메뉴 건너뛰기




Volumn 17, Issue 9, 2008, Pages 1301-1314

New VEGF antagonists as possible therapeutic agents in vascular disease

Author keywords

Atherosclerosis; Diabetic retinopathy; Nanotechnology; Tumour growth; Vascular endothelial growth factor

Indexed keywords

ADENOVIRUS VECTOR; AE 941; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ANTINEOPLASTIC AGENT; AXITINIB; BEVACIZUMAB; CETUXIMAB; DOCETAXEL; DOXORUBICIN; MACROGOL; N (3,3 DIMETHYL 6 INDOLINYL) 2 (4 PYRIDINYLMETHYLAMINO)NICOTINAMIDE; PACLITAXEL; PEGAPTANIB; PLACEBO; PROTEIN ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; RANIBIZUMAB; RECEPTOR BLOCKING AGENT; RUBOXISTAURIN; SMALL INTERFERING RNA; TG 100572; THROMBOCYTE GROWTH FACTOR ANTIBODY; TOPOTECAN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR BLOCKING AGENT; VINCA ALKALOID;

EID: 52949084355     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.9.1301     Document Type: Review
Times cited : (13)

References (111)
  • 1
    • 36148937125 scopus 로고    scopus 로고
    • Tumour vascularization: Sprouting angiogenesis and beyond
    • Hillen F, Griffioen AW. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 2007;26:489-502
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 489-502
    • Hillen, F.1    Griffioen, A.W.2
  • 3
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 4
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, Le Couter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Le Couter, J.3
  • 5
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20:4368-80
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 6
    • 10344249918 scopus 로고    scopus 로고
    • Molecular regulation of the VEGF family - inducers of angiogenesis and lymphangiogenesis
    • McColl BK, Stacker SA, Achen MG. Molecular regulation of the VEGF family - inducers of angiogenesis and lymphangiogenesis. APMIS 2004;112:463-80
    • (2004) APMIS , vol.112 , pp. 463-480
    • McColl, B.K.1    Stacker, S.A.2    Achen, M.G.3
  • 7
    • 0032584108 scopus 로고    scopus 로고
    • Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular pertneability factor is necessary; but not sufficient for tumorigenicity of human colorectal carcinoma cells
    • Okada F, Rak JW, Croix BS, et al. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular pertneability factor is necessary; but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc Natl Acad Sci USA 1998;95:3609-14
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3609-3614
    • Okada, F.1    Rak, J.W.2    Croix, B.S.3
  • 8
    • 0035570863 scopus 로고    scopus 로고
    • Quantitative analysis of gene expressions of vascular endothelial growth factor-related factors and their receptors in renal cell carcinoma
    • Tsuchiya N, Sato K, Akao T, et al. Quantitative analysis of gene expressions of vascular endothelial growth factor-related factors and their receptors in renal cell carcinoma. Tohoku J Exp Med 2001;195:101-13
    • (2001) Tohoku J Exp Med , vol.195 , pp. 101-113
    • Tsuchiya, N.1    Sato, K.2    Akao, T.3
  • 9
    • 0034830831 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development
    • Liang D, Chang JR, Chin AJ, et al. The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development Mech Dev 2001; 108:29-43
    • (2001) Mech Dev , vol.108 , pp. 29-43
    • Liang, D.1    Chang, J.R.2    Chin, A.J.3
  • 10
    • 25144511910 scopus 로고    scopus 로고
    • The vascular indothelial growth factor (VEGF)/ VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H, Shibuya M. The vascular indothelial growth factor (VEGF)/ VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 2005;109:227-41
    • (2005) Clin Sci (Lond) , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 11
    • 0032564411 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C induces angiogenesis in vivo
    • Can Y, Linden, P, Farnebo J, et al. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 1998;95:14389-94
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14389-14394
    • Can, Y.1    Linden, P.2    Farnebo, J.3
  • 12
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
    • Saharinen P Tammela T, Karkkinen MJ, et al. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation; Trends Immunol 2004;25:387-95
    • (2004) Trends Immunol , vol.25 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkinen, M.J.3
  • 13
    • 33947714052 scopus 로고    scopus 로고
    • Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma
    • Ding S, Li C, Lin S, et al. Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma. Oncol Rep 2007;17:369-75
    • (2007) Oncol Rep , vol.17 , pp. 369-375
    • Ding, S.1    Li, C.2    Lin, S.3
  • 14
    • 0348049834 scopus 로고    scopus 로고
    • VEGF signalling: Integration and multi-tasking in endothelial cell biology
    • Zachary I. VEGF signalling: integration and multi-tasking in endothelial cell biology, Biochem Soc Trans 2003;31:1171-7
    • (2003) Biochem Soc Trans , vol.31 , pp. 1171-1177
    • Zachary, I.1
  • 15
    • 0029004025 scopus 로고
    • Vascular permeability factor/ vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak HF, Brown LF, Detmar M, et al. Vascular permeability factor/ vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995;146:1029-39
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3
  • 16
    • 34447310236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 (VEGFR-1/ Flt-1): A dual regulator for angiogenesis
    • Shibuya M. Vascular endothelial growth factor receptor-1 (VEGFR-1/ Flt-1): a dual regulator for angiogenesis. Angiogenesis 2006;9:225-30
    • (2006) Angiogenesis , vol.9 , pp. 225-230
    • Shibuya, M.1
  • 17
    • 18844417604 scopus 로고    scopus 로고
    • Gene therapy for ischemic cardiovascular diseases: Some lessons learned from the first clinical trials
    • Yla-Herttuala S, Markkanen JE, Rissanen TT. Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials. Trends Cardiovasc Med 2004;14:295-300
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 295-300
    • Yla-Herttuala, S.1    Markkanen, J.E.2    Rissanen, T.T.3
  • 18
    • 33847643631 scopus 로고    scopus 로고
    • Drug insight: VEGF as a therapeutic target for breast cancer
    • Schneider BP, Sledge GW Jr. Drug insight: VEGF as a therapeutic target for breast cancer. Nat Clin Pract Oncol 2007;4:181-9
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 181-189
    • Schneider, B.P.1    Sledge Jr., G.W.2
  • 19
    • 33846834110 scopus 로고    scopus 로고
    • Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer
    • Kramer I, Lipp HP. Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer. J Clin Pharm Ther 2007;32:1-14
    • (2007) J Clin Pharm Ther , vol.32 , pp. 1-14
    • Kramer, I.1    Lipp, H.P.2
  • 20
    • 7244236494 scopus 로고    scopus 로고
    • Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
    • Wang ES, Turuya-Feldstein J, Wu, Y, et al. Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo. Blood 2004;104:2893-902.
    • (2004) Blood , vol.104 , pp. 2893-2902
    • Wang, E.S.1    Turuya-Feldstein, J.2    Wu, Y.3
  • 21
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 1995;92:10457-61
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 22
    • 13144262858 scopus 로고    scopus 로고
    • Parecrine expression of a native soluble vascular endothelial growth factor receptor inhibits, tumor growth, metastasis, and mortality rate
    • Goldman CK, Kendall Cabrera G, et al. Parecrine expression of a native soluble vascular endothelial growth factor receptor inhibits, tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci USA 1998;95:8795-800
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8795-8800
    • Goldman, C.K.1    Kendall Cabrera, G.2
  • 23
    • 43649089524 scopus 로고    scopus 로고
    • Cheiradone: A vascular endothelial cell growth factor receptor antagonist
    • Hussain S, Slevin M, Mesaik MA, et al. Cheiradone: a vascular endothelial cell growth factor receptor antagonist. BMC Cell Biol 2008;9:7
    • (2008) BMC Cell Biol , vol.9 , pp. 7
    • Hussain, S.1    Slevin, M.2    Mesaik, M.A.3
  • 24
    • 39449130466 scopus 로고    scopus 로고
    • Update on the treatment of diabetic retinopathy
    • Wilkinson-Berka JL, Millar AG. Update on the treatment of diabetic retinopathy. Sci World J 2008;6:98-120
    • (2008) Sci World J , vol.6 , pp. 98-120
    • Wilkinson-Berka, J.L.1    Millar, A.G.2
  • 25
    • 33947316803 scopus 로고    scopus 로고
    • Ocular drug development future directions
    • Sherris D. Ocular drug development future directions. Angiogenesis 2007; 10:71-6
    • (2007) Angiogenesis , vol.10 , pp. 71-76
    • Sherris, D.1
  • 26
    • 34248174810 scopus 로고    scopus 로고
    • A chronic grey matter penumbra, lateral microvascular intussusception and venous peduncular avulsion underlie diabetic vitreous haemorrhage
    • McLeod D. A chronic grey matter penumbra, lateral microvascular intussusception and venous peduncular avulsion underlie diabetic vitreous haemorrhage. Br J Ophthalmol 2007;91:677-89:
    • (2007) Br J Ophthalmol , vol.91 , pp. 677-689
    • McLeod, D.1
  • 27
    • 34547899988 scopus 로고    scopus 로고
    • Focus on molecules: Opticin
    • Le Goff MM, Bishop PN. Focus on molecules: opticin. Exp Eye Res 2007;85:303-4
    • (2007) Exp Eye Res , vol.85 , pp. 303-304
    • Le Goff, M.M.1    Bishop, P.N.2
  • 28
    • 39449099625 scopus 로고    scopus 로고
    • Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy
    • Kakehashi A, Inoda S, Mameuda C, et al. Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy. Diabetes Res Clin Prac 2007;79:438-45
    • (2007) Diabetes Res Clin Prac , vol.79 , pp. 438-445
    • Kakehashi, A.1    Inoda, S.2    Mameuda, C.3
  • 29
    • 41449099709 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in the development of diabetic retinopathy in patients with type 1 diabetes mellitus
    • Ermakova NA, Syrodeeva ON, Antsiferov MB, et al. Role of vascular endothelial growth factor in the development of diabetic retinopathy in patients with type 1 diabetes mellitus. Vestn Oftalmol 2008;124:25-8
    • (2008) Vestn Oftalmol , vol.124 , pp. 25-28
    • Ermakova, N.A.1    Syrodeeva, O.N.2    Antsiferov, M.B.3
  • 30
    • 35548939420 scopus 로고    scopus 로고
    • The future implications of anti-vascular endothelial growth factor therapy in ophthalmic practice
    • Hussain N, Ghanekar Y, Kanr I. The future implications of anti-vascular endothelial growth factor therapy in ophthalmic practice. Indian J Ophthalmol 2007;55:445-50
    • (2007) Indian J Ophthalmol , vol.55 , pp. 445-450
    • Hussain, N.1    Ghanekar, Y.2    Kanr, I.3
  • 31
    • 33947542681 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy
    • Starita C, Patel M, Katz B, et al. Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy. Dev Ophthalmol 2007;39:122-48
    • (2007) Dev Ophthalmol , vol.39 , pp. 122-148
    • Starita, C.1    Patel, M.2    Katz, B.3
  • 32
    • 11144239923 scopus 로고    scopus 로고
    • VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for age related macular degeneration
    • Gragouclas ES, Adamis AP, Cunningham ET, et al. VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for age related macular degeneration. N Engl J Med 2004;351:2805-16
    • (2004) N Engl J Med , vol.351 , pp. 2805-2816
    • Gragouclas, E.S.1    Adamis, A.P.2    Cunningham, E.T.3
  • 33
    • 33748979577 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor agents and their development: Therapeutic implications in ocular disease
    • Kaiser PK. Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular disease. Am J Ophthalmol 2006; 142:660-8
    • (2006) Am J Ophthalmol , vol.142 , pp. 660-668
    • Kaiser, P.K.1
  • 34
    • 34948859043 scopus 로고    scopus 로고
    • Targeted pharmacotherapy of retinal diseases with ranibizumab
    • Campochiaro PA. Targeted pharmacotherapy of retinal diseases with ranibizumab Drugs Today 2007;43:529-37
    • (2007) Drugs Today , vol.43 , pp. 529-537
    • Campochiaro, P.A.1
  • 35
    • 38449100932 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for ocular neovascular disease
    • Andreoli CM, Miller JW. Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol 2007;18:502-8
    • (2007) Curr Opin Ophthalmol , vol.18 , pp. 502-508
    • Andreoli, C.M.1    Miller, J.W.2
  • 36
    • 34247182509 scopus 로고    scopus 로고
    • Bevacizumab for neovascular ocular diseases
    • Lynch SS, Cheng CM. Bevacizumab for neovascular ocular diseases. Ann Pharmacother 2007;41:614-25
    • (2007) Ann Pharmacother , vol.41 , pp. 614-625
    • Lynch, S.S.1    Cheng, C.M.2
  • 37
    • 35349022642 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy
    • Sawada O, Kawamura H, Kakinoki M, et al. Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy. Arch Ophthalmol 2007;125:1363-6
    • (2007) Arch Ophthalmol , vol.125 , pp. 1363-1366
    • Sawada, O.1    Kawamura, H.2    Kakinoki, M.3
  • 38
    • 39149083402 scopus 로고    scopus 로고
    • PKCβII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression
    • Amadio M, Scapagaini G, Lupo G, et al. PKCβII/HuR/VEGF: a new molecular cascade in retinal pericytes for the regulation of VEGF gene expression Pharmacol Res 2008;57:60-6
    • (2008) Pharmacol Res , vol.57 , pp. 60-66
    • Amadio, M.1    Scapagaini, G.2    Lupo, G.3
  • 39
    • 33845455480 scopus 로고    scopus 로고
    • Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy
    • Idris I, Donnelly R. Protein kinase C beta inhibition: a novel therapeutic strategy for diabetic microangiopathy. Diab Vasc Dis Res 2006;3:172-8.
