Edible vaccinas: A new approach to oral immunization

Indian Journal of Biotechnology

Volumn 7, Issue 3, 2008, Pages 283-294

  Mishra, Neeraj ^a   Gupta, Prem N ^a   Khatri, Kapil ^a   Goyal, Amit K ^a   Vyas, Suresh P ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Autoimmunity; Edible vaccine; Mucosal immunity; Oral immunization; Transgenic plant

Indexed keywords

ANTHRAX VACCINE; CHOLERA VACCINE; EDIBLE VACCINE; ESCHERICHIA COLI ENTEROTOXIN; GLUTAMATE DECARBOXYLASE 67; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; LEUKOTOXIN; MALARIA VACCINE; MEASLES VACCINE; RECOMBINANT MEROZOITE SURFACE PROTEIN 1; RECOMBINANT MEROZOITE SURFACE PROTEIN 4; RECOMBINANT MEROZOITE SURFACE PROTEIN 5; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTHRAX; ANTIBODY RESPONSE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CATTLE DISEASE; CHOLERA; CLINICAL TRIAL; DEVELOPING COUNTRY; DIABETES MELLITUS; DRUG EFFICACY; DRUG RESEARCH; DRUG STORAGE; FOOD INTAKE; GENETIC ENGINEERING; GENETIC TRANSFORMATION; HEPATITIS B; HUMAN; IMMUNIZATION; IMMUNOGENICITY; IMMUNOPHARMACOLOGY; IMMUNOSTIMULATION; MALARIA; MEASLES; MUCOSAL IMMUNITY; NONHUMAN; PATENT; POTATO; PROTEIN SYNTHESIS; REVIEW; RHIZOBIUM RADIOBACTER; TRANSGENIC PLANT; UNSPECIFIED SIDE EFFECT; VACCINE PRODUCTION;

TRANSMISSIBLE GASTROENTERITIS VIRUS;

EID: 54049095231     PISSN: 09725849     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (99)

1. Streatfield S J, Plant based vaccines for animals health, Rev Sci Tech Off Int Epiz, 24 (2005) 189-199.
2. Daniell H, Streatfield S J & Wyckoff K, Medical molecular farming: Production of antibiotics, biopharmaceuticals and edible vaccines in plants, Trends Plant Sci, 6 (2001) 219-226.
3. Mor T S, Gomez-Lim M A & Palmer K E, Edible vaccines: A concept comes of age, Trends Microbiol, 6 (1998) 449-453.
4. Tacket C O & Mason H S, A review of oral vaccination with transgenic vegetables, Microbes Infect, 1 (1999) 777-783.
5. Marsa L, Enhancing the benefits of nature, Omni, 16 (1994) 14.
6. Gidding G, Allison G, Brooks D & Carter A, Transgenic plants as factories for biopharmaceuticals, Nat Biotechnol, 18 (2000) 1151-1155.
7. Conrad U & Fiedler U, Expression of engineered antibodies in plant cells, Plant Mol Biol, 26 (1994) 1023-1050.
8. Webster D E, Thomas D E, Strugnell R A, Dry I B & Wesselingh S L, Appetizing solutions: An edible vaccine for measles, Med J Aust, 176 (2002) 434-437.
9. Hiatt A, Cafferkey R & Bowdish K, Production of antibodies in transgenic plants, Nature (Lond), 342 (1989) 76-78.
10. Mason H S & Arntzen C J, Transgenic plant as vaccine production system, Trends Biotechnol, 13 (1995) 388-392.
11. Mason H S, Lam D M K & Arntzen C J, Expression of hepatitis B surface antigen in transgenic plants, Proct Natl Acad Sci USA, 89 (1992) 11745-11749.
12. Johnson E, Edible Plant Vaccines, Nat Biotechnol, 14 (1996) 1533.
13. Washam C, Biotechnology creating edible vaccine, Ann Iinternal Med, 127 (1997) 499.
14. Yu J & Langride W H, A plant based multicomponent vaccine protects mice from enteric diseases, Nat Biotechnol, 19 (2001) 548-552.
