Transient enhanced expression of Cdk5 activator p25 after acute and chronic d-amphetamine administration

Annals of the New York Academy of Sciences

Volumn 1139, Issue , 2008, Pages 89-102

  Mlewski, Estela Cecilia ^a   Krapacher, Favio Ariel ^a   Ferreras, Soledad ^a   Paglini, Gabriela ^a  

^a INSTITUTO DE INVESTIGACIÓN MÉDICA MERCEDES Y MARTÍN FERREYRA   (Argentina)

Author keywords

Amphetamine; cdk5; cdk5 activity; Locomotor activity; P Pak1 pThr212 ; p25; p35; Pak1; Periadolescent; Sensitization; Striatum; Synaptic plasticity; Synaptosomes

Indexed keywords

CALPAIN; CYCLIN DEPENDENT KINASE 5; DEXAMPHETAMINE; P21 ACTIVATED KINASE 1; PROTEIN P25; TRANSCRIPTION FACTOR FOSB;

ADOLESCENT; ANIMAL EXPERIMENT; BEHAVIOR; CHRONIC DRUG ADMINISTRATION; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC TRANSMISSION; DRUG DEPENDENCE; ENZYME ACTIVATION; ENZYME ACTIVITY; MALE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SENSITIZATION; SYNAPTOSOME;

RATTUS;

EID: 53549122253     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1432.039     Document Type: Conference Paper

References (61)

