The winged-helix protein brain factor 1 interacts with Groucho and Hes proteins to repress transcription

Molecular and Cellular Biology

Volumn 21, Issue 6, 2001, Pages 1962-1972

  Yao, Jing ^a   Lai, Eseng ^b   Stifani, Stefano ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN FACTOR 1; HELIX LOOP HELIX PROTEIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; PROTEIN; PROTEIN GROUCHO; PROTEIN HES; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STEM CELL; TELENCEPHALON; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HELIX-LOOP-HELIX MOTIFS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RATS; REPRESSOR PROTEINS; TELENCEPHALON; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0035018256     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.6.1962-1972.2001     Document Type: Article

References (55)

1. Akazawa, C., Y. Sasai, S. Nakanishi, and R. Kageyama. 1992. Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J. Biol. Chem. 267:21879-21885.
2. Aronson, B. D., A. L. Fisher, K. Blechman, M. Caudy, and J. P. Gergen. 1997. Groucho-dependent and -independent repression activities of Runt domain proteins. Mol. Cell. Biol. 17:5581-5587.
3. Artavanis-Tsakonas, S., M. D. Rand, and R. J. Lake. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770-776.
4. Bae, S., Y. Bessho, M. Hojo, and R. Kageyama. 2000. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 127: 2933-2943.
5. Bourguignon, C., J. Li, and N. Papalopulu. 1998. XBF-1, a winged helix transcription factor with dual activity, has a role in positioning neurogenesis in Xenopus competent ectoderm. Development 125:4889-4900.
6. Castella, P., S. Sawai, K. Nakao, J. A. Wagner, and M. Caudy. 2000. HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression. Mol. Cell. Biol. 20:6170-6183.
7. Chang, H. W., J. Li, D. Kretzschmar, and P. K. Vogt. 1995. Avian cellular homolog of the qin oncogene. Proc. Natl. Acad. Sci. USA 92:447-451.
8. Chen, H., A. Thiagalindam, H. Chopra, M. W. Borges, J. N. Feder, B. D. Nelkin, S. B. Baylin, and D. G. Ball. 1997. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl. Acad. Sci. USA 94:5355-5360.
9. Chen, G., J. Fernandez, S. Mische, and A. J. Courey. 1999. A functional interaction between the histone deacetylase rpd3 and the corepressor Groucho in Drosophila development. Genes Dev. 13:2218-2230.
10. Choi, C. Y., Y. H. Kim, H. J. Kwon, and Y. Kim. 1999. The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription. J. Biol. Chem. 274:33194-33197.
11. Dehni, G., Y. Liu, J. Husain, and S. Stifani. 1995. TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. Mech. Dev. 53:369-381.
12. Delidakis, C., A. Preiss, D. A. Hartley, and S. Artavanis-Tsakonas. 1991. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics 129:803-823.
13. Dou, C. L., S. Li, and K. Lai. 1999. Dual role of brain factor I in regulating growth and patterning of the cerebral hemispheres. Cereb. Cortex 9:543-550.
14. Fisher, A. L., S. Ohsako, and M. Caudy. 1996. The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a four-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16:2670-26.77.
15. Fode, C., G. Gradwohl, X. Morin, A. Dierich, M. Le Meur, C. Goridis, and F. Guillemot. 1998. The bHLH protein NEUROGENIN2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20:483-494.
16. Furuta, Y., D. W. Piston, and B. L. M. Hogan. 1997. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124:2203-2212.
17. Ghosh, A., and M. E. Greenberg. 1995. Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron 15:89-103.
18. Grbavec, D., R. Lo, Y. Liu, and S. Stifani. 1998. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Eur. J. Biochem. 258:339-349.
19. Grbavec, D., R. Lo, Y. Liu, A. Greenfield, and S. Stifani. 1999. Groucho/transducin-like Enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. Biochem. J. 337:13-17.
20. Guillemot, F., L. C., Lo, J. E. Johnson, A. Auerbach, D. J. Anderson, and A. L. Joyner. 1993. Mammalian achaete-scute homolog I is required for early development of olfactory and autonomic neurons. Cell 75:463-476.
21. NICI and imparting a neural fate. Development 127:1301-1314.
22. Hatini, V., W. Tao, and K. Lai. 1994. Expression of winged helix genes, BF-1 and BF-2, define adjacent domains within the developing forebrain and retina. J. Neurobiol. 25:1293-1309.
23. Heitzler, P., M. Bourouis, L. Ruel, C. Carteret, and P. Simpson. 1996. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signaling in Drosophila. Development 122:161-171.
24. Huh, S., V. Hatini, R. C. Marcus, S. C. Li, and E. Lai. 1999. Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression. Dev. Biol. 211:53-63.
25. Husain, J., R. Lo, D. Grbavec, and S. Stifani. 1996. Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions. Biochem. J. 317:523-531.
26. Ishibashi, M., K. Moriyoshi, Y. Sasai, K. Shiota, S. Nakanishi, and R. Kageyama. 1994. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. EMBO J. 13:1799-1805.