15. Tacket C O, Mason H S, Losonky G, Clements J D, Wasserman S et al, Immunogenicity in human of a recombinant bacterial antigen delivered in transgenic potato, Nat Med, 4 (1998) 607-609.
16. Tacket C O, Mason H S, Losonsky B, Estes M K, Levin M M et al, Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes, J Infect Dis, 182 (2000) 302-305.
17. Yusibev V, Hooper D C, Spitsin S V, Fleysh, N., Kean, R.B et al, Expression implants and immunogenicity of plant virus-based experimental rabies vaccine, Vaccine, 20 (25-26) (2002) 3155-3164.
18. Mason H S, Ball J M, Shi J J, Jiang X, Estes M K et al, Expression of Norwalk virus caspid protein in transgenic tobacco and potato and its oral immunogenicity in mice, Proc Natl Acad Sci USA, 93 (1996) 5335-5340.
19. Hooper D C, Pierard L, Modelska, A, Otvos L J, Fu Z F et al, Rabies ribonucleocapsid as an oral immunogen and immunological enhancer, Proc Natl Acad Sci USA, 91 (1994) 10908-10912.
20. Tuboly T, Yub W, Baileyb A, Degrandisc S, Dub S et al, Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants, Vaccine, 18 (2000) 2023-2028.
21. Streatfield S J, Jilka J M, Hood E E, Turner D D, Bailey M R et al, Plant-based vaccines: Unique advantages, Vaccine, 19 (2001) 2742-2748.
22. Castanon, S, Marin M, Martin-Alonso J, Boga J, Casais R et al, Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus, J Virol, 73 (1999) 4452-4455.
23. http://www.istc.ru
24. Arakawa T, Expression of cholera toxin B subunit oligomers in transgenic potato plants, Transgenic Res, 6 (1997) 403-413.
25. Moss W J, Cutts F & Griffin D E, Implications of human immunodeficiency eradications of measles, Infect Dis, 29 (1999) 106-112.
26. Korban S S, Krasnyanski S F & Buetow D E, Food as production and delivery vehicles for human vaccine, J Am Coll Nutr, 21, 3 Suppl (2002) 2125-2175.
27. Rudzik R, Claney R L, Perey Y E, Day R P & Bienenstock J, Repopulation with IgA-containing cells of bronchial and intestinal lamina propria after transfer of homologous Peyer's patch and bronchial lymphocytes, J Immunol, 144 (1975) 1599.
28. Yuki Y & Kiono H, New generation of mucosal adjuvants for the induction of protective immunity, Rev Med Virol, 13 (2003) 292-310.
29. Mariotti D, Fontana G S & Santini L, Genetic transformation of grain legumes: Phaseolus vutgaris L. and P. coccineus, J Genet Breed, 43 (1989) 77-82.
30. Mercenier A, Wiedermann U & Breiteneder H, Edible genetically modified microorganisms and plants for improved health, Curr Opin Biotechnol, 12 (2001) 510-515.
31. Chikwamba R, Cunnick J, Hathway D, McMuray J, Mason H et al, A functional antigen in a practical crop: LT-B producing maize protects mice against Escherichia coli heat liable enterotoxin (LT) and cholera toxin (CT), Transgenic Res, 11(2002) 479-493.
32. McClean P & Grafton K F, Regeneration of dry bean (Phaseolus vulgaris) via organogenesis, Plant Sci, 60 (1989) 117-119.
33. Franklin C I, Trieu T, Gonazales R A & Dixon R A, Plant regeneration from seeding explants of green bean (Phaseolus vulgaris L.) via organogenesis, Plant Cell Tissue Organ Cult, 24 (1991) 199-206.
34. De la Riva G A, Gonzalez-Cabrera J, Vasquez-Padron R & Ayra-Pardo C, Agrobacterium tumefaciens: a natural tool for plant transformation, Electronic J Biotechnol, 1(1998) 118-132.
