Role of the Endothelium in the Vascular Effects of the Thrombin Receptor (Protease-Activated Receptor Type 1) in Humans

Journal of the American College of Cardiology

Volumn 51, Issue 18, 2008, Pages 1749-1756

  Gumundsdottir, Ingibjörg J ^a   Lang, Ninian N ^a   Boon, Nicholas A ^b   Ludlam, Christopher A ^a   Webb, David J ^a   Fox, Keith A ^a   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; NITRIC OXIDE; PROSTACYCLIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN RECEPTOR; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTERY BLOOD FLOW; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; NORMAL HUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; VASODILATATION;

ADULT; ATHEROSCLEROSIS; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; FEMALE; HUMANS; MALE; NITRIC OXIDE; PILOT PROJECTS; PLATELET ACTIVATION; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; VASOCONSTRICTION; VASODILATION;

EID: 43049123825     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2007.12.047     Document Type: Article

References (27)

1. Patterson C., Stouffer G.A., Madamanchi N., and Runge M.S. New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology. Circ Res 88 (2001) 987-997
2. Swift S., Leger A.J., Talavera J., Zhang L., Bohm A., and Kuliopulos A. Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism. J Biol Chem 281 (2006) 4109-4116
3. Vu T., Hung D., Wheaton V., and Coughlin S. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 (1991) 1057-1068
4. Hollenberg M.D., and Compton S.J. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54 (2002) 203-217
5. O'Brien P., Prevost N., Molino M., et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem 275 (2000) 13502-13509
6. Coughlin S.R. Thrombin signalling and protease-activated receptors. Nature 407 (2000) 258-264
7. Ossovskaya V.S., and Bunnett N.W. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84 (2004) 579-621
8. Kinlough-Rathbone R.L., Rand M.L., and Packham M.A. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood 82 (1993) 103-106
9. Gu{A figure is presented}mundsdóttir I.J., Megson I.L., Kell J.S., et al. Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation 114 (2006) 1625-1632
10. Aellig W.H. A new technique for recording compliance of human hand veins. Br J Clin Pharmacol 11 (1981) 237-243
11. Sogo N., Wilkinson I.B., MacCallum H., et al. A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium. Clin Pharmacol Ther 68 (2000) 75-81
12. Newby D.E., Sciberras D.G., Mendel C.M., Gertz B.J., Boon N.A., and Webb D.J. Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability. Br J Clin Pharmacol 43 (1997) 493-499
13. Newby D.E., Wright R.A., Labinjoh C., et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation 99 (1999) 1411-1415
14. Champion H.C., and Kadowitz P.J. Vasodilator responses to acetylcholine, bradykinin, and substance P are mediated by a TEA-sensitive mechanism. Am J Physiol 273 (1997) R414-R422
15. Honing M.L., Smits P., Morrison P.J., and Rabelink T.J. Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization. Hypertension 35 (2000) 1314-1318
16. Inokuchi K., Hirooka Y., Shimokawa H., et al. Role of endothelium-derived hyperpolarizing factor in human forearm circulation. Hypertension 42 (2003) 919-924
17. Harding S.A., Sarma J., Josephs D.H., et al. Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers. Circulation 109 (2004) 1926-1929
18. Haynes W.G., Strachan F.E., and Webb D.J. Endothelin ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Circulation 92 (1995) 357-363
19. Oliver J.J., Webb D.J., and Newby D.E. Stimulated tissue plasminogen activator release as a marker of endothelial function in humans. Arterioscler Thromb Vasc Biol 25 (2005) 2470-2479
20. Smith D.T., Hoetzer G.L., Greiner J.J., Stauffer B.L., and DeSouza C.A. Endothelial release of tissue-type plasminogen activator in the human forearm: role of nitric oxide. J Cardiovasc Pharmacol 42 (2003) 311-314
21. Brown N.J., Gainer J.V., Murphey L.J., and Vaughan D.E. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway. Circulation 102 (2000) 2190-2196
22. Muldowney III J.A., Painter C.A., Sanders-Bush E., Brown N.J., and Vaughan D.E. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. Thromb Haemost 97 (2007) 263-271
23. Kawabata A., Saifeddine M., Al-Ani B., Leblond L., and Hollenberg M. Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther 288 (1999) 358-370
24. Gu{A figure is presented}mundsdóttir I., Megson I., Kell J., et al. Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation 114 (2006) 1625-1632
25. Ossovskaya V., and Bunnett N. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84 (2004) 579-621
26. Newby D.E., Wright R.A., Ludlam C.A., Fox K.A., Boon N.A., and Webb D.J. An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium. Thromb Haemost 78 (1997) 1242-1248
27. Stein C.M., Brown N., Vaughan D.E., Lang C.C., and Wood A.J. Regulation of local tissue-type plasminogen activator release by endothelium-dependent and endothelium-independent agonists in human vasculature. J Am Coll Cardiol 32 (1998) 117-122