The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver

Medical Hypotheses

Volumn 71, Issue 5, 2008, Pages 730-736

  Tao, Kai Shan ^a   Wang, Wen ^a,b   Wang, Ling ^a   Cao, Da Yong ^a   Li, Yong Qi ^a   Wu, Sheng Xi ^b   Dou, Ke Feng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CAFESTOL; CAFFEINE; CHLOROGENIC ACID; DITERPENE; KAHWEOL; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CANCER RISK; CANCER STAGING; CARCINOGENESIS; CHEMOPROPHYLAXIS; COFFEE; DETOXIFICATION; DIET; DRUG MECHANISM; ENZYME ACTIVITY; LIVER; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; CAFFEINE; CHLOROGENIC ACID; COFFEE; DITERPENES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; LIVER NEOPLASMS; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; RESPONSE ELEMENTS;

ANIMALIA;

EID: 52949101322     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.06.026     Document Type: Article

References (50)

1. Giovannucci E. Meta-analysis of coffee consumption and risk of colorectal cancer. Am J Epidemiol 147 (1998) 1043-1152
2. Larsson S.C., and Wolk A. Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology 132 (2007) 1740-1745
3. La Vecchia C. Coffee, liver enzymes, cirrhosis and liver cancer. J Hepatol 42 (2005) 444-446
4. Luo J, Inoue M, Iwasaki M, Sasazuki S, Otani T, Ye W, Tsugane S. JPHC study group. Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study). Eur J Cancer Prev 2007;16:542-8.
5. Abel E.L., Hendrix S.O., McNeeley S.G., Johnson K.C., Rosenberg C.A., Mossavar-Rahmani Y., et al. Daily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian women. Eur J Cancer Prev 16 5 (2007) 446-452
6. Spiller M.A. The chemical components of coffee. Prog Clin Biol Res 158 (1984) 91-147
7. Gross G., Jaccaud E., and Huggett A.C. Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food Chem Toxicol 35 (1997) 547-554
8. Urgert R., Schulz A.G., and Katan M.B. Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in humans. Am J Clin Nutr 61 (1995) 149-154
9. Okano J., Nagahara T., Matsumoto K., and Murawaki Y. Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway. Basic Clin Pharmacol Toxicol 102 (2008) 543-551
10. Tanaka T., Kojima T., Suzui M., and Mori H. Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis. Cancer Res 53 (1993) 3908-3913
11. Mori H., Kawabata K., Matsunaga K., Ushida J., Fujii K., Hara A., et al. Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis. Biofactors 12 (2000) 101-105
12. Moolgavkar S.H. The multistage theory of carcinogenesis and the age distribution of cancer in man. J Natl Cancer Inst 61 (1978) 49-52
13. Wattenberg L.W. Chemoprevention of cancer. Cancer Res 45 (1985) 1-8
14. Hossain S.U., and Bhattacharya S. Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene 2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes. Bioorg Med Chem Lett 17 (2007) 1149-1154
15. Yu S., and Kong A.N. Targeting carcinogen metabolism by dietary cancer preventive compounds. Curr Cancer Drug Targets 7 (2007) 416-424
16. Stiborová M., Arlt V.M., Henderson C.J., Wolf C.R., Frei E., Schmeiser H.H., et al. Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149 (2005) 191-197
17. Schilter B., Perrin I., Cavin C., and Huggett A.C. Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol. Carcinogenesis 17 (1996) 2377-2384
18. Cavin C., Holzhäuser D., Constable A., Huggett A.C., and Schilter B. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis 19 (1998) 1369-1375
19. Lam L.K., Sparnins V.L., and Wattenberg L.W. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. Cancer Res 42 (1982) 1193-1198
20. Swedmark S., Romert L., Morgenstern R., and Jenssen D. Studies on glutathione transferases belonging to class pi in cell lines with different capacities for conjugating (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Carcinogenesis 13 (1992) 1719-1723
21. Fields W.R., Li Y., and Townsend A.J. Protection by transfected glutathione S-transferase isozymes against carcinogen-induced alkylation of cellular macromolecules in human MCF-7 cells. Carcinogenesis 15 (1994) 1155-1160
22. Lin D., Meyer D.J., Ketterer B., Lang N.P., and Kadlubar F.F. Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis. Cancer Res 54 (1994) 4920-4926
23. Hayes P.C., May L., Hayes J.D., and Harrison D.J. Glutathione S-transferases in human liver cancer. Gut 32 (1991) 1546-1549
24. Pulford D.J., and Hayes J.D. Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5′-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1. Biochem J 318 (1996) 75-84
