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Volumn 363, Issue 1507, 2008, Pages 3213-3222

Genetics of addictions: Strategies for addressing heterogeneity and polygenicity of substance use disorders

Author keywords

Addictions; Animal models; Genetic; Heterogeneity; Neuroimaging; Translational

Indexed keywords

GENETICS; HETEROGENEITY; MODEL; NERVOUS SYSTEM DISORDER; NEUROLOGY; PHENOTYPE; PSYCHOLOGY;

EID: 51449119864     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2008.0104     Document Type: Conference Paper
Times cited : (46)

References (88)
  • 1
    • 0037173086 scopus 로고    scopus 로고
    • Cocaine sensitization and reward are under the influence of circadian genes and rhythm
    • doi:10.1073/pnas.142039099
    • Abarca, C., Albrecht, U. & Spanagel, R. 2002 Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc. Natl Acad. Sci. USA 99, 9026-9030. (doi:10.1073/pnas.142039099)
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 9026-9030
    • Abarca, C.1    Albrecht, U.2    Spanagel, R.3
  • 2
    • 85020792611 scopus 로고    scopus 로고
    • American Psychiatric Association 1994 Dignostic and statistical manual of mental disorders, 4th edn. Washinton, DC: APA. (DSM/IV)
    • American Psychiatric Association 1994 Dignostic and statistical manual of mental disorders, 4th edn. Washinton, DC: APA. (DSM/IV)
  • 3
    • 0033551867 scopus 로고    scopus 로고
    • Requirement of circadian genes for cocaine sensitization in Drosophila
    • doi:10.1126/science.285.5430.1066
    • Andretic, R., Chaney, S. & Hirsh, J. 1999 Requirement of circadian genes for cocaine sensitization in Drosophila. Science 285, 1066-1068. (doi:10.1126/science.285.5430.1066)
    • (1999) Science , vol.285 , pp. 1066-1068
    • Andretic, R.1    Chaney, S.2    Hirsh, J.3
  • 4
    • 0343883512 scopus 로고    scopus 로고
    • The variable effects of stress on alcohol use from adolescence to early adulthood
    • doi:10.3109/10826080009148415
    • Aseltine Jr, R. H. & Gore, S. L. 2000 The variable effects of stress on alcohol use from adolescence to early adulthood. Subst. Use Misuse 35, 643-668. (doi:10.3109/10826080009148415)
    • (2000) Subst. Use Misuse , vol.35 , pp. 643-668
    • Aseltine Jr, R.H.1    Gore, S.L.2
  • 5
    • 9644272348 scopus 로고    scopus 로고
    • mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior
    • doi:10.1038/sj.npp.1300381
    • Backstrom, P., Bachteler, D., Koch, S., Hyytia, P. & Spanagel, R. 2004 mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29, 921-928. (doi:10.1038/sj.npp.1300381)
    • (2004) Neuropsychopharmacology , vol.29 , pp. 921-928
    • Backstrom, P.1    Bachteler, D.2    Koch, S.3    Hyytia, P.4    Spanagel, R.5
  • 6
    • 12344265724 scopus 로고    scopus 로고
    • Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    • doi:10.1038/sj.npp.1300598
    • Bart, G., Kreek, M. J., Ott, J., LaForge, K. S., Proudnikov, D., Pollak, L. & Heilig, M. 2005 Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 30, 417-422. (doi:10.1038/sj.npp.1300598)
    • (2005) Neuropsychopharmacology , vol.30 , pp. 417-422
    • Bart, G.1    Kreek, M.J.2    Ott, J.3    LaForge, K.S.4    Proudnikov, D.5    Pollak, L.6    Heilig, M.7
  • 7
    • 0035099773 scopus 로고    scopus 로고
    • Bau, C. H., Spode, A., Ponso, A. C., Elias, E. P., Garcia, C. E., Costa, F. T. & Hutz, M. H. 2001 Heterogeneity in early onset alcoholism suggests a third group of alcoholics. Alcohol 23, 9-13. (doi:10.1016/S0741- 8329(00)00120-8)
    • Bau, C. H., Spode, A., Ponso, A. C., Elias, E. P., Garcia, C. E., Costa, F. T. & Hutz, M. H. 2001 Heterogeneity in early onset alcoholism suggests a third group of alcoholics. Alcohol 23, 9-13. (doi:10.1016/S0741- 8329(00)00120-8)
  • 8
    • 0021144410 scopus 로고
    • Event-related brain potentials in boys at risk for alcoholism
    • doi:10.1126/science.6474187
    • Begleiter, H., Porjesz, B., Bihari, B. & Kissin, B. 1984 Event-related brain potentials in boys at risk for alcoholism. Science 225, 1493-1496. (doi:10.1126/science.6474187)
    • (1984) Science , vol.225 , pp. 1493-1496
    • Begleiter, H.1    Porjesz, B.2    Bihari, B.3    Kissin, B.4
  • 9
    • 37349024299 scopus 로고    scopus 로고
    • Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
    • doi:10.1016/j.biopsych.2007.04.026
    • Blomeyer, D., Treutlein, J., Esser, G., Schmidt, M. H., Schumann, G. & Laucht, M. 2008 Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol. Psychiatry 63, 146-151. (doi:10.1016/j.biopsych.2007.04.026)
    • (2008) Biol. Psychiatry , vol.63 , pp. 146-151
    • Blomeyer, D.1    Treutlein, J.2    Esser, G.3    Schmidt, M.H.4    Schumann, G.5    Laucht, M.6
  • 10
    • 0033288960 scopus 로고    scopus 로고
    • The role of stress in alcohol use, alcoholism treatment, and relapse
    • Brady, K. T. & Sonne, S. C. 1999 The role of stress in alcohol use, alcoholism treatment, and relapse. Alcohol Res. Health 23, 263-271.
