NB2030; OXIDOREDUCTASE; PENICILLIN BINDING PROTEIN; PEPTIDYLTRANSFERASE; PRODRUG; PROTEIN P99; PROTEIN PC1; PROTEIN TEM 1; TETRAZOLE DERIVATIVE; TRICLOFOS; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOACCUMULATION; BIOSYNTHESIS; BIOTRANSFORMATION; CELL MEMBRANE; CELL STRUCTURE; CHEMISTRY; CONTROLLED STUDY; DRUG ACTIVATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENTEROBACTER CLOACAE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HYDROLYSIS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; ULTRASTRUCTURE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BIOTRANSFORMATION; CARRIER PROTEINS; CELL MEMBRANE; CEPHALOSPORINS; CLONING, MOLECULAR; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEXOSYLTRANSFERASES; KINETICS; MICROBIAL SENSITIVITY TESTS; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; OXIDOREDUCTASES; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; SPECTROPHOTOMETRY, ULTRAVIOLET; STAPHYLOCOCCUS AUREUS; TETRAZOLES; TRICLOSAN;

EID: 9144256610     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.2.477-483.2004     Document Type: Article

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