35. Lee R W H, Strommer J, Hodgins D, Shewen P E, Niu Y et al, Towards development of an edible vaccine against bovine pneumatic pasteurellosis using transgenic white clover expressing a Mannheimia fusion protein, Infect Immun, 69 (2001) 5786-5793.
36. Taylor N J & Fauquet C M, Microparticle bombardment as a tool in plant science and agricultural biotechnology, DNA Cell Biol, 21 (2002) 963-977.
37. Maliga T, Engineering the plastid genome of higher plants, Curr Opin Plan Biol, 5 (2002) 164-172.
38. Daniell H, Khan M S & Allison L, Milestones in the chloroplast genetic engineering: An environmentally friendly era in biotechnology, Trends Plant Sci, 7 (2) (2002) 84-91.
39. Arntzen C J, Pharmaceutical foodstuff- oral immunization with transgenic plants, Nat Med (Vaccine Supplement), 4 (1998) 502-503.
40. Webster D E, Cooney M L, Huang Z, Drew D R, Ramshaw I A et al, Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine, J Virol, 76 (2002) 7910-7912.
41. Steinberg J, Edible vaccine trial: No small potatoes, NIH Res, 8 (1996) 26.
42. Hassler S, Bananas and biotech consumers, Bio/Technology, 13 (1995) 417.
43. Kapusta J, Modelska A, Figlerowicz M., Pniewski T, Letellier M et al, A plant derived edible vaccine against hepatitis B virus, FASEB J , 13 (1999) 1796-1799.
44. Stoger E, Vaquero C, Torres E, Sack M, Nicholson L et al, Cereal crops as viable production and storage systems for pharmaceutical sc Fv antibodies. Plant Mol Biol, 42 (2000) 583-590.
45. Farran L, Sanchez-Serrano J J, Medina J F, Prieto J & Mingo-Castel A M, Targeted expression of human serum albumin to potato tubers, Transgenic Res, 11 (2002) 337-346.
46. Yu J & Langridge W, Expression of rotavirus capsid protein VP6 in transgenic potato and its oral immunogenicity in mice, Transgenic Res, 12 (2003) 163-169.
47. Biemelt S, Sonnewold U, Gaimbacher P, Willmitzer L & Muller M, Production of human papillomavius type 16 viral- like particle in transgenic plants, J Virol, 77 (2003) 9211-9220.
48. Ohya L, Itchod N, Ohashi K, Onema M, Sugimoto C et al, Expression of biologically- active human tumour necrosis factor- α in transgenic potato plant, J Interferon Cytokine Res, 22 (2002) 371-378.
49. Dewilde C, Peeters K, Jacobs A, Peck L & Depicker A, Expression of antibodies and Fab fragments in transgenic potato plants: A case study for bulk production in crop plants, Mol Breed, 9 (2002) 271-282.
50. Arakawa T, Chong D K X & Langridge W H R, Efficacy of a food plant- based oral cholera toxin- B subunit vaccine, Nat Biotechnol, 16 (1998) 292-297.
51. Lauterslager T G, Stok W & Hilgers, L A, Improvement of the systemic prime/oral boost strategy for systemic and local response, Vaccine, 21 (2003) 1391-1399.
52. Ma J K C, Hiatt A, Hein M, Vine N D, Wang F et al, Generation and assembly of secretory antibodies in plants, Sciences, 268 (1995) 716-719.
53. Ma J K C, Hikmat B Y, Wycoff K, Vine N D, Chargelegue, D et al, Characterization of recombinant plant monoclonal secretory antibodies in preventive immunotherapy in human, Nat Med, 4 (1998) 601-606.
54. McGarvey P B, Hammond J, Dienelt, M M, Hooper D C, Fu Z F et al, Expression of rabies virus glycoprotein in transgenic Tomatoes, Bio/ Technology, 134 (1995) 1484-1487.
55. Wu Y Z, Li J T, Mou Z R, Fei L, Ni B, et al, Oral immunization with rotavirus VP7 expressed in transgenic potatoes induced high titres of mucosal neutralizing IgA, Virology, 313 (2003) 337-342.