25. Huber W.W., Prustomersky S., Delbanco E., Uhl M., Scharf G., Turesky R.J., et al. Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol. Arch Toxicol 76 (2002) 209-217
26. Huber W.W., Scharf G., Rossmanith W., Prustomersky S., Grasl-Kraupp B., Peter B., et al. The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. Arch Toxicol 75 (2002) 685-694
27. Huber W.W., Rossmanith W., Grusch M., Haslinger E., Prustomersky S., Peter-Vörösmarty B., et al. Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. Food Chem Toxicol 46 (2008) 1230-1238
28. Cavin C., Marin-Kuan M., Langouët S., Bezençon C., Guignard G., Verguet C., et al. Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. Food Chem Toxicol 46 (2008) 1239-1248
29. Cavin C., Mace K., Offord E.A., and Schilter B. Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells. Food Chem Toxicol 39 (2001) 549-556
30. Hammons G.J., Fletcher J.V., Stepps K.R., Smith E.A., Balentine D.A., Harbowy M.E., et al. Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. Nutr Cancer 33 (1999) 46-52
31. Chen Y., Jungsuwadee P., Vore M., Butterfield D.A., and St Clair D.K. Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 7 (2007) 147-156
32. Kalinina E., Novichkova M., Scherbak N.P., Solomka V., and Saprin A.N. GSH-dependent redox regulation and antioxidant enzymes in the formation of resistance to doxorubicin in K562 human erythroleukemia cells. Adv Exp Med Biol 500 (2001) 241-244
33. Huber W.W., Teitel C.H., Coles B.F., King R.S., Wiese F.W., Kaderlik K.R., et al. Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities. Environ Mol Mutagen 44 (2004) 265-276
34. McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., et al. The cap 'n' collar basic leucine zipper transcription factor Nrf2 controls not only the basal expression of intestinal detoxification and glutathione biosynthetic enzymes but also their induction by cancer chemopreventive agents. Cancer Res 61 (2001) 3299-3307
35. Scharf G., Prustomersky S., and Huber W.W. Elevation of glutathione levels by coffee components and its potential mechanisms. Adv Exp Med Biol 500 (2001) 535-539
36. Zhang Y., Guan L., Wang X., Wen T., Xing J., and Zhao J. Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. Free Radic Res 42 (2008) 362-371
37. Buchner J., Ehrnsperger M., Gaestel M., and Walke S. Purification and characterization of small heat shock proteins. Methods Enzymol 290 (1998) 339-349
38. Hayes JD, Ellis EM, Neal GE, Harrison DJ, Manson MM. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. In: Downes CP, Wolf CR, Lane DP, editors. Cellular responses to stress. Biochemical society symposium 64. Portland Press, London; 1999. p. 141-68.
39. Yanaka A., Zhang S., Tauchi M., Suzuki H., Shibahara T., Matsui H., et al. Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. Inflammopharmacology 13 (2005) 83-90
40. Prestera T., Talalay P., Alam J., Ahn Y.I., Lee P.J., and Choi A.M.K. Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1 (1995) 827-837
41. Mulcahy R.T., Wartman M.A., Bailey H.H., and Gipp J.J. Constitutive and b-naphthoflavone-induced expression of the human g-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 272 (1997) 7445-7454
42. Alam J., Stewart D., Touchard C., Boinapally S., Choi A.M.K., and Cook J.L. Nrf2, a cap 'n' collar transcription factor regulates induction of the heme oxygenase-1 gene. J Biol Chem 274 (1999) 26071-26078
43. Dhakshinamoorthy S., and Jaiswal A.K. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase 1 gene. Oncogene 20 (2001) 3906-3917
44. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13 (1999) 76-86
45. Itoh K., Wakabayashi N., Katoh Y., Ishii T., O'Connor T., and Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8 (2003) 379-391
46. Motohashi H., and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10 (2004) 549-557
47. Kobayashi M., Itoh K., Suzuki T., Osanai H., Nishikawa K., Katoh Y., et al. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 7 (2002) 807-820
48. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99 (2002) 11908-11913
49. Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D., Kang M.I., Kobayashi A., Yamamoto M., et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 101 (2004) 2040-2045
50. enugopal R., and Jaiswal A.K. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regular the human antioxidant response element-mediated expression of NAD(P)H: quinone oxidoreductase1 gene. Proc Natl Acad Sci USA 93 (1996) 14960-14965