Roles of peripheral P2X and P2Y receptors in the development of melittin-induced nociception and hypersensitivity

Neurochemical Research

Volumn 33, Issue 10, 2008, Pages 2085-2091

  Lu, Zhuo Min ^a   Xie, Fang ^a   Fu, Han ^a   Liu, Ming Gang ^b   Cao, Fa Le ^a   Hao, Jian ^a   Chen, Jun ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Adenosine triphosphate (ATP); Bee venom; Melittin; Persistent spontaneous nociception; Primary mechanical hyperalgesia; Primary thermal hyperalgesia

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; CIBACRON BLUE F3GA; MELITTIN; PROTEIN INHIBITOR; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y RECEPTOR; RB 2; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE COURSE; DOSE RESPONSE; DRUG INHIBITION; HYPERALGESIA; HYPERSENSITIVITY; INFLAMMATION; MALE; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; HYPERSENSITIVITY; MALE; MELITTEN; NOCICEPTORS; PAIN; PHENOLS; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

APOIDEA;

EID: 51749087490     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9689-6     Document Type: Article

References (53)

1. WR Lariviere R Melzack 1996 The bee venom test: a new tonic-pain test Pain 66 271 277
2. J Chen C Luo HL Li 1999 Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test Pain 83 67 76
3. HS Chen J Chen 2000 Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: effect of systemic MK-801, a non-competitive NMDA receptor antagonist Eur J Pain 4 389 401
4. J Chen HS Chen 2001 Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection Pain 91 367 376
5. Chen J (2003) The bee venom test: a novel useful animal model for study of spinal coding and processing of pathological pain information. In: Chen J, Chen ACN, Han JS, Willis WD (eds) Experimental pathological pain: from molecules to brain functions. Science Press, Beijing, pp 77-110
6. Chen J (2007) Processing of different 'phenotypes' of pain by different spinal signaling pathways. In: Kumamoto E (ed) Cellular and molecular mechanisms for the modulation of nociceptive transmission in the peripheral and central nervous system. Research Signpost, Kerala, pp 147-165
7. J Chen C Luo HL Li 1998 The contribution of spinal neuronal changes to development of prolonged, tonic nociceptive responses of the cat induced by subcutaneous bee venom injection Eur J Pain 2 359 376
8. HJ You J Chen 1999 Differential effects of subcutaneous injection of formalin and bee venom on responses of wide-dynamic-range neurons in spinal dorsal horn of the rat Eur J Pain 31 177 180
9. JH Zheng Z Jian J Chen 2002 Detection of deterministic behavior within the tissue injury-induced persistent firing of nociceptive neurons in the dorsal horn of the rat spinal cord J Comput Neurosci 13 23 34
10. E Habermann 1972 Bee and wasp venoms Science 177 314 322
11. KC Li J Chen 2004 Altered pain-related behaviors and spinal neuronal responses produced by s.c. injection of melittin in rats Neuroscience 126 753 762
12. YN Chen KC Li Z Li 2006 Effects of bee venom peptidergic components on rat pain-related behaviors and inflammation Neuroscience 138 631 640
13. Hao J, Liu MG, Yu YQ et al (2008) Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia. Neuroscience (in press)
14. G Burnstock NW John 1996 Purinergic receptors: their role in nociception and primary afferent neurotransmission Curr Opin Neurobiol 6 526 532
15. MJ Stebbing EM McLachlan P Sah 1998 Are there functional P2X receptors on cell bodies in intact root ganglia of rats? Neuroscience 86 1235 1244
16. SG Hamilton A Wade SB McMahon 1999 The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogue in the rat Br J Pharmacol 126 326 332
17. SP Cook EW McClesky 2002 Cell damage excites nociceptors through release of cytosolic ATP Pain 95 41 47
18. M Tominaga M Wada M Masu 2001 Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia Proc Natl Acad Sci USA 98 6951 6956
19. M Zimmermann 1983 Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 109 110
