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Volumn 5, Issue 10, 2008, Pages 2318-2329

Role of increased penile expression of transforming growth factor-β1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats

Author keywords

Diabetes Mellitus; Erectile dysfunction; Fibrosis; Smad; Transforming growth factor beta

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLOOD CLOTTING FACTOR 8; COLLAGEN TYPE 1; COLLAGEN TYPE 4; FIBRONECTIN; HYDROXYPROLINE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 53549106900     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.00977.x     Document Type: Article
Times cited : (57)

References (38)
  • 2
    • 0031035913 scopus 로고    scopus 로고
    • Sexual dysfunction in the diabetic BB/WOR rat: A role of central neuropathy
    • McVary KT, Rathnau CH, McKenna KE. Sexual dysfunction in the diabetic BB/ WOR rat: A role of central neuropathy. Am J Physiol 1997;272:R259-67.
    • (1997) Am J Physiol , vol.272
    • McVary, K.T.1    Rathnau, C.H.2    McKenna, K.E.3
  • 3
    • 0033067451 scopus 로고    scopus 로고
    • Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model
    • El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res 1999;11:123-32.
    • (1999) Int J Impot Res , vol.11 , pp. 123-132
    • El-Sakka, A.I.1    Lin, C.S.2    Chui, R.M.3    Dahiya, R.4    Lue, T.F.5
  • 6
    • 42949151517 scopus 로고    scopus 로고
    • Strain differences in susceptibility to in vivo erectile dysfunction following 6 weeks of induced hyperglycemia in the mouse
    • Chitaley K, Luttrell I. Strain differences in susceptibility to in vivo erectile dysfunction following 6 weeks of induced hyperglycemia in the mouse. J Sex Med 2008;5:1149-55.
    • (2008) J Sex Med , vol.5 , pp. 1149-1155
    • Chitaley, K.1    Luttrell, I.2
  • 8
    • 33947129737 scopus 로고    scopus 로고
    • Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat
    • Wingard C, Fulton D, Husain S. Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat. J Sex Med 2007;4:348-62.
    • (2007) J Sex Med , vol.4 , pp. 348-362
    • Wingard, C.1    Fulton, D.2    Husain, S.3
  • 11
    • 0346728613 scopus 로고    scopus 로고
    • Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes
    • Jesmin S, Sakuma I, Salah-Eldin A, Nonomura K, Hattori Y, Kitabatake A. Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes. J Mol Endocrinol 2003;31:401-18.
    • (2003) J Mol Endocrinol , vol.31 , pp. 401-418
    • Jesmin, S.1    Sakuma, I.2    Salah-Eldin, A.3    Nonomura, K.4    Hattori, Y.5    Kitabatake, A.6
  • 12
    • 0031760289 scopus 로고    scopus 로고
    • Improvement of erectile function in diabetic rats by insulin: Possible role of the insulin-like growth factor system
    • Abdelbaky TM, Brock GB, Huynh H. Improvement of erectile function in diabetic rats by insulin: Possible role of the insulin-like growth factor system. Endocrinology 1998;139:3143-7.
    • (1998) Endocrinology , vol.139 , pp. 3143-3147
    • Abdelbaky, T.M.1    Brock, G.B.2    Huynh, H.3
  • 13
    • 0028836204 scopus 로고
    • PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle
    • Moreland RB, Traish AM, McMillin MA, Smith B, Goldstein I, Saenz de Tejada I. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol 1995;153:826-34.
    • (1995) J Urol , vol.153 , pp. 826-834
    • Moreland, R.B.1    Traish, A.M.2    McMillin, M.A.3    Smith, B.4    Goldstein, I.5    Saenz de Tejada, I.6
  • 15
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev 2000;14:627-44.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 16
    • 0036387022 scopus 로고    scopus 로고
    • Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells
    • Isono M, Chen S, Won HS, Carmen Iglesias-De La Cruz MC, Ziyadeh F. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 2002;296:1356-65.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 1356-1365
    • Isono, M.1    Chen, S.2    Won, H.S.3    Carmen Iglesias-De La Cruz, M.C.4    Ziyadeh, F.5
  • 17
    • 0035014583 scopus 로고    scopus 로고
    • Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse
    • Hong SW, Isono M, Chen S, Iglesias-De La Cruz MC, Han DC, Ziyadeh FN. Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 2001;158:1653-63.
    • (2001) Am J Pathol , vol.158 , pp. 1653-1663
    • Hong, S.W.1    Isono, M.2    Chen, S.3    Iglesias-De La Cruz, M.C.4    Han, D.C.5    Ziyadeh, F.N.6
  • 19
    • 0037007226 scopus 로고    scopus 로고
    • Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    • Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J 2002;21:1743-53.
    • (2002) EMBO J , vol.21 , pp. 1743-1753
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Rosendahl, A.4    Sideras, P.5    ten Dijke, P.6
  • 21
    • 0029881336 scopus 로고    scopus 로고
    • A simplified method for the analysis of hydroxyproline in biological tissues
    • Kesave Reddy G, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996;29:225-9.