    • (2006) Diab Vasc Dis Res , vol.3 , pp. 172-178
    • Idris, I.1    Donnelly, R.2
  • 40
    • 32944477380 scopus 로고    scopus 로고
    • Inhibition of ocular neovascularization by hedgehog blockade
    • Surace EM, Balaggan KS, Tessitore A. et al. Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther 2006;13:573-9
    • (2006) Mol Ther , vol.13 , pp. 573-579
    • Surace, E.M.1    Balaggan, K.S.2    Tessitore, A.3
  • 41
    • 41149178633 scopus 로고    scopus 로고
    • Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema
    • Doukas J, Mahesh S, Umeda N, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol 2008;216:29-37
    • (2008) J Cell Physiol , vol.216 , pp. 29-37
    • Doukas, J.1    Mahesh, S.2    Umeda, N.3
  • 42
    • 41149110687 scopus 로고    scopus 로고
    • Development of prodrug 4-chloro-3- (5-methyl-3- 4-(2-pyrrolidin-1-ylethoxy) phenyl] amino}-1,2,4-benzotriazin,in-7-yl) phenyl benzoate (TG100801): A topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration
    • Palanki MS, Akiyama H, Campochiaro P, et al. Development of prodrug 4-chloro-3- (5-methyl-3- 4-(2-pyrrolidin-1-ylethoxy) phenyl] amino}-1,2,4-benzotriazin,in-7-yl) phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. J Med Chem 2008;51:1546-59
    • (2008) J Med Chem , vol.51 , pp. 1546-1559
    • Palanki, M.S.1    Akiyama, H.2    Campochiaro, P.3
  • 43
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signalling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo N, Mailhos C, Ju M, et al. Inhibition of platelet-derived growth factor B signalling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 2006;168:2036-53
    • (2006) Am J Pathol , vol.168 , pp. 2036-2053
    • Jo, N.1    Mailhos, C.2    Ju, M.3
  • 44
    • 34548435126 scopus 로고    scopus 로고
    • Inhibition of corneal neovascularization with a nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract
    • Shakiba Y, Mostafie A. Inhibition of corneal neovascularization with a nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract. Arch Med Res 2007;38:789-91
    • (2007) Arch Med Res , vol.38 , pp. 789-791
    • Shakiba, Y.1    Mostafie, A.2
  • 45
    • 35348972972 scopus 로고    scopus 로고
    • Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia-inducible factor-1alpha
    • Forooghian F, Das B. Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia-inducible factor-1alpha. Am J Ophthalmol 2007; 144:761-8
    • (2007) Am J Ophthalmol , vol.144 , pp. 761-768
    • Forooghian, F.1    Das, B.2
  • 46
    • 33846878752 scopus 로고    scopus 로고
    • Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector
    • Syonh MP, Lee FL, Kuo PC, et al. Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector. Mol Vis 2007;13:133-41
    • (2007) Mol Vis , vol.13 , pp. 133-141
    • Syonh, M.P.1    Lee, F.L.2    Kuo, P.C.3
  • 47
    • 0037174957 scopus 로고    scopus 로고
    • Slevin M, Kumar S, Gaffney J. Angiogenic oligosaccharides of hyaluronan induce multiple signalling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem 2002;277-41046-59
    • Slevin M, Kumar S, Gaffney J. Angiogenic oligosaccharides of hyaluronan induce multiple signalling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem 2002;277-41046-59
  • 48
    • 40949105216 scopus 로고    scopus 로고
    • Management of proliferative diabetic retinopathy
    • Gunduz K, Bakri SJ. Management of proliferative diabetic retinopathy. Compr Ophthalmol Update 2007;8:245-56
    • (2007) Compr Ophthalmol Update , vol.8 , pp. 245-256
    • Gunduz, K.1    Bakri, S.J.2
  • 49
    • 33947308655 scopus 로고    scopus 로고
    • Combination therapy for the treatment of ocular neovascularization
    • Bradley J, Ju M, Robinsom GS. Combination therapy for the treatment of ocular neovascularization. Angiogenesis 2007;10:141-8
    • (2007) Angiogenesis , vol.10 , pp. 141-148
    • Bradley, J.1    Ju, M.2    Robinsom, G.S.3
  • 50
    • 49349103253 scopus 로고    scopus 로고
    • Intravitreous anti-VEGF for diabetic retinopathy: Hopes and fears fi)r a new therapeutic strategy
    • Epub ahead of print
    • Simo R, Hernandez C. Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears fi)r a new therapeutic strategy. Diabetologia 2008 [Epub ahead of print],
    • (2008) Diabetologia
    • Simo, R.1    Hernandez, C.2
  • 51
    • 33646527453 scopus 로고    scopus 로고
    • Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy
    • Simo F, Carrasco E, Garcia-Ramirez M, et al. Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Curr Diabetes Rev 2006;2:71-98
    • (2006) Curr Diabetes Rev , vol.2 , pp. 71-98
    • Simo, F.1    Carrasco, E.2    Garcia-Ramirez, M.3
  • 52
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 53
    • 11844254414 scopus 로고    scopus 로고
    • Jain RK Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62
    • Jain RK Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62
  • 54
    • 38749084161 scopus 로고    scopus 로고
    • Taming vessels to treat cancer
    • Jain RK. Taming vessels to treat cancer. Sci Am 2008;298:56-63
    • (2008) Sci Am , vol.298 , pp. 56-63
    • Jain, R.K.1
  • 56
    • 34249689557 scopus 로고    scopus 로고