    • (1999) Alcohol Res. Health , vol.23 , pp. 263-271
    • Brady, K.T.1    Sonne, S.C.2
  • 11
  • 12
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • doi:10.1038/ 35052543
    • Cardon, L. R. & Bell, J. I. 2001 Association study designs for complex diseases. Nat. Rev. Genet. 2, 91-99. (doi:10.1038/ 35052543)
    • (2001) Nat. Rev. Genet , vol.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 13
    • 33745684557 scopus 로고    scopus 로고
    • Gene-environment interactions in psychiatry: Joining forces with neuroscience
    • doi:10.1038/nrn1925
    • Caspi, A. & Moffitt, T. E. 2006 Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 7, 583-590. (doi:10.1038/nrn1925)
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 583-590
    • Caspi, A.1    Moffitt, T.E.2
  • 15
    • 0023257348 scopus 로고
    • Neurogenetic adaptive mechanisms in alcoholism
    • doi:10.1126/science.2882604
    • Cloninger, C. R. 1987a Neurogenetic adaptive mechanisms in alcoholism. Science 236, 410-416. (doi:10.1126/science.2882604)
    • (1987) Science , vol.236 , pp. 410-416
    • Cloninger, C.R.1
  • 16
    • 0023260397 scopus 로고
    • A systematic method for clinical description and classification of personality variants. A proposal
    • Cloninger, C. R. 1987b A systematic method for clinical description and classification of personality variants. A proposal. Arch. Gen. Psychiatry 44, 573-588.
    • (1987) Arch. Gen. Psychiatry , vol.44 , pp. 573-588
    • Cloninger, C.R.1
  • 17
    • 0019466547 scopus 로고
    • Inheritance of alcohol abuse. Cross-fostering analysis of adopted men
    • Cloninger, C. R., Bohman, M. & Sigvardsson, S. 1981 Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch. Gen. Psychiatry 38, 861-868.
    • (1981) Arch. Gen. Psychiatry , vol.38 , pp. 861-868
    • Cloninger, C.R.1    Bohman, M.2    Sigvardsson, S.3
  • 18
    • 0018361336 scopus 로고
    • The familial incidence of alcoholism: A review
    • Cotton, N. S. 1979 The familial incidence of alcoholism: a review. J. Stud. Alcohol 40, 89-116.
    • (1979) J. Stud. Alcohol , vol.40 , pp. 89-116
    • Cotton, N.S.1
  • 19
    • 27144492737 scopus 로고    scopus 로고
    • The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems
    • doi:10.1124/jpet.105.090449
    • Cowen, M. S., Djouma, E. & Lawrence, A. J. 2005 The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J. Pharmacol. Exp. Ther. 315, 590-600. (doi:10.1124/jpet.105.090449)
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , pp. 590-600
    • Cowen, M.S.1    Djouma, E.2    Lawrence, A.J.3
  • 20
    • 33749024625 scopus 로고    scopus 로고
    • Alcohol-related genes: Contributions from studies with genetically engineered mice
    • doi:10.1111/j.1369- 1600.2006.00038.x
    • Crabbe, J. C., Phillips, T. J., Harris, R. A., Arends, M. A. & Koob, G. F. 2006 Alcohol-related genes: contributions from studies with genetically engineered mice. Addict. Biol. 11, 195-269. (doi:10.1111/j.1369- 1600.2006.00038.x)
    • (2006) Addict. Biol , vol.11 , pp. 195-269
    • Crabbe, J.C.1    Phillips, T.J.2    Harris, R.A.3    Arends, M.A.4    Koob, G.F.5
  • 21
    • 0038324103 scopus 로고    scopus 로고
    • Candidate genes for alcohol dependence: A review of genetic evidence from human studies
    • doi:10.1097/01.ALC.0000065436.24221.63
    • Dick, D. M. & Foroud, T. 2003 Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin. Exp. Res. 27, 868-879. (doi:10.1097/01.ALC.0000065436.24221.63)
    • (2003) Alcohol Clin. Exp. Res , vol.27 , pp. 868-879
    • Dick, D.M.1    Foroud, T.2
  • 22
    • 0035156589 scopus 로고    scopus 로고
    • Exploring gene-environment interactions: Socioregional moderation of alcohol use
    • doi:10.1037/0021-843X.110.4.625
    • Dick, D. M., Rose, R. J., Viken, R. J., Kaprio, J. & Koskenvuo, M. 2001 Exploring gene-environment interactions: socioregional moderation of alcohol use. J. Abnorm. Psychol. 110, 625-632. (doi:10.1037/0021-843X.110.4.625)