1. Kalivas, P.W. et al. 1993. The pharmacology and neural circuitry of sensitization to psychostimulants. Behav. Pharmacol. 4 : 315 334.
2. Spear L.P. 2000. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 24 : 417 463.
3. Chen, J. et al. 1995. Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments. Mol. Pharmacol. 48 : 880 889.
4. Kelz, M.B. et al. 1999. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401 : 272 276.
5. Nestler, E.J. 2001. Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2 : 119 128.
6. Mc Clung, C.A & Nestler, E.J. 2003. Regulation of gene expression and cocaine reward by CREB and Delta FosB. Nat. Neurosci. 6 : 1208 1215.
7. Ehrlich, M.E. et al. 2002. Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. J. Neurosci. 22 : 9155 9159.
8. Bibb, J.A. et al. 2001. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410 : 376 380.
9. Kumar, A. et al. 2005. Chromatin remodelling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48 : 303 314.
10. Ishiguro, K. et al. 1994. Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. FEBS Lett. 342 : 203 208.
11. LEW, J. et al. 1994. A brain-specific activator of cyclin-dependent kinase 5. Nature 371 : 423 426.
12. Tsai, L.H. et al. 1994. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371 : 419 423.
13. Tang, D. et al. 1995. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J. Biol. Chem. 270 : 26897 26903.
14. Nikolic, M. et al. 1996. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev. 10 : 816 825.
15. Ohshima, T. et al. 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA 93 : 11173 11178.
16. Chae, T. et al. 1997. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18 : 29 42.
17. Paglini, G. et al. 1998. Evidence for the participation of the neuron specific cdk5 activator, p35 during laminin enhanced axonal growth. J. Neurosci. 18 : 9858 9869.
18. Ratner, N. et al. 1998. A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein. J. Neurosci. 18 : 7717 7726.
19. Kwon, Y.T. & L.H. Tsai. 1998. A novel disruption of cortical development in p35(-/-) mice distinct from reeler. J. Comp. Neurol. 395 : 510 522.
20. Ohshima, T. et al. 1999. Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J. Neurosci. 19 : 6017 6026.
21. Kwon, Y.T. et al. 1999. Callosal axon guidance defects in p35 (-/-) mice. J. Comp. Neurol. 415 : 218 229.
22. Paglini, G. et al. 2001. The CDK5/p35 kinase associates with the Golgi apparatus and regulates membrane traffic. EMBO Rep. 2 : 1139 1144.
23. Paglini, G. & A. Caceres. 2001. The role of the Cdk5-p35 kinase in neuronal development. Eur. J. Biochem. 268 : 1528 1533.
24. Smith D.S & L.H. Tsai. 2002. Cdk5 behind the wheel: a role in trafficking and transport? Trends Cell Biol. 12 : 28 36.
25. Chergui, K. et al. 2004. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc. Natl. Acad. Sci. USA 101 : 2191 2196.
26. Bibb, J.A. et al. 1999. Phosphorylation of DARPP-32 by cdk5 modulates dopamine signaling in neurons. Nature 402 : 669 671.
27. Kusakawa, G. et al. 2000. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J. Biol. Chem. 275 : 17166 17172.
28. LEE, M.S. et al. 2000. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405 : 360 364.
29. Nath, R. et al. 2000. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. Biochem. Biophys. Res. Commun. 274 : 16 21.
30. Ahlijanian, M.K. et al. 2000. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc. Natl. Acad. Sci. USA 97 : 2910 2915.
31. Bian, F. et al. 2002. Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. J. Comp. Neurol. 446 : 257 66.
32. Patrick, G.N. et al. 1999. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402 : 615 622.
33. Patrick, G.N. et al. 1998. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 273 : 24057 24064.
34. De Camilli, P. et al. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J. Cell Biol. 96 : 1355 1373.
35. Benavidez, E. & A. Arce. 2002. Effects of phosphorylation and cytoskeleton-affecting reagents on GABA A receptor recruitment into synaptosomes following acute stress. Pharmacol. Biochem. Behav. 72 : 497 506.
36. Pigino, G. et al. 1997. Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. J. Cell Sci. 110 : 257 270.
37. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 : 680 685.
38. Dhavan, R. & L.H. Tsai. 2001. A decade of CDK5. Nat. Rev. Mol. Cell. Biol. 2 : 749 759.
39. Navone, F. et al. 1986. Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J. Cell Biol. 103 : 2511 2527.
40. Hunt, C.A. et al. 1996. PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses. J. Neurosci. 16 : 1380 1388.
41. Fischer, A. et al. 2005. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48 : 825 38.
42. Rashid, T. et al. 2001. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J. Biol. Chem. 276 : 49043 49052.
43. Hayashi, M.L. et al. 2004. Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42 : 773 787.
44. Zhang, H. et al. 2005. A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J. Neurosci. 25 : 3379 3388.
45. Sananbenesi, F. et al. 2007. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat. Neurosci. 10 : 1012 1019.
46. Fischer, A. et al. 2002. Cyclin-dependent kinase 5 is required for associative learning. J. Neurosci. 22 : 3700 3707.
47. Angelo, M. et al. 2006. Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J. Neurochem. 99 : 353 370.
48. Hope, B.T. et al. 1994. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13 : 1235 1244.
49. Kelz, M.B. & E.J. Nestler. 2000. ΔFosB: a molecular switch underlying long-term neural plasticity. Curr. Opin. Neurol. 13 : 715 720.
50. Takahashi, S. et al. 2005. Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc. Natl Acad. Sci. USA 102 : 1737 1742.
51. Chen, P.C & J.C. Chen. 2005. Enhanced Cdk5 Activity and p35 Translocation in the ventral striatum of acute and chronic methamphetamine- treated rats. Neuropsychopharmacology 30 : 538 549.
52. Cruz, J.C. et al. 2003. Aberrant cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40 : 471 483.
53. Giese, K.P. et al. 2005. Is there a role of the cyclin dependent kinase 5 activator p25 in Alzheimer's disease? NeuroReport 16 : 1725 1730.
54. Taylor, J.R. et al. 2007. Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proc. Natl. Acad. Sci. USA 104 : 4147 4152.
55. Hyman, S.E. & R.C. Malenka. 2001. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat. Rev. Neurosci. 2 : 695 703.
56. Robinson, T.E. & B. Kolb. 1999. Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur. J. Neurosci. 11 : 1598 1604.
57. Robinson, T.E. et al. 2001. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse 39 : 257 266.
58. Li, Y. et al. 2003. The location of persistent amphetamine induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen. Neuropsychopharmacology 28 : 1082 1085.
59. Robinson, T.E. & Kolb, B. 2004. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47 : 33 46.
60. Norrholm, S.D. et al. 2003. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience 116 : 19 22.
61. Nikolic, M. et al. 1998. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 395 : 194 198.