Synthesis of 1α,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1α,25-dihydroxyvitamin D3 antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2579-2583

  Kato, Yuko ^a   Nakano, Yusuke ^a   Sano, Hiroko ^a   Tanatani, Aya ^a   Kobayashi, Hisayoshi ^a   Shimazawa, Rumiko ^a   Koshino, Hiroyuki ^b   Hashimoto, Yuichi ^a   Nagasawa, Kazuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Antagonist; Lactam; Vitamin D

Indexed keywords

CALCITRIOL; CELL NUCLEUS RECEPTOR; COLECALCIFEROL RECEPTOR; ISOXAZOLIDINE DERIVATIVE; LACTAM DERIVATIVE; VITAMIN D DERIVATIVE; CALCITRIOL RECEPTOR; DIHYDROXY VITAMIN D3; DIHYDROXY-VITAMIN D3; DRUG DERIVATIVE; LACTAM; VITAMIN D;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CYCLOADDITION; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROMYELOCYTIC LEUKEMIA; RECEPTOR BINDING; REDUCTION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IC 50; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CELL DIFFERENTIATION; DRUG DESIGN; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS; PROTEIN BINDING; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D;

EID: 1942540511     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.076     Document Type: Article

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