Transforming growth factor-β1 (TGF-β1) is sufficient to induce fibrosis of rabbit corpus cavernosum in vivo

Journal of Urology

Volumn 162, Issue 3 I, 1999, Pages 910-915

  Nehra, Ajay ^a   Gettman, Matthew T ^b   Nugent, Matthew ^b   Bostwick, David G ^b   Barrett, David M ^b   Goldstein, Irwin ^b   Krane, Robert J ^b   Moreland, Robert B ^b  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

Animal model; Corporal fibrosis; Corporal veno occlusive dysfunction; Male sexual dysfunction; Rabbit; TGF 1

Indexed keywords

RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DOSE RESPONSE; FIBROSIS; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0032834919     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199909010-00089     Document Type: Article

References (45)

1. Andersson, K-E. and Wagner, G.: The physiology of penile erection. Physiol. Rev., 75: 191, 1995.
2. Lue, T. and Dahiya, M.: Molecular biology of erectile function and dysfunction. Mol. Urol., 1: 35, 1997.
3. Moreland, R. B.: Is there a role of hypoxema in penile fibrosis? Int. J. Impotence Res., 10: 113, 1998.
4. Persson, C., Diederichs, W., Lue, T. F., Yen, T. S. B., Fishman, I. J., McLin, P. and Tanagho, E. A.: Correlation of altered penile ultrastructure with clinical arterial evaluation. J. Urol., 142: 1462, 1989.
5. Jevtich, M., Khawand, N. Y. and Vidic, B.: Clinical significance of ultrastructural findings in the corpus cavernosa of normal and impotent men. J. Urol., 143: 289, 1990.
6. Mersdorf, A., Goldsmith, P. C., Diederichs, W., Padula, C. A., Lue, T. F., Fishman, I. J. and Tanagho, E. A.: Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J. Urol., 145: 749, 1991.
7. Wespes, E., Goes, P. M., Schiffmann, S., Deprierreux, M., Vanderhaeghen, J. J. and Schulman, CC.: Computerized analysis of smooth muscle fibers in potent and impotent patients. J. Urol., 146: 1015, 1991.
8. Luangkhot, R., Rutchik, S., Agarwal, V., Puglia, K., Bhargava, G. and Melman, A.: Collagen alterations in the corpus cavernosum of men with sexual dysfunction. J. Urol., 148: 467, 1992.
9. Nehra, A., Goldstein, I., Pabby, A., de las Morenas, A., Udelson, D., Krane, R. J., Saenz de Tejada, I. and Moreland, R. B.: Mechanisms of venous leak in erectile dysfunction in patients with vascular risks factors: a clinicopathologic correlation of corporal veno-occlusion. J. Urol., 156: 1320, 1996.
10. Wespes, E., Sattar, A. A., Golzarian, J., Wery, D., Daoud, N. and Schulman, C. C.: Corporeal veno-occlusive dysfunction: predominantly intracavernous smooth muscle pathology. J. Urol., 157: 1678, 1997.
11. Border, W. A. and Ruoslahti, E.: Transforming growth factor-β in disease: the dark side of tissue repair. J. Clin. Invest., 90:1, 1992.
12. Border, W. A. and Noble, N. A.: Transforming growth factor β in tissue fibrosis. New Engl. J. Med., 331: 1286, 1994.
13. Majack, R. A.: Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures. J. Cell. Biol., 105: 465, 1987.
14. Raghow, R., Irush, P. and Kang, A. H.: Coordinate regulation of transforming growth factor β gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis. J. Clin. Invest., 84: 1836, 1989.
15. 1 and α in chronic liver disease. Effects of interferon alpha therapy. N. Engl. J. Med., 324: 933, 1991.
16. 1 is increased in human vascular restenosis lesions. J. Clin. Invest., 90: 1582, 1992.
17. 1. J. Vase. Res., 30: 293, 1993.
18. 1 in human corpus cavernosum smooth muscle. J. Urol., 153: 826, 1995.
19. 1 expression and PGE production in human corpus cavernosum smooth muscle cells. Mol. Urol., 2: 41, 1998.
20. Kim, N., Vardi, Y., Padma-Nathan, H., Daley, J., Goldstein, I. and Saenz de Tejada I.: Oxygen tension regulates the nitric oxide pathway: Physiological role in penile erection. J. Clin. Invest., 91: 437, 1993.
21. Edelman, E. R., Nugent, M. A., Smith, L. T. and Karnovsky, M. J.: Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J. Clin. Invest., 89: 465, 1992.
22. Nugent, M. A., Chen, O. and Edelman, E. R.: Controlled release of fibroblast growth factor: activity in cell culture. Mater. Res. Soc. Symp. Proceed., 252: 273, 1992.
23. Nehra, A., Azadzoi, K. M., Moreland, R. B., Pabby, A., Siroky, M. B., Krane, R. J., Goldstein, I., and Udelson, D. G.: Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J. Urol., 159: 2229, 1998.
