Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor α

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1126-1134

  Ng, Valerie Y ^a   Huang, Yong ^a   Reddy, L Manmohan ^b   Falck, John R ^b   Lin, Emil T ^a   Kroetz, Deanna L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; APOLIPOPROTEIN A1; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 2C11; CYTOCHROME P450 4A1; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; FATTY ACID; FIBRIC ACID DERIVATIVE; ICOSANOID; OXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR EFFECT; CATALYSIS; CELL PROLIFERATION; DNA RESPONSIVE ELEMENT; ENZYME DEGRADATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; KIDNEY TUBULE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

8,11,14-EICOSATRIENOIC ACID; ALKANE 1-MONOOXYGENASE; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEIN A-II; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; EPOXIDE HYDROLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; PEROXISOME PROLIFERATORS; PPAR ALPHA; PPAR GAMMA; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; RETINOID X RECEPTORS; RNA, MESSENGER; STEROID 16-ALPHA-HYDROXYLASE; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 34250731775     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013839     Document Type: Article

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