    • (1996) Clin Biochem , vol.29 , pp. 225-229
    • Kesave Reddy, G.1    Enwemeka, C.S.2
  • 23
    • 0028218461 scopus 로고
    • Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta
    • Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. J Clin Invest 1994;93:536-42.
    • (1994) J Clin Invest , vol.93 , pp. 536-542
    • Ziyadeh, F.N.1    Sharma, K.2    Ericksen, M.3    Wolf, G.4
  • 24
    • 10144243313 scopus 로고    scopus 로고
    • Elevated plasma levels of transforming growth factor-beta 1 in NIDDM
    • Pfeiffer A, Drewes C, Middelberg-Bisping K, Schatz H. Elevated plasma levels of transforming growth factor-beta 1 in NIDDM. Diabetes Care 1996;19:1113-7.
    • (1996) Diabetes Care , vol.19 , pp. 1113-1117
    • Pfeiffer, A.1    Drewes, C.2    Middelberg-Bisping, K.3    Schatz, H.4
  • 26
    • 0028197596 scopus 로고
    • Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase
    • Grainger DJ, Kemp PR, Witchell CM, Weissberg PL, Metcalfe JC. Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase. Biochem J 1994;299:227-35.
    • (1994) Biochem J , vol.299 , pp. 227-235
    • Grainger, D.J.1    Kemp, P.R.2    Witchell, C.M.3    Weissberg, P.L.4    Metcalfe, J.C.5
  • 27
    • 0027250532 scopus 로고
    • Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest
    • Reddy KB, Howe PH. Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest. J Cell Physiol 1993;156:48-55.
    • (1993) J Cell Physiol , vol.156 , pp. 48-55
    • Reddy, K.B.1    Howe, P.H.2
  • 28
    • 14644439839 scopus 로고    scopus 로고
    • Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism
    • Redondo S, Ruiz E, Santos-Gallego CG, Padilla E, Tejerina T. Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism. Diabetes 2005;54:811-7.
    • (2005) Diabetes , vol.54 , pp. 811-817
    • Redondo, S.1    Ruiz, E.2    Santos-Gallego, C.G.3    Padilla, E.4    Tejerina, T.5
  • 32
    • 0842308799 scopus 로고    scopus 로고
    • Expression of cavernous transforming growth factor-beta1 and its type II receptor in patients with erectile dysfunction
    • Ryu JK, Han JY, Chu YC, Song SU, Lee KH, Yoon SM, Suh JK, Kim SJ. Expression of cavernous transforming growth factor-beta1 and its type II receptor in patients with erectile dysfunction. Int J Androl 2004;27:42-9.
    • (2004) Int J Androl , vol.27 , pp. 42-49
    • Ryu, J.K.1    Han, J.Y.2    Chu, Y.C.3    Song, S.U.4    Lee, K.H.5    Yoon, S.M.6    Suh, J.K.7    Kim, S.J.8
  • 33
    • 0026557672 scopus 로고
    • Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta 1
    • Nakamura T, Miller D, Ruoslahti E, Border WA. Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta 1. Kidney Int 1992;41:1213-21.
    • (1992) Kidney Int , vol.41 , pp. 1213-1221
    • Nakamura, T.1    Miller, D.2    Ruoslahti, E.3    Border, W.A.4
  • 34
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996;45:522-30.
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 35
    • 0035321412 scopus 로고    scopus 로고
    • Age-associated changes in collagen content and its subtypes within rat corpora cavernosa with computerized histomorphometric analysis
    • Lin JS, Tsai YS, Lin YM, Lin CS, Chow NH. Age-associated changes in collagen content and its subtypes within rat corpora cavernosa with computerized histomorphometric analysis. Urology 2001;57:837-42.
    • (2001) Urology , vol.57 , pp. 837-842
    • Lin, J.S.1    Tsai, Y.S.2    Lin, Y.M.3    Lin, C.S.4    Chow, N.H.5
  • 36
    • 33748902582 scopus 로고    scopus 로고
    • Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: Implications for vaginal fibrosis
    • Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF, Berman J. Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: Implications for vaginal fibrosis. Fertil Steril 2006;86(4 suppl):1152-63.
    • (2006) , vol.86 , Issue.4 SUPPL. , pp. 1152-1163
    • Ferrini, M.G.1    Nolazco, G.2    Vernet, D.3    Gonzalez-Cadavid, N.F.4    Berman, J.5
  • 37
    • 0016582626 scopus 로고
    • Quantification of collagen in renal glomeruli isolated from human nondiabetic and diabetic kidneys
    • Klein L, Butcher DL, Sudilovsky O, Kikkawa R, Miller M. Quantification of collagen in renal glomeruli isolated from human nondiabetic and diabetic kidneys. Diabetes 1975;24:1057-65.
    • (1975) Diabetes , vol.24 , pp. 1057-1065
    • Klein, L.1    Butcher, D.L.2    Sudilovsky, O.3    Kikkawa, R.4    Miller, M.5
  • 38
    • 0036755020 scopus 로고    scopus 로고
    • The efficacy of sildenafil citrate (Viagra) in clinical populations: An update
    • Carson CC, Burnett AL, Levine LA, Nehra A. The efficacy of sildenafil citrate (Viagra) in clinical populations: An update. Urology 2002;60(2 suppl):12-27.
    • (2002) Urology , vol.60 , Issue.2 SUPPL. , pp. 12-27
    • Carson, C.C.1    Burnett, A.L.2    Levine, L.A.3    Nehra, A.4


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