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Volumn 6, Issue SUPPL. 5, 2008, Pages

NCCN task force report: mTOR inhibition in solid tumors

Author keywords

Cancer; Deforolimus; Everolimus; Malignancy; mTOR; mTOR inhibition; NCCN Clinical Practice Guidelines; Rapamycin; Targeted therapy; Temsirolimus

Indexed keywords

ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AP 23573; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; INTERFERON; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OCTREOTIDE; PACLITAXEL; PEMETREXED; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; SORAFENIB; SUNITINIB; TAXANE DERIVATIVE; TEMSIROLIMUS; TRASTUZUMAB; UNINDEXED DRUG; VORINOSTAT; MTOR PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RIDAFOROLIMUS; TARGET OF RAPAMYCIN KINASE;

EID: 54749149761     PISSN: 15401405     EISSN: 15401413     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (49)

References (72)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for caner therapy
    • Bjornsti MA, Houghton PJ. The TOR pathway: a target for caner therapy. Nat Rev 2004;4:335-348.
    • (2004) Nat Rev , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 3
    • 33745307617 scopus 로고    scopus 로고
    • Shaw RJ, Cantley LC. Ras, PI3K and mTOR signaling controls tumour cell growth. Nature 2006;441:424-430.
    • Shaw RJ, Cantley LC. Ras, PI3K and mTOR signaling controls tumour cell growth. Nature 2006;441:424-430.
  • 4
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induced upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo R, She QB, et al. mTOR inhibition induced upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, R.2    She, Q.B.3
  • 5
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged sirolimus treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged sirolimus treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006; 22:159-168.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3
  • 6
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatina DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatina, D.M.2
  • 7
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 2005;102:8204-8209.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 8
    • 33846879810 scopus 로고    scopus 로고
    • The von Hippel-lindau tumor suppressor protein and clear cell renal carcinoma
    • Kaelin WG. The von Hippel-lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007;13(2 Suppl):680s-684s.
    • (2007) Clin Cancer Res , vol.13 , Issue.2 SUPPL.
    • Kaelin, W.G.1
  • 9
    • 0042342564 scopus 로고    scopus 로고
    • The von Hippel-Lindau protein, vascular endothelial growth factors, and kidney cancer
    • George DJ, Kaelin WG. The von Hippel-Lindau protein, vascular endothelial growth factors, and kidney cancer. N Engl J Med 2003;349:419-421.
    • (2003) N Engl J Med , vol.349 , pp. 419-421
    • George, D.J.1    Kaelin, W.G.2
  • 10
    • 33746800144 scopus 로고    scopus 로고
    • Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
    • Phung TL, Ziv K, Dabydeen D, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 2006;10:159-170.
    • (2006) Cancer Cell , vol.10 , pp. 159-170
    • Phung, T.L.1    Ziv, K.2    Dabydeen, D.3
  • 11
    • 34250619165 scopus 로고    scopus 로고
    • The mammalian target of sirolimus signaling pathway: Twists and turns in the road to cancer therapy
    • Abraham RT, Gibbons JJ. The mammalian target of sirolimus signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res 2007;13:3109-3114.
    • (2007) Clin Cancer Res , vol.13 , pp. 3109-3114
    • Abraham, R.T.1    Gibbons, J.J.2
  • 12
    • 38649104213 scopus 로고    scopus 로고
    • A phase 1b study of oral rapamycin (sirolimus) in patients with advanced malignancies [abstract]
    • Ratain MJ, Napoli KL, Knightley Moshier K, et al. A phase 1b study of oral rapamycin (sirolimus) in patients with advanced malignancies [abstract]. J Clin Oncol 2007:25 (Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Ratain, M.J.1    Napoli, K.L.2    Knightley Moshier, K.3
  • 13
    • 33750236103 scopus 로고    scopus 로고
    • Pharmacodynamic-guided, modified continuous reassessment method (mCRM)-based, dose finding study of rapamycin in adult patients with solid tumors [abstract]
    • Jimeno A, Kulesza P, Cusatis G, et al. Pharmacodynamic-guided, modified continuous reassessment method (mCRM)-based, dose finding study of rapamycin in adult patients with solid tumors [abstract]. J Clin Oncol 2006: 24;(Suppl 1)
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 1
    • Jimeno, A.1    Kulesza, P.2    Cusatis, G.3
  • 14
    • 30044432434 scopus 로고    scopus 로고
    • Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
    • Thomas GV, Tran C, Mellinghoff IK, et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006;12:122-127.
