How host-bacterial interactions lead to IgA synthesis in the gut

Trends in Immunology

Volumn 29, Issue 11, 2008, Pages 523-531

  Suzuki, Keiichiro ^a   Fagarasan, Sidonia ^a  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

B LYMPHOCYTE; BACTERIUM; BIOLOGY; CELL LINE; CELL MIGRATION; COMPREHENSION; GERMINAL CENTER; HOMEOSTASIS; HOST; IMMUNE SYSTEM; IMMUNOGLOBULIN PRODUCTION; INTESTINE; INTESTINE LYMPHATIC TISSUE; INTROSPECTION; LYMPH FOLLICLE; MICROBIAL COMMUNITY; NONHUMAN; PERITONEUM CELL; PEYER PATCH; REGULATORY MECHANISM; REVIEW;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BACTERIA; CELL MOVEMENT; GASTROINTESTINAL TRACT; HUMANS; IMMUNOGLOBULIN A; LYMPHOID TISSUE;

EID: 53849124658     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2008.08.001     Document Type: Review

References (70)

1. Sonnenburg J.L., et al. Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?. Nat. Immunol. 5 (2004) 569-573
2. Turnbaugh P.J., et al. The human microbiome project. Nature 449 (2007) 804-810
3. Rakoff-Nahoum S., et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
4. Salzman N.H., et al. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin. Immunol. 19 (2007) 70-83
5. Brandl K., et al. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J. Exp. Med. 204 (2007) 1891-1900
6. Macpherson A.J., et al. The immune geography of IgA induction and function. Mucosal Immunol. 1 (2008) 11-22
7. Nishikawa S., et al. Organogenesis of peripheral lymphoid organs. Immunol. Rev. 195 (2003) 72-80
8. Randall T.D., et al. Development of secondary lymphoid organs. Annu. Rev. Immunol. 26 (2008) 627-650
9. Hamada H., et al. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J. Immunol. 168 (2002) 57-64
10. Veiga-Fernandes H., et al. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446 (2007) 547-551
11. Yokota Y., et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397 (1999) 702-706
12. Eberl G., et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5 (2004) 64-73
13. Yoshida H., et al. Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches. Immunity 17 (2002) 823-833
14. Ansel K.M., et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406 (2000) 309-314
15. Finke D., et al. CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5. Immunity 17 (2002) 363-373
16. Kanamori Y., et al. Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J. Exp. Med. 184 (1996) 1449-1459
17. Pabst O., et al. Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes. Eur. J. Immunol. 35 (2005) 98-107
18. Eberl G., and Littman D.R. Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305 (2004) 248-251
19. McDonald K.G., et al. CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. Am. J. Pathol. 170 (2007) 1229-1240
20. Naito T., et al. RORgamma(t) is dispensable for the development of intestinal mucosal T cells. Mucosal Immunol. 1 (2008) 198-207
21. Taylor R.T., et al. Lymphotoxin-independent expression of TNF-related activation-induced cytokine by stromal cells in cryptopatches, isolated lymphoid follicles, and Peyer's patches. J. Immunol. 178 (2007) 5659-5667
22. Tsuji M., et al. Requirement for adult RORgammat+LTi cells in formation of isolated lymphoid follicles and T-independent generation of IgA in the gut. Immunity 29 (2008) 261-271
23. Lorenz R.G., et al. Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function. J. Immunol. 170 (2003) 5475-5482
24. Suzuki K., et al. Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2482-2486
25. Fagarasan S., et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298 (2002) 1424-1427
26. King C., et al. T follicular helper (T(FH)) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26 (2008) 471-766
27. Casola S., et al. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5 (2004) 317-327
28. Cebra J.J. Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 69 (1999) 1046S-1051S
29. Muramatsu M., et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
30. Tsuji M., et al. Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis. Semin. Immunol. 20 (2008) 59-66
31. Macpherson A.J., et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288 (2000) 2222-2226
32. Allen C.D., et al. Imaging of germinal center selection events during affinity maturation. Science 315 (2007) 528-531
33. Hardtke S., et al. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106 (2005) 1924-1931
34. Haynes N.M., et al. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179 (2007) 5099-5108
35. Meyer-Bahlburg A., et al. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J. Exp. Med. 204 (2007) 3095-3101
36. Kadaoui K.A., and Corthesy B. Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer's patches with restriction to mucosal compartment. J. Immunol. 179 (2007) 7751-7757
37. Neutra M.R., et al. Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 14 (1996) 275-300
38. Macpherson A.J., and Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303 (2004) 1662-1665
39. Strober W., et al. IgA B cell development. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn Vol.1 (2005), Academic Press 583-616
40. Sato A., et al. CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J. Immunol. 171 (2003) 3684-3690
41. Iwasaki A., and Kelsall B.L. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190 (1999) 229-239
42. Mora J.R., et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314 (2006) 1157-1160
43. Martinoli C., et al. Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity 27 (2007) 975-984
44. Halle S., et al. Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar Typhimurium. Infect. Immun. 75 (2007) 1577-1585
45. Tezuka H., et al. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448 (2007) 929-933
46. Litinskiy M.B., et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3 (2002) 822-829
47. He B., et al. Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26 (2007) 812-826
48. Fagarasan S., et al. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 413 (2001) 639-643
49. Shikina T., et al. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J. Immunol. 172 (2004) 6259-6264
50. Boursier L., et al. Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria. Gastroenterology 128 (2005) 1879-1889
51. Bergqvist P., et al. Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers. J. Immunol. 177 (2006) 7772-7783
52. Crouch E.E., et al. Regulation of AID expression in the immune response. J. Exp. Med. 204 (2007) 1145-1156
53. Jang M.H., et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6110-6115
54. Vallon-Eberhard A., et al. Transepithelial pathogen uptake into the small intestinal lamina propria. J. Immunol. 176 (2006) 2465-2469
55. Rescigno M., et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2 (2001) 361-367
56. Niess J.H., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 (2005) 254-258
57. Iwata M., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21 (2004) 527-538
58. Gohda M., et al. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J. Immunol. 180 (2008) 5335-5343
59. Feng N., et al. Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. J. Immunol. 176 (2006) 5749-5759
60. Kang H.S., et al. Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat. Immunol. 3 (2002) 576-582
61. Ha S.A., et al. Regulation of B1 cell migration by signals through Toll-like receptors. J. Exp. Med. 203 (2006) 2541-2550
62. Berberich S., et al. The peritoneal micromilieu commits B cells to home to body cavities and the small intestine. Blood 109 (2007) 4627-4634
63. Brandtzaeg P. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25 (2007) 5467-5484
64. Harris N.L., et al. Mechanisms of neonatal mucosal antibody protection. J. Immunol. 177 (2006) 6256-6262
65. Rey J., et al. Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells. J. Immunol. 172 (2004) 3026-3033
66. Suzuki K., et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 1981-1986
67. Peterson D.A., et al. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2 (2007) 328-339
68. Macpherson A.J., et al. IgA production without mu or delta chain expression in developing B cells. Nat. Immunol. 2 (2001) 625-631
69. Velazquez P., et al. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J. Immunol. 180 (2008) 4629-4638
70. Martin F., and Kearney J.F. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13 (2001) 195-201