27. Ishibashi, M., S. L. Ang, K. Shiota, S. Nakanishi, R. Kageyama, and F. Guillemot. 1995. Targeted disruption of mammalian hairy and Enhancer of split homolog 1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9:3136-3148.
28. Jennings, B., A. Preiss, C. Delidakis, and S. Bray. 1994. The Notch signaling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120:3537-3548.
29. Jimenez, G., Z. Paroush, and D. Ish-Horowicz. 1997. Groucho acts as a ceorepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 11:3072-3082.
30. Kaestner, K., W. Knochel, and D. Martinez. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14:142-146.
31. Kageyama, R., M. Ishibashi, K. Takebayashi, K. Tomita. 1997. bHLH transcription factors and mammalian neuronal differentiation. Int. J. Biochem. Cell Biol. 29:1389-1399.
32. Koop, K. E., L. M. MacDonald, and C. C. Lobe. 1996. Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech. Dev. 59:73-87.
33. Lee, J. E., S. M. Hollenberg, L. Snider, D. L. Turner, N. Lipnick, and H. Weintraub. 1995. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-844.
34. Levanon, D., K. E. Goldstein, Y. Bernstein, H. Tang, D. Goldenberg, S. Stifani, Z. Paroush, and Y. Groner. 1998. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc. Natl. Acad. Sci. USA 95:11590-11595.
35. Li, J., H. W. Chang, E. Lai, E. Parker, and P. K. Vogt. 1995. The oncogene Qin codes for a transcriptional repressor. Cancer Res. 55:5540-5544.
36. Ma, Q., C. Kintner, and D. J. Anderson. 1996. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87:43-52.
37. Ma, Q., Z. Chen, I. del Barco Barrantes, J. L. de la Pompa, and D. J. Anderson. 1998. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20:469-482.
38. Mariani, F. V. and R. M. Harland. 1998. XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. Development 125:5014-5031.
39. McLarren, K. W., K. Lo, D. Grbavec, K. Thirunavukkarasu, G. Karsenty, and S. Stifani. 2000. The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the Runt-related factor Cbfal. J. Biol. Chem. 275:530-538.
40. McLarren, K. W., F. Theriault, and S. Stifani. 2001. Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression ability of the basic helix loop helix factor Hes1. J. Biol. Chem. 276.-1578-1584.
41. Ohtsuka, T., M. Ishibashi, G. Gradwohl, S. Nakanishi, F. Guillemot, and K. Kageyama. 1999. Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation. EMBO J. 18:2196-2207.
42. Palaparti, A., A. Baratz, and S. Stifani. 1997. The Groucho/Transducin-like Enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J. Biol. Chem. 272:26604-26610.
43. Paroush, Z., R. L. Finley, T. Kidd, S. M. Wainwright, P. W. Ingham, R. Brent, and D. Ish-Horowicz. 1994. Groucho is required for Drosophila neurogencis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79:805-815.
44. Sasai, Y., R. Kageyama, Y. Tarawa, R. Shigemoto, and S. Nakanishi. 1992. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 5:2620-2634.
45. Shanmugan, K., M. S. Keatherstone, and H. U. Saragovi. 1997. Residues flanking the HOX YPWM motif contribute to cooperative interactions with PBX. J. Biol. Chem. 272:19081-19087.
46. Slack, R. S., H. El-Bizri, J. Wong, D. J. Belliveau, and F. D. Miller. 1998. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. J. Cell Biol. 140:1497-1509.
47. Stifani, S., C. M. Blaumueller, N. J. Redhead, K. K. Hill, and S. Artavanis-Tsakonas. 1992. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat. Genet. 2:119-127.
48. Tao, W., and E. Lai. 1992. Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron 8:957-966.
49. Taunton, J., C. A. Massig, and S. L. Schreiber. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
50. Tolkunova, E. N., M. Fujioka, M. Kobayashi, D. Deka, and J. B. Jaynes. 1998. Two distinct types of repression domain in Engrailed: one interacts with the Groucho corepressor and is preferentially active on integrated target genes. Mol. Cell. Biol. 18:2804-2814.
51. Wang, J. C., M. Waltner-Law, K. Yamada, H. Osawa, S. Stifani, and D. K. Granner. 2000. Transducin-like Enhancer of split proteins, the human homologs of Drosophila Groucho, interact with hepatic nuclear factor 3β. J. Biol. Chem. 275:18418-18423.
52. Weinmaster, G. 1997. The ins and outs of Notch signaling. Mol. Cell. Neurosci. 9:91-102.
53. Xuan, S., C. A. Baptista, C. Balas, W. Tao, V. C. Soares, and E. Lai. 1995. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14:1141-1152.
54. Van, J., V. Liu, J. Husain, R. Lo, A. Palaparti, J. Henderson, and S. Stifani. 1998. Combinatorial expression patterns of individual TLH proteins during cell determination and differentiation suggest non-redundant functions for mammalian homologs of Drosophila Groucho. Dev. Growth Differ. 40:133-146.
55. Yao, J., Y. Liu, R. Lo, I. Tretjakoff, A. Peterson, and S. Stifani. 2000. Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue Transducin-like Enhancer of split 1 in postmitotic neurons. Mech. Dev. 93:1115-115.