Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection

Pain

Volumn 91, Issue 3, 2001, Pages 367-376

  Chen, Jun ^a   Chen, Hui Sheng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bee venom test; Capsaicin sensitive primary afferents; Formalin test; Heat hyperalgesia; Mechanical hyperalgesia; Persistent spontaneous nociception

Indexed keywords

BEE VENOM; CAPSAICIN; FORMALDEHYDE; PENTOBARBITAL;

ALLODYNIA; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEAT SENSITIVITY; HYPERALGESIA; MALE; NERVE INJURY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SAPHENOUS NERVE; SCIATIC NERVE; SENSORY NERVE; SENSORY STIMULATION; WITHDRAWAL REFLEX;

ADMINISTRATION, TOPICAL; ANIMALS; BEE VENOMS; CAPSAICIN; HEAT; HYPERALGESIA; MALE; NERVE FIBERS; NEURONS, AFFERENT; NOCICEPTORS; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE;

EID: 0035083675     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00458-9     Document Type: Article

References (49)

1. Formalin injection in the tail facilitates hindpaw withdraw reflex induced by thermal stimulation in the rat: Effect of paracetamol
2. The neuropharmacology of capsaicin: A review of some recent observations
3. The capsaicin receptor: A heat-activated ion channel in the pain pathway
4. A capsaicin-receptor homologue with a high threshold for noxious heat
5. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
6. A novel pathological pain model characterized by both prolonged persistent nociception and hyperalgesia induced by subcutaneous bee venom injection
7. Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: Effect of systemic MK-801, a non-competitive NMDA receptor antagonist
8. The contribution of spinal neuronal changes to development of prolonged, tonic nociceptive responses of the cat induced by subcutaneous bee venom injection
9. Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat
10. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: A comparative study with the formalin test
11. Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: A behavioral study in the conscious rat
12. Long-term hypersensitivity of spinal dorsal horn neurons to heat and mechanical stimulation induced by subcutaneous bee venom injection in anaesthetized rats and cats
13. Behavioral evidence in rats for a peptidergic-noradrenergic interaction in cutaneous sensory and vascular function
14. Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw
15. Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats
16. Detection of static and dynamic components of mechanical allodynia in rat models of neurogenic pain: Are they signalled by distinct primary sensory neurones?
17. Capsaicin and sensory neurones - A review
18. The time course and specificity of the changes in the behavioural and dorsal cell responses to noxious stimuli following peripheral nerve capsaicin treatment in the rat
19. Secondary hyperalgesia persistent in capsaicin desensitized skin
20. Local application of capsaicin to one sciatic nerve of the adult rat induces a marked depleption in the peptide content of the lumbar dorsal horn
21. Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats
22. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
23. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neuron
24. Secondary hyperalgesia to punctate stimuli is mediated by A-fiber nociceptors
25. Different patterns of hyperalgesia induced by experimental inflammation in human skin
26. Critical role of the capsaicin-sensitive nerve fibers in the development of the causalgic symptoms produced by transecting some but not all of the nerves innervating the rat tail
27. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain
28. The bee venom test: A new tonic-pain test
29. Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat
30. Spatial and temporal expression of c-Fos protein in the spinal cord of anesthetized rat induced by subcutaneous bee venom injection
31. Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex
32. Effects of neonatal capsaicin treatment on nociceptive thresholds in the rat
33. Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation
34. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats
35. The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test
36. A-fibers mediate mechanical hyperalgesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats
37. Intradermal injection of capsaicin in humans produces rapid degeneration and subcutaneous reinnervation of epidermal nerve fibers: Correlation with sensory function
38. Sensory functions of epidermal nerve fibers in humans
39. Vanilloid (capsaicin) receptors and mechanisms
40. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
41. Dissociated secondary hyperalgesia in a subject with a large-fiber sensory neuropathy
42. Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade
43. Central plastic responses to pain
44. Effects of the capsaicin analogue resiniferotoxin on spinal nociceptive mechanisms in the rat: Behavioral, electrophysiological and in situ hybridization studies
45. Differential effects of subcutaneous injection of formalin and bee venom on responses of wide-dynamic-range neurons in spinal dorsal horn of the rat
46. Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord
47. Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat
48. Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat
49. Ethical guidelines for investigations of experimental pain in conscious animals