    • VEGF targeted cancer therapy strategies: Current progress, hurdles and future prospects
    • Duda DG, Batchelor TT, Willen CG, et al. VEGF targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med 2007;13:223-30
    • (2007) Trends Mol Med , vol.13 , pp. 223-230
    • Duda, D.G.1    Batchelor, T.T.2    Willen, C.G.3
  • 57
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang WC, WU X, Peale FV, et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006;281:951-61
    • (2006) J Biol Chem , vol.281 , pp. 951-961
    • Liang, W.C.1    WU, X.2    Peale, F.V.3
  • 58
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry AM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-734
    • (2003) N Engl J Med , vol.349 , pp. 427-734
    • Yang, J.C.1    Haworth, L.2    Sherry, A.M.3
  • 59
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular eadothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee CG, Heijn M, Di Tomaso E, et al. Anti-vascular eadothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000;60:5565-70
    • (2000) Cancer Res , vol.60 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    Di Tomaso, E.3
  • 60
    • 0035836697 scopus 로고    scopus 로고
    • Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer
    • Kuo CJ, Farnebo F, Yu EY, et al. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci USA 2001;98:4605-10
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4605-4610
    • Kuo, C.J.1    Farnebo, F.2    Yu, E.Y.3
  • 61
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002;99:11393-8
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 62
    • 33746445268 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of intravenous VEGF Trap plus FOLFOX4 in a combination phase I clinical trial of patients with advanced solid tumours [abstract]
    • Mulay M, Limentani SA, Carroll M, et al. Safety and pharmacokinetics of intravenous VEGF Trap plus FOLFOX4 in a combination phase I clinical trial of patients with advanced solid tumours [abstract]. Proc Am Soc Clin Oncol 2006;24
    • (2006) Proc Am Soc Clin Oncol , pp. 24
    • Mulay, M.1    Limentani, S.A.2    Carroll, M.3
  • 63
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effect of vascular-targeting agents and the implications for combination with conventional therapies
    • Horsman MR, Siemann DW. Pathophysiologic effect of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res 2006;66:11520-39
    • (2006) Cancer Res , vol.66 , pp. 11520-11539
    • Horsman, M.R.1    Siemann, D.W.2
  • 64
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and, EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabenero J. The role of VEGF and, EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Ress 2007;5:203-20
    • (2007) Mol Cancer Ress , vol.5 , pp. 203-220
    • Tabenero, J.1
  • 65
    • 0034256094 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors
    • Sun L, McMahon G. Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors. Drug Discov Today 2000;5:344-54
    • (2000) Drug Discov Today , vol.5 , pp. 344-354
    • Sun, L.1    McMahon, G.2
  • 67
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and Potent inhibitor of vascular endothelial growth factor receptor kinases, impairs vascular endotheliual growth factor responses and tumour growth after oral administration
    • Wood J, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and Potent inhibitor of vascular endothelial growth factor receptor kinases, impairs vascular endotheliual growth factor responses and tumour growth after oral administration. Cancer Res 2000;60:2178-89
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.1    Bold, G.2    Buchdunger, E.3
  • 68
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine-kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong AT, Shawver LK, Sun L, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine-kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59:99-106
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, A.T.1    Shawver, L.K.2    Sun, L.3
  • 69
    • 0036718003 scopus 로고    scopus 로고
    • Results of phase I dose-escalating study of the anti-angiogenic agent, SU5416 in patients with advanced malignancies
    • Stopeck A, Sheldon M, Vahedian M, et al. Results of phase I dose-escalating study of the anti-angiogenic agent, SU5416 in patients with advanced malignancies. Clin Cancer Res 2002;8:2798-805
    • (2002) Clin Cancer Res , vol.8 , pp. 2798-2805
    • Stopeck, A.1    Sheldon, M.2    Vahedian, M.3
  • 70
    • 0035282940 scopus 로고    scopus 로고
    • The anti-angiogenic protein kinase inhibitors SU5416 and SU6668 inhibits the SCF receptor (KIT) ina hunan myeloid leukaemia cell line and in acute myeloid leukaemia blasts
    • Smolich B, Yuen D, West KA, et al. The anti-angiogenic protein kinase inhibitors SU5416 and SU6668 inhibits the SCF receptor (KIT) ina hunan myeloid leukaemia cell line and in acute myeloid leukaemia blasts. Blood 2001;97:1413-21
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.1    Yuen, D.2    West, K.A.3
  • 71
    • 10744222964 scopus 로고    scopus 로고
    • Pharmacological characterisation of CP-547,632, a novel vascular endothelial growth factor receptor-2 throsine kinase inhibitor for cancer theraphy
