Inhibition of ocular neovascularization by Hedgehog blockade

Molecular Therapy

Volumn 13, Issue 3, 2006, Pages 573-579

  Surace, Enrico M ^a,d   Balaggan, Kamaljit S ^b   Tessitore, Alessandra ^a   Mussolino, Claudio ^a,d   Cotugno, Gabriella ^a,d   Bonetti, Ciro ^a   Vitale, Aniello ^a   Ali, Robin R ^b   Auricchio, Alberto ^a,c,d  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SEMM European School of Molecular Medicine   (Italy)

Author keywords

CNV; Cyclopamine; Neovascularization; ROP; Sonic hedgehog

Indexed keywords

PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DEVELOPED COUNTRY; DIABETIC RETINOPATHY; DRUG TARGETING; EYE DISEASE; HYPOXIA; MOUSE; NONHUMAN; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; SUBRETINAL NEOVASCULARIZATION; VISUAL IMPAIRMENT;

ANIMALIA; ERINACEIDAE;

EID: 32944477380     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.10.010     Document Type: Article

References (31)

1. N.M. Bressler S.B. Bressler S.L. Fine (S.J. Ryan Ed.), Retina 2001 Mosby St. Louis/London/Philadelphia/Sydney/Toronto
2. M.D.B. Davis A.B. Blody (S.J. Ryan Ed.), Retina 2001 Mosby St. Louis/ London/Philadelphia/Sidney/Toronto
3. L.E. Smith Pathogenesis of retinopathy of prematurity Acta Paediatr. Suppl. 91 2002 26-28
4. P.A. Campochiaro S.F. Hackett Ocular neovascularization: A valuable model system Oncogene 22 2003 6537-6548
5. P.A. Campochiaro Retinal and choroidal neovascularization J. Cell. Physiol. 184 2000 301-310
6. G.D. Yancopoulos et. al. Vascular-specific growth factors and blood vessel formation Nature 407 2000 242-248
7. J. Ruberte et al Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease J. Clin. Invest. 113 2004 1149-1157
8. D.W. Dawson et. al. Pigment epithelium-derived factor: A potent inhibitor of angiogenesis Science 285 1999 245-248
9. M. Zhang O. Volpert Y.H. Shi N. Bouck Maspin is an angiogenesis inhibitor Nat. Med. 6 2000 196-199
10. J.E. Ming E. Roessler M. Muenke Human developmental disorders and the Sonic hedgehog pathway Mol. Med. Today 4 1998 343-349
11. M. Pasca di Magliano M. Hebrok Hedgehog signalling in cancer formation and maintenance Nat. Rev. Cancer 3 2003 903-911
12. A.M. Jensen V.A. Wallace Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina Development 124 1997 363-371
13. T. Takabatake et. al. Hedgehog and patched gene expression in adult ocular tissues FEBS Lett. 410 1997 485-489
14. V.A. Wallace M.C. Raff A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve Development 126 1999 2901-2909
15. Y.P. Wang et. al. Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells Nat. Neurosci. 5 2002 831-832
16. L. Lum P.A. Beachy The Hedgehog response network: Sensors, switches, and routers Science 304 2004 1755-1759
17. M.K. Cooper J.A. Porter K.E. Young P.A. Beachy Teratogen-mediated inhibition of target tissue response to Shh signaling Science 280 1998 1603-1607
18. J.K. Chen J. Taipale M.K. Cooper P.A. Beachy Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Genes Dev. 16 2002 2743-2748
19. D.M. Berman et. al. Medulloblastoma growth inhibition by hedgehog pathway blockade Science 297 2002 1559-1561
20. D.N. Watkins et. al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 2003 313-317
21. D.M. Berman et. al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 2003 846-851
22. S.P. Thayer et. al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851-856
23. S.S. Karhadkar et. al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis Nature 431 2004 707-712
24. R. Pola et. al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors Nat. Med. 7 2001 706-711
25. N.D. Lawson A.M. Vogel B.M. Weinstein Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation Dev. Cell. 3 2002 127-136
26. S. Kanda et. al. Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase J. Biol. Chem. 278 2003 8244-8249
27. R. Pola et. al. Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia Circulation 108 2003 479-485
28. L.E. Smith et. al. Oxygen-induced retinopathy in the mouse Invest. Ophthalmol. Visual Sci. 35 1994 101-111
29. M. Fruttiger et. al. PDGF mediates a neuron-astrocyte interaction in the developing retina Neuron 17 1996 1117-1131
30. M. Tripodi A. Filosa M. Armentano M. Studer The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain Development 131 2004 6119-6129
31. M.C. Tiveron M.R. Hirsch J.F. Brunet The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system J. Neurosci. 16 1996 7649-7660