메뉴 건너뛰기




Volumn 8, Issue , 2008, Pages 98-120

Update on the treatment of diabetic retinopathy

Author keywords

Advanced glycation end products; Angiotensin; Corticosteroids; Diabetic retinopathy; Growth hormone; Protein kinase C; VEGF

Indexed keywords

2 ISOPROPYLIDENEHYDRAZONO 4 OXO 5 THIAZOLIDINYLACETANILIDE; ADENOVIRAL PIGMENT EPITHELIAL DERIVED GROWTH FACTOR; ADVANCED GLYCATION END PRODUCT; ALDOSE REDUCTASE INHIBITOR; ALT 946; AMINOGUANIDINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ARI 809; ATORVASTATIN; BEVACIZUMAB; CANDESARTAN; CORTICOSTEROID; FIBRIC ACID DERIVATIVE; FLUOCINOLONE ACETONIDE; GROWTH FACTOR; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDAPAMIDE; INSULIN; LIPID; MECAMYLAMINE; MIDOSTAURIN; PEGAPTANIB; PERINDOPRIL; PLACEBO; PROTEIN KINASE C INHIBITOR; RANIBIZUMAB; RUBOXISTAURIN; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 39449130466     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2008.25     Document Type: Review
Times cited : (36)

References (200)
  • 1
    • 84878766014 scopus 로고    scopus 로고
    • The World Health Organization website, last accessed September 2006
    • The World Health Organization website. http://www.who.int/mediacentre/ factsheets/fs236/en/ last accessed September 2006.
  • 3
    • 0024793671 scopus 로고
    • The relationship of retinal microaneurysm counts to the 4-year progression of diabetic retinopathy
    • Klein, R., Meuer, S.M., Moss, S.E., and Klein, B.E. (1989): The relationship of retinal microaneurysm counts to the 4-year progression of diabetic retinopathy. Arch. Ophthalmol. 107, 1780-1785.
    • (1989) Arch. Ophthalmol , vol.107 , pp. 1780-1785
    • Klein, R.1    Meuer, S.M.2    Moss, S.E.3    Klein, B.E.4
  • 4
    • 0028896755 scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema
    • Klein, R., Klein, B.E., Moss, S.E., and Cruickshanks, K.J. (1995) The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema. Ophthalmology 102, 7-16.
    • (1995) Ophthalmology , vol.102 , pp. 7-16
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Cruickshanks, K.J.4
  • 5
    • 0037623520 scopus 로고    scopus 로고
    • Retinopathy
    • Watkins, P.J. (2003) Retinopathy. BMJ 326, 924-926.
    • (2003) BMJ , vol.326 , pp. 924-926
    • Watkins, P.J.1
  • 6
    • 0348048874 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Frank, R.N. (2004) Diabetic retinopathy N. Engl. J. Med. 350, 48-58.
    • (2004) N. Engl. J. Med , vol.350 , pp. 48-58
    • Frank, R.N.1
  • 7
    • 0010752531 scopus 로고
    • Visual prognosis of proliferating diabetic retinopathy
    • Beetham, W.P. (1963) Visual prognosis of proliferating diabetic retinopathy. Br. J. Ophthalmol. 47, 611-619.
    • (1963) Br. J. Ophthalmol , vol.47 , pp. 611-619
    • Beetham, W.P.1
  • 8
    • 0014634510 scopus 로고
    • Ruby-laser photocoagulation of early diabetic neovascular retinopathy: Preliminary report of a long-term controlled study
    • Beetham, W.P., Aiello, L.M., Balodimos, M.C., and Koncz, L. (1969) Ruby-laser photocoagulation of early diabetic neovascular retinopathy: preliminary report of a long-term controlled study. Trans. Am. Ophthalmol. Soc. 67, 39-67.
    • (1969) Trans. Am. Ophthalmol. Soc , vol.67 , pp. 39-67
    • Beetham, W.P.1    Aiello, L.M.2    Balodimos, M.C.3    Koncz, L.4
  • 9
    • 0017912754 scopus 로고    scopus 로고
    • Photocoagulation treatment of proliferative diabetic retinopathy: the second report of diabetic retinopathy study findings. Ophthalmology 85, 82-106.
    • (1978) Photocoagulation treatment of proliferative diabetic retinopathy: the second report of diabetic retinopathy study findings. Ophthalmology 85, 82-106.
  • 10
    • 0025892104 scopus 로고    scopus 로고
    • Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 98, 766-785.
    • (1991) Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 98, 766-785.
  • 11
    • 0023202345 scopus 로고
    • Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Early Treatment Diabetic Retinopathy Study Research Group (1987) Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2. Ophthalmology 94, 761-774.
    • (1987) Ophthalmology , vol.94 , pp. 761-774
  • 12
    • 0038420704 scopus 로고    scopus 로고
    • Type 1 diabetes patients with severe nonproliferative retinopathy may benefit from panretinal photocoagulation
    • Lovestam-Adrian, M., Agardh, C.D., Torffvit, O., and Agardh, E. (2003) Type 1 diabetes patients with severe nonproliferative retinopathy may benefit from panretinal photocoagulation. Acta Ophthalmol. Scand. 81, 221-225.
    • (2003) Acta Ophthalmol. Scand , vol.81 , pp. 221-225
    • Lovestam-Adrian, M.1    Agardh, C.D.2    Torffvit, O.3    Agardh, E.4
  • 13
    • 1842778938 scopus 로고    scopus 로고
    • Clinical variables and their relation to visual outcome after vitrectomy in eyes with diabetic retinal traction detachment
    • La Heij, E.C., Tecim, S., Kessels, A.G., Liem, A.T., Japing, W.J., and Hendrikse, F. (2004) Clinical variables and their relation to visual outcome after vitrectomy in eyes with diabetic retinal traction detachment. Graefes Arch. Clin. Exp. Ophthalmol. 242, 210-217.
    • (2004) Graefes Arch. Clin. Exp. Ophthalmol , vol.242 , pp. 210-217
    • La Heij, E.C.1    Tecim, S.2    Kessels, A.G.3    Liem, A.T.4    Japing, W.J.5    Hendrikse, F.6
  • 14
    • 0023687179 scopus 로고
    • Early vitrectomy for severe proliferative diabetic retinopathy in eyes with useful vision. Results of a randomized trial - Diabetic Retinopathy Vitrectomy Study
    • The Diabetic Retinopathy Vitrectomy Study Research Group
    • The Diabetic Retinopathy Vitrectomy Study Research Group (1988) Early vitrectomy for severe proliferative diabetic retinopathy in eyes with useful vision. Results of a randomized trial - Diabetic Retinopathy Vitrectomy Study Report 3. Ophthalmology 95, 1307-1320.
    • (1988) Ophthalmology , vol.95 , pp. 1307-1320
  • 15
    • 0032471009 scopus 로고    scopus 로고
    • Visual field loss after argon laser panretinal photocoagulation in diabetic retinopathy: Full- versus mild-scatter coagulation
    • Pahor, D. (1998) Visual field loss after argon laser panretinal photocoagulation in diabetic retinopathy: full- versus mild-scatter coagulation. Int. Ophthalmol. 22, 313-319.
    • (1998) Int. Ophthalmol , vol.22 , pp. 313-319
    • Pahor, D.1
  • 16
    • 0038016408 scopus 로고    scopus 로고
    • Perspectives on diabetic retinopathy
    • Aiello, L.M. (2003) Perspectives on diabetic retinopathy. Am. J. Ophthalmol. 136, 122-135.
    • (2003) Am. J. Ophthalmol , vol.136 , pp. 122-135
    • Aiello, L.M.1
  • 17
    • 0032773140 scopus 로고    scopus 로고
    • Vitrectomy in the management of diabetic retinopathy
    • Smiddy, W.E. and Flynn, H.W, Jr. (1999) Vitrectomy in the management of diabetic retinopathy. Surv. Ophthalmol. 43, 491-507.
    • (1999) Surv. Ophthalmol , vol.43 , pp. 491-507
    • Smiddy, W.E.1    Flynn Jr., H.W.2
  • 18
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977-986.
    • (1993) N. Engl. J. Med , vol.329 , pp. 977-986
  • 19
    • 0032511583 scopus 로고    scopus 로고
    • U.K. Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837-853.
    • U.K. Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837-853.
  • 20
    • 0032958316 scopus 로고
    • Epidemiology of Diabetes Interventions and Complications (EDIC). Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort
    • Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
    • Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group (1993) Epidemiology of Diabetes Interventions and Complications (EDIC). Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care 22, 99-111.
    • (1993) Diabetes Care , vol.22 , pp. 99-111
  • 21
    • 0034628425 scopus 로고    scopus 로고
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2000) Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N. Engl. J. Med. 342, 381-389
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2000) Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N. Engl. J. Med. 342, 381-389.
  • 22
    • 33746460818 scopus 로고    scopus 로고
    • The effect of glucose variability on the risk of microvascular complications in type 1 diabetes
    • Kilpatrick, E.S., Rigby, A.S., and Atkin, S.L. (2006) The effect of glucose variability on the risk of microvascular complications in type 1 diabetes. Diabetes Care 29, 1486-1490.
