Stochastic niche structure and diversity maintenance in the T cell repertoire

Journal of Theoretical Biology

Volumn 255, Issue 2, 2008, Pages 237-249

  Stirk, Emily R ^a   Molina París, Carmen ^a   van den Berg, Hugo A ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Birth and death process; Competition; Continuous time Markov chain; Lymphocyte homeostasis; Quasi stationary probability distribution

Indexed keywords

T LYMPHOCYTE RECEPTOR;

CYTOLOGY; IMMUNE RESPONSE; STOCHASTICITY;

ANTIGEN PRESENTING CELL; ARTICLE; CELL STRUCTURE; CELL SURVIVAL; IMMUNE SYSTEM; MOLECULAR CLONING; PRIORITY JOURNAL; STOCHASTIC MODEL; T LYMPHOCYTE; THYMOCYTE;

ANTIBODY DIVERSITY; CELL SURVIVAL; CLONE CELLS; HOMEOSTASIS; HUMANS; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; STOCHASTIC PROCESSES; T-LYMPHOCYTES;

EID: 54249123081     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2008.07.017     Document Type: Article

References (65)

1. Abbas A.K., and Lichtman A.H. Cellular and Molecular Immunology (2005), Elsevier Saunders
2. Acuto O., and Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat. Rev. Immunol. 3 (2003) 939-951
3. Allen L.J.S. An Introduction to Stochastic Processes with Applications to Biology (2003), Prentice-Hall
4. Anderton S.M., and Wraith D.C. Selection and fine-tuning of the autoimmune T cell repertoire. Nat. Rev. Immunol. 2 (2002) 487-498
5. Arstila T.P., Casrouge A., Baron V., Even J., Kanellopoulos J., and Kourilsky P. A direct estimate of the human α β T cell receptor diversity. Science 286 (1999) 958-961
6. Aspinall R., and Andrew D. Thymic involution in aging. J. Clin. Immunol. 20 (2000) 250-256
7. Bain L.J., and Engelhardt M. Introduction to Probability and Mathematical Statistics (2000), Duxbury Press
8. Begon M., Harper J.L., and Townsend C.R. Ecology: Individuals, Populations and Communities (1990), Blackwell Scientific Publication, Oxford, UK
9. Berzins S.P., Boyd R.L., and Miller J.F.A.P. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187 (1998) 1839-1848
10. Borghans J.A.M., and de Boer R.J. Quantification of T-cell dynamics: from telomeres to DNA labeling. Immunol. Rev. 216 (2007) 35-47
11. Boyman O., Purton J.F., Surh C.D., and Sprent J. Cytokines and T cell homeostasis. Curr. Opin. Immunol. 19 (2007) 320-326 10.1016/j.coi.2007.04.015
12. Callard R.E., Stark J., and Yates A.J. Fratricide: a mechanism for T memory-cell homeostasis. Trends Immunol. 24 (2003) 370-375
13. Correia-Neves M., Waltzinger C., Mathis D., and Benoist C. The shaping of the T cell repertoire. Immunity 14 (2001) 21-32 10.1016/S1074-7613(01)00086-3
14. Davenport M.P., Price D.A., and McMichael A.J. The T cell repertoire in infection and vaccination: implications for control of persistent viruses. Curr. Opin. Immunol. 19 (2007) 294-300 10.1016/j.coi.2007.04.001
15. de Boer R.J., and Perelson A.S. T cell repertoires and competitive exclusion. J. Theor. Biol. 169 (1994) 375-390 10.1006/jtbi.1994.1160
16. de Boer R.J., and Perelson A.S. Towards a general function describing T cell proliferation. J. Theor. Biol. 175 (1995) 567-576 10.1006/jtbi.1995.0165
17. de Boer R.J., and Perelson A.S. Competitive control of the self-renewing T cell repertoire. Int. Immunol. 9 (1997) 779-790
18. Dembo A., and Zeitouni O. Large Deviations Techniques and Applications (1998), Springer, New York
