Allosteric modulation of the adenosine A1 receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3629-3635

  Van Der Klein, Pieter A M ^a   Kourounakis, Angeliki P ^a   IJzerman, Ad P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

(2 AMINO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 3 YL)(4 CHLOROPHENYL)METHANONE; (2 AMINO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 3 YL)[3 (TRIFLUOROMETHYL)PHENYL]METHANONE; 2 AMINO 3 (3,4 DICHLOROBENZOYL) 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE; 2 AMINO 3 BENZOYLTHIOPHENE DERIVATIVE; 2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; BENZOIC ACID DERIVATIVE; CHLOROPHENOL; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

AGONIST; ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; BRAIN; RATS; RECEPTORS, PURINERGIC P1; THIOPHENES; XANTHINES;

EID: 0033539111     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991051d     Document Type: Article

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