    • (2001) J. Abnorm. Psychol , vol.110 , pp. 625-632
    • Dick, D.M.1    Rose, R.J.2    Viken, R.J.3    Kaprio, J.4    Koskenvuo, M.5
  • 23
    • 33645779095 scopus 로고    scopus 로고
    • Endophenotypes successfully lead to gene identification: Results from the collaborative study on the genetics of alcoholism
    • doi:10.1007/s10519-005- 9001-3
    • Dick, D. M. et al. 2006 Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. Behav. Genet. 36, 112-126. (doi:10.1007/s10519-005- 9001-3)
    • (2006) Behav. Genet , vol.36 , pp. 112-126
    • Dick, D.M.1
  • 24
    • 34247847741 scopus 로고    scopus 로고
    • The genetics of alcoholism: Identifying specific genes through family studies
    • doi:10.1111/j.1369-1600.2006.00035.x
    • Edenberg, H. J. & Foroud, T. 2006 The genetics of alcoholism: identifying specific genes through family studies. Addict. Biol. 11, 386-396. (doi:10.1111/j.1369-1600.2006.00035.x)
    • (2006) Addict. Biol , vol.11 , pp. 386-396
    • Edenberg, H.J.1    Foroud, T.2
  • 25
    • 12144288685 scopus 로고    scopus 로고
    • Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    • doi:10.1086/383283
    • Edenberg, H. J. et al. 2004 Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am. J. Hum. Genet. 74, 705-714. (doi:10.1086/383283)
    • (2004) Am. J. Hum. Genet , vol.74 , pp. 705-714
    • Edenberg, H.J.1
  • 26
    • 0033023444 scopus 로고    scopus 로고
    • Genetics of alcoholism and substance abuse
    • doi:10.1016/S0193-953X(05)70077-0
    • Enoch, M. A. & Goldman, D. 1999 Genetics of alcoholism and substance abuse. Psychiatr. Clin. North Am. 22, 289-299. (doi:10.1016/S0193-953X(05)70077-0)
    • (1999) Psychiatr. Clin. North Am , vol.22 , pp. 289-299
    • Enoch, M.A.1    Goldman, D.2
  • 27
    • 0037328997 scopus 로고    scopus 로고
    • Genetics of alcoholism using intermediate phenotypes
    • doi:10.1097/01.ALC.0000052702.77807.8C
    • Enoch, M. A., Schuckit, M. A., Johnson, B. A. & Goldman, D. 2003 Genetics of alcoholism using intermediate phenotypes. Alcohol Clin. Exp. Res. 27, 169-176. (doi:10.1097/01.ALC.0000052702.77807.8C)
    • (2003) Alcohol Clin. Exp. Res , vol.27 , pp. 169-176
    • Enoch, M.A.1    Schuckit, M.A.2    Johnson, B.A.3    Goldman, D.4
  • 28
    • 0029793674 scopus 로고    scopus 로고
    • Both ethanol and ifenprodil inhibit NMDA-evoked release of various neurotransmitters at different, yet proportional potency: Potential relation to NMDA receptor subunit composition
    • doi:10.1007/BF00171062
    • Fink, K. & Gothert, M. 1996 Both ethanol and ifenprodil inhibit NMDA-evoked release of various neurotransmitters at different, yet proportional potency: potential relation to NMDA receptor subunit composition. Naunyn Schmiedebergs Arch. Pharmacol. 354, 312-319. (doi:10.1007/BF00171062)
    • (1996) Naunyn Schmiedebergs Arch. Pharmacol , vol.354 , pp. 312-319
    • Fink, K.1    Gothert, M.2
  • 29
    • 0032422129 scopus 로고    scopus 로고
    • Linkage of an alcoholism-related severity phenotype to chromosome 16
    • Foroud, T. et al. 1998 Linkage of an alcoholism-related severity phenotype to chromosome 16. Alcohol Clin. Exp. Res. 22, 2035-2042.
    • (1998) Alcohol Clin. Exp. Res , vol.22 , pp. 2035-2042
    • Foroud, T.1
  • 30
    • 36849072543 scopus 로고    scopus 로고
    • Glutamatergic substrates of drug addiction and alcoholism
    • doi:10.1016/j.bcp.2007.06.039
    • Gass, J. T. & Olive, M. F. 2008 Glutamatergic substrates of drug addiction and alcoholism. Biochem. Pharmacol. 75, 218-265. (doi:10.1016/j.bcp.2007.06.039)
    • (2008) Biochem. Pharmacol , vol.75 , pp. 218-265
    • Gass, J.T.1    Olive, M.F.2
  • 31
    • 0027429261 scopus 로고
    • Recent developments in alcoholism: Genetic transmission
    • Goldman, D. 1993 Recent developments in alcoholism: genetic transmission. Recent Dev. Alcohol 11, 231-248.