    • Beebe JS, Jani JP, Knauthe E, et al. Pharmacological characterisation of CP-547,632, a novel vascular endothelial growth factor receptor-2 throsine kinase inhibitor for cancer theraphy. Cancer Res 2003;63:7301-9
    • (2003) Cancer Res , vol.63 , pp. 7301-7309
    • Beebe, J.S.1    Jani, J.P.2    Knauthe, E.3
  • 72
    • 34147131736 scopus 로고    scopus 로고
    • Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: Rationale and clinical applications for non-small cell lung cancer
    • Byers LA, Heymach JV. Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small cell lung cancer. Clin Lung Cancer 2007;(Suppl 2);S79-85
    • (2007) Clin Lung Cancer , Issue.SUPPL. 2
    • Byers, L.A.1    Heymach, J.V.2
  • 73
    • 41649104479 scopus 로고    scopus 로고
    • Dual inhibition of VEGFR and EGFR signalling reduces the incidence and size of intestinal adenornas in Ape (min/+) mice
    • Alfredez D, Wilkinson RW, Watkins J, et al. Dual inhibition of VEGFR and EGFR signalling reduces the incidence and size of intestinal adenornas in Ape (min/+) mice. Mol Cancer Ther 2008;7:590-8
    • (2008) Mol Cancer Ther , vol.7 , pp. 590-598
    • Alfredez, D.1    Wilkinson, R.W.2    Watkins, J.3
  • 74
    • 23044525453 scopus 로고    scopus 로고
    • kliment'eva chemicai features of medicinal plants (review)
    • Lokava M, Ya GN, Buzuk SM, et al. kliment'eva chemicai features of medicinal plants (review). Appl Biochem Microbiol 2001;37:229-37
    • (2001) Appl Biochem Microbiol , vol.37 , pp. 229-237
    • Lokava, M.1    Ya, G.N.2    Buzuk, S.M.3
  • 76
    • 37649022050 scopus 로고    scopus 로고
    • Anti-tumor and antiangiogenic growth factor hairpin ribozymes target human hepatocellular carcinoma cell cultures and xenografts
    • Li LH, Gou ZJ, Yan LL, et al. Anti-tumor and antiangiogenic growth factor hairpin ribozymes target human hepatocellular carcinoma cell cultures and xenografts. World J Gastroenterol 2007;13:6425-32
    • (2007) World J Gastroenterol , vol.13 , pp. 6425-6432
    • Li, L.H.1    Gou, Z.J.2    Yan, L.L.3
  • 77
    • 33746440212 scopus 로고    scopus 로고
    • Induction of complete regressions of oncogene- induced breast tumours in mice in: Molecular approaches to controlling cancer
    • Lab Press: NY; ;
    • Benezra R, Henke E, Ciarrocchi A, et al. Induction of complete regressions of oncogene- induced breast tumours in mice in: molecular approaches to controlling cancer. Cold Spr Harb Symp Quant Biol LXX Cold Spr Harb Lab Press: NY; 2005;volume 70 p. 375-81
    • (2005) Cold Spr Harb Symp Quant Biol LXX Cold Spr Harb , vol.70 , pp. 375-381
    • Benezra, R.1    Henke, E.2    Ciarrocchi, A.3
  • 78
    • 47949096436 scopus 로고    scopus 로고
    • Eichhorn ME, Strieth S, Luedemann S, et al. Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumour microcirculation in highly vascularized melanomas on short-term anti VEGFR treatment. Cancer Biol Ther 2008;7: [Epub ahead of print]
    • Eichhorn ME, Strieth S, Luedemann S, et al. Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumour microcirculation in highly vascularized melanomas on short-term anti VEGFR treatment. Cancer Biol Ther 2008;7: [Epub ahead of print]
  • 79
    • 43249131771 scopus 로고    scopus 로고
    • Successful inhibition of intracranial - glioblastoma multiforme xenograft growth via systemic adenovirai delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: Laboratory investigation
    • Szentirmai O, Baker CH, Bullain SS, et al. Successful inhibition of intracranial - glioblastoma multiforme xenograft growth via systemic adenovirai delivery of soluble endostatin and soluble vascular endothelial growth factor receptor-2: laboratory investigation. J Neurosurg 2008; 108:979-88
    • (2008) J Neurosurg , vol.108 , pp. 979-988
    • Szentirmai, O.1    Baker, C.H.2    Bullain, S.S.3
  • 80
    • 39649104546 scopus 로고    scopus 로고
    • Murata N, Takashima Y, Toyoshima K, et al. Anti-tumour effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice. J Control Release 2008; 126:246-54
    • Murata N, Takashima Y, Toyoshima K, et al. Anti-tumour effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice. J Control Release 2008; 126:246-54
  • 81
    • 50349088012 scopus 로고    scopus 로고
    • Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 (alpha) enhances the efficacy of chemotherapy in drug resistant tumor
    • Wang Y, Saad M, Pakunlu RI, et al. Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 (alpha) enhances the efficacy of chemotherapy in drug resistant tumor. Clin Cancer Res 2008;14:3607-16
    • (2008) Clin Cancer Res , vol.14 , pp. 3607-3616
    • Wang, Y.1    Saad, M.2    Pakunlu, R.I.3
  • 82
    • 40949141801 scopus 로고    scopus 로고
    • Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide
    • Zhou Q, Guo P, Gallo JM. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 2008;14:1540-9
    • (2008) Clin Cancer Res , vol.14 , pp. 1540-1549
    • Zhou, Q.1    Guo, P.2    Gallo, J.M.3
  • 83
    • 46749102930 scopus 로고    scopus 로고
    • Atherothrombosis and plaque heterology: Different location or a unique disease?