24. Coffey, R. J., Kost, L. J., Lyons, R. M., Moses, H. L. and LaRusso, N. F.: Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism and biliary excretion. J. Clin. Invest., 80: 750, 1990.
25. 1 induced corporal fibrosis: implications for penile ischemia-associated fibrosis. J. Urol., 155: 622A(Abstract 1243), 1996.
26. Smiddy, W. E., Glaser, B. M., Green, W. R., Connor, T. B. Jr., Roberts, A. B., Lucas, R. and Sporn, M. B.: Transforming growth factor beta. A biologic chorioretinal glue. Arch. Ophthalmol., 107: 577, 1989.
27. 1-induced collagen synthesis in human corpus cavernosum smooth muscle cells. Int. J. Impotence Res., 1999.
28. 1 in erectile failure: a survey ofworldwide experience. J. Urol., 155: 802, 1996.
29. 1) in penile and prostate growth in the rat during sexual maturation. J. Androl., 19: 50, 1998.
30. El-Sakka, A. I., Hassoba, H. M., Pillarisetty, R. J., Dahiya, R. and Lue, T. F.: Peyronie's disease is associated with an increase in transforming growth factor-β protein expression. J. Urol., 158: 1391, 1997.
31. El-Sakka, A. I., Hassoba, H. M., Chui, R. M., Bhatnagar, R. S., Dahiya, R. and Lue, T. F.: An animal model of Peyronie's-like condition associated with an increase in transforming growth factor-β mRNA and protein expression. J. Urol., 158: 2284, 1997.
32. El-Sakka, A. I., Hassan, M. U., Nunes, L., Bhatnagar, R. S., Yen, T. S. and Lue, T. F.: Histological and ultrastructural alterations in an animal model of Peyronie's disease. Br. J. Urol., 81: 445, 1998.
33. Newhall, P. N., Traish, A. M. and Moreland, R. B.: An organ culture model system for the study of collagen synthesis in corpus cavernosum in situ. Int. J. Impotence Res., 10: 77, 1998.
34. Shirai, Y., Kawato, S., Ito, N., Tamura, S., Takaishi, K, Kiso, S., Tsushima, H. and Matsuzawa, Y.: Elevated levels of plasma transforming growth factor-beta in patients with hepatocellular carcinoma. Jap. J. Cancer Res., 83: 676, 1992.
35. Wakefield, L. M., Letterio, J. J., Chen, T., Danielpour, D., Allison, R. S. H., Pai, L. H., Denicoff, A. M., Noone, M. H., Cowan, K. H., O'Shaughnessy, J. A. and Sporn, M. B.: Transforming growth factor-beta 1 circulates in normal plasma and is unchanged in advanced metastatic breast cancer. Clin. Cancer Res., 1: 129, 1995.
36. Wunderlich, H., Steiner, T., Kosmehl, H., Junker, U., Reinhold, D., Reichelt, O., Zermann, D. H. and Schubert, J.: Increased transforming growth factor beta 1 plasma levels in patients with renal cell carcinoma: a tumor-specific marker? Urol. Int., 60: 205, 1998.
37. Munger, J. S., Harpel, J. G., Gliezes, P. E., Mazzieri, R., Nunes, I. and Rifkin, D. B.: Latent transforming growth factor-beta: structural features and mechanisms of activation. Kidney Int., 51: 1376, 1997.
38. Nocera, M. and Chu, T. M.: Characterization of latent transforming growth factor-beta from human seminal plasma. Am. J. Reprod. Immunol., 33: 282, 1995.
39. Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V. and Kehrl, J. H.: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA, 83: 4167, 1986.
40. Mustoe, T. A., Pierce, G. F., Thomason, A., Gramates, P., Sporn, M. B. and Deuel, T. F.: Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science, 237: 1333, 1987.
41. Quaglino, D. Jr., Nanney, L. B., Ditesheim, J. A. and Davidson, J. M.: Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin incisional wound model. J. Invest. Dermatol., 97: 34, 1991.
42. Jones, S. C., Curtsinger, L. J., Whalen, J. D., Pietsch, J. D., Ackerman, D., Brown, G. L. and Schultz, G. S.: Effect of topical recombinant TGF-beta on healing of partial thickness injuries. J. Surg. Res., 51: 344, 1991.
43. Beck, L. S., Chen, T. L., Mikalauski, P. and Ammann, A. J.: Recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) enhances healing and strength of granulation skin wounds. Growth Factors, 3: 267, 1990.
44. Beck, L. S., Chen, T. L., Hirabayashi, S. E., DeGuzman, L., Lee, W. P., McFatridge, L. L., Xu, Y. and Bates, R. L. and Ammann, A. J.: Accelerated healing of ulcer wounds in the rabbit ear by recombinant human transforming growth factor-beta 1. Growth Factors, 2: 273, 1990.
45. Nabel, E. G., Shum, L., Pompili, V. J., Yang, Z. Y., San, H., Shu, H. B., Liptay, S., Gold, L., Gordon, D. and Derynck, R.: Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc. Natl. Acad. Sci. USA, 90: 10759, 1993.