Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene

Vaccine

Volumn 16, Issue 13, 1998, Pages 1336-1343

  Mason, Hugh S ^a   Tariq A, Haq ^b,c   Clements, John D ^d   Arntzen, Charles J ^a  

^a United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^b Texas A and M Institute for Biosciences and Technology   (United States)

^c Alpha Diagnostics International Inc   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diarrhoeal disease; E. coli; Enterotoxin LT B; Mouse; Plant vaccine; Potato

Indexed keywords

BACTERIAL VACCINE; ESCHERICHIA COLI ENTEROTOXIN; GANGLIOSIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL IMMUNITY; CARCASS; CONTROLLED STUDY; ESCHERICHIA COLI; FECES LEVEL; GENE EXPRESSION; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; INTESTINE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLANT GROWTH; POTATO; PRIORITY JOURNAL; TRANSGENIC PLANT; VACCINATION;

EID: 0032146489     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)80020-0     Document Type: Article

References (20)

1. 1 Sixma, T.K., Pronk, S.E. and Kalk, K.H. et al. Crystal structure of cholera toxin-related heat-labile enterotoxin from E. coli. Nature 1991, 351, 371-377.
2. 2 Clemens, J.D., Sack, D.A. and Harris, J.R. et al. Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up. Lancet 1990, 335, 270-273.
3. 3 Clemens, J.D., van Loon, F. and Sack, D.A. et al. Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera. J. Infect. Dis. 1991, 163, 1235-1242.
4. 4 Lebens, M., Johansson, S., Osek, J., Lindblad, M. and Holmgren, J. Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines. Bio/Technology 1993, 11, 1574-1578.
5. 5 Schonberger, O., Hirst, T.R. and Pines, O. Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae. Mol. Microbiol. 1991, 5, 2663-2671.
6. 6 Arntzen C.J. and Mason, H.S. Oral vaccine production in the edible tissues of transgenic plants. In: New Generation Vaccines, Second Edition (Eds Levine, M.M., Woodrow, G.C., Kaper, J.B. and Cobon, G.S.). Marcel Dekker, New York, 1997, pp. 263-277.
7. 7 Haq, T.A., Mason, H.S., Clements, J.D. and Arntzen, C.J. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 1995, 268, 714-716.
8. 8 Clements, J.D. and el-Morshidy, S. Construction of a potential live oral bivalnet vaccine for typhoid and cholera-Escherichia coli-related diarrheas. Infect. Immun. 1984, 46, 564-569.
9. 9 Wada, K., Aota, S., Tsuchiya, R., Ishibashi, F., Gojobori, T. and Ikemura, T. Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res. 1990, 18, (Suppl.), 2367-2411.
10. 10 Perlak, F.J., Fuchs, R.L., Dean, D.A., McPherson, S.L. and Fischhoff, D.A. Modification of the coding sequence enhances plant expression of insect control proteins. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 3324-3328.
11. 11 Adang, M.J., Brody, M.S. and Cardineau, G. et al. The reconstruction and expression of a Bacillus thruingiensis cryIIIA gene in protoplasts and potato plants. Plant Mol. Biol. 1993, 21, 1131-1145.
12. 12 Newman, T.C., Ohme-Takagi, M., Taylor, C.B. and Green, P.J. DST sequences, highly conserved among plant SAUR genes, target reporter transcripts for rapid decay in tobacco. Plant Cell 1993, 5, 701-714.
13. 13 Wenzler, H., Mignery, G., May, G. and Park, W. A rapid and efficient transformation method for the production of large numbers of trangenic potato plants. Plant Sci. 1989, 63, 79-85.
14. 14 Mason, H.S., Lam, D.M.K. and Arntzen, C.J. Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 11745-11749.
15. 15 Dickinson, B.L. and Clements, J.D. Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect Immun. 1995, 63, 1617-1623.
16. 16 Guidry, J.J., Cardenas, L., Cheng, E. and Clements, J.D. Role of receptor binding in toxicity, immunogenicity and adjuvanticity of Escherichia coli heat-labile enterotoxin. Infect. Immun. 1997, 65, 4943-4950.
17. 17 Richardson, S.H., Giles, J.C. and Kriger, K.S. Sealed adult mice: a new model for enterotoxin evaluation. Infect. Immun. 1984, 43, 482-486.
18. 18 Hirst, T.R. Biogenesis of cholera toxin and related oligomeric enterotoxins. In: Handbook of Natural Toxins, volume 8: Bacterial Toxins and Virulence Factors in Disease (Eds Moss, J., Iglewski, B., Vaughan, M. and Tu, A.T.). Marcel Dekker, New York, 1995, pp. 123-184.
19. 19 Hein, M.B., Yeo, T.-C., Wang, F. and Sturtevant, A. Expression of cholera toxin subunits in plants. Ann. N.Y. Acad. Sci. 1996, 792, 50-56.
20. 20 Arakawa, T., Chong, D.K.X. and Langridge, W.H.R. Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nature Biotech. 1998, 16, 292-297.