    • Slevin M, Wang Q, Font MA, et al. Atherothrombosis and plaque heterology: different location or a unique disease? Pathobiology 2008;75:209-25
    • (2008) Pathobiology , vol.75 , pp. 209-225
    • Slevin, M.1    Wang, Q.2    Font, M.A.3
  • 84
    • 25444522479 scopus 로고    scopus 로고
    • Role of angiogenesis in cardiovascular disease: A critical appraisal
    • Khurana R, Simons M, Martin JF, et al. Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation 2005;112:1813-24
    • (2005) Circulation , vol.112 , pp. 1813-1824
    • Khurana, R.1    Simons, M.2    Martin, J.F.3
  • 85
    • 0032865511 scopus 로고    scopus 로고
    • Angiogenesis and the atherosclerotic carotid plaque: An association between symptomatology and plaque morphology
    • McCarthy MJ, Loftus IM, Thompson MM, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg 1999;30:261-8
    • (1999) J Vasc Surg , vol.30 , pp. 261-268
    • McCarthy, M.J.1    Loftus, I.M.2    Thompson, M.M.3
  • 86
    • 52049095030 scopus 로고    scopus 로고
    • Angiogenesis and inflammation in carotid atherosclerosis
    • Krupinski J, Font A, Luque A, et al. Angiogenesis and inflammation in carotid atherosclerosis. Front Biosci 2008;13:6472-82
    • (2008) Front Biosci , vol.13 , pp. 6472-6482
    • Krupinski, J.1    Font, A.2    Luque, A.3
  • 87
    • 52049126373 scopus 로고    scopus 로고
    • Overexpression of hypoxia/ inflammatory markers in atherosclerotic carotid plaques
    • Luque A, Turu M, Juan-Babot O, et al. Overexpression of hypoxia/ inflammatory markers in atherosclerotic carotid plaques. Front Biosci 2008;13:6483-90
    • (2008) Front Biosci , vol.13 , pp. 6483-6490
    • Luque, A.1    Turu, M.2    Juan-Babot, O.3
  • 88
    • 34247611898 scopus 로고    scopus 로고
    • Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis
    • Altaf N, MacSweeney ST, Gladman J, Auer DP. Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis. Stroke 2007;38:633-5
    • (2007) Stroke , vol.38 , pp. 633-635
    • Altaf, N.1    MacSweeney, S.T.2    Gladman, J.3    Auer, D.P.4
  • 89
    • 38549087553 scopus 로고    scopus 로고
    • NO king? Pathophysiological benefit with uncertain clinical impact
    • Simko F. Is NO king? Pathophysiological benefit with uncertain clinical impact. Physiol Res 2007;56:S1-6
    • (2007) Physiol Res , vol.56
    • Is, S.F.1
  • 90
    • 43049123825 scopus 로고    scopus 로고
    • Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans
    • Gudmundsdottir IJ, Lang NN, Boon NA, et al. Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans. J Am Coll Cardiol 2008;51:1749-56
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1749-1756
    • Gudmundsdottir, I.J.1    Lang, N.N.2    Boon, N.A.3
  • 91
    • 0035047885 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances atherosclerotic plaque progression
    • Celletti FL, Waugh JM, Amabile PG, et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med 2001;7:425-9
    • (2001) Nat Med , vol.7 , pp. 425-429
    • Celletti, F.L.1    Waugh, J.M.2    Amabile, P.G.3
  • 92
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by plgf treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-flt1
    • Lutton A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by plgf treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-flt1. Nat Med 2002;8:831-40
    • (2002) Nat Med , vol.8 , pp. 831-840
    • Lutton, A.1    Tjwa, M.2    Moons, L.3
  • 93
    • 0033044609 scopus 로고    scopus 로고
    • Adventitial angiogenesis early after coronary angioplasty: Correlation with arterial remodeling
    • Pels K, Labinaz M, Hoffert C, et al. Adventitial angiogenesis early after coronary angioplasty: correlation with arterial remodeling. Arterioscler Thromb Vasc Biol 1999;19:229-38
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 229-238
    • Pels, K.1    Labinaz, M.2    Hoffert, C.3
  • 94
    • 0345059062 scopus 로고    scopus 로고
    • Effect of adventitial vegf(165) gene transfer on vascular thickening after coronary artery balloon injury
    • Pels K, Deiner C, Coupland SE, et al. Effect of adventitial vegf(165) gene transfer on vascular thickening after coronary artery balloon injury. Cardiovasc Res 2003;60:664-72
    • (2003) Cardiovasc Res , vol.60 , pp. 664-672
    • Pels, K.1    Deiner, C.2    Coupland, S.E.3
  • 95
    • 0036079448 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-mediated neointima progression with angiostatin or paclitaxel
    • Celletti FL, Waugh JM, Amabile PG, et al. Inhibition of vascular endothelial growth factor-mediated neointima progression with angiostatin or paclitaxel. J Vasc Interv Radiol 2002;13:703-7
    • (2002) J Vasc Interv Radiol , vol.13 , pp. 703-707
    • Celletti, F.L.1    Waugh, J.M.2    Amabile, P.G.3
  • 96
    • 6444243603 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells
    • Ohtani K, Egashira K, Hiasa K, et al. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation 2004;110:2444-52