    • (2006) Diabetes Care , vol.29 , pp. 1486-1490
    • Kilpatrick, E.S.1    Rigby, A.S.2    Atkin, S.L.3
  • 23
    • 0027921773 scopus 로고    scopus 로고
    • Wang, P.H., Lau, J., and Chalmers, T.C. (1993) Meta-analysis of the effects of intensive glycemic control on late complications of type I diabetes mellitus. Online J. Curr. Clin. Trials. Doc. No. 60.
    • Wang, P.H., Lau, J., and Chalmers, T.C. (1993) Meta-analysis of the effects of intensive glycemic control on late complications of type I diabetes mellitus. Online J. Curr. Clin. Trials. Doc. No. 60.
  • 24
    • 9844260061 scopus 로고    scopus 로고
    • Risk of adverse effects of intensified treatment in insulin-dependent diabetes mellitus: A meta-analysis
    • Egger, M., Davey Smith, G., Stettler, C., and Diem, P. (1997) Risk of adverse effects of intensified treatment in insulin-dependent diabetes mellitus: a meta-analysis. Diabetes Med. 14, 919-928.
    • (1997) Diabetes Med , vol.14 , pp. 919-928
    • Egger, M.1    Davey Smith, G.2    Stettler, C.3    Diem, P.4
  • 25
    • 0031729874 scopus 로고    scopus 로고
    • Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial. Arch. Ophthalmol. 116, 874-886.
    • (1998) Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial. Arch. Ophthalmol. 116, 874-886.
  • 26
    • 0029609775 scopus 로고
    • Dyslipoproteinemias in diabetes
    • Steiner, G. (1995) Dyslipoproteinemias in diabetes. Clin. Invest. Med. 18, 282-287.
    • (1995) Clin. Invest. Med , vol.18 , pp. 282-287
    • Steiner, G.1
  • 28
    • 0026093735 scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate
    • Klein, B.E., Moss, S.E., Klein, R., and Surawicz, T.S. (1991) The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology 98, 1261-1265.
    • (1991) Ophthalmology , vol.98 , pp. 1261-1265
    • Klein, B.E.1    Moss, S.E.2    Klein, R.3    Surawicz, T.S.4
  • 29
    • 0029757496 scopus 로고    scopus 로고
    • Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS)
    • Chew, E.Y., Klein, M.L., Ferris, F.L, 3rd, Remaley, N.A., Murphy, R.P., Chantry, K., Hoogwerf, B.J., and Miller, D. (1996) Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS) Report 22. Arch. Ophthalmol. 114, 1079-1084.
    • (1996) Arch. Ophthalmol , vol.114 , pp. 1079-1084
    • Chew, E.Y.1    Klein, M.L.2    Ferris 3rd, F.L.3    Remaley, N.A.4    Murphy, R.P.5    Chantry, K.6    Hoogwerf, B.J.7    Miller, D.8
  • 30
    • 0016330270 scopus 로고
    • Double-blind trial of Atromid-S in exudative diabetic retinopathy
    • Cullen, J.F., Town, S.M., and Campbell, C.J. (1974) Double-blind trial of Atromid-S in exudative diabetic retinopathy. Trans. Ophthalmol. Soc. U. K. 94, 554-562.
    • (1974) Trans. Ophthalmol. Soc. U. K , vol.94 , pp. 554-562
    • Cullen, J.F.1    Town, S.M.2    Campbell, C.J.3
  • 33
    • 33847130131 scopus 로고    scopus 로고
    • Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats
    • Mooradian, AD. and Haas, M.J. (2007) Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats. Am. J. Ther. 14, 41-45.
    • (2007) Am. J. Ther , vol.14 , pp. 41-45
    • Mooradian, A.D.1    Haas, M.J.2
  • 35
    • 17844365882 scopus 로고    scopus 로고
    • Effect of HMG-CoA-reductase inhibitors on survival in type 2 diabetes patients with end stage diabetic nephropathy
    • Gotz, A.K., Boger, C.A., Hirschmann, C., Schmitz, G., Riegger, G.A., and Kramer, B.K. (2005) Effect of HMG-CoA-reductase inhibitors on survival in type 2 diabetes patients with end stage diabetic nephropathy. Eur. J. Med. Res. 10, 155-160.
    • (2005) Eur. J. Med. Res , vol.10 , pp. 155-160
    • Gotz, A.K.1    Boger, C.A.2    Hirschmann, C.3    Schmitz, G.4    Riegger, G.A.5    Kramer, B.K.6
  • 36
    • 0036180956 scopus 로고    scopus 로고
    • Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia
    • Sen, K., Misra, A., Kumar, A., and Pandey, R.M. (2002) Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia. Diabetes Res. Clin. Pract. 56, 1-11.
    • (2002) Diabetes Res. Clin. Pract , vol.56 , pp. 1-11
    • Sen, K.1    Misra, A.2    Kumar, A.3    Pandey, R.M.4
  • 38
    • 1842608809 scopus 로고    scopus 로고
    • Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema
    • Gupta, A., Gupta, V., Thapar, S., and Bhansali, A. (2004) Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema. Am. J. Ophthalmol. 137:675-682.
    • (2004) Am. J. Ophthalmol , vol.137 , pp. 675-682
    • Gupta, A.1    Gupta, V.2    Thapar, S.3    Bhansali, A.4
  • 39
    • 33846241184 scopus 로고    scopus 로고
    • Effect of atorvastatin on ocular blood flow velocities in atients with diabetic retinopathy
    • Ozkiris, A., Erkilic, K., Koc, A., and Mistik, S. (2007) Effect of atorvastatin on ocular blood flow velocities in atients with diabetic retinopathy. Br. J. Ophthalmol. 91, 69-73.
    • (2007) Br. J. Ophthalmol , vol.91 , pp. 69-73
    • Ozkiris, A.1    Erkilic, K.2    Koc, A.3    Mistik, S.4
  • 40
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial
    • Colhoun, H.M., Betteridge, D.J., Durrington, P.N., Hitman, G.A., Neil, H.A., Livingstone, S.J., Thomason, M.J., Mackness, M.I., Charlton-Menys, V., and Fuller, J.H. (2004) Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364, 685-696.
    • (2004) Lancet , vol.364 , pp. 685-696
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3    Hitman, G.A.4    Neil, H.A.5    Livingstone, S.J.6    Thomason, M.J.7    Mackness, M.I.8    Charlton-Menys, V.9    Fuller, J.H.10
  • 41
    • 33746431474 scopus 로고    scopus 로고
    • Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN)
    • Knopp, R.H., d'Emden, M., Smilde, J.G., and Pocock, S.J. (2006) Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN). Diabetes Care 29, 1478-1485.
    • (2006) Diabetes Care , vol.29 , pp. 1478-1485
    • Knopp, R.H.1    d'Emden, M.2    Smilde, J.G.3    Pocock, S.J.4
  • 42
    • 0018864599 scopus 로고
    • Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians
    • Knowler, W.C., Bennett, P.H., and Ballintine, E.J. (1980) Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. N. Engl. J. Med. 302, 645-650.
    • (1980) N. Engl. J. Med , vol.302 , pp. 645-650
    • Knowler, W.C.1    Bennett, P.H.2    Ballintine, E.J.3
  • 43
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group (1998) Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317, 703-713.
    • (1998) BMJ , vol.317 , pp. 703-713
  • 44
    • 0034074955 scopus 로고    scopus 로고
    • Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes
    • Estacio, R.O., Jeffers, B.W., Gifford, N., and Schrier, R.W. (2000) Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes. Diabetes Care 23(Suppl 2), B54-64.
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 2
    • Estacio, R.O.1    Jeffers, B.W.2    Gifford, N.3    Schrier, R.W.4
  • 46
    • 33751195532 scopus 로고    scopus 로고
    • Rationale and design of the AdRem study: Evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus
    • Stolk, R.P., Vingerling, J.R., Cruickshank, J.K., Hughes, A.D., Stanton, A., Juming, L., Patel, A., Thom, S.A., and Grobbee, D.E. (2007) Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus. Contemp. Clin. Trials 28, 6-17.
    • (2007) Contemp. Clin. Trials , vol.28 , pp. 6-17
    • Stolk, R.P.1    Vingerling, J.R.2    Cruickshank, J.K.3    Hughes, A.D.4    Stanton, A.5    Juming, L.6    Patel, A.7    Thom, S.A.8    Grobbee, D.E.9
  • 47
    • 0032477583 scopus 로고    scopus 로고
    • Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus
    • Chaturvedi, N., Sjolie, A.K., Stephenson, J.M., Abrahamian, H., Keipes, M., Castellarin, A., Rogulja-Pepeonik, Z., and Fuller, J.H. (1998) Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus. Lancet 351, 28-31.
    • (1998) Lancet , vol.351 , pp. 28-31
    • Chaturvedi, N.1    Sjolie, A.K.2    Stephenson, J.M.3    Abrahamian, H.4    Keipes, M.5    Castellarin, A.6    Rogulja-Pepeonik, Z.7    Fuller, J.H.8
  • 48
    • 0025087033 scopus 로고
    • Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy
    • Larsen, M., Hommel, E., Parving, H.H., and Lund-Andersen, H. (1990) Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy. Graefes Arch. Clin. Exp. Ophthalmol. 228, 505-509.