    • (2006) Nat Med , vol.12 , pp. 122-127
    • Thomas, G.V.1    Tran, C.2    Mellinghoff, I.K.3
  • 15
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev 2006;5:671-688.
    • (2006) Nat Rev , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 16
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of sirolimus kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of sirolimus kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-918.
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 17
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik I, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999;17:2530-2540.
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, I.3
  • 18
    • 23344454218 scopus 로고    scopus 로고
    • Update of a phase 1 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma [abstract]
    • Smith JW, Ko Y, Dutcher J, et al. Update of a phase 1 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma [abstract]. J Clin Oncol 2004;22(Suppl 1)
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 1
    • Smith, J.W.1    Ko, Y.2    Dutcher, J.3
  • 19
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal cell carcinoma. N Engl J Med 2007;356: 2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 20
    • 34547636060 scopus 로고    scopus 로고
    • Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma receiving temsirolimus or interferon alpha [abstract]
    • Dutcher JP, Szczylik C, Tannir N, et al. Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma receiving temsirolimus or interferon alpha [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Dutcher, J.P.1    Szczylik, C.2    Tannir, N.3
  • 21
    • 33746651683 scopus 로고    scopus 로고
    • Aphase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC) [abstract]
    • Amato R, Misellati A, Khan M, Chiang S. Aphase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC) [abstract]. J Clin Oncol 2006;24(Suppl 1)
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 1
    • Amato, R.1    Misellati, A.2    Khan, M.3    Chiang, S.4
  • 22
    • 55249103589 scopus 로고    scopus 로고
    • RAD001 vs placebo in patients with metastatic renal cell carcinoma after progression on VEGFr-TKI therapy: Results from a randomized, double blind, multicenter phase-III study [abstract]
    • Motzer RJ, Escudier B, Oudard S, et al. RAD001 vs placebo in patients with metastatic renal cell carcinoma after progression on VEGFr-TKI therapy: results from a randomized, double blind, multicenter phase-III study [abstract]. J Clin Oncol 2008;26(Suppl 1)
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 1
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 23
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S, Scheulen ME, Johnston S, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-5322.
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 24
    • 8344231370 scopus 로고    scopus 로고
    • Phase II, 3 arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer. Preliminary results [abstract]
    • Baselga J, Fumoleau P, Gil M, et al. Phase II, 3 arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer. Preliminary results [abstract]. J Clin Oncol 2004;22(Suppl 1)
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 1
    • Baselga, J.1    Fumoleau, P.2    Gil, M.3
  • 25
    • 34447106387 scopus 로고    scopus 로고
    • Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic disease [abstract]
    • Presented at the December 14-17, San Antonio, Texas
    • Chow LW, Sun Y, Jassem J, et al. Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic disease [abstract]. Presented at the 29th Annual San Antonio Breast Cancer Symposium; December 14-17, 2006; San Antonio, Texas.
    • (2006) 29th Annual San Antonio Breast Cancer Symposium
    • Chow, L.W.1    Sun, Y.2    Jassem, J.3
  • 26
    • 67449165247 scopus 로고    scopus 로고
    • Phase II double blind randomized trial of daily oral RAD001 plus letrozole or placebo plus letrozole as neoadjuvant therapy for estrogen positive breast cancer [abstract]
    • Presented at the December 13-16, San Antonio, Texas
    • Baselga J, Semiglazov V van Dam P, et al. Phase II double blind randomized trial of daily oral RAD001 plus letrozole or placebo plus letrozole as neoadjuvant therapy for estrogen positive breast cancer [abstract]. Presented at the 30th Annual San Antonio Breast Cancer Symposium; December 13-16, 2007; San Antonio, Texas.
