Calibration of the channel that determines the ω-hydroxylation regiospecificity of cytochrome P4504A1: Catalytic oxidation of 12-halododecanoic acids

Journal of Biological Chemistry

Volumn 280, Issue 24, 2005, Pages 22697-22705

  He, Xiang ^a   Cryle, Max J ^b   De Voss, James J ^b   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALIBRATION; CARBON; FATTY ACIDS; HYDROXYLATION; OXIDATION; WATER;

INCUBATIONS; OXIDIZING SPECIES; OXOHALONIUM SPECIES; REGIOSPECIFICITY;

PIGMENTS;

12 HALODODECANOIC ACID; 12 HYDROXYLAURIC ACID; 12 OXODODECANOIC ACID; ALDEHYDE; BROMIDE; CARBON; CHLORIDE; CYTOCHROME P450 4A1; HALIDE; IODIDE; LAURIC ACID DERIVATIVE; OXYGEN; UNCLASSIFIED DRUG; WATER;

ARTICLE; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME MECHANISM; FATTY ACID OXIDATION; HUMAN; HYDROLYSIS; HYDROXYLATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STEREOSPECIFICITY;

ALDEHYDES; ANIMALS; BROMINE; CALIBRATION; CARBON; CHLORINE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROLYSIS; HYDROXYLATION; IODINE; KINETICS; LAURIC ACIDS; MASS SPECTROMETRY; MODELS, CHEMICAL; OXYGEN; PROTEIN STRUCTURE, TERTIARY; RATS; SPECTROPHOTOMETRY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TIME FACTORS; ULTRAVIOLET RAYS; WATER;

EID: 20744459030     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502632200     Document Type: Article

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