19. Dutilh B.E., and de Boer R.J. Decline in excision circles requires homeostatic renewal or homeostatic death of naïve T cells. J. Theor. Biol. 224 (2003) 351-358 10.1016/S0022-5193(03)00172-3
20. Effros R.B., and Pawelec G. Replicative senescence of T cells: does the Hayflick limit lead to immune exhaustion?. Immunol. Today 18 (1997) 450-454
21. Ernst B., Lee D.S., Chang J.M., Sprent J., and Surh C.D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11 (1999) 173-181
22. Ferreira C., Barthlott T., Garcia S., Zamoyska R., and Stockinger B. Differential survival of naïve CD4 and CD8 T cells. J. Immunol. 165 (2000) 3689-3694
23. Fraser C., Ferguson N.M., Wolf F.D., Ghani A.C., Garnett G.P., and Anderson R.M. Antigen-driven T cell turnover. J. Theor. Biol. 219 (2002) 117-192 10.1006/yjtbi.3085
24. Freitas A.A., and Rocha B. Lymphocyte lifespans: homeostasis, selection and competition. Immunol. Today 14 (1993) 25-29
25. Freitas A.A., and Rocha B. Peripheral T cell survival. Curr. Opin. Immunol. 11 (1999) 152-156 10.1016/S0952-7915(99)80026-0
26. Freitas A.A., and Rocha B. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 18 (2000) 83-111
27. + T cells expressing the same or different T cell receptors. Proc. Natl. Acad. Sci. USA 101 (2004) 3041-3046
28. Goldrath A.W., and Bevan M.J. Selecting and maintaining a diverse T cell repertoire. Nature 402 (1999) 255-262
29. + T cells in lymphopenic hosts. Immunity 11 (1999) 183-190
30. Goronzy J.J., and Weyand C.M. T cell development and receptor diversity during aging. Curr. Opin. Immunol. 17 (2005) 468-475 10.1016/j.coi.2005.07.020
31. Goronzy J.J., Lee W.-W., and Weyand C.M. Aging and T cell diversity. Exp. Gerontol. 42 (2007) 400-406 10.1016/j.exger.2006.11.016
32. Grossman Z., and Paul W.E. Autoreactivity, dynamic tuning and selectivity. Curr. Opin. Immunol. 13 (2001) 687-698
33. Hardin G. The competitive exclusion principle. Science 131 (1960) 1292-1297
34. Jameson S.C. Maintaining the norm: T cell homeostasis. Nat. Rev. Immunol. 2 (2002) 547-556
35. + T cell compartment during aging. J. Immunol. 180 (2008) 1499-1507
36. Krangel M.S., Hernandez-Munain C., Lauzurica P., McMurray M., Roberts J.L., and Zhong X.P. Developmental regulation of V(D)J recombination at the TCR α δ locus. Immunol. Rev. 165 (1998) 131-147
37. Kreuwel H.T.C., and Sherman L.A. The T cell repertoire available for recognition of self-antigens. Curr. Opin. Immunol. 13 (2001) 639-643
38. Kubo R., Toda M., and Hashitsume N. Statistical Physics II: Nonequilibrium Statistical Mechanics. second ed. (1991), Springer, Berlin
39. Laugel B., van den Berg H.A., Gostick E., Cole D.K., Wooldridge L., Boulter J., Milicic A., Price D.A., and Sewell A.K. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J. Biol. Chem. 282 (2007) 23799-23810
40. Mahajan V.S., Leskov I.B., and Chen J. Homeostasis of T cell diversity. Cell. Mol. Immunol. 2 (2005) 1-10
41. Marrack P., Bender J., Hildeman D., Jordan M., Mitchell T., Murakami M., Sakamoto A., Schaefer B.C., Swanson B., and Kappler J. Homeostasis of α β TCR+ T cells. Nat. Immunol. 1 (2000) 107-111
42. Mason D. A very high level of crossreactivity is an essential feature of the T cell receptor. Immunol. Today 19 (1998) 395-404 10.1016/S0167-5699(98)01299-7
43. McLean A.R., and Michie C.A. In vivo estimates of division and death rates of human lymphocytes. Proc. Natl. Acad. Sci. USA 92 (1995) 3707-3711