    • (2007) 30th Annual San Antonio Breast Cancer Symposium
    • Baselga, J.1    Semiglazov, V.2    van Dam, P.3
  • 27
    • 72749090197 scopus 로고    scopus 로고
    • Biomarker analysis of pa phase II double blind randomized trial of daily oral RAD - 1 plus letrozole or placebo plus letrozole as neoadjuvant therapy for patients with estrogen receptor positive breast cancer
    • Presented at the December 13-16, San Antonio, Texas
    • Gardner H, Bandaru R, Barrett C, et al. Biomarker analysis of pa phase II double blind randomized trial of daily oral RAD - 1 plus letrozole or placebo plus letrozole as neoadjuvant therapy for patients with estrogen receptor positive breast cancer. Presented at the 30th Annual San Antonio Breast Cancer Symposium; December 13-16, 2007; San Antonio, Texas.
    • (2007) 30th Annual San Antonio Breast Cancer Symposium
    • Gardner, H.1    Bandaru, R.2    Barrett, C.3
  • 28
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567-578.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 29
    • 54749145145 scopus 로고    scopus 로고
    • Cetuximab extends survival of patients with recurrent or metastatic squamous cell cancer of the head and neck when added to first line platinum based therapy [abstract]
    • Vermorken J, Moesia R, Vega V, et al. Cetuximab extends survival of patients with recurrent or metastatic squamous cell cancer of the head and neck when added to first line platinum based therapy [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Vermorken, J.1    Moesia, R.2    Vega, V.3
  • 30
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes E, et al. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004;22:77-85.
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.3
  • 31
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003;21:1980-1987.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 32
    • 33947422073 scopus 로고    scopus 로고
    • Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy
    • Jimeno A, Kulesza P, Wheelhouse J, et al. Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. Br J Cancer 2007;96:952-959.
    • (2007) Br J Cancer , vol.96 , pp. 952-959
    • Jimeno, A.1    Kulesza, P.2    Wheelhouse, J.3
  • 33
    • 33947235680 scopus 로고    scopus 로고
    • Mammalian target of sirolimus inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
    • Nathan CO, Amirghahari N, Rong X, et al. Mammalian target of sirolimus inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. Cancer Res 2007;67:2160-2168.
    • (2007) Cancer Res , vol.67 , pp. 2160-2168
    • Nathan, C.O.1    Amirghahari, N.2    Rong, X.3
  • 34
    • 39049086390 scopus 로고    scopus 로고
    • Mammalian target of sirolimus is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium
    • Yeager N, Brewer C, Cai KQ, et al. Mammalian target of sirolimus is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res 2008;68:444-449.
    • (2008) Cancer Res , vol.68 , pp. 444-449
    • Yeager, N.1    Brewer, C.2    Cai, K.Q.3
  • 35
    • 33750510023 scopus 로고    scopus 로고
    • A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
    • Duran I, Kortmansky J, Singh D, et al. A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 2006;95:1148-1154.
    • (2006) Br J Cancer , vol.95 , pp. 1148-1154
    • Duran, I.1    Kortmansky, J.2    Singh, D.3
  • 36
    • 39049100718 scopus 로고    scopus 로고
    • Phase II study of RAD001 (everolimus) and depot octreotide in advanced low grade neuroendocrine carcinoma [abstract]
    • Yao JC, Phan A, Chang DZ, et al. Phase II study of RAD001 (everolimus) and depot octreotide in advanced low grade neuroendocrine carcinoma [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Yao, J.C.1    Phan, A.2    Chang, D.Z.3
  • 37
    • 34548720158 scopus 로고    scopus 로고
    • Sorafenib improves survival in advanced Hepatocellular Carcinoma (HCC): Results of a Phase III randomized placebo-controlled trial (SHARP trial) [abstract]
    • Llovet J, Ricci S, Mazzaferro P, et al. Sorafenib improves survival in advanced Hepatocellular Carcinoma (HCC): results of a Phase III randomized placebo-controlled trial (SHARP trial) [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Llovet, J.1    Ricci, S.2    Mazzaferro, P.3
  • 38
    • 33750576103 scopus 로고    scopus 로고
    • Molecular and pathologic aspects of endometrial carcinogenesis
    • Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006;24:4783-4791.