    • (1993) Recent Dev. Alcohol , vol.11 , pp. 231-248
    • Goldman, D.1
  • 32
    • 37249087373 scopus 로고    scopus 로고
    • Deconstruction of vulnerability to complex diseases: Enhanced effect sizes and power of intermediate phenotypes
    • Goldman, D. & Ducci, F. 2007 Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes. Sci. World J. 7, 124-130.
    • (2007) Sci. World J , vol.7 , pp. 124-130
    • Goldman, D.1    Ducci, F.2
  • 33
    • 21344469970 scopus 로고    scopus 로고
    • The genetics of addictions: Uncovering the genes
    • doi:10.1038/nrg1635
    • Goldman, D., Oroszi, G. & Ducci, F. 2005 The genetics of addictions: uncovering the genes. Nat. Rev. Genet. 6, 521-532. (doi:10.1038/nrg1635)
    • (2005) Nat. Rev. Genet , vol.6 , pp. 521-532
    • Goldman, D.1    Oroszi, G.2    Ducci, F.3
  • 34
    • 34248386413 scopus 로고    scopus 로고
    • Pharmacogenetics of alcohol dependence
    • eds P. Gorwood & M. Hamon, pp, Heidelberg, Germany: Springer
    • Gorwood, P., Schumann, G., Treutlein, J. & Ades, J. 2006 Pharmacogenetics of alcohol dependence. In Psychopharmacogenetics (eds P. Gorwood & M. Hamon), pp. 177-202. Heidelberg, Germany: Springer.
    • (2006) Psychopharmacogenetics , pp. 177-202
    • Gorwood, P.1    Schumann, G.2    Treutlein, J.3    Ades, J.4
  • 35
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • doi:10.1176/appi.ajp.160.4.636
    • Gottesman, I. I. & Gould, T. D. 2003 The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636-645. (doi:10.1176/appi.ajp.160.4.636)
    • (2003) Am. J. Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 36
    • 0015541474 scopus 로고
    • Genetic theorizing and schizophrenia
    • Gottesman, I. I. & Shields, J. 1973 Genetic theorizing and schizophrenia. Br. J. Psychiatry 122, 15-30.
    • (1973) Br. J. Psychiatry , vol.122 , pp. 15-30
    • Gottesman, I.I.1    Shields, J.2
  • 37
    • 0025731207 scopus 로고
    • Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal
    • doi:10.1016/0006-8993(91)90125-F
    • Gulya, K., Grant, K. A., Valverius, P., Hoffman, P. L. & Tabakoff, B. 1991 Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res. 547, 129-134. (doi:10.1016/0006-8993(91)90125-F)
    • (1991) Brain Res , vol.547 , pp. 129-134
    • Gulya, K.1    Grant, K.A.2    Valverius, P.3    Hoffman, P.L.4    Tabakoff, B.5
  • 38
    • 33750056368 scopus 로고    scopus 로고
    • Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress
    • doi:10.1073/pnas. 0604419103
    • Hansson, A. C. et al. 2006 Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc. Natl Acad. Sci. USA 103, 15 236-15 241. (doi:10.1073/pnas. 0604419103)
    • (2006) Proc. Natl Acad. Sci. USA , vol.103
    • Hansson, A.C.1
  • 39
    • 0037247423 scopus 로고    scopus 로고
    • Imaging genomics
    • doi:10.1093/bmb/65.1.259
    • Hariri, A. R. & Weinberger, D. R. 2003 Imaging genomics. Br. Med. Bull. 65, 259-270. (doi:10.1093/bmb/65.1.259)
    • (2003) Br. Med. Bull , vol.65 , pp. 259-270
    • Hariri, A.R.1    Weinberger, D.R.2
  • 40
    • 0037135137 scopus 로고    scopus 로고
    • Serotonin transporter genetic variation and the response of the human amygdala
    • doi:10.1126/science.1071829
    • Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F. & Weinberger, D. R. 2002 Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403. (doi:10.1126/science.1071829)
    • (2002) Science , vol.297 , pp. 400-403
    • Hariri, A.R.1    Mattay, V.S.2    Tessitore, A.3    Kolachana, B.4    Fera, F.5    Goldman, D.6    Egan, M.F.7    Weinberger, D.R.8
  • 41
    • 0030734275 scopus 로고    scopus 로고
    • Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in women and men
    • doi:10.1017/ S0033291797005643
    • Heath, A. C. et al. 1997 Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol. Med. 27, 1381-1396. (doi:10.1017/ S0033291797005643)
    • (1997) Psychol. Med , vol.27 , pp. 1381-1396
    • Heath, A.C.1
  • 42
    • 16644400562 scopus 로고    scopus 로고
    • Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
    • doi:10.1038/nn1366
    • Heinz, A. et al. 2005 Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat. Neurosci. 8, 20-21. (doi:10.1038/nn1366)
    • (2005) Nat. Neurosci , vol.8 , pp. 20-21
    • Heinz, A.1
  • 43
    • 0034746374 scopus 로고    scopus 로고
    • P300 event-related potential amplitude as an endophenotype of alcoholism - evidence from the collaborative study on the genetics of alcoholism
    • Hesselbrock, V., Begleiter, H., Porjesz, B., O'Connor, S. & Bauer, L. 2001 P300 event-related potential amplitude as an endophenotype of alcoholism - evidence from the collaborative study on the genetics of alcoholism. J. Biomed. Sci. 8, 77-82.
