Edible genetically modified microorganisms and plants for improved health

Current Opinion in Biotechnology

Volumn 12, Issue 5, 2001, Pages 510-515

  Mercenier, Annick ^a   Wiedermann, Ursula ^b   Breiteneder, Heimo ^b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; HEPATITIS B SURFACE ANTIGEN; VACCINE; VIRUS ANTIGEN;

BIOTECHNOLOGY; DNA MODIFICATION; ESCHERICHIA COLI; FOOD CONTROL; FOOD INDUSTRY; HUMAN; IMMUNOMODULATION; LACTIC ACID BACTERIUM; MICROORGANISM; NONHUMAN; PLANT; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; VIBRIO CHOLERAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; RESPIRATORY SYNCYTIAL VIRUS; VIBRIO CHOLERAE;

EID: 0035476709     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(00)00255-X     Document Type: Review

References (48)

1. Immunomodulators and delivery systems for vaccination by mucosal routes
2. Oral tolerance and regulation of immunity to dietary antigens
3. Oral tolerance in disease
4. Oral tolerance, an active immunological process mediated by multiple mechanisms
5. A review of oral vaccination with transgenic vegetables
6. Lactic acid bacteria as live vaccines
7. Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
8. Immunization against rabies with plant-derived antigen
9. Expression of hepatitis B surface antigen in transgenic plants
10. Immunogenicity of transgenic plant-derived hepatitis B surface antigen
11. A plant-derived edible vaccine against hepatitis B virus
12. Regulation of house dust mite responses by intranasally applied peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo
13. Production of hepatitis surface antigen in transgenic plants for oral immunization
14. Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
15. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
16. Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response
17. Oral immunization with a recombinant bacterial antigen produced in transgenic plants
18. Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene
19. Efficacy of a food plant-based oral cholera toxin B subunit vaccine
20. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato
21. Enteric vaccines in present and future
22. Double-blind, randomized, placebo controlled pilot study evaluating the efficacy and reactogenicity of an oral ETEC-B subunit inactivated whole cell vaccine against travellers' diarrhea
23. Immune modulation by the cholera-like enterotoxins: From adjuvant to therapeutic
24. Mucosal vaccines: Non-toxic derivatives of LT and CT as mucosal adjuvants
25. Antigen delivery systems: New approaches to mucosal immunization
26. Mucosal immunization with recombinant Lactococcus lactis
27. Development of non-pathogenic Staphylococci as vaccine delivery vehicles
28. Lactic acid bacteria as antigen delivery vehicles for oral immunisation purposes
29. Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization
30. Lactic acid bacteria as vaccine delivery vehicles
31. Recombinant Gram-positive bacteria as vehicles of vaccine antigens
32. Recombinant Streptococcus gordonii as a live vehicle for vaccine antigens
33. Oral vaccination of mice against tetanus with recombinant Lactococcus lactis
34. Vaginal immunization of cynomolgus monkeys (Macaca fascicularis) with Streptococcus gordonii expressing HIV-1 and HPV-16 antigens
35. Commensal bacteria as vectors for mucosal vaccines against sexually transmitted diseases: Vaginal colonisation with recombinant streptococci induces local and systemic antibodies in mice
36. Immunisation of mice against tetanus toxin with fragments of tetanus toxin synthesised in Escherichia coli
37. Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains
38. Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum
39. Engineering the microflora to vaccinate the mucosa: Serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli
40. Immunogenicity of the B monomer of Escherichia coli heat-labile toxin expressed on the surface of Streptococcus gordonii
41. Vaginal immunisation with recombinant Gram-positive bacteria
42. Mucosal delivery of murine interkeukin-2 (IL-2) and IL-6 by recombinant strains of Lactococcus lactis coexpressing antigen and cytokine
43. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
44. Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria
45. Instruments for oral disease-intervention strategies: Recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral tolerance induction in multiple sclerosis
46. Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways