Synthesis and biological evaluation of allosteric A1-adenosine receptor modulators structurally related to (2-amino-4,5,6,7-tetrahydro-benzo[b] thiophen-3-yl)-(4-chloro-phenyl)-methanone, a potent compound useful to reduce neuropathic pain

Medicinal Chemistry Research

Volumn 14, Issue 3, 2005, Pages 125-142

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Pavani, Maria Giovanna ^a   Tabrizi, Mojgan Aghazadeh ^a   Iaconinoto, Maria Antonietta ^a   Carrion, Maria Dora ^a   Lopez Cara, Carlota ^a   Shryock, John C ^b   Leung, Edward ^c   Moorman, Allan R ^c   Gessi, Stefania ^a   Merighi, Stefania ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c King Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 AMINO 4,5 DIHYDROTHIENO[2,3 B]THIOPHEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 3 YL)(4 CHLOROPHENYL)METHANONE DERIVATIVE; (2 AMINO 4,7 DIHYDRO 5H THIENO[2,3 C]THIOPYRAN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 6 BENZYL 4,5,6,7 TETRAHYDROBENZO[B]THIOPEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 6 HYDROXY 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 6 PHENYL 4,5,6,7 TETRAHYDROBENZO[B]THIOPEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 6 SPIRO(1,4 DIOXALAN 2 YL) 4,5,6,7 TETRAHYDROBENZO[B]THIOPEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO BENZO[B]THIOPHEN 3 YL)(4 CHLOROPHENYL)METHANONE; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; [2 AMINO 6 (4 METHOXYPHENYL) 4H 1,5,7 TRITHIAINDEN 3 YL](4 CHLOROPHENYL)METHANONE; [2 AMINO 6 [(METHANESULFONYL)OXY] 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 3 YL](4 CHLOROPHENYL)METHANONE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; RAT;

EID: 33747088125     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-005-0129-8     Document Type: Article

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