    • (1990) Graefes Arch. Clin. Exp. Ophthalmol , vol.228 , pp. 505-509
    • Larsen, M.1    Hommel, E.2    Parving, H.H.3    Lund-Andersen, H.4
  • 49
    • 0036670365 scopus 로고    scopus 로고
    • The retinal renin-angiotensin system: Implications for therapy in diabetic retinopathy
    • Sjolie, A.K. and Chaturvedi, N. (2002) The retinal renin-angiotensin system: implications for therapy in diabetic retinopathy. J. Hum. Hypertens. 16(Suppl 3), S42-46.
    • (2002) J. Hum. Hypertens , vol.16 , Issue.SUPPL. 3
    • Sjolie, A.K.1    Chaturvedi, N.2
  • 50
    • 33947709971 scopus 로고    scopus 로고
    • The relationship of retinopathy in persons without diabetes to the 15-year incidence of diabetes and hypertension: Beaver Dam Eye Study
    • Klein, R., Klein, B.E., Moss, S.E., and Wong, T.Y. (2006) The relationship of retinopathy in persons without diabetes to the 15-year incidence of diabetes and hypertension: Beaver Dam Eye Study. Trans. Am. Ophthalmol. Soc. 104, 98-107.
    • (2006) Trans. Am. Ophthalmol. Soc , vol.104 , pp. 98-107
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Wong, T.Y.4
  • 51
    • 3142557899 scopus 로고    scopus 로고
    • Prospective cohort study of retinal vessel diameters and risk of hypertension
    • Wong, T.Y., Shankar, A., Klein, R., Klein, B.E., and Hubbard, L.D. (2004) Prospective cohort study of retinal vessel diameters and risk of hypertension. BMJ 329, 79.
    • (2004) BMJ , vol.329 , pp. 79
    • Wong, T.Y.1    Shankar, A.2    Klein, R.3    Klein, B.E.4    Hubbard, L.D.5
  • 53
    • 18344394857 scopus 로고    scopus 로고
    • Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus
    • Wong, T.Y., Shankar, A., Klein, R., Klein, B.E., and Hubbard, L.D. (2005) Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus. Arch. Intern. Med. 165, 1060-1065.
    • (2005) Arch. Intern. Med , vol.165 , pp. 1060-1065
    • Wong, T.Y.1    Shankar, A.2    Klein, R.3    Klein, B.E.4    Hubbard, L.D.5
  • 54
    • 0346724529 scopus 로고    scopus 로고
    • The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy
    • Klein, R., Klein, B.E., Moss, S.E., Wong, T.Y., Hubbard, L., Cruickshanks, K.J., and Palta, M. (2004) The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch. Ophthalmol. 122, 76-83.
    • (2004) Arch. Ophthalmol , vol.122 , pp. 76-83
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Wong, T.Y.4    Hubbard, L.5    Cruickshanks, K.J.6    Palta, M.7
  • 55
    • 33750550642 scopus 로고    scopus 로고
    • The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy
    • Wilkinson-Berka, J.L., Wraight, C., and Werther, G. (2006) The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy. Curr. Med. Chem. 13, 3307-3317.
    • (2006) Curr. Med. Chem , vol.13 , pp. 3307-3317
    • Wilkinson-Berka, J.L.1    Wraight, C.2    Werther, G.3
  • 56
    • 0024272670 scopus 로고    scopus 로고
    • Franken, A.A., Derkx, F.H., Schalekamp, M.A., Man in t'Veld, A.J., Hop, W.C., van Rens, E.H., and de Jong, P.T. (1988) Association of high plasma prorenin with diabetic retinopathy. J. Hypertens. Suppl. 6, S461-463.
    • Franken, A.A., Derkx, F.H., Schalekamp, M.A., Man in t'Veld, A.J., Hop, W.C., van Rens, E.H., and de Jong, P.T. (1988) Association of high plasma prorenin with diabetic retinopathy. J. Hypertens. Suppl. 6, S461-463.
  • 57
    • 0021889169 scopus 로고
    • Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications
    • Luetscher, J.A., Kraemer, F.B., Wilson, D.M., Schwartz, H.C., and Bryer-Ash, M. (1985) Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N. Engl. J. Med. 312, 1412-1417.
    • (1985) N. Engl. J. Med , vol.312 , pp. 1412-1417
    • Luetscher, J.A.1    Kraemer, F.B.2    Wilson, D.M.3    Schwartz, H.C.4    Bryer-Ash, M.5
  • 61
    • 16244376186 scopus 로고    scopus 로고
    • The renin-angiotensin system and the developing retinal vasculature
    • Sarlos, S. and Wilkinson-Berka, J.L. (2005) The renin-angiotensin system and the developing retinal vasculature. Invest. Ophthalmol. Vis. Sci. 46, 1069-1077.
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 1069-1077
    • Sarlos, S.1    Wilkinson-Berka, J.L.2
  • 62
    • 0026059554 scopus 로고
    • Angiotensin II binding receptors in retinal and optic nerve head blood vessels. An autoradiographic approach
    • Ferrari-Dileo, G., Davis, E.B., and Anderson, D.R. (1991) Angiotensin II binding receptors in retinal and optic nerve head blood vessels. An autoradiographic approach. Invest. Ophthalmol. Vis. Sci. 32, 21-26.
    • (1991) Invest. Ophthalmol. Vis. Sci , vol.32 , pp. 21-26
    • Ferrari-Dileo, G.1    Davis, E.B.2    Anderson, D.R.3
  • 64
    • 0032824992 scopus 로고    scopus 로고
    • Angiotensin II receptor subtype gene expression and cellular localization in the retina and non-neuronal ocular tissues of the rat
    • Wheeler-Schilling, T.H., Kohler, K., Sautter, M., and Guenther, E. (1999) Angiotensin II receptor subtype gene expression and cellular localization in the retina and non-neuronal ocular tissues of the rat. Eur. J. Neurosci. 11, 3387-3394.
    • (1999) Eur. J. Neurosci , vol.11 , pp. 3387-3394
    • Wheeler-Schilling, T.H.1    Kohler, K.2    Sautter, M.3    Guenther, E.4
  • 66
    • 33847752236 scopus 로고    scopus 로고
    • Retinal dysfunction in diabetic ren-2 rats is ameliorated by treatment with valsartan but not atenolol
    • Phipps, J.A., Wilkinson-Berka, J.L., and Fletcher, E.L. (2007) Retinal dysfunction in diabetic ren-2 rats is ameliorated by treatment with valsartan but not atenolol. Invest. Ophthalmol. Vis Sci. 48, 927-934.
    • (2007) Invest. Ophthalmol. Vis Sci , vol.48 , pp. 927-934
    • Phipps, J.A.1    Wilkinson-Berka, J.L.2    Fletcher, E.L.3
  • 67
    • 33947326902 scopus 로고    scopus 로고
    • Valsartan but not atenolol improves vascular pathology in diabetic Ren-2 rat retina
    • Wilkinson-Berka, J.L., Tan, G., Jaworski, K., and Ninkovic, S. (2007) Valsartan but not atenolol improves vascular pathology in diabetic Ren-2 rat retina. Am. J. Hypertens. 20, 423-430.
    • (2007) Am. J. Hypertens , vol.20 , pp. 423-430
    • Wilkinson-Berka, J.L.1    Tan, G.2    Jaworski, K.3    Ninkovic, S.4
  • 72
    • 0036785429 scopus 로고    scopus 로고
    • Inhibitory effect of losartan, an AT1 angiotensin II receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic rats
    • Mori, F., Hikichi, T., Nagaoka, T., Takahashi, J., Kitaya, N., and Yoshida, A. (2002) Inhibitory effect of losartan, an AT1 angiotensin II receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic rats. Br. J. Ophthalmol. 86, 1172-1174.
    • (2002) Br. J. Ophthalmol , vol.86 , pp. 1172-1174
    • Mori, F.1    Hikichi, T.2    Nagaoka, T.3    Takahashi, J.4    Kitaya, N.5    Yoshida, A.6
  • 73
    • 33947183418 scopus 로고    scopus 로고
    • Effects of angiotensin-converting enzyme inhibitors and betaadrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy
    • Zheng, Z., Chen, H., Xu, X., Li, C., and Gu, Q. (2007) Effects of angiotensin-converting enzyme inhibitors and betaadrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy. Exp. Eye Res. 84, 745-752.
    • (2007) Exp. Eye Res , vol.84 , pp. 745-752
    • Zheng, Z.1    Chen, H.2    Xu, X.3    Li, C.4    Gu, Q.5
  • 74
    • 33845957564 scopus 로고    scopus 로고
    • The regulation of the inflammatory response through nuclear factor-kappab pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases
    • Ruiz-Ortega, M., Esteban, V., and Egido, J. (2007) The regulation of the inflammatory response through nuclear factor-kappab pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases. Trends Cardiovasc. Med. 17, 19-25.
    • (2007) Trends Cardiovasc. Med , vol.17 , pp. 19-25
    • Ruiz-Ortega, M.1    Esteban, V.2    Egido, J.3
  • 75
    • 0033119158 scopus 로고    scopus 로고
    • Pharmacologic modulation of protein kinase C isozymes: The role of RACKs and subcellular localisation
    • Csukai, M. and Mochly-Rosen, D. (1999) Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation. Pharmacol. Res. 39, 253-259.