    • (2001) J. Biomed. Sci , vol.8 , pp. 77-82
    • Hesselbrock, V.1    Begleiter, H.2    Porjesz, B.3    O'Connor, S.4    Bauer, L.5
  • 44
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • doi:10.1038/nrg1521
    • Hirschhorn, J. N. & Daly, M. J. 2005 Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95-108. (doi:10.1038/nrg1521)
    • (2005) Nat. Rev. Genet , vol.6 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 45
    • 47349092911 scopus 로고    scopus 로고
    • Genome-wide association studies: Progress in identifying genetic biomarkers in common, complex diseases
    • Kingsmore, S. F., Lindquist, I. E., Mudge, J. & Beavis, W. D. 2007 Genome-wide association studies: progress in identifying genetic biomarkers in common, complex diseases. Biomark. Insights 2, 283-292.
    • (2007) Biomark. Insights , vol.2 , pp. 283-292
    • Kingsmore, S.F.1    Lindquist, I.E.2    Mudge, J.3    Beavis, W.D.4
  • 46
    • 36849038927 scopus 로고    scopus 로고
    • Approach to the genetics of alcoholism: A review based on pathophysiology
    • doi:10.1016/j.bcp.2007.06.021
    • Kohnke, M. D. 2007 Approach to the genetics of alcoholism: a review based on pathophysiology. Biochem. Pharmacol 75, 160-177. (doi:10.1016/j.bcp.2007.06.021)
    • (2007) Biochem. Pharmacol , vol.75 , pp. 160-177
    • Kohnke, M.D.1
  • 47
    • 0037795575 scopus 로고    scopus 로고
    • Toward a detailed computational model for the mammalian circadian clock
    • doi:10.1073/pnas.1132112100
    • Leloup, J. C. & Goldbeter, A. 2003 Toward a detailed computational model for the mammalian circadian clock. Proc. Natl Acad. Sci. USA 100, 7051-7056. (doi:10.1073/pnas.1132112100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7051-7056
    • Leloup, J.C.1    Goldbeter, A.2
  • 48
    • 0028081936 scopus 로고
    • Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits
    • Masood, K., Wu, C., Brauneis, U. & Weight, F. F. 1994 Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol. Pharmacol. 45, 324-329.
    • (1994) Mol. Pharmacol , vol.45 , pp. 324-329
    • Masood, K.1    Wu, C.2    Brauneis, U.3    Weight, F.F.4
  • 49
    • 0026571276 scopus 로고
    • Sex and age effects on the inheritance of alcohol problems: A twin study
    • doi:10.1037/0021-843X.101.1.3
    • McGue, M., Pickens, R.W. & Svikis, D. S. 1992 Sex and age effects on the inheritance of alcohol problems: a twin study. J. Abnorm. Psychol. 101, 3-17. (doi:10.1037/0021-843X.101.1.3)
    • (1992) J. Abnorm. Psychol , vol.101 , pp. 3-17
    • McGue, M.1    Pickens, R.W.2    Svikis, D.S.3
  • 50
    • 0030680941 scopus 로고    scopus 로고
    • Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA-receptor function
    • doi:10.1126/science.278.5338.698
    • Miyakawa, T., Yagi, T., Kitazawa, H., Yasuda, M., Kawai, N., Tsuboi, K. & Niki, H. 1997 Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278, 698-701. (doi:10.1126/science.278.5338.698)
    • (1997) Science , vol.278 , pp. 698-701
    • Miyakawa, T.1    Yagi, T.2    Kitazawa, H.3    Yasuda, M.4    Kawai, N.5    Tsuboi, K.6    Niki, H.7
  • 51
    • 0041383898 scopus 로고    scopus 로고
    • A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    • doi:10.1038/sj.npp.1300219
    • Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R. & O'Brien, C. P. 2003 A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28, 1546-1552. (doi:10.1038/sj.npp.1300219)
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1546-1552
    • Oslin, D.W.1    Berrettini, W.2    Kranzler, H.R.3    Pettinati, H.4    Gelernter, J.5    Volpicelli, J.R.6    O'Brien, C.P.7
  • 52
    • 0035123295 scopus 로고    scopus 로고
    • Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat cortex
    • Pandey, S. C., Roy, A. & Mittal, N. 2001 Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat cortex. J. Pharmacol. Exp. Ther. 296, 857-868.
