2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 6165-6172

  Ferguson, Gemma N ^a   Valant, Celine ^a,b   Horne, James ^a   Figler, Heidi ^c   Flynn, Bernard L ^a   Linden, Joel ^c   Chalmers, David K ^a   Sexton, Patrick M ^a,b   Christopoulos, Arthur ^b,c   Scammells, Peter J ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 3 (4 TERT BUTYLPHENYL) 4 OXO 3,4 DIHYDROTHIENO[3,4 D]PYRIDAZINE 1 CARBOXYLATE; ADENOSINE A1 RECEPTOR ANTAGONIST; ETHYL 5 AMINO 3 (3 CHLOROPHENYL) 4 OXO 3,4 DIHYDROTHIENO[3,4 D]PYRIDAZINE 1 CARBOXYLATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; NONHUMAN; PHARMACOPHORE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MOLECULAR STRUCTURE; PYRIDAZINES; RECEPTOR, ADENOSINE A1; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 53549108359     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800557d     Document Type: Article

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