Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy

Biochemical and Biophysical Research Communications

Volumn 305, Issue 4, 2003, Pages 1002-1007

  Fujimoto, Masaki ^a   Maezawa, Yoshiro ^a   Yokote, Koutaro ^a   Joh, Kensuke ^b   Kobayashi, Kazuki ^a   Kawamura, Harukiyo ^a   Nishimura, Motonobu ^b   Roberts, Anita B ^c   Saito, Yasushi ^a   Mori, Seijiro ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAKURA NATIONAL HOSPITAL   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Diabetic glomerulopathy; Fibronectin; Smad3; Transforming growth factor ; Type IV collagen

Indexed keywords

ALBUMIN; COLLAGEN TYPE 4; FIBRONECTIN; MESSENGER RNA; SMAD3 PROTEIN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE MODEL; ELECTRON MICROSCOPY; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; KIDNEY CORTEX; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; NULL ALLELE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; TISSUE LEVEL; UPREGULATION; URINARY EXCRETION; WILD TYPE;

EID: 0037566734     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00885-4     Document Type: Article

References (30)

1. Sharma K., Ziyadeh F.N. Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse. Am. J. Physiol. 267:1994;F1094-F1101.
2. Yamamoto T., Nakamura T., Noble N.A., Ruoslahti E., Border W.A. Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc. Natl. Acad. Sci. USA. 90:1993;1814-1818.
3. Nakamura T., Fukui M., Ebihara I., Osada S., Nagaoka I., Tomino Y., Koide H. mRNA expression of growth factors in glomeruli from diabetic rats. Diabetes. 42:1993;450-456.
4. Sharma K., Jin Y., Guo J., Ziyadeh F.N. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in streptozotocin-induced diabetic mice. Diabetes. 45:1996;522-530.
5. Isono M., Mogyorosi A., Han D.C., Hoffman B.B., Ziyadeh F.N. Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney. Am. J. Physiol. 278:2000;F830-F838.
6. Hong S.W., Isono M., Chen S., Iglesias-De La Cruz M.C., Han D.C., Ziyadeh F.N. Increased glomerular and tubular expression of transforming growth factor-β1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am. J. Pathol. 158:2001;1653-1663.
7. Rocco M.V., Chen Y., Goldfarb S., Ziyadeh F.N. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int. 41:1992;107-114.
8. Wolf G., Sharma K., Chen Y., Ericksen M., Ziyadeh F.N. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β Kidney Int. 42:1992;647-656.
9. Han D.C., Isono M., Hoffman B.B., Ziyadeh F.N. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-β J. Am. Soc. Nephrol. 10:1999;1891-1899.
10. Riser B.L., Ladson-Wofford S., Sharba A., Cortes P., Drake K., Guerin C.J., Yee J., Choi M.E., Segarini P.R., Narins R.G. TGF-β receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. Kidney Int. 56:1999;428-439.
11. Ziyadeh F.N., Sharma K., Ericksen M., Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β J. Clin. Invest. 93:1994;536-542.
12. Ziyadeh F.N., Hoffman B.B., Han D.C., Iglesias-De La Cruz M.C., Hong S.W., Isono M., Chen S., McGowan T.A., Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc. Natl. Acad. Sci. USA. 97:2000;8015-8020.
13. Massague J., Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19:2000;1745-1754.
14. Heldin C.-H., Miyazono K., ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature. 390:1997;465-471.
15. Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J.L., Heuchel R., Itoh S., Kawabata M., Heldin N.E., Heldin C.-H., ten Dijke P. Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signalling. Nature. 389:1997;631-635.
16. Ashcroft G.S., Yang X., Glick A.B., Weinstein M., Letterio J.L., Mizel D.E., Anzano M., Greenwell-Wild T., Wahl S.M., Deng C., Roberts A.B. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1:1999;260-266.
17. ′ -phosphate J. Nutr. Sci. Vitaminol. 37:1991;149-159.
18. Takemoto M., Yokote K., Yamazaki M., Ridall A.L., Butler W.T., Matsumoto T., Tamura K., Saito Y., Mori S. Enhanced expression of osteopontin by high glucose in cultured rat aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 258:1999;722-726.
19. Takemoto M., Asker N., Gerhardt H., Lundkvist A., Johansson B.R., Saito Y., Betsholtz C. A new method for large scale isolation of kidney glomeruli from mice. Am. J. Pathol. 161:2002;799-805.
20. Nerlich A., Schleicher E. Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. Am. J. Pathol. 139:1991;889-899.
21. Lohi J., Korhonen M., Leivo I., Kangas L., Tani T., Kalluri R., Miner J.H., Lehto V.-P., Virtanen I. Expression of type IV collagen α1(IV)-α6(IV) polypeptides in normal and developing human kidney and in renal cell carcinomas and oncocytomas. Int. J. Cancer. 72:1997;43-49.
22. Kalluri R., Shield C.F., Todd P., Hudson B.G., Neilson E.G. Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membrane to Endoproteolysis. J. Clin. Invest. 99:1997;2470-2478.
23. Zhao J., Shi W., Wang Y.-L., Chen H., Bringas P., Datto M.B., Frederick J.P., Wang X.-F., Warburton D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 282:2002;L585-L593.
24. Flanders K.C., Sullivan C.D., Fujii M., Sowers A., Anzano M.A., Arabshahi A., Major C., Deng C., Russo A., Mitchell J.B., Roberts A.B. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am. J. Pathol. 160:2002;1057-1068.
25. Isono M., Chen S., Hong S.W., Iglesias-de la Cruz M.C., Ziyadeh F.N. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem. Biophys. Res. Commun. 296:2002;1356-1365.
26. Piek E., Ju W.J., Heyer J., Escalante-Alcalde D., Stewart C.L., Weinstein M., Deng C., Kucherlapati R., Bottinger E.P., Roberts A.B. Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts. J. Biol. Chem. 276:2001;19945-19953.
27. Roberts A.B., Bottinger E.P., Ashcroft G., Mitchell J.B., Flanders K.C. Is Smad3 a major player in signal transduction pathways leading to fibrogenesis? Chest. 120:2001;S43-S47.
28. Furuta T., Saito T., Ootaka T., Soma J., Obara K., Abe K., Yoshinaga K. The role of macrophages in diabetic glomerulosclerosis. Am. J. Kidney Dis. 21:1993;480-485.
29. Klahr S., Schreiner G., Ichikawa I. The progression of renal disease. N. Engl. J. Med. 318:1988;1657-1666.
30. Rovin B.H., Schreiner G.F. Cell-mediated immunity in glomerular disease. Annu. Rev. Med. 42:1991;25-33.