20. N Koyama K Hirata K Hori 2000 Computer-assisted infrared thermographic study of axon reflex induced by intradermal melittin Pain 84 133 139
21. N Koyama K Hirata K Hori 2002 Biphasic vasomotor reflex responses of the hand skin following intradermal injection of melittin into the forearm skin Eur J Pain 6 447 453
22. H Sumikura OK Andersen AM Drewes 2003 A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans Neurosci Lett 337 147 150
23. H Sumikura OK Andersen AM Drewes 2006 Secondary heat hyperalgesia induced by melittin in humans Eur J Pain 10 121 125
24. G Burnstock 1996 A unifying purinergic hypothesis for the initiation of pain Lancet 347 1604 1605
25. SP Cook L Vulchanova KM Hargeaves 1997 Distinct ATP receptors on pain-sensing and stretch-sensing neurons Nature 387 505 508
26. BD Grubb RJ Evans 1999 Characterization of cultured dorsal root ganglion neuron P2X receptors Eur J Neurosci 11 149 154
27. CE Jahr TM Jessell 1985 Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate J Neurosci 5 2281 2289
28. J Li ER Perl 1995 ATP modulation of synaptic transmission in the spinal substantia gelatinosa J Neurosci 15 3357 3365
29. V Ralevic G Burnstock 1998 Receptors for purines and pyrimidines Pharmacol Rev 50 413 492
30. BR Bianchi KJ Lynch E Touma 1999 Pharmacological characterization of recombinant human and rat P2X receptor subtypes Eur J Pharmacol 376 127 138
31. KA Jacobson MF Jarvis M Williams 2002 Perspective: purine and pyrimidine (P2) receptors as drug targets J Med Chem 45 4057 4093
32. MP Abbracchio JM Boeynaems EA Barnard 2003 Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family Trends Pharmacol Sci 24 52 55
33. G Collo RA North E Kawashima 1996 Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels J Neurosci 16 2495 2507
34. L Vulchanova U Arvidsson M Riedl 1996 Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry Proc Natl Acad Sci USA 15 8063 8067
35. 3 receptor subunits in rat and monkey sensory neurons and their central terminals Neurophamacology 36 1229 1242
36. 3-deficient mice Nature 407 1011 1015
37. 3 receptors Nature 407 1015 1017
38. 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Nature 424 778 783
39. GY Xu LYM Huang 2002 Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons J Neurosci 22 93 102
40. 3 purinoceptors in sensory neurons in naïve rats and following neuropathic injury Pain 80 273 282
41. 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration Br J Pharmacol 140 1381 1388
42. MF Jarvis EC Burgard S McGaraughty 2002 A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat Proc Natl Acad Sci USA 99 17179 17184
43. P Honore K Kage J Mikusa 2002 Analgesic profile of intrathecal P2X (3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats Pain 99 11 19
44. YH Zhang Y Chen ZQ Zhao 2001 Alteration of spontaneous firing rate of primary myelinated afferents by ATP in adjuvant-induced inflamed rats Brain Res Bull 54 141 144
45. JA Roberts C Vial HR Digby 2006 Molecular properties of P2X receptors Pflugers Arch 452 486 500
46. Y Dai T Fukuoka H Wang 2004 Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons Pain 108 258 266
47. 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats Eur J Pharmacol 504 45 53
48. B Bechinger 1997 Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin J Membrane Biol 156 197 211
49. Garrett RH, Grisham CM (1999) Membrane transport. In: Garrett PH, Grisham CM (eds) Biochemistry, 2nd edn. Harcourt, Inc., Orlando, pp 296-326
50. K Matsuzaki S Yoneyama K Miyajima 1997 Pore formation and translocation of melittin Biophys J 73 831 838
51. R Smith F Separovic TJ Milne A Whittaker FM Bennett BA Cornell A Makriyannis 1994 Structure and orientation of the pore-forming peptide, melittin, in lipid bilayer J Mol Biol 241 456 466
52. JL Gordon 1986 Extracellular ATP: effects, sources and fate Biochem J 233 309 319
53. 1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation Proc Natl Acad Sci USA 93 10465 10470