    • (2004) Circulation , vol.110 , pp. 2444-2452
    • Ohtani, K.1    Egashira, K.2    Hiasa, K.3
  • 97
    • 0030669594 scopus 로고    scopus 로고
    • VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
    • Laitinen M, Zachary I, Breier G, et al. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther 1997;8:1737-44
    • (1997) Hum Gene Ther , vol.8 , pp. 1737-1744
    • Laitinen, M.1    Zachary, I.2    Breier, G.3
  • 98
    • 2942610574 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbits
    • Khurana R, Shafi S, Martin J, Zachary I. Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol 2004;24:1074-80
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1074-1080
    • Khurana, R.1    Shafi, S.2    Martin, J.3    Zachary, I.4
  • 99
    • 0033970878 scopus 로고    scopus 로고
    • Pr39, a peptide regulator of angiogenesis
    • Li J, Post M, Volk R, et al. Pr39, a peptide regulator of angiogenesis. Nat Med 2000;6:49-55
    • (2000) Nat Med , vol.6 , pp. 49-55
    • Li, J.1    Post, M.2    Volk, R.3
  • 100
    • 0037968240 scopus 로고    scopus 로고
    • Gene transfer as a tool to induce therapeutic vascular growth
    • Yla-Herttuala S, Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 2003;9:694-701
    • (2003) Nat Med , vol.9 , pp. 694-701
    • Yla-Herttuala, S.1    Alitalo, K.2
  • 101
    • 33750842076 scopus 로고    scopus 로고
    • Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
    • Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol 2006;39:469-78
    • (2006) J Biochem Mol Biol , vol.39 , pp. 469-478
    • Shibuya, M.1
  • 102
    • 15344342455 scopus 로고    scopus 로고
    • Genentech discloses safety concerns over avastin
    • Ratner M. Genentech discloses safety concerns over avastin. Nat Biotechnol 2004;22:1198
    • (2004) Nat Biotechnol , vol.22 , pp. 1198
    • Ratner, M.1
  • 103
    • 33749048760 scopus 로고    scopus 로고
    • Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis
    • Matsumoto T, Mugishima H. Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis. J Atheroscler Thromb 2006;13:130-5
    • (2006) J Atheroscler Thromb , vol.13 , pp. 130-135
    • Matsumoto, T.1    Mugishima, H.2
  • 104
    • 33846911463 scopus 로고    scopus 로고
    • Orientation of endothelial cell division is regulated by VEGF signalling during blood vessel formation
    • Zeng G, Taylor SM, McColm JR, et al. Orientation of endothelial cell division is regulated by VEGF signalling during blood vessel formation. Blood 2007;109:1345-52
    • (2007) Blood , vol.109 , pp. 1345-1352
    • Zeng, G.1    Taylor, S.M.2    McColm, J.R.3
  • 105
    • 33748155036 scopus 로고    scopus 로고
    • Angiogenic gene therapy in patients with nonrevascularizable ischaemic heart disease: A phase 2 randomized, controlled trial of AdVEGF (121) versus maximum medical treatment
    • Stewart DJ, Hilton JD, Arnold JM, et al. Angiogenic gene therapy in patients with nonrevascularizable ischaemic heart disease: a phase 2 randomized, controlled trial of AdVEGF (121) versus maximum medical treatment. Gene Ther 2006;13:1503-11
    • (2006) Gene Ther , vol.13 , pp. 1503-1511
    • Stewart, D.J.1    Hilton, J.D.2    Arnold, J.M.3
  • 106
    • 34249933136 scopus 로고    scopus 로고
    • Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction
    • Hao X, Silva EA, Mansson-Broberg A, et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Dis 2007;75:178-85
    • (2007) Cardiovasc Dis , vol.75 , pp. 178-185
    • Hao, X.1    Silva, E.A.2    Mansson-Broberg, A.3
  • 107
    • 37349021515 scopus 로고    scopus 로고
    • Nanosphere-mediated delivery of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs
    • Kang SW, Lim HW, Seo SW, et al. Nanosphere-mediated delivery of vascular endothelial growth factor gene for therapeutic angiogenesis in mouse ischemic limbs. Biomaterials 2008;29:1109-17
    • (2008) Biomaterials , vol.29 , pp. 1109-1117
    • Kang, S.W.1    Lim, H.W.2    Seo, S.W.3
  • 108
    • 42549142820 scopus 로고    scopus 로고
    • Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
    • Li SD, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol Ther 2008;16:942-6
    • (2008) Mol Ther , vol.16 , pp. 942-946
    • Li, S.D.1    Chono, S.2    Huang, L.3
  • 109
    • 38849152122 scopus 로고    scopus 로고
    • Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration
    • Amrite AC, Edelhauser HF, Singh SR, Kompella UB. Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration. Mol Vis 2008;14:150-60
    • (2008) Mol Vis , vol.14 , pp. 150-160
    • Amrite, A.C.1    Edelhauser, H.F.2    Singh, S.R.3    Kompella, U.B.4
  • 110
    • 52949137851 scopus 로고    scopus 로고
    • Age-related macular degeneration: A target for nanotechnology derived medicines
    • Birch DG, Liang FQ. Age-related macular degeneration: a target for nanotechnology derived medicines. Int J Nanomed 2007;2:65-77
    • (2007) Int J Nanomed , vol.2 , pp. 65-77
    • Birch, D.G.1    Liang, F.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.