Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8

Archives of Biochemistry and Biophysics

Volumn 441, Issue 2, 2005, Pages 174-181

  Stark, Katarina ^a   Wongsud, Buanus ^a   Burman, Robert ^a   Oliw, Ernst H ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Docosahexaenoic acid; Electrospray ionization; Epoxidation; Fatty acid 2 hydroxylase; Mass spectrometry; Normal phase HPLC; Prostaglandin H; Site directed mutagenesis; side chain hydroxylation

Indexed keywords

15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 4F12; CYTOCHROME P450 4F8; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; PROSTAGLANDIN H 19 HYDROXYLASE; PROSTAGLANDIN H2; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; CYP4F12 PROTEIN, HUMAN; CYP4F8 PROTEIN, HUMAN; GLYCINE; MIXED FUNCTION OXIDASE; OXYGEN; RECOMBINANT PROTEIN; TYROSINE; UNSATURATED FATTY ACID; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYSIS; ELECTROSPRAY; EPOXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MASS SPECTROMETRY; MISSENSE MUTATION; OXYGENATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVATION; GENETICS; METHODOLOGY; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION; PROTEIN BINDING; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYSIS; ENZYME ACTIVATION; FATTY ACIDS, UNSATURATED; GLYCINE; MIXED FUNCTION OXYGENASES; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; OXYGEN; PROTEIN BINDING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 27244455867     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2005.07.003     Document Type: Article

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