P-glycoprotein senses its substrates and the lateral membrane packing density: Consequences for the catalytic cycle

Biochemistry

Volumn 47, Issue 38, 2008, Pages 10197-10207

  Äänismaa, Päivi ^a   Gatlik Landwojtowicz, Ewa ^a   Seelig, Anna ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; CELL MEMBRANES; CHEMOTHERAPY; CYTOLOGY; DRUG DELIVERY; DRUG DOSAGE;

ACTIVATION ENTHALPIES; ATP HYDROLYSIS; ATP-ASE ACTIVITY; BLOOD-BRAIN BARRIER; CATALYTIC CYCLING; CYTOSOLIC; EXTRACELLULAR; LATERAL MEMBRANE; P GLYCOPROTEINS; PACKING DENSITIES; PROMAZINE; TEMPERATURE DEPENDENCES; VERAPAMIL;

GLYCOPROTEINS;

ADENOSINE TRIPHOSPHATASE; MULTIDRUG RESISTANCE PROTEIN 1; PROMAZINE; VALSPODAR; VERAPAMIL;

ARTICLE; BINDING AFFINITY; CATALYSIS; CELL MEMBRANE; CONCENTRATION (PARAMETERS); ENERGY YIELD; ENTHALPY; ENTROPY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FUNCTIONAL PROTEOMICS; HYDROLYSIS; MEMBRANE BINDING; MEMBRANE TRANSPORT; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMAL CONDUCTIVITY;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CATALYSIS; CELL MEMBRANE; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; MICE; NIH 3T3 CELLS; P-GLYCOPROTEIN; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRANSPORT VESICLES;

EID: 52249103044     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800209h     Document Type: Article

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