    • (1999) Pharmacol. Res , vol.39 , pp. 253-259
    • Csukai, M.1    Mochly-Rosen, D.2
  • 76
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • Koya, D., Haneda, M., Nakagawa, H., Isshiki, K., Sato, H., Maeda, S., Sugimoto, T., Yasuda, H., Kashiwagi, A., Ways, D.K., King, G.L., and Kikkawa, R. (2000) Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 14, 439-447.
    • (2000) FASEB J , vol.14 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3    Isshiki, K.4    Sato, H.5    Maeda, S.6    Sugimoto, T.7    Yasuda, H.8    Kashiwagi, A.9    Ways, D.K.10    King, G.L.11    Kikkawa, R.12
  • 77
    • 0037315791 scopus 로고    scopus 로고
    • Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
    • Kelly, D.J., Zhang, Y., Hepper, C., Gow, R.M., Jaworski, K., Kemp, B.E., Wilkinson-Berka, J.L., and Gilbert, R.E. (2003) Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes 52, 512-518.
    • (2003) Diabetes , vol.52 , pp. 512-518
    • Kelly, D.J.1    Zhang, Y.2    Hepper, C.3    Gow, R.M.4    Jaworski, K.5    Kemp, B.E.6    Wilkinson-Berka, J.L.7    Gilbert, R.E.8
  • 79
    • 0031891448 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases
    • Kowluru, R.A., Jirousek, M.R., Stramm, L., Farid, N., Engerman, R.L., and Kern, T.S. (1998) Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases. Diabetes 47, 464-469.
    • (1998) Diabetes , vol.47 , pp. 464-469
    • Kowluru, R.A.1    Jirousek, M.R.2    Stramm, L.3    Farid, N.4    Engerman, R.L.5    Kern, T.S.6
  • 80
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
    • Aiello, L.P., Bursell, S.E., Clermont, A., Duh, E., Ishii, H., Takagi, C., Mori, F., Ciulla, T.A., Ways, K., Jirousek, M., Smith, L.E., and King, G.L. (1997) Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 46, 1473-1480.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3    Duh, E.4    Ishii, H.5    Takagi, C.6    Mori, F.7    Ciulla, T.A.8    Ways, K.9    Jirousek, M.10    Smith, L.E.11    King, G.L.12
  • 82
    • 32944465911 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema
    • Strom, C., Sander, B., Klemp, K., Aiello, L.P., Lund-Andersen, H., and Larsen, M. (2005) Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 46, 3855-3858.
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 3855-3858
    • Strom, C.1    Sander, B.2    Klemp, K.3    Aiello, L.P.4    Lund-Andersen, H.5    Larsen, M.6
  • 83
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial
    • PKC-DRS Study Group
    • PKC-DRS Study Group (2005) The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes 54, 2188-2197.
    • (2005) Diabetes , vol.54 , pp. 2188-2197
  • 85
    • 33947236725 scopus 로고    scopus 로고
    • Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial
    • PKC-DMES Study Group
    • PKC-DMES Study Group (2007) Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial. Arch. Ophthalmol. 125, 318-324.
    • (2007) Arch. Ophthalmol , vol.125 , pp. 318-324
  • 86
    • 1542742166 scopus 로고    scopus 로고
    • Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412
    • Campochiaro, P.A. (2004) Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest. Ophthalmol. Vis. Sci. 45, 922-931.
    • (2004) Invest. Ophthalmol. Vis. Sci , vol.45 , pp. 922-931
    • Campochiaro, P.A.1
  • 87
    • 84878764835 scopus 로고    scopus 로고
    • National Institutes of Health USA. Effect of Ruboxistaurin on Clinically Significant Macula Edema.ClinicalTrials.gov identifier: NCT00133952. Last accessed 14th May 2007.
    • National Institutes of Health USA. Effect of Ruboxistaurin on Clinically Significant Macula Edema.ClinicalTrials.gov identifier: NCT00133952. Last accessed 14th May 2007.
  • 88
    • 0035153678 scopus 로고    scopus 로고
    • Advanced glycation end products, their receptors and diabetic angiopathy
    • Wautier, J.L. and Guillausseau, P.J. (2001) Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metab. 27, 535-542.
    • (2001) Diabetes Metab , vol.27 , pp. 535-542
    • Wautier, J.L.1    Guillausseau, P.J.2
  • 89
    • 0034985014 scopus 로고    scopus 로고
    • Advanced glycation: An important pathological event in diabetic and age related ocular disease
    • Stitt, A.W. (2001) Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br. J. Ophthalmol. 85, 746-753.
    • (2001) Br. J. Ophthalmol , vol.85 , pp. 746-753
    • Stitt, A.W.1
  • 90
    • 0021231172 scopus 로고
    • Nonenzymatic glycosylation and the pathogenesis of diabetic complications
    • Brownlee, M., Vlassara, H., and Cerami, A. (1984) Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann. Intern. Med. 101, 527-537.
    • (1984) Ann. Intern. Med , vol.101 , pp. 527-537
    • Brownlee, M.1    Vlassara, H.2    Cerami, A.3
  • 91
    • 0031019612 scopus 로고    scopus 로고
    • Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats
    • Stitt, A.W., Li, Y.M., Gardiner, T.A., Bucala, R., Archer, D.B., and Vlassara, H. (1997) Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am. J. Pathol. 150, 523-531.
    • (1997) Am. J. Pathol , vol.150 , pp. 523-531
    • Stitt, A.W.1    Li, Y.M.2    Gardiner, T.A.3    Bucala, R.4    Archer, D.B.5    Vlassara, H.6
  • 92
    • 4544341580 scopus 로고    scopus 로고
    • Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema
    • Boehm, B.O., Schilling, S., Rosinger, S., Lang, G.E., Lang, G.K., Kientsch-Engel, R., and Stahl, P. (2004) Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema. Diabetologia 47, 1376-1379.
    • (2004) Diabetologia , vol.47 , pp. 1376-1379
    • Boehm, B.O.1    Schilling, S.2    Rosinger, S.3    Lang, G.E.4    Lang, G.K.5    Kientsch-Engel, R.6    Stahl, P.7
  • 93
    • 20344380180 scopus 로고    scopus 로고
    • Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy
    • Yokoi, M., Yamagishi, S.I., Takeuchi, M., Ohgami, K., Okamoto, T., Saito, W., Muramatsu, M., Imaizumi, T., and Ohno, S. (2005) Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy. Br. J. Ophthalmol. 89, 673-675.
    • (2005) Br. J. Ophthalmol , vol.89 , pp. 673-675
    • Yokoi, M.1    Yamagishi, S.I.2    Takeuchi, M.3    Ohgami, K.4    Okamoto, T.5    Saito, W.6    Muramatsu, M.7    Imaizumi, T.8    Ohno, S.9
  • 96
    • 33847765812 scopus 로고    scopus 로고
    • Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products
    • Kaji, Y., Usui, T., Ishida, S., Yamashiro, K., Moore, T.C., Moore, J., Yamamoto, Y., Yamamoto, H., and Adamis, A.P. (2007) Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. Invest. Ophthalmol. Vis. Sci. 48, 858-865.
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 858-865
    • Kaji, Y.1    Usui, T.2    Ishida, S.3    Yamashiro, K.4    Moore, T.C.5    Moore, J.6    Yamamoto, Y.7    Yamamoto, H.8    Adamis, A.P.9
  • 97
    • 34247354628 scopus 로고    scopus 로고
    • Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes
    • Canning, P., Glenn, J.V., Hsu, D.K., Liu, F.T., Gardiner, T.A., and Stitt, A.W. (2007) Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes. Exp. Diabetes Res. 2007, 51837.
    • (2007) Exp. Diabetes Res , vol.2007 , pp. 51837
    • Canning, P.1    Glenn, J.V.2    Hsu, D.K.3    Liu, F.T.4    Gardiner, T.A.5    Stitt, A.W.6
  • 99
    • 0141961133 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes
    • Gardiner, T.A., Anderson, H.R., and Stitt, A.W. (2003) Inhibition of advanced glycation end-products protects against retinal capillary basement membrane expansion during long-term diabetes. J. Pathol. 201, 328-333.
    • (2003) J. Pathol , vol.201 , pp. 328-333
    • Gardiner, T.A.1    Anderson, H.R.2    Stitt, A.W.3
  • 101
    • 0026323337 scopus 로고
    • Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
    • Hammes, H.P., Martin, S., Federlin, K., Geisen, K., and Brownlee, M. (1991) Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc. Natl. Acad. Sci. U. S. A. 88, 11555-11558.
    • (1991) Proc. Natl. Acad. Sci. U. S. A , vol.88 , pp. 11555-11558
    • Hammes, H.P.1    Martin, S.2    Federlin, K.3    Geisen, K.4    Brownlee, M.5
  • 103
    • 0036829609 scopus 로고    scopus 로고
    • ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat
    • Wilkinson-Berka, J.L., Kelly, D.J., Koerner, S.M., Jaworski, K., Davis, B., Thallas, V., and Cooper, M.E. (2002) ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. Diabetes 51, 3283-3289.