    • (2006) J Clin Oncol , vol.24 , pp. 4783-4791
    • Hecht, J.L.1    Mutter, G.L.2
  • 39
    • 33750271928 scopus 로고    scopus 로고
    • Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer - NCIC IND 160 [abstract]
    • Oza AM, Elit L, Biagi J, et al. Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer - NCIC IND 160 [abstract]. J Clin Oncol 2006;24(Suppl 1)
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 1
    • Oza, A.M.1    Elit, L.2    Biagi, J.3
  • 40
    • 54749106323 scopus 로고    scopus 로고
    • AP23573 as a single agent in advanced endometrial cancer [abstract]
    • Columbo N, McMeekin S, Schwartz P, et al. AP23573 as a single agent in advanced endometrial cancer [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Columbo, N.1    McMeekin, S.2    Schwartz, P.3
  • 41
    • 34547130295 scopus 로고    scopus 로고
    • RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model [abstract]
    • Mabuchi S, Altomare DA, Cheung M, et al. RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model [abstract]. Clin Cancer Res 2007;13:4261-4270.
    • (2007) Clin Cancer Res , vol.13 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.A.2    Cheung, M.3
  • 42
    • 34047253075 scopus 로고    scopus 로고
    • RAD001 (everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
    • Mabuchi S, Altomare DA, Connolly DC, et al. RAD001 (everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res 2007;67:2408-2413.
    • (2007) Cancer Res , vol.67 , pp. 2408-2413
    • Mabuchi, S.1    Altomare, D.A.2    Connolly, D.C.3
  • 43
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group study
    • Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group study. J Clin Oncol 2007;25:5165-5171.
    • (2007) J Clin Oncol , vol.25 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3
  • 44
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • Cannistra SA, Matulonis US, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007;25:5180-5186.
    • (2007) J Clin Oncol , vol.25 , pp. 5180-5186
    • Cannistra, S.A.1    Matulonis, U.S.2    Penson, R.T.3
  • 45
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
    • Garcia AA, Hirte H, Fleming G, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol 2008;26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 46
    • 6044230919 scopus 로고    scopus 로고
    • Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
    • David O, Jett J, LeBeau H, et al. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 2004;10:6865-6871.
    • (2004) Clin Cancer Res , vol.10 , pp. 6865-6871
    • David, O.1    Jett, J.2    LeBeau, H.3
  • 47
    • 0035872199 scopus 로고    scopus 로고
    • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard J, Clark AS, Ni Y, Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001;61:3986-3997.
    • (2001) Cancer Res , vol.61 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3    Dennis, P.A.4
  • 48
    • 14844366111 scopus 로고    scopus 로고
    • ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
    • Engelman JA, Jänne PA, Mermel C, et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A 2005;102:3788-3793.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3788-3793
    • Engelman, J.A.1    Jänne, P.A.2    Mermel, C.3
  • 49
    • 6044259204 scopus 로고    scopus 로고
    • Targeting mammalian target of sirolimus synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
    • Mondesire WH, Jian W, Zhang H, et al. Targeting mammalian target of sirolimus synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells. Clin Cancer Res 2004;10:7031-7042.
    • (2004) Clin Cancer Res , vol.10 , pp. 7031-7042
    • Mondesire, W.H.1    Jian, W.2    Zhang, H.3
  • 50
    • 36349016185 scopus 로고    scopus 로고
    • Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade
    • Liu JL, Mao Z, LaFortune TA, et al. Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res 2007;67:11054-11063.