56. Karaman S, Cunnick J & Wang K, Analysis of immune response in young and aged mice vaccinated with corn-derived antigen Escherichia coli heat labile enterotoxin, Mol Biotechnol, 32 (2006) 31-42.
57. Ma Y, Lin S, Gao Y, Li M, Zhang J et al, Expression of ORF2 partial gene of hepatitis E virus in tomatoes and immunoactivity of expressed product, World J Gastroenterorol, 9 (2003) 2211-2215.
58. Mason H S, Haq F A, Clement J D & Arntzen C J, Edible vaccine protects mice against Escherichia Coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene, Vaccine, 16 (1998) 1336-1343.
59. Azhar Aziz M, Singh S, Anand Kumar P & Bhatnagar R, Expression of protective antigen in transgenic plants: A step towards edible vaccine against anthrax, Biochem Biophy Res Cummun, 299 (2002) 345-351.
60. Fuhrmann M, Production of antigens in Chlamyclomonas reinhardtii: green microalgae as a novel source of recombinant proteins, Methods Mol Med, 94 (2004) 191-195.
61. Warzecha H, Mason H S, Lane C, Tryggvesson A, Rybicki E et al, Oral immunogenicity of human Papillomavirus-like particles expressed in potato, J Virol, 77 (2003) 8702-8711.
62. Lightwlers M V, Vaccines for prevention of custicerosis, Acta Trop, 87 (2003) 129-135.
63. Tregoning J, Maliga P, Dougan G & Nixon P J, New advances in the production of edible plant vaccine: Chloroplast expression of tetanus vaccine antigen, Tet C, Photochemistry, 65 (2004) 989-994.
64. www.niaid.nih.gov
65. Blanas E, Carbone F R, Allison J, Miller J F & Heath W R, Induction of autoimmune diabetes by oral administration of auto antigen, Science, 274(5293) (1996) 1707-1709.
66. Carrillo C, Wigdorovitz A, Oliveros J K, Zamorano P I, Sadir A M et al, Protective immune response to foot and mouse disease virus with VP1 expressed in transgenic plants, J Virol, 72 (1998) 1685-1690.
67. Wigdorovitz A, Carrillo M, Dus Santos M, Trono K, Peralta A et al, Induction of a protective antibody response to foot and mouth disease in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1, Virology, 255 (1999) 347-353.
68. Wang L, Goschnick M W & Coppel R L, Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge, Infect Immunol, 72 (2004) 6172-6175.
69. Arakawa T, Yu J, Chong D K, Hough J, Engen P C et al, A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes, Nat Biotechnol, 16 (1998) 934-938.
70. Centers for disease control and prevention, Global measles control and regional elimination, MMWR Morb Mortal Wkly Rep, 48 (1999) 1124-1130.
71. Cutts F, Henao- Restrepo A M & Olive J, Measles elimination: Progress and challenges, Vaccine, 17 S 47 (1999) 52.
72. Osterhaus A, Van Amerongen G & Van Binnendijk R, Vaccine strategies to overcome maternal antibody mediated inhibition of measles vaccine, Vaccine, 16 (1998) 1479-1481.
73. Huang Z, Dry I & Webster D, Plant derived measles virus haemaagglutinn protein induces neutralizing antibodies in mice, Vaccine, 19 (2001) 2163-2171.
74. Polack F P, Auwaerter P G & Lee S H, Production atypical measles in rhesus macaques: Evidence for diseases mediated by immune complex formation and eosinophillis in the presence of fusion inhibiting antibody, Nat Med, 5 (1999) 629-634.
75. Ishiwada N, Addae M M & Tetteh J K, vaccine modified measles in previously immunized children in Accra, Ghana: clinical, virological and serological parameters, Trop Med. Int. Health, 6 (2001) 694-698.
76. Varsanyi T M, Morein B, Love A & Norrby E, Protection against lethal measles virus infection in mice by immune stimulating complexes containing the haemagglutinn or fusion protein, J Virol, 61 (1967) 3896-3901.