    • (2002) Diabetes , vol.51 , pp. 3283-3289
    • Wilkinson-Berka, J.L.1    Kelly, D.J.2    Koerner, S.M.3    Jaworski, K.4    Davis, B.5    Thallas, V.6    Cooper, M.E.7
  • 104
    • 0030906581 scopus 로고    scopus 로고
    • Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation
    • Nakamura, S., Makita, Z., Ishikawa, S., Yasumura, K., Fujii, W., Yanagisawa, K., Kawata, T., and Koike, T. (1997) Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation. Diabetes 46, 895-899.
    • (1997) Diabetes , vol.46 , pp. 895-899
    • Nakamura, S.1    Makita, Z.2    Ishikawa, S.3    Yasumura, K.4    Fujii, W.5    Yanagisawa, K.6    Kawata, T.7    Koike, T.8
  • 105
    • 0344443743 scopus 로고    scopus 로고
    • Modification of proteins in vitro by physiological levels of glucose: Pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions
    • Voziyan, P.A., Khalifah, R.G., Thibaudeau, C., Yildiz, A., Jacob, J., Serianni, A.S., and Hudson, B.G. (2003) Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions. J. Biol. Chem. 278, 46616-46624.
    • (2003) J. Biol. Chem , vol.278 , pp. 46616-46624
    • Voziyan, P.A.1    Khalifah, R.G.2    Thibaudeau, C.3    Yildiz, A.4    Jacob, J.5    Serianni, A.S.6    Hudson, B.G.7
  • 106
    • 35548975242 scopus 로고    scopus 로고
    • Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy
    • Williams, M.E., Bolton, W.K., Khalifah, R.G., Degenhardt, T.P., Schotzinger, R.J., and McGill., J.B. (2007) Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Am. J. Nephrol. 27, 605-614.
    • (2007) Am. J. Nephrol , vol.27 , pp. 605-614
    • Williams, M.E.1    Bolton, W.K.2    Khalifah, R.G.3    Degenhardt, T.P.4    Schotzinger, R.J.5    McGill, J.B.6
  • 107
    • 23744516038 scopus 로고    scopus 로고
    • Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: A rational approach to second-generation Amadorin design
    • Khalifah, R.G., Chen, Y., and Wassenberg, J.J. (2005) Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: a rational approach to second-generation Amadorin design. Ann. N .Y. Acad. Sci. 1043, 793-806.
    • (2005) Ann. N .Y. Acad. Sci , vol.1043 , pp. 793-806
    • Khalifah, R.G.1    Chen, Y.2    Wassenberg, J.J.3
  • 108
    • 0041877502 scopus 로고    scopus 로고
    • LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin- diabetic rats
    • Figarola, J.L., Scott, S., Loera, S., Tessler. C., Chu, P., Weiss, L., Hardy, J., and Rahbar, S. (2003) LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin- diabetic rats. Diabetologia 46, 1140-1152.
    • (2003) Diabetologia , vol.46 , pp. 1140-1152
    • Figarola, J.L.1    Scott, S.2    Loera, S.3    Tessler, C.4    Chu, P.5    Weiss, L.6    Hardy, J.7    Rahbar, S.8
  • 109
    • 39449086332 scopus 로고    scopus 로고
    • Inhibition of NADPH oxidase prevents AGE mediated damage in diabetic nephropathy through a protein kinase C-{alpha} dependent pathway
    • Oct 24 [e-pub ahead of print
    • Thallas-Bonke, V., Thorpe, S.R., Coughlan, M.T., Fukami, K., Yap, F.Y., Sourris, K., Penfold, S., Bach, L.A., Cooper. M.E., and Forbes, J.M. (2007) Inhibition of NADPH oxidase prevents AGE mediated damage in diabetic nephropathy through a protein kinase C-{alpha} dependent pathway. Diabetes Oct 24 [e-pub ahead of print]
    • (2007) Diabetes
    • Thallas-Bonke, V.1    Thorpe, S.R.2    Coughlan, M.T.3    Fukami, K.4    Yap, F.Y.5    Sourris, K.6    Penfold, S.7    Bach, L.A.8    Cooper, M.E.9    Forbes, J.M.10
  • 110
    • 33847344765 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes
    • Figarola, J.L., Shanmugam, N., Natarajan, R., and Rahbar, S. (2007) Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes. Diabetes 56, 647-655.
    • (2007) Diabetes , vol.56 , pp. 647-655
    • Figarola, J.L.1    Shanmugam, N.2    Natarajan, R.3    Rahbar, S.4
  • 111
    • 16244371321 scopus 로고    scopus 로고
    • The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    • Little, W.C., Zile, M.R., Kitzman, D.W., Hundley, W.G., O'Brien, T.X., and Degroof, R.C. (2005) The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J. Card. Fail. 11, 191-195.
    • (2005) J. Card. Fail , vol.11 , pp. 191-195
    • Little, W.C.1    Zile, M.R.2    Kitzman, D.W.3    Hundley, W.G.4    O'Brien, T.X.5    Degroof, R.C.6
  • 113
    • 0026659883 scopus 로고
    • Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    • Neeper, M., Schmidt, A.M., Brett, J., Yan, S.D., Wang, F., Pan, Y.C., Elliston, K., Stern, D., and Shaw, A. (1992) Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267, 14998-15004.
    • (1992) J. Biol. Chem , vol.267 , pp. 14998-15004
    • Neeper, M.1    Schmidt, A.M.2    Brett, J.3    Yan, S.D.4    Wang, F.5    Pan, Y.C.6    Elliston, K.7    Stern, D.8    Shaw, A.9
  • 114
    • 0031717894 scopus 로고    scopus 로고
    • Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
    • Park, L., Raman, K.G., Lee, K.J., Lu, Y., Ferran, L.J., Jr., Chow, W.S., Stern, D., and Schmidt, A.M. (1998) Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat. Med. 4, 1025-1031.
    • (1998) Nat. Med , vol.4 , pp. 1025-1031
    • Park, L.1    Raman, K.G.2    Lee, K.J.3    Lu, Y.4    Ferran Jr., L.J.5    Chow, W.S.6    Stern, D.7    Schmidt, A.M.8
  • 115
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze, F., Clamens, S., Simorre-Pinatel, V., Mathis, A., Chollet, P., Favard, C., Bayard, F., and Plouet, J. (1994) Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol. 112, 1476-1482.
    • (1994) Arch. Ophthalmol , vol.112 , pp. 1476-1482
    • Malecaze, F.1    Clamens, S.2    Simorre-Pinatel, V.3    Mathis, A.4    Chollet, P.5    Favard, C.6    Bayard, F.7    Plouet, J.8
  • 116
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., and Keshet, E. (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1, 1024-1028.
    • (1995) Nat. Med , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 117
    • 0029074024 scopus 로고
    • Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
    • Stone, J., Itin, A., Alon, T., Pe'er, J., Gnessin, H., Chan-Ling, T., and Keshet, E. (1995) Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J. Neurosci. 15, 4738-4747.
    • (1995) J. Neurosci , vol.15 , pp. 4738-4747
    • Stone, J.1    Itin, A.2    Alon, T.3    Pe'er, J.4    Gnessin, H.5    Chan-Ling, T.6    Keshet, E.7
  • 118
    • 1942454791 scopus 로고    scopus 로고
    • Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor
    • Csaky, K.G., Baffi, J.Z., Byrnes, G.A., Wolfe, J.D., Hilmer, S.C., Flippin, J., and Cousins, S.W. (2004) Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor. Exp. Eye Res. 78, 1107-1116.
    • (2004) Exp. Eye Res , vol.78 , pp. 1107-1116
    • Csaky, K.G.1    Baffi, J.Z.2    Byrnes, G.A.3    Wolfe, J.D.4    Hilmer, S.C.5    Flippin, J.6    Cousins, S.W.7
  • 119
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti, D.A., Barber, A.J., Hollinger, L.A., Wolpert, E.B., and Gardner, T.W. (1999) Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem. 274, 23463-23467.
    • (1999) J. Biol. Chem , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 123
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara, N. (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25, 581-611.
    • (2004) Endocr. Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 129
    • 33748957021 scopus 로고    scopus 로고
    • A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema
    • Chun, D.W., Heier, J.S., Topping, T.M., Duker, J.S., and Bankert, J.M. (2006) A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology 133, 1706-1712.
    • (2006) Ophthalmology , vol.133 , pp. 1706-1712
    • Chun, D.W.1    Heier, J.S.2    Topping, T.M.3    Duker, J.S.4    Bankert, J.M.5
  • 130
    • 84878767951 scopus 로고    scopus 로고
    • National Institutes of Health USA. RESOLVE: Safety and Efficacy of Ranibizumb in Diabetic Macular Edema with Center Involvement. National Institutes of Health USA; ClinicalTrials.gov Identifier: NCT00284050.
    • National Institutes of Health USA. RESOLVE: Safety and Efficacy of Ranibizumb in Diabetic Macular Edema with Center Involvement. National Institutes of Health USA; ClinicalTrials.gov Identifier: NCT00284050.
  • 132
    • 33644502828 scopus 로고    scopus 로고
    • Avery, R.L., Pieramici, D.J., Rabena, M.D., Castellarin, A.A., Nasir, M.A., and Giust, M.J. (2006) Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology 133, 363-372 e365.
    • Avery, R.L., Pieramici, D.J., Rabena, M.D., Castellarin, A.A., Nasir, M.A., and Giust, M.J. (2006) Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology 133, 363-372 e365.
  • 134
    • 33646464279 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage
    • Spaide, R.F. and Fisher, Y.L. (2006) Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage. Retina 26, 275-278.