    • (2007) Cancer Res , vol.67 , pp. 11054-11063
    • Liu, J.L.1    Mao, Z.2    LaFortune, T.A.3
  • 51
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005; 353:123-132.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 52
    • 32944482803 scopus 로고    scopus 로고
    • Molecular context of the EGFR mutations: Evidence for the activation of mTOR/S6K signaling
    • Conde E, Angulo B, Tang M, et al. Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res 2006;12(3 Pt 1):710-717.
    • (2006) Clin Cancer Res , vol.12 , Issue.3 PART 1 , pp. 710-717
    • Conde, E.1    Angulo, B.2    Tang, M.3
  • 53
    • 33845227643 scopus 로고    scopus 로고
    • Sirolimus synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
    • Buck E, Eyzaguirre A, Brown E, et al. Sirolimus synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 2006;5:2676-2684.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2676-2684
    • Buck, E.1    Eyzaguirre, A.2    Brown, E.3
  • 54
    • 20444445920 scopus 로고    scopus 로고
    • Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/ PTEN/AKT/mammalian target of sirolimus signaling pathway and activation of hypoxia inducible factor-1alpha
    • Phillips RJ, Mestas J, Gharaee-Kermani M, et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/ PTEN/AKT/mammalian target of sirolimus signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem 2005;280:22473-22481.
    • (2005) J Biol Chem , vol.280 , pp. 22473-22481
    • Phillips, R.J.1    Mestas, J.2    Gharaee-Kermani, M.3
  • 55
    • 54949104315 scopus 로고    scopus 로고
    • A phase II study of RAD001 monotherapy in patients with advanced non-small cell lung cancer failing prior platinum-based chemotherapy or prior chemotherapy and EGFR inhibitors [abstract]
    • Papadimitrakopoulou V, Sorda JC, Douillard JY, et al. A phase II study of RAD001 monotherapy in patients with advanced non-small cell lung cancer failing prior platinum-based chemotherapy or prior chemotherapy and EGFR inhibitors [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Papadimitrakopoulou, V.1    Sorda, J.C.2    Douillard, J.Y.3
  • 56
    • 40349115320 scopus 로고    scopus 로고
    • Combined inhibition of mTOR and EGFR with everolimus (RAD001) and gefitinib in patients with non small cell lung cancer who have smoked cigarettes: A phase II trial [abstract]
    • Kris MG, Riely GJ, Azzoli CG, et al. Combined inhibition of mTOR and EGFR with everolimus (RAD001) and gefitinib in patients with non small cell lung cancer who have smoked cigarettes: a phase II trial [abstract]. J Clin Oncol 2007;25(Suppl 1)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Kris, M.G.1    Riely, G.J.2    Azzoli, C.G.3
  • 57
    • 35848959875 scopus 로고    scopus 로고
    • A randomized, phase II trial of two dose levels of temsirolimus in patients with extensive-stage small cell lung cancer who have responding or stable disease after induction chemotherapy. A trial of the Eastern Cooperative Oncology Group (E1 500)
    • Pandya KJ, Dahlberg S, Hidalgo M, et al. A randomized, phase II trial of two dose levels of temsirolimus in patients with extensive-stage small cell lung cancer who have responding or stable disease after induction chemotherapy. A trial of the Eastern Cooperative Oncology Group (E1 500). J Thorac Oncol 2007;2:1036-1041.
    • (2007) J Thorac Oncol , vol.2 , pp. 1036-1041
    • Pandya, K.J.1    Dahlberg, S.2    Hidalgo, M.3
  • 58
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004;351:1502-1512.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    de Wit, R.2    Berry, W.R.3
  • 59
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
    • McMenamin ME, Soung P, Perera S, et al. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999;59:4291-4296.
    • (1999) Cancer Res , vol.59 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3
  • 60
    • 15444349266 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN/ MMAC1 in primary prostate cancer
    • Cairns F, Okami K, Halachmi S, et al. Frequent inactivation of PTEN/ MMAC1 in primary prostate cancer. Cancer Res 1997; 57:4997-5000.
