Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol

Archives of Biochemistry and Biophysics

Volumn 460, Issue 2, 2007, Pages 172-176

  Rochel, Natacha ^a,b,c,d   Hourai, Shinji ^a,b,c,d   Pérez García, Xenxo ^a,b,c,d   Rumbo, Antonio ^a,b,c,d   Mourino, Antonio ^a,b,c,d   Moras, Dino ^a,b,c,d  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

1 ,25(OH)2D3; 21 Nor calcitriol 20(22),23 diyne; Crystal structure; Vitamin D nuclear receptor

Indexed keywords

21 NORCALCITRIOL 20(22),23 DIYNE; CALCITRIOL DERIVATIVE; CELL NUCLEUS RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; BINDING AFFINITY; CHEMICAL STRESS; CRYSTAL STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SYNTHESIS;

BINDING SITES; CALCITRIOL; ENTROPY; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247105422     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.01.031     Document Type: Article

References (22)

1. Laudet V., and Gronemeyer H. The Nuclear Receptor Facts Book (2002), Academic Press, London
2. Bouillon R., Okamura W.H., and Norman A.W. Endocr. Rev. 16 (1995) 200-257
3. Smith C.L., and O'Malley B.W. Endocr. Rev. 25 (2004) 45-71
4. Norman A.W., Mizwicki M.T., and Norman D.P. Nat. Rev. Drug. Discov. 3 (2004) 27-41
5. Beckman M.J., and Deluca H.F. Prog. Med. Chem. 35 (1998) 1-56
6. Carlberg C., and Mourino A. Exp. Opin. Ther. Pat. 13 (2003) 761-772
7. Rochel N., Wurtz J.M., Mitschler A., Klaholz B., and Moras D. Mol. Cell 5 (2000) 173-179
8. Tocchini-Valentini G., Rochel N., Wurtz J.M., Mitschler A., and Moras D. Proc. Natl. Acad. Sci. USA 98 (2001) 5491-5496
9. Tocchini-Valentini G., Rochel N., Wurtz J.M., and Moras D. J. Med. Chem. 47 (2004) 1956-1961
10. F. Ciesielski, N. Rochel, D. Moras, J. Steroid. Biochem. Mol. Biol. (in press).
11. Vanhooke J.L., Benning M.M., Bauer C.B., Pike J.W., and DeLuca H.F. Biochemistry 43 (2004) 4010-4101
12. Eelen G., Verlinden L., Rochel N., Claessens F., De Clercq P., Vandewalle M., Tocchini-Valentini G., Moras D., Bouillon R., and Verstuyf A. Mol. Pharm. 67 (2005) 1566-1573
13. Hourai S., Fujishima T., Kittaka A., Suhara Y., Takayama H., Rochel N., and Moras D. J. Med. Chem. 49 (2006) 5199-5205
14. M.J. Calverley, Proceedings of 12th Workshop on Vitamin D, Maastricht, Netherlands 6-10th, 2003, 202.
15. Perez-Garcia X., Rumbo A., Larriba M.J., Ordonez P., Munoz A., and Mourino A. Org. Lett. 5 (2003) 4033-4036
16. Otwinowski Z., and Minor W. Methods Enzymol. 276 (1997) 307-326
17. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., et al. Acta Crystallogr. D Biol.Crystallogr. 54 (1998) 905-921
18. Jones T.A., Zou J.Y., and Cowan S.W. Kjeldgaard. Acta Crystallogr. A 47 (1991) 110-119
19. Heery D.M., Kalkhoven E., Hoare S., and Parker M.G. Nature 387 (1997) 733-736
20. Darimont B.D., Wagner R.L., Apriletti J.W., Stallcup M.R., Kushner P.J., Baxter J.D., Fletterick R.J., and Yamamoto K.R. Genes Dev. 12 (1998) 3343-3356
21. Nolte R.T., Wisely G.B., Westin S., Cobb J.E., Lambert M.H., Kurokawa R., Rosenfeld M.G., Willson T.M., Glass C.K., and Milburn M.V. Nature 395 (1998) 137-143
22. Shiau A.K., Barstad D., Loria P.M., Cheng L., Kushner P.J., Agard D.A., and Greene G.L. Cell 95 (1998) 927-937