    • (2006) Retina , vol.26 , pp. 275-278
    • Spaide, R.F.1    Fisher, Y.L.2
  • 135
    • 33749631288 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study)
    • Jorge, R., Costa, R.A., Calucci, D., Cintra, L.P., and Scott, I.U. (2006) Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study). Retina 26, 1006-1013.
    • (2006) Retina , vol.26 , pp. 1006-1013
    • Jorge, R.1    Costa, R.A.2    Calucci, D.3    Cintra, L.P.4    Scott, I.U.5
  • 137
    • 34547106467 scopus 로고    scopus 로고
    • National Eye Institute Clinical Studies Database, Avastin, Last updated 17th August 2006
    • National Eye Institute Clinical Studies Database. A phase 2 evaluation of anti-VEGF therapy for diabetic macular edema: bevacizumab (Avastin). http://www.nei.nih.gov/neitrials/viewStudyWeb.aspx?id=129; Last updated 17th August 2006.
    • A phase 2 evaluation of anti-VEGF therapy for diabetic macular edema: Bevacizumab
  • 138
    • 39449110602 scopus 로고    scopus 로고
    • Intravitreal Bevacizumab for management of Active Progressive Proliferative Diabetic Retinopathy (PDR). ClinicalTrials.gov Identifier: NCT00370721
    • National Institutes of Health USA
    • National Institutes of Health USA. Intravitreal Bevacizumab for management of Active Progressive Proliferative Diabetic Retinopathy (PDR). ClinicalTrials.gov Identifier: nCT00370721; Last updated 6th October 2006.
    • (2006) Last updated 6th October
  • 139
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • Byrne, A.M., Bouchier-Hayes, D.J., and Harmey, J.H. (2005) Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell Mol. Med. 9, 777-794.
    • (2005) J. Cell Mol. Med , vol.9 , pp. 777-794
    • Byrne, A.M.1    Bouchier-Hayes, D.J.2    Harmey, J.H.3
  • 140
    • 29244451854 scopus 로고    scopus 로고
    • Regulators of angiogenesis and strategies for their therapeutic manipulation
    • Milkiewicz, M., Ispanovic, E., Doyle, J.L., and Haas, T.L. (2006) Regulators of angiogenesis and strategies for their therapeutic manipulation. Int. J. Biochem. Cell Biol. 38, 333-357.
    • (2006) Int. J. Biochem. Cell Biol , vol.38 , pp. 333-357
    • Milkiewicz, M.1    Ispanovic, E.2    Doyle, J.L.3    Haas, T.L.4
  • 141
    • 0034104295 scopus 로고    scopus 로고
    • VPF/VEGF and the angiogenic response
    • Dvorak, H.F. (2000) VPF/VEGF and the angiogenic response. Semin. Perinatol, 24, 75-78.
    • (2000) Semin. Perinatol , vol.24 , pp. 75-78
    • Dvorak, H.F.1
  • 142
    • 4644297564 scopus 로고    scopus 로고
    • Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin epidemiologic study of diabetic retinopathy
    • Klein, B.E., Klein, R., McBride, P.E., Cruickshanks, K.J., Palta, M., Knudtson, M.D., Moss, S.E., and Reinke, J.O. (2004) Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin epidemiologic study of diabetic retinopathy. Arch. Intern. Med. 164, 1917-1924.
    • (2004) Arch. Intern. Med , vol.164 , pp. 1917-1924
    • Klein, B.E.1    Klein, R.2    McBride, P.E.3    Cruickshanks, K.J.4    Palta, M.5    Knudtson, M.D.6    Moss, S.E.7    Reinke, J.O.8
  • 143
    • 0032808594 scopus 로고    scopus 로고
    • Do age-related macular degeneration and cardiovascular disease share common antecedents?
    • Snow, K.K. and Seddon, J.M. (1999) Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol. 6, 125-143.
    • (1999) Ophthalmic Epidemiol , vol.6 , pp. 125-143
    • Snow, K.K.1    Seddon, J.M.2
  • 144
    • 33846626856 scopus 로고    scopus 로고
    • Is diabetic retinopathy an independent risk factor for ischemic stroke?
    • Cheung, N., Rogers, S., Couper, D.J., Klein, R., Sharrett, A.R., and Wong, T.Y. (2007) Is diabetic retinopathy an independent risk factor for ischemic stroke? Stroke 38, 398-401.
    • (2007) Stroke , vol.38 , pp. 398-401
    • Cheung, N.1    Rogers, S.2    Couper, D.J.3    Klein, R.4    Sharrett, A.R.5    Wong, T.Y.6
  • 145
    • 34447135411 scopus 로고    scopus 로고
    • Diabetic retinopathy and the risk of coronary heart disease: The Atherosclerosis Risk in Communities Study
    • Cheung, N., Wang, J.J., Klein, R., Couper, D.J., Sharrett, A.R., and Wong, T.Y. (2007) Diabetic retinopathy and the risk of coronary heart disease: the Atherosclerosis Risk in Communities Study. Diabetes Care 30, 1742-1746.
    • (2007) Diabetes Care , vol.30 , pp. 1742-1746
    • Cheung, N.1    Wang, J.J.2    Klein, R.3    Couper, D.J.4    Sharrett, A.R.5    Wong, T.Y.6
  • 146
    • 34547702738 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    • Nishijima, K., Ng, Y.S., Zhong, L., Bradley, J., Schubert, W., Jo, N., Akita, J., Samuelsson, S.J., Robinson, G.S., Adamis, A.P., and Shima, D.T. (2007) Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am. J. Pathol. 171, 53-67.
    • (2007) Am. J. Pathol , vol.171 , pp. 53-67
    • Nishijima, K.1    Ng, Y.S.2    Zhong, L.3    Bradley, J.4    Schubert, W.5    Jo, N.6    Akita, J.7    Samuelsson, S.J.8    Robinson, G.S.9    Adamis, A.P.10    Shima, D.T.11
  • 147
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    • Kilic, U., Kilic, E., Jarve, A., Guo, Z., Spudich, A., Bieber, K., Barzena, U., Bassetti, C.L., Marti, H.H., and Hermann, D.M. (2006) Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J. Neurosci. 26, 12439-12446.
    • (2006) J. Neurosci , vol.26 , pp. 12439-12446
    • Kilic, U.1    Kilic, E.2    Jarve, A.3    Guo, Z.4    Spudich, A.5    Bieber, K.6    Barzena, U.7    Bassetti, C.L.8    Marti, H.H.9    Hermann, D.M.10
  • 148
    • 34548845583 scopus 로고    scopus 로고
    • Triamcinolone acetonide protects the rat retina from STZ-induced acute inflammation and early vascular leakage
    • Kim, Y.H., Choi, M.Y., Kim, Y.S., Park, C.H., Lee, J.H., Chung, I.Y., Yoo, J.M., Choi, W.S., Cho, G.J., and Kang, S.S. (2007) Triamcinolone acetonide protects the rat retina from STZ-induced acute inflammation and early vascular leakage. Life Sci. 81, 1167-1173.
    • (2007) Life Sci , vol.81 , pp. 1167-1173
    • Kim, Y.H.1    Choi, M.Y.2    Kim, Y.S.3    Park, C.H.4    Lee, J.H.5    Chung, I.Y.6    Yoo, J.M.7    Choi, W.S.8    Cho, G.J.9    Kang, S.S.10
  • 149
    • 34248595599 scopus 로고    scopus 로고
    • Triamcinolone suppresses retinal vascular pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia
    • Kim, Y.H., Chung, I.Y., Choi, M.Y., Kim, Y.S., Lee, J.H., Park, C.H., Kang, S.S., Roh, G.S., Choi, W.S., Yoo, J.M., and Cho, G.J. (2007) Triamcinolone suppresses retinal vascular pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia. Neurobiol. Dis. 26, 569-576.
    • (2007) Neurobiol. Dis , vol.26 , pp. 569-576
    • Kim, Y.H.1    Chung, I.Y.2    Choi, M.Y.3    Kim, Y.S.4    Lee, J.H.5    Park, C.H.6    Kang, S.S.7    Roh, G.S.8    Choi, W.S.9    Yoo, J.M.10    Cho, G.J.11
  • 150
    • 35449000570 scopus 로고    scopus 로고
    • Impact of triamcinolone acetonide on retinal endothelial cells in a retinopathy of prematurity mouse model
    • Akkoyun, I., Yilmaz, G., Oto, S., Kahraman, B., Haberal, N., and Akova, Y.A. (2007) Impact of triamcinolone acetonide on retinal endothelial cells in a retinopathy of prematurity mouse model. Acta Ophthalmol. Scand. 85, 791-794
    • (2007) Acta Ophthalmol. Scand , vol.85 , pp. 791-794
    • Akkoyun, I.1    Yilmaz, G.2    Oto, S.3    Kahraman, B.4    Haberal, N.5    Akova, Y.A.6
  • 151
    • 34247149812 scopus 로고    scopus 로고
    • Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    • Hartnett, M.E., Martiniuk, D.J., Saito, Y., Geisen, P., Peterson, L.J., and McColm, J.R. (2006) Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci, 47, 4975-4982.