    • (2001) J. Pharmacol. Exp. Ther , vol.296 , pp. 857-868
    • Pandey, S.C.1    Roy, A.2    Mittal, N.3
  • 53
    • 26444506279 scopus 로고    scopus 로고
    • Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
    • doi:10.1172/JCI24381
    • Pandey, S. C., Zhang, H., Roy, A. & Xu, T. 2005 Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J. Clin. Invest. 115, 2762-2773. (doi:10.1172/JCI24381)
    • (2005) J. Clin. Invest , vol.115 , pp. 2762-2773
    • Pandey, S.C.1    Zhang, H.2    Roy, A.3    Xu, T.4
  • 54
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and depression: Clinical and preclinical studies
    • doi:10.1196/annals.1300.016
    • Paul, I. A. & Skolnick, P. 2003 Glutamate and depression: clinical and preclinical studies. Ann. N. Y. Acad. Sci. 1003, 250-272. (doi:10.1196/annals.1300.016)
    • (2003) Ann. N. Y. Acad. Sci , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 55
    • 0025879514 scopus 로고
    • Stress and alcohol interaction: An update of human research
    • doi:10.1111/j.1530-0277.1991.tb00543.x
    • Pohorecky, L. A. 1991 Stress and alcohol interaction: an update of human research. Alcohol Clin. Exp. Res. 15, 438-459. (doi:10.1111/j.1530-0277.1991.tb00543.x)
    • (1991) Alcohol Clin. Exp. Res , vol.15 , pp. 438-459
    • Pohorecky, L.A.1
  • 56
    • 0033801879 scopus 로고    scopus 로고
    • P300 as a clinical assay: Rationale, evaluation, and findings
    • doi:10.1016/S0167-8760(00)00127-6
    • Polich, J. & Herbst, K. L. 2000 P300 as a clinical assay: rationale, evaluation, and findings. Int. J. Psychophysiol. 38, 3-19. (doi:10.1016/S0167-8760(00)00127-6)
    • (2000) Int. J. Psychophysiol , vol.38 , pp. 3-19
    • Polich, J.1    Herbst, K.L.2
  • 57
    • 0035060492 scopus 로고    scopus 로고
    • Pharmacogenetics of alcohol response and alcoholism: The interplay of genes and environmental factors in thresholds for alcoholism
    • Radel, M. & Goldman, D. 2001 Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism. Drug Metab. Dispos. 29, 489-494.
    • (2001) Drug Metab. Dispos , vol.29 , pp. 489-494
    • Radel, M.1    Goldman, D.2
  • 58
    • 10844263548 scopus 로고    scopus 로고
    • A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans
    • doi:10.1097/01.ALC.0000148114.34000.B9
    • Ray, L. A. & Hutchison, K. E. 2004 A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin. Exp. Res. 28, 1789-1795. (doi:10.1097/01.ALC.0000148114.34000.B9)
    • (2004) Alcohol Clin. Exp. Res , vol.28 , pp. 1789-1795
    • Ray, L.A.1    Hutchison, K.E.2
  • 59
    • 0032496312 scopus 로고    scopus 로고
    • Reich, T. et al. 1998 Genome-wide search for genes affecting the risk for alcohol dependence. Am. J. Med. Genet. 81, 207-215. (doi:10.1002/(SICI)1096-8628(19980508)81:3〈207::AID-AJMG1〉3.0.CO;2-T)
    • Reich, T. et al. 1998 Genome-wide search for genes affecting the risk for alcohol dependence. Am. J. Med. Genet. 81, 207-215. (doi:10.1002/(SICI)1096-8628(19980508)81:3〈207::AID-AJMG1〉3.0.CO;2-T)
  • 60
    • 0037194790 scopus 로고    scopus 로고
    • Coordination of circadian timing in mammals
    • doi:10.1038/nature00965
    • Reppert, S. M. & Weaver, D. R. 2002 Coordination of circadian timing in mammals. Nature 418, 935-941. (doi:10.1038/nature00965)
    • (2002) Nature , vol.418 , pp. 935-941
    • Reppert, S.M.1    Weaver, D.R.2
  • 61
    • 0344737713 scopus 로고    scopus 로고
    • Genetic and environmental influences on substance initiation, use, and problem use in adolescents
    • doi:10.1001/archpsyc.60.12.1256
    • Rhee, S. H., Hewitt, J. K., Young, S. E., Corley, R. P., Crowley, T. J. & Stallings, M. C. 2003 Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Arch. Gen. Psychiatry 60, 1256-1264. (doi:10.1001/archpsyc.60.12.1256)
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 1256-1264
    • Rhee, S.H.1    Hewitt, J.K.2    Young, S.E.3    Corley, R.P.4    Crowley, T.J.5    Stallings, M.C.6
  • 62
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • doi:10.1038/35015718
    • Risch, N. J. 2000 Searching for genetic determinants in the new millennium. Nature 405, 847-856. (doi:10.1038/35015718)
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 63
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • doi:10.1126/science.273.5281.1516