77. Lee R W H, Strommer J, Hodgins D, Shewan P E, Niu U et al, Towards development of an edible vaccine against Bovine Pneumonic Pasteurellosis using transgenic white clones expressing a Mannheimia haemolytica A, Leukotoxin 50 fusion protein, Infect Immun, 69 (2001) 5786-5793.
78. Marquet- Blouin E, Bouche F B, Steinmetz A & Muller, C.P., Neutralizing immunogenicity of transgenic carrot (Daucus Carota L) -derived measles virus haemagglutinn, Plant Mol. Biol., 51 (2003) 458-469.
79. Domansky N, Organ-specific expression of hepatitis B surface antigen in potato, Biotechnol Lett, 17 (1995) 863-866.
80. Richter L J, Thanavala Y, Arntzen C J & Mason H S, Production of hepatitis B surface antigen in transgenic plants for oral immunization, Nat Biotechnol, 18 (2000) 1167-1171.
81. Travis J, Scientists harvest antibodies from plants, Science News, 5 (1998) 359.
82. Leben M, Johansson S, Osek J, Lindblad M & Holmgren J, Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines, Bio/Technology, 11 (1993) 1574-1578.
83. Richter L, Mason H S & Arntzen C J, Transgenic plants created for oral immunization against diarrhoeal diseases, J Travel Med, 3 (1996) 52-56.
84. Ma S-W, Zhao D L, Yin Z Q, Mukherjee R, Singh B et al, Transgenic plants expressing auto antigens fed to mice to induce oral immune tolerance, Nat Med, 3 (1997) 793-796.
85. Ball J M, Graham D Y, Opekum A R, Gilger M A, Guerrero R A et al, Recombinant Norwalk virus-like particles given orally to volunteers: Phase I study, Gastroenterology, 117 (1999) 40-48.
86. Haq T A, Mason H S, Clements J D & Arntzen C J, Oral immunization with a recombinant bacterial antigen produced transgenic plants, Science, 268 (1995) 714-716.
87. Kong Q, Richter I, Yang Y F, Arntzen C J, Mason H S et al, Oral immunization with hepatitis B surface antigen expressed in transgenic plants, Proc Natl Acad Sci USA, 98 (2002) 11539-11544.
88. Torres E, Vaquero C, Nicholson L, Sack M, Stoger E et al, Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies, Transgenic Res, 8 (1999) 441-449.
89. Vaquero C, Sack M, Chandler J, Drossard J, Schuster F et al, Transient expression of a tumour-specific single-chain fragment and a chimeric antibody in tobacco leaves, Proc Natl Acad Sci U S, 96 (1999) 11128-11133.
90. McCormick A, Kumagai M, Hanley K, Turpen T, Hakim I et al, Rapid production of specific vaccines for lymphoma by expression of the tumour-derived single-chain Fv epitopes in tobacco plants. Proc Natl Acad Sci U S A, 96 (1999) 703-708.
91. Verch T, Yusibov V & Koprowski H, Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector, J Immunol Methods, 220 (1998) 69-75.
92. Zeitlin L, Olmsted S S, Monech T R, Co M S, Martinell B J et al, A humanized monoclonal antibody produced in transgenic plants for immunoprotection against genital herpes, Nat Biotechnol, 16 (1998) 1361-1364.
93. Khoudi H, Laberge S, Ferullo J, Bazin R, Darveau A et al, Production of a diagnostic monoclonal antibody in perennial alfalfa plants, Biotechnol Bioeng, 64 (1999) 135-143.
94. www.prodigene.com
95. Toonen J, Seeds of a new medicine, Biotechnology and Development Monitor No.27, (1996) 12-14.
96. Wilkins T, Edible vaccines I will take mine with a grain of salt, Biotech Times, 5 (1999) 2.
97. WHO and UNICEF (1996), The state of the world's vaccines and immunization, http://www.unicef.org/newsline/vpressr.htm.
98. A Pollack, Ventures aim to put farms in pharmaceutical vanguard, The New York Times, May 14 (2000).
99. Glennerster & Kremer M, A world bank vaccine commitment, Policy Brief, No.57, May 2000.