    • (2006) Invest. Ophthalmol. Vis. Sci , vol.47 , pp. 4975-4982
    • Hartnett, M.E.1    Martiniuk, D.J.2    Saito, Y.3    Geisen, P.4    Peterson, L.J.5    McColm, J.R.6
  • 152
    • 10044242430 scopus 로고    scopus 로고
    • Brooks, H.L., Jr., Caballero, S., Jr., Newell, CK., Steinmetz, R.L., Watson, D., Segal, M.S., Harrison, J.K., Scott, E.W., and Grant, M.B. (2004) Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch. Ophthalmol. 122, 1801-1807.
    • Brooks, H.L., Jr., Caballero, S., Jr., Newell, CK., Steinmetz, R.L., Watson, D., Segal, M.S., Harrison, J.K., Scott, E.W., and Grant, M.B. (2004) Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch. Ophthalmol. 122, 1801-1807.
  • 153
    • 33144475205 scopus 로고    scopus 로고
    • Infectious and noninfectious endophthalmitis after intravitreal high-dosage triamcinolone acetonide
    • Jonas, J.B., Kreissig, I., Spandau, U.H., and Harder, B. (2006) Infectious and noninfectious endophthalmitis after intravitreal high-dosage triamcinolone acetonide. Am. J. Ophthalmol. 141, 579-580.
    • (2006) Am. J. Ophthalmol , vol.141 , pp. 579-580
    • Jonas, J.B.1    Kreissig, I.2    Spandau, U.H.3    Harder, B.4
  • 155
    • 33747623255 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for refractory diabetic macular edema: Two-year results of a double-masked, placebo-controlled, randomized clinical trial
    • Gillies, M.C., Sutter, F.K., Simpson, J.M., Larsson, J., Ali, H., and Zhu, M. (2006) Intravitreal triamcinolone for refractory diabetic macular edema: two-year results of a double-masked, placebo-controlled, randomized clinical trial. Ophthalmology 133, 1533-1538.
    • (2006) Ophthalmology , vol.133 , pp. 1533-1538
    • Gillies, M.C.1    Sutter, F.K.2    Simpson, J.M.3    Larsson, J.4    Ali, H.5    Zhu, M.6
  • 157
    • 84878768117 scopus 로고    scopus 로고
    • An intravenous dexamethasone biodegradible drug delivery system for the treatment of persistent diabetic macular edema [e-absract 4289]
    • Kuppermann, B.D., Blumenkranz, M.S., Haller, J.A., and Williams, G.A. (2007) An intravenous dexamethasone biodegradible drug delivery system for the treatment of persistent diabetic macular edema [e-absract 4289]. Invest. Ophthalmol. Vis Sci. http://abstracts.iovs.org.
    • (2007) Invest. Ophthalmol. Vis Sci
    • Kuppermann, B.D.1    Blumenkranz, M.S.2    Haller, J.A.3    Williams, G.A.4
  • 159
    • 0014666298 scopus 로고
    • Serum growth hormone levels and size of pituitary tumour in untreated acromegaly
    • Wright, A.D., McLachlan, M.S, Doyle, F.H., and Fraser, T.R. (1969) Serum growth hormone levels and size of pituitary tumour in untreated acromegaly. BMJ 4, 582-584.
    • (1969) BMJ , vol.4 , pp. 582-584
    • Wright, A.D.1    McLachlan, M.S.2    Doyle, F.H.3    Fraser, T.R.4
  • 162
    • 0027143188 scopus 로고
    • Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects
    • Meyer-Schwickerath, R., Pfeiffer, A., Blum, W.F., Freyberger, H., Klein, M., Losche, C., Rollmann, R., and Schatz, H. (1993) Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. J. Clin. Invest. 92, 2620-2625.
    • (1993) J. Clin. Invest , vol.92 , pp. 2620-2625
    • Meyer-Schwickerath, R.1    Pfeiffer, A.2    Blum, W.F.3    Freyberger, H.4    Klein, M.5    Losche, C.6    Rollmann, R.7    Schatz, H.8
  • 163
    • 0022539028 scopus 로고
    • Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization
    • Grant, M., Russell, B., Fitzgerald, C., and Merimee, T.J. (1986) Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization. Diabetes 35, 416-420.
    • (1986) Diabetes , vol.35 , pp. 416-420
    • Grant, M.1    Russell, B.2    Fitzgerald, C.3    Merimee, T.J.4
  • 165
    • 0027818856 scopus 로고
    • Somatostatin analogs for diagnosis and treatment of cancer
    • Weckbecker, G., Raulf, F., Stolz, B., and Bruns, C. (1993) Somatostatin analogs for diagnosis and treatment of cancer. Pharmacol. Ther. 60, 245-264.
    • (1993) Pharmacol. Ther , vol.60 , pp. 245-264
    • Weckbecker, G.1    Raulf, F.2    Stolz, B.3    Bruns, C.4
  • 166
    • 0038798766 scopus 로고    scopus 로고
    • Functional mapping of somatostatin receptors in the retina: A review
    • Thermos, K. (2003) Functional mapping of somatostatin receptors in the retina: a review. Vision Res. 43, 1805-1815.
    • (2003) Vision Res , vol.43 , pp. 1805-1815
    • Thermos, K.1
  • 168
    • 0036956565 scopus 로고    scopus 로고
    • Octreotide inhibits growth factor-induced bovine choriocapillary endothelial cells in vitro
    • Spraul, C.W., Baldysiak-Figiel, A., Lang, G.K., and Lang, G.E. (2002) Octreotide inhibits growth factor-induced bovine choriocapillary endothelial cells in vitro. Graefes Arch. Clin. Exp. Ophthalmol. 240, 227-231.
    • (2002) Graefes Arch. Clin. Exp. Ophthalmol , vol.240 , pp. 227-231
    • Spraul, C.W.1    Baldysiak-Figiel, A.2    Lang, G.K.3    Lang, G.E.4
  • 169
    • 17144397158 scopus 로고    scopus 로고
    • Study of inhibitory effects of an antiangiogenic somatostatin-camptothecin conjugate on laser-induced choroidal neovascularization in rats
    • Bezerra, Y., Fuselier, J.A., Peyman, G.A., Oner, H., Drouant, G., and Coy, D.H. (2005) Study of inhibitory effects of an antiangiogenic somatostatin-camptothecin conjugate on laser-induced choroidal neovascularization in rats. Retina 25, 345-354.
    • (2005) Retina , vol.25 , pp. 345-354
    • Bezerra, Y.1    Fuselier, J.A.2    Peyman, G.A.3    Oner, H.4    Drouant, G.5    Coy, D.H.6
  • 170
    • 0025297227 scopus 로고
    • Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in Type I (insulin-dependent) diabetes mellitus
    • Kirkegaard, C., Norgaard, K., Snorgaard, O., Bek, T., Larsen, M., and Lund-Andersen, H. (1990) Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in Type I (insulin-dependent) diabetes mellitus. Acta Endocrinol. (Copenh.) 122, 766-772.
    • (1990) Acta Endocrinol. (Copenh.) , vol.122 , pp. 766-772
    • Kirkegaard, C.1    Norgaard, K.2    Snorgaard, O.3    Bek, T.4    Larsen, M.5    Lund-Andersen, H.6
  • 171
    • 0034082810 scopus 로고    scopus 로고
    • The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy: A randomized controlled study
    • Grant, M.B., Mames, R.N., Fitzgerald, C., Hazariwala, K.M., Cooper-DeHoff, R., Caballero, S., and Estes, K.S. (2000) The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy: a randomized controlled study. Diabetes Care 23, 504-509.
    • (2000) Diabetes Care , vol.23 , pp. 504-509
    • Grant, M.B.1    Mames, R.N.2    Fitzgerald, C.3    Hazariwala, K.M.4    Cooper-DeHoff, R.5    Caballero, S.6    Estes, K.S.7
  • 172
    • 84878756907 scopus 로고    scopus 로고
    • National Institutes of Health USA. Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients with Moderately Severe of Severe Non-Proliferative Diabetic Retinopathy or Low Risk Diabetic Retinopathy. NCT00248157; ClinicalTrials.gov Identifier: NCT00248131.
    • National Institutes of Health USA. Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients with Moderately Severe of Severe Non-Proliferative Diabetic Retinopathy or Low Risk Diabetic Retinopathy. NCT00248157; ClinicalTrials.gov Identifier: NCT00248131.
  • 173
    • 84878748787 scopus 로고    scopus 로고
    • National Institutes of Health USA. Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients with Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy. ClinicalTrials.gov Identifier: NCT00248157; Last accessed 6th August 2007.
    • National Institutes of Health USA. Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients with Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy. ClinicalTrials.gov Identifier: NCT00248157; Last accessed 6th August 2007.
  • 174
    • 39449105900 scopus 로고    scopus 로고
    • Diabetic Retinopathy - Diagnostic and Treatment Novelties
    • Presented at the
    • Grant, M. (2006) Diabetic Retinopathy - Diagnostic and Treatment Novelties. Presented at the American Association 66th Scientific Sessions.
    • (2006) American Association 66th Scientific Sessions
    • Grant, M.1
  • 175
    • 0035191536 scopus 로고    scopus 로고
    • The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy
    • Growth Hormone Antagonist for Proliferative Diabetic Retinopathy Study Group
    • Growth Hormone Antagonist for Proliferative Diabetic Retinopathy Study Group (2001) The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy. Ophthalmology 108, 2266-2272.
