Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: Structural basis for vitamin D receptor antagonism and partial agonism

Journal of Medicinal Chemistry

Volumn 51, Issue 17, 2008, Pages 5320-5329

  Nakabayashi, Makoto ^a   Yamada, Sachiko ^a,b   Yoshimoto, Nobuko ^a   Tanaka, Takashi ^a   Igarashi, Miharu ^a   Ikura, Teikichi ^a   Ito, Nobutoshi ^a   Makishima, Makoto ^b   Tokiwa, Hiroaki ^c   DeLuca, Hector F ^d   Shimizu, Masato ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c RIKKYO UNIVERSITY   (Japan)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24 ADAMANTYL 1ALPHA,24 DIHYDROXY 2 METHYLENE 22,23 DIDEHYDRO 19,25,26,27 TETRANORVITAMIN D3; 25 ADAMANTYL 1ALPHA,25 DIHYDROXY 2 METHYLENE 22,23 DIDEHYDRO 19,26,27 TRINOR 20 EPIVITAMIN D3; 26 ADAMANTYL 1ALPHA,25 DIHYDROXY 2 METHYLENE 22,23 DIDEHYDRO 19,27 DINOR 20 EPIVITAMIN D3; ADAMANTANE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; LIGAND BINDING; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADAMANTANE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; VITAMIN D;

EID: 51849126928     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8004477     Document Type: Article

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59. 3 (1) reported in this article are 2ZMI, 2ZMH, 2ZMJ, and 2ZLC, respectively.