Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse

Journal of Sexual Medicine

Volumn 5, Issue 5, 2008, Pages 1156-1166

  Carneiro, Fernando Silva ^a,b   Giachini, Fernanda R C ^a,b   Lima, Victor V ^b   Carneiro, Zidonia N ^b   Leite, Romulo ^b   Inscho, Edward W ^b   Tostes, Rita C ^a,b   Webb, R Clinton ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Adenosine; AnimalModels; Diabetes; Obesity; Sympathetic Neurotransmission

Indexed keywords

5 IODOTUBERCIDIN; ACETYLCHOLINE; ADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; DIPYRIDAMOLE; GLUCOSE; INSULIN; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ADRENERGIC ACTIVITY; ADRENERGIC NERVE; ADRENERGIC STIMULATION; ADRENERGIC TRANSMISSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; FUNCTIONAL ASSESSMENT; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; MOUSE; MOUSE STRAIN; NERVE EXCITABILITY; NEUROMODULATION; NEUROTRANSMISSION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PENIS ERECTION; PRIORITY JOURNAL;

EID: 42949138452     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00752.x     Document Type: Article

References (49)

1. I. Sáenz de Tejada J. Angulo S. Cellek N. González-Cadavid J. Heaton R. Pickard U. Simonsen Pathophysiology of erectile dysfunction J Sex Med 2 2005 26 39
2. B. Musicki A.L. Burnett Endothelial dysfunction in diabetic erectile dysfunction Int J Impot Res 19 2007 129 138
3. S. Cellek J. Rodrigo E. Lobos P. Fernandez J. Serrano S. Moncada Selective nitrergic neurodegeneration in diabetes mellitus: A nitric oxide-dependent phenomenon Br J Pharmacol 128 1999 1804 1812
4. J.F.B. Morrison D.J. Pallot R. Sheen S. Dhanasekaran E.P.K. Mensah-Brown The effects of age and streptozotocin diabetes on the sympathetic innervation in the rat penis Molec Cell Biochem 295 2007 53 58
5. M. Modan H. Halkin Hyperinsulinemia or increased sympathetic drive as links for obesity and hypertension Diab Care 14 1991 470 487
6. L. Landsberg Pathophysiology of obesity-related hypertension: Role of insulin and the sympathetic nervous system J Cardiovasc Pharm 23 1994 S1 8
7. F.S. Facchini A. Riccardo A. Stoohs G.M. Reaven Enhanced sympathetic nervous system activity. The linchpin between insulin resistance, hyperinsulinemia, and heart rate Am J Hypertens 9 1996 1013 1017
8. P.C. Perin S. Maule R. Quadri Sympathetic nervous system, diabetes, and hypertension Clin Exper Hypertens 23 2001 45 55
9. K.E. Andersson Pharmacology of penile erection Pharmacol Rev 53 2001 417 450
10. R. Leite F.R.C. Giachini F.S. Carneiro K.P. Nunes R.C. Tostes R.C. Webb Targets for the treatment of erectile dysfunction: Is NO/cGMP still the answer? Rec Pat Cardiovasc Drug Disc 2 2007 119 132
11. J. Angulo P. Cuevas S. Gabancho R. Gonzales-Corrochano S. Videla I. Sáenz de Tejada Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats J Sex Med 3 2005 341 346
12. T.R. Magee I. Kovanecz H.H. Davila M.G. Ferrini L. Cantini D. Vernet F.I. Zuniga J. Rajfer N.F. Gonzales-Cadavid Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorates aging-related erectile dysfunction in the rat J Sex Med 4 2007 633 643
13. G. Burnstock Historical review: ATP as a neurotransmitter Trends Pharmacol Sci 27 2006 166 176
14. R.C. Tostes F.R. Giachini F.S. Carneiro R. Leite E.W. Inscho R.C. Webb Determination of adenosine effects and adenosine receptors in murine corpus cavernosum J Pharmacol Exp Ther 322 2007 678 685
15. C.S. Lin G. Lin T.F. Lue Cyclic nucleotide signaling in cavernous smooth muscle J Sex Med 2 2005 478 491
16. 1 adenosine receptors Naunyn Schmiedebergs Arch Pharmacol 340 1989 679 683
17. H.A. Feldman I. Goldstein D.G. Hatzichristou R.J. Krane J.B. McKinlay Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study J Urol 151 1994 54 61
18. D.K. McCulloch I.W. Campbell F.C. Wu R.J. Prescott B.F. Clarke The prevalence of diabetic impotence Diabetologia 18 1980 279 283
19. P. Hedlund L. Ny P. Alm K.E. Andersson Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase J Urol 164 2000 868 875
20. P. Hedlund P. Alm K.E. Andersson NO synthase in cholinergic nerves and NO-induced relaxation in the rat isolated corpus cavernosum Br J Pharmacol 127 1999 349 360
21. W.G. Dail V. Barba L. Leyba R. Galindo Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue Cell Tissue Res 282 1995 109 116
22. A. Schirar F. Giuliano O. Rampin J.P. Rousseau A large proportion of pelvic neurons innervating the corpora cavernosa of the rat penis exhibit NADPH-diaphorase activity Cell Tissue Res 278 1994 517 525
23. M.R. Nangle J.R. Keast Loss of nitrergic neurotransmission to mouse corpus cavernosum in the absence of neurturin is accompanied by increased response to acetylcholine Br J Pharmacol 148 2006 423 433
24. I. Sáenz de Tejada R. Blanco I. Goldstein K. Azadzoi A. De Las Morenas R.J. Krane R.A. Cohen Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue Am J Physiol 254 1988 H459 67
25. R. Blanco I. Sáenz de Tejada I. Goldstein R.J. Krane H.H. Wotiz R.A. Cohen Dysfunctional penile cholinergic nerves in diabetic impotent men J Urol 144 1990 278 280
26. S. Yagihashi A.A. Sima Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves Diabetes 35 1986 733 743
27. P. Vollenweider L. Tappy D. Randin P. Schneiter E. Jéquier P. Nicod U. Scherrer Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans J Clin Invest 92 1993 147 154
28. J.W. Rowe J.B. Young J.J. Minaker A.L. Stevens J.A. Palotta L. Landsberg Effect of insulin and glucose infusions on sympathetic nervous system in normal man Diabetes 30 1981 219 225
29. G. Lembo R. Napoli B. Capaldo V. Rendina G. Laccarino M. Volpe Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension J Clin Invest 90 1992 24 29
30. E.A. Anderson R.P. Hoffman T.W. Balon C.A. Sinkey A.L. Mark Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans J Clin Invest 87 1991 2246 2252
31. D.S. Paramore C.G. Fanelli S.D. Shah P.E. Cryer Forearm norepinephrine spillover during standing, hyperinsulinemia, and hypoglycemia Am J Physiol 275 1998 E872 81
32. S. Gudbjornsdottir P. Friberg M. Elam S. Attvall P. Lonnroth B.G. Wallin The effect of metformin and insulin on sympathetic nerve activity, norepinephrine spillover and blood pressure in obese, insulin resistant, normoglycemic, hypertensive men Blood Pressure 3 1994 394 403
33. K.A. Gradin H. Zhu M. Jeansson U. Simonsen Enhanced neuropeptide Y immunoreactivity and vasoconstriction in mesenteric small arteries from the early non-obese diabetic mouse Eur J Pharmacol 539 2006 184 191
34. R.J. Huggett A.J. Hogarth A.F. Mackintosh D.A. Mary Sympathetic nerve hyperactivity in non-diabetic offspring of patients with type 2 diabetes mellitus Diabetologia 49 2006 2741 2744
35. H. Suzuki M. Nishizawa M. Ichikawa K. Kumagai M. Ryuzaki H. Kumagai T. Saruta H. Ikeda Basal sympathetic nerve activity is enhanced with augmentation of baroreceptor reflex in Wistar fatty rats: A model of obesity-induced NIDDM J Hypertens 17 1999 959 964
36. J. Mulhall P. Teloken G. Brock E. Kim Obesity, dyslipidemias and erectile dysfunction: A report of a subcommittee of the sexual medicine society of north America J Sex Med 5 2006 759 947
37. J. Lincoln R. Crowe P.F. Blacklay J.P. Pryor J.S. Lumley G. Burnstock Changes in the VIPergic, cholinergic and adrenergic innervation of human penile tissue in diabetic and non-diabetic impotent males J Urol 137 1987 1053 1059
38. 2 receptors but have potent pharmacological activity in vivo Biochem Pharmacol 35 1986 3021 3029
39. R.E. Klabunde Effects of dipyridamole on postischemic vasodilation and extracellular adenosine Am J Physiol 244 1983 H273 80
40. S. Gür B. Oztürk Altered relaxant responses to adenosine and adenosine 5′-triphosphate in the corpus cavernosum from men and rats with diabetes Pharmacology 60 2000 105 112
41. S. Ayan S. Yildirim C. Uçar Y. Sarioglu Y. Gültekin C. Bütüner Corporal reactivity to adenosine and prostaglandin E1 in alloxan-induced diabetic rabbit corpus cavernosum, and the effect of insulin therapy BJU Int 83 1999 108 112
42. S.V. Bratkovsky E. Aasum R.A. Riemersma E.S. Myhre T.S. Larsen Reduced coronary reserve in response to short-term ischaemia and vasoactive drugs in ex vivo hearts from diabetic mice Acta Physiol (Oxf) 186 2006 171 177
43. S. Gür I. Cinel Sodium selenate partially corrects impaired functional responses in detrusor muscle in streptozotocin-induced diabetic rats Biol Trace Elem Res 93 2003 171 188
44. M. Fahim T. Hussain S.J. Mustafa Relaxation of rat aorta by adenosine in diabetes with and without hypertension: Role of endothelium Eur J Pharmacol 412 2001 51 59
45. W. Durante A.K. Sen F.A. Sunahara Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats Br J Pharmacol 94 1988 463 468
46. T. Utkan Y. Sarioglu S. Yildirim Impaired contraction and relaxation in the aorta of streptozotocin-diabetic rats Pharmacology 56 1998 207 215
47. S.C. Kim S.Y. Ahn S.H. Park M.Y. Lee D.Y. Uhm A comparison of the relaxation responses of isolated cavernosal smooth muscles by endothelium-independent and endothelium-dependent vasodilators in diabetic men with impotence J Korean Med Sci 10 1995 1 6
48. S. Kiliç M. Salih K. Anafarta S. Baltaci A. Kosar Adenosine: A new agent in the diagnosis of impotence Int J Impot Res 6 1994 191 198
49. Y. Takahashi N. Ishii T.F. Lue E.A. Tanagho Pharmacological effects of adenosine on canine penile erection Tohoku J Exp Med 165 1991 49 58