    • (1997) Cancer Res , vol.57 , pp. 4997-5000
    • Cairns, F.1    Okami, K.2    Halachmi, S.3
  • 61
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine kinase phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li Y, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine kinase phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, Y.1    Yen, C.2    Liaw, D.3
  • 62
    • 0031922369 scopus 로고    scopus 로고
    • Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas
    • Wang SI, Parsons R, Ittmann M. Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas. Clin Cancer Res 1998;4:811-815.
    • (1998) Clin Cancer Res , vol.4 , pp. 811-815
    • Wang, S.I.1    Parsons, R.2    Ittmann, M.3
  • 63
    • 4243110417 scopus 로고    scopus 로고
    • PTEN dose dictates cancer progression in the prostate
    • Trotman LC, Niki M, Dotan ZA, et al. PTEN dose dictates cancer progression in the prostate. PloS Biol 2003;1:E59.
    • (2003) PloS Biol , vol.1
    • Trotman, L.C.1    Niki, M.2    Dotan, Z.A.3
  • 64
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007;128:157-170.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3
  • 65
    • 5144228549 scopus 로고    scopus 로고
    • High Levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    • Ayala G, Thompson T, Yang G, et al. High Levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 2004;10:6572-6578.
    • (2004) Clin Cancer Res , vol.10 , pp. 6572-6578
    • Ayala, G.1    Thompson, T.2    Yang, G.3
  • 66
    • 34447133479 scopus 로고    scopus 로고
    • Determining the risk of biochemical recurrent in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation
    • Bedolla R, Prihoda TJ, Kreisberg JI, et al. Determining the risk of biochemical recurrent in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin Cancer Res 2007;13:3860-3867.
    • (2007) Clin Cancer Res , vol.13 , pp. 3860-3867
    • Bedolla, R.1    Prihoda, T.J.2    Kreisberg, J.I.3
  • 67
    • 10744222860 scopus 로고    scopus 로고
    • Prostate specific deletion of the murine PTEN tumor suppressor gene leads to metastatic prostate cancer
    • Wang SI, Gao J, Lei Q, et al. Prostate specific deletion of the murine PTEN tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003;4:209-221.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.I.1    Gao, J.2    Lei, Q.3
  • 68
    • 16844371494 scopus 로고    scopus 로고
    • Effects of the mammalian target of sirolimus inhibitor CC1-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
    • Wu L, Birle DC, Tannock IF. Effects of the mammalian target of sirolimus inhibitor CC1-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Res 2005; 65: 2825-2831.
    • (2005) Cancer Res , vol.65 , pp. 2825-2831
    • Wu, L.1    Birle, D.C.2    Tannock, I.F.3
  • 69
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10:594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 70
    • 19944427667 scopus 로고    scopus 로고
    • Antibody based profiling of the phopshoinositide 3-kinase pathway in clinical prostate cancer
    • Thomas GV, Horvath S, Smith BL, et al. Antibody based profiling of the phopshoinositide 3-kinase pathway in clinical prostate cancer. Clin Cancer Res 2004;10:8351-8356.
    • (2004) Clin Cancer Res , vol.10 , pp. 8351-8356
    • Thomas, G.V.1    Horvath, S.2    Smith, B.L.3
  • 72
    • 54749106713 scopus 로고    scopus 로고
    • A phase II study of RAD001 in men with hormone-refractory metastatic prostate cancer [abstract]
    • Presented at the February 14-16, San Francisco, California
    • George DJ, Armstrong AJ, Creel P, et al. A phase II study of RAD001 in men with hormone-refractory metastatic prostate cancer [abstract]. Presented at the 2008 Genitourinary Cancers Symposium; February 14-16, 2008; San Francisco, California.
    • (2008) 2008 Genitourinary Cancers Symposium
    • George, D.J.1    Armstrong, A.J.2    Creel, P.3


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