44. Min B., Foucras G., Meier-Schellersheim M., and Paul W.E. Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl. Acad. Sci. USA 101 (2004) 3874-3879
45. Nasell I. Extinction and quasi-stationarity in the Verhulst logistic model. J. Theor. Biol. 211 (2001) 11-27 10.1006/jtbi.2001.2328
46. Park J.-H., Adoro S., Lucas P.J., Sarafova S.D., Alag A.S., Doan L.L., Erman B., Liu X., Ellmeier W., Bosselut R., Feigenbaum L., and Singer A. Coreceptor tuning: cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat. Immunol. 8 (2007) 1049-1059
47. Perillo N.L., Walford R.L., Newman M.A., and Effros R.B. Human T lymphocytes possess a limited in vitro life span. Exp. Gerontol. 24 (1989) 177-187
48. Pianka, E.R., 1976. Competition and niche theory. In: May, R.M. (Ed.). Theoretical Ecology. Principles and Applications, second ed. Blackwell Scientific Publication, Oxford, pp. 114-141.
49. Pollicot M., and Yuri M. Dynamical Systems and Ergodic Theory (1998), Cambridge University Press, Cambridge
50. Seddon B., Tomlinson P., and Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4 (2003) 680-686
51. Stilianakis N.I., and Seydel J. Modeling the T cell dynamics and pathogenesis of HTLV-I infection. Bull. Math. Biol. 61 (1999) 935-947
52. Tanchot C., and Rocha B. The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools. Eur. J. Immunol. 25 (1995) 2127-2136
53. Tanchot C., Rosado M.M., Agenes F., Freitas A.A., and Rocha B. Lymphocyte homeostasis. Semin. Immunol. 9 (1997) 331-337 10.1006/smim.1997.0090
54. Taylor H.M., and Karlin S. An Introduction to Stochastic Modelling. third ed. (1998), Academic Press, New York pp. 380-384
55. van den Berg H.A., and Molina-París C. Thymic presentation of autoantigens and the efficiency of negative selection. J. Theor. Med. 5 (2003) 1-22
56. van den Berg H.A., and Rand D.A. Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy. J. Theor. Biol. 224 (2003) 249-267 10.1016/S0022-5193(03)00162-0
57. van den Berg H.A., and Rand D.A. Dynamics of T cell activation threshold tuning. J. Theor. Biol. 228 (2004) 397-416
58. van den Berg H.A., Rand D.A., and Burroughs N.J. A reliable and safe T cell repertoire based on low-affinity T cell receptors. J. Theor. Biol. 209 (2001) 465-486 10.1006/jtbi.2001.2281
59. van den Berg H.A., Burroughs N.J., and Rand D.A. Quantifying the strength of ligand antagonism in TCR triggering. Bull. Math. Biol. 64 (2002) 781-808
60. van den Berg H.A., Wooldridge L., Laugel B., and Sewell A.K. Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J. Theor. Biol. 249 (2007) 395-408 10.1016/j.jtbi.2007.08.002
61. Vrisekoop N., den Braber I., de Boer A.B., Ruiter A.F.C., Ackermans M.T., van den Crabben S.N., Schrijver E.H.R., Spierenburg G., Sauerwein H.P., Hazenberg M.D., de Boer R.J., Miedema F., Borghans J.A.M., and Tesselaar K. Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool. Proc. Natl. Acad. Sci. USA 105 (2008) 6115-6120
62. Weng N.P., Palmer L.D., Levine B.L., Lane H.C., June C.H., and Hodes R.J. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160 (1997) 43-54
63. Xiao Z., Mescher M.F., and Jameson S.C. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J. Exp. Med. 204 (2007) 2667-2677
64. Yates A.J., and Callard R.E. Cell death and the maintenance of immunological memory. Discrete Continuous Dynamical Syst. B 1 (2001) 43-60
65. Zwanzig R. Nonequilibrium Statistical Mechanics (2001), Oxford University Press, Oxford