    • Risch, N. & Merikangas, K. 1996 The future of genetic studies of complex human diseases. Science 273, 1516-1517. (doi:10.1126/science.273.5281.1516)
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 64
    • 51449093982 scopus 로고    scopus 로고
    • The incentive sensitization theory of addiction: Some current issues
    • doi:10.1098/rstb.2008.0093
    • Robinson, T. E. & Berridge, K. C. 2008 The incentive sensitization theory of addiction: some current issues. Phil. Trans. R. Soc. B 363, 3137-3146. (doi:10.1098/rstb.2008.0093)
    • (2008) Phil. Trans. R. Soc. B , vol.363 , pp. 3137-3146
    • Robinson, T.E.1    Berridge, K.C.2
  • 65
    • 0034626403 scopus 로고    scopus 로고
    • Saccone, N. L. et al. 2000 A genome screen of maximum number of drinks as an alcoholism phenotype. Am. J. Med. Genet. 96, 632-637. (doi:10.1002/1096-8628(20001009)96:5〈632::AID-AJMG8〉3.0.CO;2-)
    • Saccone, N. L. et al. 2000 A genome screen of maximum number of drinks as an alcoholism phenotype. Am. J. Med. Genet. 96, 632-637. (doi:10.1002/1096-8628(20001009)96:5〈632::AID-AJMG8〉3.0.CO;2-)
  • 66
    • 0034056591 scopus 로고    scopus 로고
    • Transition to alcohol dependence: Clinical and neurobiological considerations
    • doi:10.1016/S0010- 440X(00)80014-0
    • Schmidt, L. G., Dufeu, P., Kuhn, S., Smolka, M. & Rommelspacher, H. 2000 Transition to alcohol dependence: clinical and neurobiological considerations. Compr. Psychiatry 41, 90-94. (doi:10.1016/S0010- 440X(00)80014-0)
    • (2000) Compr. Psychiatry , vol.41 , pp. 90-94
    • Schmidt, L.G.1    Dufeu, P.2    Kuhn, S.3    Smolka, M.4    Rommelspacher, H.5
  • 68
    • 35348847732 scopus 로고    scopus 로고
    • Okey Lecture 2006: Identifying the neurobiological mechanisms of addictive behaviour
    • doi:10.1111/j.1360-0443.2007.01942.x
    • Schumann, G. 2007 Okey Lecture 2006: identifying the neurobiological mechanisms of addictive behaviour. Addiction 102, 1689-1695. (doi:10.1111/j.1360-0443.2007.01942.x)
    • (2007) Addiction , vol.102 , pp. 1689-1695
    • Schumann, G.1
  • 69
    • 10744234007 scopus 로고    scopus 로고
    • Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    • doi:10.1016/S0006-3223(03)00635-8
    • Schumann, G. et al. 2003 Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biol. Psychiatry 54, 1422-1426. (doi:10.1016/S0006-3223(03)00635-8)
    • (2003) Biol. Psychiatry , vol.54 , pp. 1422-1426
    • Schumann, G.1
  • 70
    • 46849113440 scopus 로고    scopus 로고
    • Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risk drinking behaviour
    • In press
    • Schumann, G. et al. In press. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risk drinking behaviour. Arch. Gen. Psychiatry.
    • Arch. Gen. Psychiatry
    • Schumann, G.1
  • 71
    • 0035211708 scopus 로고    scopus 로고
    • How does stress increase risk of drug abuse and relapse?
    • doi:10.1007/ s002130100917
    • Sinha, R. 2001 How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl.) 158, 343-359. (doi:10.1007/ s002130100917)
    • (2001) Psychopharmacology (Berl.) , vol.158 , pp. 343-359
    • Sinha, R.1
  • 72
    • 19944433662 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    • doi:10.1523/ JNEUROSCI.1792-04.2005
    • Smolka, M. N. et al. 2005 Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J. Neurosci. 25, 836-842. (doi:10.1523/ JNEUROSCI.1792-04.2005)
    • (2005) J. Neurosci , vol.25 , pp. 836-842
    • Smolka, M.N.1
  • 73
    • 33847307696 scopus 로고    scopus 로고
    • Gene-gene effects on central processing of aversive stimuli
    • Smolka, M. N. et al. 2007 Gene-gene effects on central processing of aversive stimuli. Mol. Psychiatry 12, 307-317.
    • (2007) Mol. Psychiatry , vol.12 , pp. 307-317
    • Smolka, M.N.1
  • 74
    • 39749088094 scopus 로고    scopus 로고
    • Drugs for relapse prevention of alcoholism - 10 years of progress
    • doi:10.1016/j.tips.2007.12.005
    • Spanagel, R. & Kiefer, F. 2008 Drugs for relapse prevention of alcoholism - 10 years of progress. Trends Pharmacol. Sci. 29, 109-115. (doi:10.1016/j.tips.2007.12.005)
    • (2008) Trends Pharmacol. Sci , vol.29 , pp. 109-115
    • Spanagel, R.1    Kiefer, F.2
  • 75
    • 0036813153 scopus 로고    scopus 로고
    • The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol
    • Spanagel, R. et al. 2002 The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. J. Neurosci. 22, 8676-8683.
    • (2002) J. Neurosci , vol.22 , pp. 8676-8683
    • Spanagel, R.1
  • 76
    • 13444254068 scopus 로고    scopus 로고
    • The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    • doi:10.1038/nm1163
    • Spanagel, R. et al. 2005 The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat. Med. 11, 35-42. (doi:10.1038/nm1163)
    • (2005) Nat. Med , vol.11 , pp. 35-42
    • Spanagel, R.1
  • 77
    • 0034091898 scopus 로고    scopus 로고
    • Functions of glutamate transporters in the brain
    • doi:10.1016/S0168-0102(00)00104-8
    • Tanaka, K. 2000 Functions of glutamate transporters in the brain. Neurosci. Res. 37, 15-19. (doi:10.1016/S0168-0102(00)00104-8)
    • (2000) Neurosci. Res , vol.37 , pp. 15-19
    • Tanaka, K.1
  • 78
    • 84969213492 scopus 로고    scopus 로고
    • The Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678. (doi:10.1038/nature05911)
    • The Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678. (doi:10.1038/nature05911)
  • 79
    • 0025852722 scopus 로고
    • Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men
    • Thomasson, H. R. et al. 1991 Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J. Hum. Genet. 48, 677-681.
    • (1991) Am. J. Hum. Genet , vol.48 , pp. 677-681
    • Thomasson, H.R.1
  • 80
    • 17344362093 scopus 로고    scopus 로고
    • Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    • doi:10.1038/520
    • Timpl, P. et al. 1998 Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19, 162-166. (doi:10.1038/520)
    • (1998) Nat. Genet , vol.19 , pp. 162-166
    • Timpl, P.1
  • 81
    • 33745712822 scopus 로고    scopus 로고
    • Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
    • doi:10.1038/sj.mp.4001813
    • Treutlein, J. et al. 2006 Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol. Psychiatry 11, 594-602. (doi:10.1038/sj.mp.4001813)
    • (2006) Mol. Psychiatry , vol.11 , pp. 594-602
    • Treutlein, J.1
  • 83
    • 0031959272 scopus 로고    scopus 로고
    • The role of glutamatergic neurotransmission in the pathophysiology of alcoholism
    • doi:10.1146/annurev.med.49.1.173
    • Tsai, G. & Coyle, J. T. 1998 The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu. Rev. Med. 49, 173-184. (doi:10.1146/annurev.med.49.1.173)
    • (1998) Annu. Rev. Med , vol.49 , pp. 173-184
    • Tsai, G.1    Coyle, J.T.2
  • 84
    • 0036805791 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    • doi:10.1016/S0022-3999(02)00429-4
    • Tsigos, C. & Chrousos, G. P. 2002 Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. Psychosom. Res. 53, 865-871. (doi:10.1016/S0022-3999(02)00429-4)
    • (2002) J. Psychosom. Res , vol.53 , pp. 865-871
    • Tsigos, C.1    Chrousos, G.P.2
  • 85
    • 36849069820 scopus 로고    scopus 로고
    • Higher order addiction molecular genetics: Convergent data from genome-wide association in humans and mice
    • doi:10.1016/j.bcp.2007.06. 042
    • Uhl, G. R., Drgon, T., Johnson, C., Fatusin, O. O., Liu, Q. R., Contoreggi, C., Li, C. Y., Buck, K. & Crabbe, J. 2008 Higher order addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem. Pharmacol. 75, 98-111. (doi:10.1016/j.bcp.2007.06. 042)
    • (2008) Biochem. Pharmacol , vol.75 , pp. 98-111
    • Uhl, G.R.1    Drgon, T.2    Johnson, C.3    Fatusin, O.O.4    Liu, Q.R.5    Contoreggi, C.6    Li, C.Y.7    Buck, K.8    Crabbe, J.9
  • 86
    • 43449130407 scopus 로고    scopus 로고
    • Neuropharmacology of alcohol addiction
    • doi:10.1038/bjp.2008.30
    • Vengeliene, V., Bilbao, A., Molander, A. & Spanagel, R. 2008 Neuropharmacology of alcohol addiction. Br. J. Pharmacol. 154, 299-315. (doi:10.1038/bjp.2008.30)
    • (2008) Br. J. Pharmacol , vol.154 , pp. 299-315
    • Vengeliene, V.1    Bilbao, A.2    Molander, A.3    Spanagel, R.4
  • 87
    • 10944220561 scopus 로고    scopus 로고
    • Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol
    • doi:10.1111/j.1460-9568.2004.03793.x
    • Werner, C., Raivich, G., Cowen, M., Strekalova, T., Sillaber, I., Buters, J. T., Spanagel, R. & Hofmann, F. 2004 Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur. J. Neurosci. 20, 3498-3506. (doi:10.1111/j.1460-9568.2004.03793.x)
    • (2004) Eur. J. Neurosci , vol.20 , pp. 3498-3506
    • Werner, C.1    Raivich, G.2    Cowen, M.3    Strekalova, T.4    Sillaber, I.5    Buters, J.T.6    Spanagel, R.7    Hofmann, F.8
  • 88
    • 1642301421 scopus 로고    scopus 로고
    • Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers
    • doi:10.1038/sj.npp. 1300395
    • Zimmermann, U., Spring, K., Kunz-Ebrecht, S. R., Uhr, M., Wittchen, H. U. & Holsboer, F. 2004 Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. Neuropsychopharmacology 29, 1156-1165. (doi:10.1038/sj.npp. 1300395)
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1156-1165
    • Zimmermann, U.1    Spring, K.2    Kunz-Ebrecht, S.R.3    Uhr, M.4    Wittchen, H.U.5    Holsboer, F.6


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