Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbits

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 6, 2004, Pages 1074-1080

  Khurana, Rohit ^a   Shafi, Shahida ^a   Martin, John ^a   Zachary, Ian ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Atherosclerosis; Collar; Endothelium; Vascular smooth muscle; VCAM

Indexed keywords

BETA GALACTOSIDASE; LIPOSOME; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ADVENTITIA; ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; GENE EXPRESSION; GENE TRANSFER; HYPERCHOLESTEROLEMIA; INTIMA; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CAROTID STENOSIS; DIET, ATHEROGENIC; GENE THERAPY; HYPERCHOLESTEROLEMIA; INTERCELLULAR ADHESION MOLECULE-1; LIPOSOMES; MACROPHAGES; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; PROSTHESES AND IMPLANTS; RABBITS; TUNICA INTIMA; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 2942610574     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000128127.57688.e0     Document Type: Article

References (38)

1. Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med. 2002;8:1249-1256.
2. Li AC, Glass CK. The macrophage foam cell as a target for therapeutic intervention. Nat Med. 2002;8:1235-1242.
3. Davies MG, Hagen PO. Pathophysiology of vein graft failure: a review. Eur J Vasc Endovasc Surg. 1995;9:7-18.
4. Booth RF, Martin JF, Honey AC, Hassall DG, Beesley JE, Moncada S. Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis. 1989;76:257-268.
5. Kockx MM, De Meyer GR, Jacob WA, Bult H, Herman AG. Triphasic sequence of neointimal formation in the cuffed carotid artery of the rabbit. Arterioscler Thromb. 1992;12:1447-1457.
6. Beesley JE, Honey AC and Martin JF. Ultrastructural Assessment of Lesion Development in the Collared Rabbit Carotid Artery Model. Cells Materials. 1992;2:201-208.
7. Kockx MM, De Meyer GR, Andries LJ, Bult H, Jacob WA, Herman AG. The endothelium during cuff-induced neointima formation in the rabbit carotid artery. Arterioscler Thromb. 1993;13:1874-1884.
8. De Meyer GR, Van Put DJ, Kockx MM, Van Schil P, Bosmans R, Bult H, Buyssens N, Vanmaele R, Herman AG. Possible mechanisms of collar-induced intimal thickening. Arterioscler Thromb Vasc Biol. 1997;17:1924-1930.
9. Laitinen M, Zachary I, Breier G, Pakkanen T, Hakkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Yla-Herttuala S. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther. 1997;8:1737-1744.
10. De Meyer GR, Kockx MM, Cromheeke KM, Seye CI, Herman AG, Bult H. Periadventitial inducible nitric oxide synthase expression and intimal thickening. Arterioscler Thromb Vasc Biol. 2000;20:1896-1902.
11. Ferrara, N. Role of Vascular endothelial growth factor in regulation of physiological angiogenesis. Amer J Physiol Cell Physiol. 2001;280: C1358-C1366.
12. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Fltl, two receptors for vascular endothelial growth factor. J Biol Chem. 1994;269:26988-26995.
13. 2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett. 1997;420:28-32.
14. Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996;98:2018-2026.
15. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphafidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem. 1998;273:30336-30343.
16. 2+. Biochem J. 2001;353:503-512.
17. Takahashi T, Yamaguchi S, Chida K, Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 2001;20:2768-2678.
18. Abedi H, Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem. 1997;272:15442-15451.
19. Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal vascularization. J Clin Invest. 1999;103:1231-1236.
20. Zachary I, Mathur A, Yla-Herttuala S, Martin JF. Vascular Protection: A Novel Nonangiogenic Cardiovascular Role for VEGF. Arterioscler Thromb Vasc Biol. 2000;20:1512-1520.
21. Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agrawal R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Yla-Herttuala S. Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum Gene Ther. 1997;8:1645-1650.
22. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J, Cybulsky MI, Smith JD. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol. 2001;21:1662-1667.
23. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos JC, Connelly PW, Milstone DS. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001;107:1255-1262.
24. Kai H, Kuwahara F, Tokuda K, Shibata R, Kusaba K, Niiyama H, Tahara N, Nagata T, Imaizumi T. Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization. Hypertension. 2002;39:455-459.
25. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD, Cybulsky MI. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res. 1999;85:199-200.
26. Allen S, Khan S, Al-Mohanna F, Batten P, Yacoub M. Native low density lipoprotein induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. J Clin Invest. 1998;101:1064-1075.
27. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002;106:1390-1396.
28. Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, Folkman J. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999;99:1726-1732.
29. Celletti FL, Waugh JM, Amabile PG, Brendolan A, Hilfiker PR, Dake MD. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med. 2001;7:425-429.
30. Zhao Q, Egashira K, Inoue S, Usui M, Kitamoto S, Ni W, Ishibashi M, Hiasa Ki K, Ichiki T, Shibuya M, Takeshita A. Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis. Circulation. 2002;105:1110-1115.
31. Clauss M, Weich H, Breier G, Knies U, Rockl W, Waltenberger J, Risau W. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem. 1996;271:17629-17634.
32. Kuenen BC, Levi M, Meijers JC, Kakkar AK, van Hinsbergh VW, Kostense PJ, Pinedo HM, Hoekman K. Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler Thromb Vasc Biol. 2002;22:1500-1505.
33. Scalia R, Booth G, Lefer DJ. Vascular endothelial growth factor attenuates leukocyte-endothelium interaction during acute endothelial dysfunction: essential role of endothelium-derived nitric oxide. FASEB J. 1999;13:1039-1046.
34. Kuzuya M, Ramos MA, Kanda S, Koike T, Asai T, Maeda K, Shitara K, Shibuya M, Iguchi A. VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor. Arterioscler Thromb Vasc Biol. 2001;21:765-770.
35. Mason JC, Lidington EA, Ahmad SR, Haskard DO. bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction. Am J Physiol Cell Physiol. 2002;282:C578-C87.
36. Hanyu M, Kume N, Ikeda T, Minami M, Kita T, Komeda M. VCAM-1 expression precedes macrophage infiltration into subendothelium of vein grafts interposed into carotid arteries in hypercholesterolemic rabbits - a potential role in vein graft atherosclerosis. Atherosclerosis. 2001;158:313-319.
37. Zwolak RM, Kirkman TR, Clowes AW. Atherosclerosis in rabbit vein grafts. Arteriosclerosis. 1989;9:374-379.
38. Campeau L, Enjalbert M, Lesperance J, Bourassa MG, Kwiterovich P Jr, Wacholder S, Sniderman A. The relation of risk factors to the development of atherosclerosis in saphenous-vein bypass grafts and the progression of disease in the native circulation. A study 10 years after aortocoronary bypass surgery. N Engl J Med. 1984;311:1329-1332.