    • (2001) Ophthalmology , vol.108 , pp. 2266-2272
  • 177
    • 34548445134 scopus 로고    scopus 로고
    • An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy
    • Wilkinson-Berka, J.L., Lofthouse, S., Jaworski, K., Ninkovic, S., Tachas, G., and Wraight, C. (2007) An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy. Mol. Vis. 13:1529-1538.
    • (2007) Mol. Vis , vol.13 , pp. 1529-1538
    • Wilkinson-Berka, J.L.1    Lofthouse, S.2    Jaworski, K.3    Ninkovic, S.4    Tachas, G.5    Wraight, C.6
  • 178
    • 0016411408 scopus 로고    scopus 로고
    • (175) Hyperglycemia, polyol metabolism, and complications of diabetes mellitus
    • Gabbay, K.H. (175) Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annu. Rev. Med. 26, 521-536.
    • Annu. Rev. Med , vol.26 , pp. 521-536
    • Gabbay, K.H.1
  • 179
    • 33644663628 scopus 로고    scopus 로고
    • Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice
    • Cheung, A.K., Fung, M.K., Lo. A.C., Lam, T.T., So, K.F., Chung, S.S., and Chung, S.K. (2005) Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 54, 3119-3125.
    • (2005) Diabetes , vol.54 , pp. 3119-3125
    • Cheung, A.K.1    Fung, M.K.2    Lo, A.C.3    Lam, T.T.4    So, K.F.5    Chung, S.S.6    Chung, S.K.7
  • 180
    • 0142138124 scopus 로고    scopus 로고
    • Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats
    • Kato, N., Yashima, S., Suzuki, T., Nakayama, Y., and Jomori, T. (2003) Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats. J. Diabetes Complications 17, 374-379.
    • (2003) J. Diabetes Complications , vol.17 , pp. 374-379
    • Kato, N.1    Yashima, S.2    Suzuki, T.3    Nakayama, Y.4    Jomori, T.5
  • 181
    • 0344305690 scopus 로고    scopus 로고
    • Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs
    • Cusick, M., Chew, E.Y., Ferris, F., 3rd, Cox, T.A., Chan, C.C., and Kador, P.F. (2003) Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs. Arch. Ophthalmol. 121, 1745-1751.
    • (2003) Arch. Ophthalmol , vol.121 , pp. 1745-1751
    • Cusick, M.1    Chew, E.Y.2    Ferris 3rd, F.3    Cox, T.A.4    Chan, C.C.5    Kador, P.F.6
  • 182
    • 0344837811 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    • Obrosova, I.G., Minchenko, A.G., Vasupuram, R., White, L., Abatan, O.I., Kumagai, A.K., Frank R.N., and Stevens, M.J. (2003) Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes 52, 864-871.
    • (2003) Diabetes , vol.52 , pp. 864-871
    • Obrosova, I.G.1    Minchenko, A.G.2    Vasupuram, R.3    White, L.4    Abatan, O.I.5    Kumagai, A.K.6    Frank, R.N.7    Stevens, M.J.8
  • 183
    • 0037317423 scopus 로고    scopus 로고
    • A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    • Asnaghi, V., Gerhardinger, C., Hoehn, T., Adeboje, A., and Lorenzi, M. (2003) A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes 52, 506-511.
    • (2003) Diabetes , vol.52 , pp. 506-511
    • Asnaghi, V.1    Gerhardinger, C.2    Hoehn, T.3    Adeboje, A.4    Lorenzi, M.5
  • 184
    • 0025073693 scopus 로고
    • A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group
    • Sorbinil Retinopathy Trial Research Group (1990) A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch. Ophthalmol. 108, 1234-1244.
    • (1990) Arch. Ophthalmol , vol.108 , pp. 1234-1244
  • 185
    • 0032693720 scopus 로고    scopus 로고
    • (199) Aldose reductase inhibitors: Therapeutic implications for diabetic complications
    • Oates, P.J. and Mylari, B.L. (199) Aldose reductase inhibitors: therapeutic implications for diabetic complications. Expert Opin. Investig. Drugs 8, 2095-2119.
    • Expert Opin. Investig. Drugs , vol.8 , pp. 2095-2119
    • Oates, P.J.1    Mylari, B.L.2
  • 186
    • 33750869527 scopus 로고    scopus 로고
    • A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy
    • Sun, W., Oates, P.J., Coutcher, J.B., Gerhardinger, C., and Lorenzi, M. (2006) A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes 55, 2757-2762.
    • (2006) Diabetes , vol.55 , pp. 2757-2762
    • Sun, W.1    Oates, P.J.2    Coutcher, J.B.3    Gerhardinger, C.4    Lorenzi, M.5
  • 188
    • 0032813888 scopus 로고    scopus 로고
    • High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes
    • Bursell, S.E., Clermont, A.C., Aiello, L.P., Aiello, L.M., Schlossman, D.K., Feener, E.P., Laffel, L., and King, G.L. (1999) High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care 22, 1245-1251.
    • (1999) Diabetes Care , vol.22 , pp. 1245-1251
    • Bursell, S.E.1    Clermont, A.C.2    Aiello, L.P.3    Aiello, L.M.4    Schlossman, D.K.5    Feener, E.P.6    Laffel, L.7    King, G.L.8
  • 189
    • 33846265299 scopus 로고    scopus 로고
    • Ocular neovascularization: Basic mechanisms and therapeutic advances
    • Dorrell, M., Uusitalo-Jarvinen, H., Aguilar, E., and Friedlander, M. (2007) Ocular neovascularization: basic mechanisms and therapeutic advances. Surv. Ophthalmol. 52(Suppl. 1), S3-19.
    • (2007) Surv. Ophthalmol , vol.52 , Issue.SUPPL. 1
    • Dorrell, M.1    Uusitalo-Jarvinen, H.2    Aguilar, E.3    Friedlander, M.4
  • 190
    • 33747893515 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy
    • Zhang, S.X., Wang, J.J., Gao, G., Parke, K., and Ma, J.X. (2006) Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J. Mol. Endocrinol. 37, 1-12.
    • (2006) J. Mol. Endocrinol , vol.37 , pp. 1-12
    • Zhang, S.X.1    Wang, J.J.2    Gao, G.3    Parke, K.4    Ma, J.X.5
  • 191
    • 0035956869 scopus 로고    scopus 로고
    • Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
    • Stellmach, V., Crawford, S.E., Zhou, W., and Bouck, N. (2001) Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc. Natl. Acad. Sci. U. S. A. 98, 2593-2597.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 2593-2597
    • Stellmach, V.1    Crawford, S.E.2    Zhou, W.3    Bouck, N.4
  • 192
    • 33644893607 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    • Zhang, S.X., Wang, J.J., Gao, G., Shao, C., Mott, R., and Ma, J.X. (2006) Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J. 20, 323-325.
    • (2006) FASEB J , vol.20 , pp. 323-325
    • Zhang, S.X.1    Wang, J.J.2    Gao, G.3    Shao, C.4    Mott, R.5    Ma, J.X.6
  • 193
    • 0035514256 scopus 로고    scopus 로고
    • Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD)
    • Rasmussen, H., Chu, K.W., Campochiaro, P., Gehlbach, P.L., Haller, J.A., Handa, J.T., Nguyen, Q.D., and Sung, J.U. (2001) Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum. Gene Ther. 12, 2029-2032.
    • (2001) Hum. Gene Ther , vol.12 , pp. 2029-2032
    • Rasmussen, H.1    Chu, K.W.2    Campochiaro, P.3    Gehlbach, P.L.4    Haller, J.A.5    Handa, J.T.6    Nguyen, Q.D.7    Sung, J.U.8
  • 194
    • 0037401890 scopus 로고    scopus 로고
    • Saishin, Y., Saishin, Y., Takahashi, K., Lima e Silva, R., Hylton, D., Rudge, J.S., Wiegand, S.J., and Campochiaro, P.A. (2003) VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J. Cell Physiol. 195, 241-248.
    • Saishin, Y., Saishin, Y., Takahashi, K., Lima e Silva, R., Hylton, D., Rudge, J.S., Wiegand, S.J., and Campochiaro, P.A. (2003) VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J. Cell Physiol. 195, 241-248.
  • 196
    • 33747874091 scopus 로고    scopus 로고
    • Nguyen, Q.D., Shah, S.M., Hafiz, G., Quinlan, E., Sung, J., Chu, K., Cedarbaum, J.M., and Campochiaro, P.A. (2006) A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 113, 1522.e1-1522.e14.
    • Nguyen, Q.D., Shah, S.M., Hafiz, G., Quinlan, E., Sung, J., Chu, K., Cedarbaum, J.M., and Campochiaro, P.A. (2006) A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 113, 1522.e1-1522.e14.
  • 199
    • 34047144378 scopus 로고    scopus 로고
    • Caballero, S., Sengupta, N., Afzal, A., Chang, K.H., Li, Calzi, S., Guberski, D.L., Kern, T.S., and Grant, M.B. (2007) Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes 56, 960-967.
    • Caballero, S., Sengupta, N., Afzal, A., Chang, K.H., Li, Calzi, S., Guberski, D.L., Kern, T.S., and Grant, M.B. (2007) Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes 56, 960-967.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.