Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes

Journal of Molecular Endocrinology

Volumn 31, Issue 3, 2003, Pages 401-418

  Jesmin, S ^a   Sakuma, I ^a   Salah Eldin, A ^b   Nonomura, K ^a   Hattori, Y ^a   Kitabatake, A ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ISOENZYME; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM; ERECTILE DYSFUNCTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULIN RESISTANCE; MALE; MEDICAL DOCUMENTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PATHOPHYSIOLOGY; PENIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE INJURY; TISSUE SECTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; IMPOTENCE; INSULIN RESISTANCE; MALE; NITRIC OXIDE SYNTHASE; PENIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED OLETF; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 0346728613     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0310401     Document Type: Article

References (49)

1. Aiello LP, Avery RL, Vrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE et al. 1994 Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. New England Journal of Medicine 331 1480-1487.
2. Akingba AG & Burnett AL 2001 Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat. Molecular Urology 5 189-197.
3. Alici B, Gümüstas MK, Özkara H, Akkus E, Demirel G, Yencilek F & Hattat H 2000 Apoptosis in the erectile tissues of diabetic and healthy rats. BJU International 85 326-329.
4. Andersson KE & Wagner G 1995 Physiology of penile erection. Physiological Reviews 75 191-236.
5. Azadzoi KM & Saenz de Tejada I 1992 Diabetes mellitus impairs neurogenic and endothelium-mediated relaxation of rabbit corpus cavernosum smooth muscle. Journal of Urology 148 1587-1591.
6. Bloch W, Klotz T, Sedlaczek P, Zumbé J, Engelmann U & Addicks K 1998 Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum. Urological Research 26 129-135.
7. Bredt DS, Hwang PM & Snyder SH 1990 Localization of nitric oxide synthase indicating a neural role of nitric oxide. Nature 347 768-770.
8. Burnett AL 1997 Nitric oxide in the penis: physiology and pathology. Journal of Urology 157 320-324.
9. Burnett AL, Lowenstein CJ, Bredt DS, Chang TSK & Snyder SH 1992 Nitric oxide: a physiologic mediator of the penile erection. Science 257 401-403.
10. Bush PA, Aronson WJ, Buga GM, Rajter J & Ignarro IJ 1992 Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. Journal of Urology 147 1650-1655.
11. Cellek S, Rodrigo J, Lobos E, Fernández P, Serrano J & Moncada S 1999 Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. British Journal of Pharmacology 128 1804-1812.
12. Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP et al. 2002 Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states. A possible explanation for impaired collateral formation in cardiac tissue. Circulation 105 373-379.
13. Dimmeler S & Zeiher AM 2000 Endothelial cell apoptosis in angiogenesis and vessel regression. Circulation Research 87 434-439.
14. Ellenberg M 1971 Impotence in diabetes. The neurologic factor. Annals of Internal Medicine 75 213-219.
15. Escrig A, Marin R, Abreu P, Gonzalez-Mora JL & Mas M 2002 Changes in mating behavior, erectile function, and nitric oxide levels in penile corpus cavernosa in streptozotocin-diabetic rats. Biology of Reproduction 66 185-189.
16. Ferrara N 2001 Role of vascular endothelial growth factor in regulation of physiological angiogenesis. American Journal of Physiology 280 C1358-C1366.
17. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V & Ferrara N 1998 Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. Journal of Biological Chemistry 273 30336-30343.
18. González-Cadavid NF, Ignarro I, & Rajfer J 1999 Nitric oxide and cyclic GMP in the penis. Molecular Urology 3 51-59.
19. Hovind P, Taronow L, Oestergaard PB & Parving HH 2000 Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy. Kidney International 57 S56-S61.
20. Hurt KJ, Musicki B, Palese MA, Crone JK, Becker RE, Moriarity JL, Snyder SH & Burnett AL 2002 Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. PNAS 99 4061-4066.
21. Jesmin S, Hattori Y, Sakuma I, Mowa CN & Kitabatake A 2002a Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. American Journal of Physiology 283 H1387-H1397.
22. Jesmin S, Sakuma I, Hattori Y, Fujii S & Kitabatake A 2002b Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodeling in a Type II diabetic rat model. Diabetologia 45 402-415.
23. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M & Natori T 1992 Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long Evans Tokushima Fatty (OLETF) strain. Diabetes 41 1422-1428.
24. Lee M-C, el-Sakka AI, Graziottin TM, Ho H-C, Lin C-S & Lue TF 2002 The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. Journal of Urology 167 761-767.
25. Lin C-S, Ho H-C, Chen K-C, Lin G, Nunes L & Lue TF 2002 Intracavernosal injection of vascular endothelial growth factor induces nitric oxide synthase isoforms. BJU International 89 955-960.
26. McCulloch DK, Campbell IW, Wu FC, Prescott RJ & Clarke BF 1980 The prevalence of diabetic impotence. Diabetologia 18 279-283.
27. MacManus JP & Linnik MD 1997 Gene expression induced by cerebral ischemia: an apoptotic perspective. Journal Cerebral Blood Flow and Metabolism 17 815-832.
28. Mac-Naul KL & Hutchinson NI 1993 Differential expression of iNOS and eNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions. Biochemical and Biophysical Research Communications 196 1330-1334.
29. 1-adrenoceptor mRNA expression in rat heart. Biochemical Pharmacology 58 881-885.
30. Mazure NM, Chen EY, Laderoute KR & Giaccia AJ 1997 Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90 3322-3331.
31. Merry DE & Korsmeyer SJ 1997 Bcl-2 gene family in the nervous system. Annual Review of Neuroscience 20 245-267.
32. Nör JE, Christensen J, Mooney DJ & Polverini PJ 1999 Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. American Journal of Pathology 154 375-384.
33. Papapetropoulos A, García-Cardeña G, Madri JA & Sessa WC 1997 Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. Journal of Clinical Investigation 100 3131-3139.
34. Pickard RS, Powell PH & Zai MA 1995 Nitric oxide and cyclic GMP formation following relaxant nerve stimulation in isolated human corpus cavernosum. British Journal of Urology 75 516-522.
35. Saenz de Tejada I, Goldstein I, Azadzoi KM, Krane RJ & Cohen RA 1989 Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. New England Journal of Medicine 320 1025-1030.
36. el-Sakka AI, Lin CS, Chui RM, Dahiya R & Lue TF 1999 Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an annual model. International Journal of Impotence Research 11 123-132.
37. Schwartz D, Mendonca M, Schwartz I, Xia Y, Satriano J, Wilson CB & Blantz RC 1997 Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lypopolysaccharide administration provokes renal dysfunction in rats. Journal of Clinical Investigation 100 439-448.
38. Seftel AD, Vaziri ND, Ni Z, Razmjouci K, Fogarty J, Hampel N, Polak J, Wang RZ, Ferguson K, Block C & Haas C 1997 Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology 50 1016-1026.
39. Seftel AD, Maclennan GF, Chen ZJ, Liu S, Ferguson K, Deorco G, Levine F, Hampel N & Ho-Chang C 1999 Loss of TGFbeta, apoptosis, and Bcl-2 in erectile dysfunction and upregulation of p53 and HIF-1 alpha in diabetes-associated erectile dysfunction. Molecular Urology 3 103-107.
40. Segawa Y, Shirao Y, Yamagishi S, Higashide F, Kobayashi M, Katsuno F, Iyobe A, Harada H, Sato F, Miyata H et al. 1998 Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy. Ophthalmic Research 30 333-339.
41. Sheehy AM, Phung YT, Riemer RK & Black SM 1997 Growth factor induction of nitric oxide synthase in rat pheochromocytoma cells. Molecular Brain Research 52 71-77.
42. Sullivan ME, Keoghane SR & Miller MAW 2001 Vascular risk factors and erectile dysfunction. BJU International 87 838-845.
43. Tamura M, Kagawa S, Kimura K, Kawanishi Y, Tsuno Y & Ishimura K 1995 Coexistence of nitric oxide synthase, tyrosine hydroxylase and vasoactive intestinal polypeptide in human penile tissue: a triple histochemical and immunohistochemical study. Journal of Urology 153 530-534.
44. Thakker GD, Hajjar DP, Muller WA & Rosengart TK 1999 The role of phosphatidylinositol 3′-kinase in vascular endothelial growth factor signaling. Journal of Biological Chemistry 274 10002-10007.
45. Thornberry NA & Lazebnik Y 1998 Caspases: enemies within. Science 281 1312-1316.
46. Tsuchida K, Makita Z, Yamagishi S, Atsumi T, Miyoshi H, Obara S, Ishida S, Yasumura K & Koike T 1999 Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195. Diabetologia 42 579-588.
47. dp (Type II) rats with erectile dysfunction. Endocrinology 136 5709-5717.
48. 2+-induced apoptosis through calcineurin dephosphorylation of Bad. Science 284 339-343.
49. Yagi K, Kim S, Wanibuchi H, Yamashita T, Yamamura Y & Iwao H 1997 Characterizations of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long Evans Tokushima fatty rats. Hypertension 29 728-735.