Increased glomerular and tubular expression of transforming growth factor-β1, its type II receptor, and activation of the smad signaling pathway in the db/db mouse

American Journal of Pathology

Volumn 158, Issue 5, 2001, Pages 1653-1663

  Hong, Soon Won ^a   Isono, Motohide ^a   Chen, Sheldon ^a   Iglesias De La Cruz, M Carmen ^a   Han, Dong Cheol ^a   Ziyadeh, Fuad N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SMAD PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GLOMERULOSCLEROSIS; GLOMERULUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY FIBROSIS; KIDNEY TUBULE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

EID: 0035014583     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9440(10)64121-1     Document Type: Article

References (41)

1. Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy
2. Expression of transforming growth factor-beta isoforms in human glomerular disease
3. Quantification of glomerular TGF-beta 1 mRNA in patients with diabetes mellitus
4. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy
5. Expression of transforming growth factor-β1 during diabetic renal hypertrophy
6. Expression of transforming growth factor-β and type IV collagen in early streptozotocin-induced diabetes
7. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and enhanced extracellular matrix gene expression in streptozotocin-diabetic mice
8. Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse
9. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule
10. Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by high glucose concentration
11. Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells
12. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: Mediation by autocrine activation of TGF-β
13. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta
14. Extracellular signal-regulated kinase mediates stimulation of TGF-β1 and matrix by high glucose in mesangial cells
15. TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain
16. Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-beta receptor protein expressions
17. Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney
18. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
19. Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria
20. Early immunopathologic events in experimental diabetic nephropathy: A study in db/db mice
21. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists: A novel treatment strategy
22. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
23. Long-term prevention of renal insufficiency, excess matrix gene expression and glomerular mesangial matrix expression by treatment with monoclonal anti-TGF-β antibody in db/db diabetic mice
24. TGF-β signaling from cell membrane to nucleus through SMAD proteins
25. Smads: Transcriptional activators of TGF-beta responses
26. Transcriptional control by TGF-β/Smad signaling
27. Expression cloning of the TGF-β type II receptor, a functional trans-membrane serine/threonine kinase
28. In situ non-radioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry
29. Human Smad3 and Smad4 are sequence-specific transcription activators
30. In situ DNA-protein binding: A novel method for detecting DNA-binding activity of transcription factor in brain
31. Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195
32. The renal TGF-β system in the db/db mouse model of diabetic nephropathy
33. Insulin, insulin-like growth factors and the kidney
34. Role of insulin and IGF-1 receptors in proliferation of cultured renal proximal tubule cells
35. Insulin inhibits TGF-β1 transcriptional activity and mRNA levels in cell culture
36. Modulation of proximal tubular cell TGF-β1 production by insulin A2804
37. Direct binding of Smad3 and Smad4 to critical TGF-β-inducible elements in the promoter of human plasminogen activator inhibitor-type I gene
38. The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cells
39. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-β
40. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
41. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling