Neurogenetic studies of alcohol addiction

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 363, Issue 1507, 2008, Pages 3201-3211

  Crabbe, John C ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Alcohol; Candidate genes; Genetic animal models

Indexed keywords

ALCOHOL; GENE EXPRESSION; GENETICS; MODEL; NEUROLOGY;

ANIMALIA; RODENTIA;

NEUROTRANSMITTER RECEPTOR;

ALCOHOLISM; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; INBRED STRAIN; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REVIEW;

ALCOHOLISM; ANIMALS; ANIMALS, INBRED STRAINS; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; MICE; RATS; RECEPTORS, NEUROTRANSMITTER;

EID: 51449099030     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2008.0101     Document Type: Conference Paper

References (122)

1. Allan, A. M. & Harris, R. A. 1991 Neurochemical studies of genetic differences in alcohol action. In The genetic basis for alcohol and drug actions (eds J. C. Crabbe & R. A. Harris), pp. 105-152. New York, NY: Plenum Press.
2. Anton, R. F., Oroszi, G., O'Malley, S., Couper, D., Swift, R., Pettinati, H. & Goldman, D. 2008 An evaluation of μ-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch. Gen. Psychiatry 65, 135-144. (doi:10.1001/archpsyc.65.2.135)
3. Arias, A., Feinn, R. & Kranzler, H. 2006 Association of an Asn40Asp (A118G) polymorphism in the μ-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend. 83, 262-268. (doi:10.1016/j.drugalcdep.2005.11.024)
4. Bailey, D. W. 1971 Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11, 325-327.
5. Beckley, E. H., Fretwell, A. M., Tanchuck, M. A., Gililland, K. R., Crabbe, J. C. & Finn, D. A. 2008 Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice. Neuropharmacology 54, 365-374. (doi:10.1016/j.neuropharm.2007.10.006)
6. Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L. & Phillips, T. J. 1997 Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behav. Genet. 27, 55-66. (doi:10.1023/A:1025615409383)
7. Bell, R. L., Rodd, Z. A., Lumeng, L., Murphy, J. M. & McBride, W. J. 2006 The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict. Biol. 11, 270-288. (doi:10.1111/j.1369-1600. 2005.00029.x)
8. Bennett, B., Carosone-Link, P., Zahniser, N. R. & Johnson, T. E. 2006 Confirmation and fine mapping of ethanol sensitivity QTLs, and candidate gene testing in the LxS recombinant inbred mice. J. Pharmacol. Exp. Ther. 319, 299-307. (doi:10.1124/jpet.106.103572)
9. Bennett, B., Downing, C., Carosone-Link, P., Ponicsan, H., Ruf, C. & Johnson, T. E. 2007 Quantitative trait locus mapping for acute functional tolerance to ethanol in the LxS recombinant inbred panel. Alcohol. Clin. Exp. Res. 31, 200-208. (doi:10.1111/j.1530-0277.2006.00296.x)
10. A receptor regulation of voluntary ethanol drinking requires PKC ε. Synapse 60, 411-419. (doi:10.1002/syn.20314)
11. Bice, P., Foroud, T., Bo, R., Castelluccio, P., Lumeng, L., Li, T.-K. & Carr, L. G. 1998 Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Mamm. Genome 9, 949-955. (doi:10.1007/s003359900905)
12. Blomeyer, D., Treutlein, J., Esser, G., Schmidt, M. H., Schumann, G. & Laucht, M. 2008 Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol. Psychiatry 63, 146-151. (doi:10.1016/j.biopsych.2007.04.026)
13. Bonsch, D., Lenz, B., Reulbach, U., Kornhuber, J. & Bleich, S. 2004a Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J. Neural Transm. 111, 1611-1616. (doi:10.1007/s00702-004-0232-x)
14. Bonsch, D., Reulbach, U., Bayerlein, K., Hillemacher, T., Kornhuber, J. & Bleich, S. 2004b Elevated α synuclein mRNA levels are associated with craving in patients with alcoholism. Biol. Psychiatry 56, 984-986. (doi:10.1016/j.biopsych.2004.09.016)
15. Bonsch, D., Greifenberg, V., Bayerlein, K., Biermann, T., Reulbach, U., Hillemacher, T., Kornhuber, J. & Bleich, S. 2005a α-Synuclein protein levels are increased in alcoholic patients and are linked to craving. Alcohol. Clin. Exp. Res. 29, 763-765. (doi:10.1097/01.ALC. 0000164360.43907.24)
16. Bonsch, D., Lenz, B., Kornhuber, J. & Bleich, S. 2005b DNA hypermethylation of the α synuclein promoter in patients with alcoholism. Neuroreport 16, 167-170. (doi:10.1097/00001756-200502080-00020)
17. Bowers, B. J., Radcliffe, R. A., Smith, A. M., Miyamoto-Ditmon, J. & Wehner, J. M. 2006 Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCγ mice. Alcohol 40, 19-33. (doi:10.1016/j.alcohol.2006.09.004)
18. Broadbent, J., Muccino, K. J. & Cunningham, C. L. 2002 Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behav. Neurosci. 116, 138-148. (doi:10.1037/0735-7044.116.1.138)
19. Buck, K. J., Metten, P., Belknap, J. K. & Crabbe, J. C. 1997 Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci. 17, 3946-3955.
20. Carr, L. G., Foroud, T., Bice, P., Gobbett, T., Ivashina, J., Edenberg, H. J., Lumeng, L. & Li, T. K. 1998 A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcohol. Clin. Exp. Res. 22, 884-887.
21. Carr, L. G., Kimpel, M. W., Liang, T., McClintick, J. N., McCall, K., Morse, M. & Edenberg, H. J. 2007 Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. Alcohol. Clin. Exp. Res. 31, 1089-1098. (doi:10.1111/j.1530-0277.2007.00397.x)
22. Chesler, E. J. et al. 2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37, 233-242. (doi:10.1038/ng1518)
23. 1 receptor knockout. Pharmacol. Biochem. Behav. 86, 813-821. (doi:10.1016/j.pbb.2007.03.009)
24. Clarimon, J., Gray, R. R., Williams, L. N., Enoch, M. A., Robin, R. W., Albaugh, B., Singleton, A., Goldman, D. & Mulligan, C. J. 2007 Linkage disequilibrium and association analysis of α-synuclein and alcohol and drug dependence in two American Indian populations. Alcohol. Clin. Exp. Res. 31, 546-554.
25. Colombo, G., Lobina, C., Carai, M. A. & Gessa, G. L. 2006 Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Addict. Biol. 11, 324-338. (doi:10.1111/j.1369-1600.2006.00031.x)
26. Cowmeadow, R. B., Krishnan, H. R. & Atkinson, N. S. 2005 The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila. Alcohol. Clin. Exp. Res. 29, 1777-1786. (doi:10.1097/01.alc.0000183232.56788.62)
27. Crabbe, J. C. & Morris, R. G. M. 2004 Festina lente: late night thoughts on high-throughput screening of mouse behavior. Nat. Neurosci. 7, 1175-1179. (doi:10.1038/nn1343)
28. Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N. & Schafer, G. L. 1996 Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat. Genet. 14, 98-101. (doi:10.1038/ng0996-98)
29. Crabbe, J. C., Phillips, T. J., Harris, R. A., Arends, M. A. & Koob, G. F. 2006 Alcohol-related genes: contributions from studies with genetically engineered mice. Addict. Biol. 11, 195-269. (doi:10.1111/j.1369- 1600.2006.00038.x)
30. Crabbe, J. C., Metten, P., Rhodes, J. S., Yu, C.-H., Brown, L. L., Phillips, T. J. & Finn, D. A. Submitted. A line of mice selected for drinking in the dark to intoxication.
31. Cunningham, C. L. & Phillips, T. J. 2003 Genetic basis of ethanol reward. In Molecular biology of drug addiction (ed. R. Maldonado), pp. 263-294. Totowa, NJ: Humana Press, Inc.
32. Cunningham, C. L., Henderson, C. M. & Bormann, N. M. 1998 Extinction of ethanol-induced conditioned place preference and conditioned place aversion: effects of naloxone. Psychopharmacology (Berl.) 139, 62-70. (doi:10.1007/s002130050690)
33. Dahl, J. P., Doyle, G. A., Oslin, D. W., Buono, R. J., Ferraro, T. N., Lohoff, F. W. & Berrettini, W. H. 2005 Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence. J. Psychiatr. Res. 39, 475-479. (doi:10.1016/j.jpsychires.2004.12.004)
34. Downing, C., Carosone-Link, P., Bennett, B. & Johnson, T. 2006 QTL mapping for low-dose ethanol activation in the LxS recombinant inbred strains. Alcohol. Clin. Exp. Res. 30, 1111-1120. (doi:10.1111/j.1530-0277. 2006.00137.x)
35. Enoch, M. A. & Goldman, D. 2001 The genetics of alcoholism and alcohol abuse. Curr. Psychiatry Rep. 3, 144-151. (doi:10.1007/s11920-001-0012-3)
36. Falconer, D. S. & Mackay, T. F. C. 1996 Introduction to quantitative genetics, 4th edn. Harlow, UK: Longman.
37. Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C. & Buck, K. J. 2002 Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a<1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J. Neurosci. 22, 3730-3738.
38. Finn, D. A., Ford, M. M., Wiren, K. M., Roselli, C. E. & Crabbe, J. C. 2004 The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacol. Therapeut. 101, 91-112. (doi:10.1016/j.pharmthera.2003.10.006)
39. 12-41. Alcohol. Clin. Exp. Res. 31, 939-949. (doi:10.1111/j.1530-0277.2007.00379.x)
40. Flint, J., Valdar, W., Shifman, S. & Mott, R. 2005 Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6, 271-286. (doi:10.1038/nrg1576)
41. Foroud, T. et al. 2007 Association of alcohol craving with α-synuclein (SNCA). Alcohol. Clin. Exp. Res. 31, 537-545. (doi:10.1111/j.1530-0277.2007.00505.x)
42. Francis, D., Diorio, J., Liu, D. & Meaney, M. J. 1999 Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286, 1155-1158. (doi:10.1126/science.286.5442.1155)
43. Francis, D. D., Szegda, K., Campbell, G., Martin, W. D. & Insel, T. R. 2003 Epigenetic sources of behavioral differences in mice. Nat. Neurosci. 6, 445-446.
44. Gelernter, J., Gueorguieva, R., Kranzler, H. R., Zhang, H., Cramer, J., Rosenheck, R. & Krystal, J. H. 2007 Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA cooperative study. Alcohol. Clin. Exp. Res. 31, 555-563.
45. Green, A. S. & Grahame, N. J. 2008 Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol? Alcohol 42, 1-11. (doi:10.1016/j.alcohol.2007.10.005)
46. Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R. & Peltz, G. 2001 In silico mapping of complex disease-related traits in mice. Science 292, 1915-1918. (doi:10.1126/science.1058889)
47. Hamre, K. M., Goldowitz, D., Wilkinson, S. & Matthews, D. B. 2007 Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav. Neurosci. 121, 665-678. (doi:10.1037/0735-7044.121.4.665)
48. Heilig, M. & Egli, M. 2006 Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol. Ther. 111, 855-876. (doi:10.1016/j.pharmthera.2006.02.001)
49. Hitzemann, R. et al. 2004 On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol. Clin. Exp. Res. 28, 1437-1448. (doi:10.1097/01.ALC.0000139827.86749.DA)
50. Hood, H. M., Metten, P., Crabbe, J. C. & Buck, K. J. 2006 Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 5, 1-10. (doi:10.1111/j.1601-183X.2005.00122.x)
51. Kakihana, R. 1979 Alcohol intoxication and withdrawal in inbred strains of mice: behavioral and endocrine studies. Behav. Neural Biol. 26, 97-105. (doi:10.1016/S0163-1047(79)92933-9)
52. Kalant, H. 1998 Research on tolerance: what can we learn from history? Alcohol. Clin. Exp. Res. 22, 67-76.
53. Kalant, H., LeBlanc, A. E. & Gibbins, R. J. 1971 Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 23, 135-191.
54. Kamdar, N. K., Miller, S. A., Syed, Y. M., Bhayana, R., Gupta, T. & Rhodes, J. S. 2007 Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice. Psychopharmacology 192, 207-217. (doi:10.1007/s00213-007-0711-5)
55. Kim, J. S. & Shukla, S. D. 2006 Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol Alcohol. 41, 126-132.
56. Kumar, A. et al. 2005 Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48, 303-314. (doi:10.1016/j.neuron.2005.09.023)
57. Lê, A. D., Israel, Y., Juzytsch, W., Quan, B. & Harding, S. 2001 Genetic selection for high and low alcohol consumption in a limited-access paradigm. Alcohol. Clin. Exp. Res. 25, 1613-1620. (doi:10.1111/j.1530-0277.2001.tb02168.x)
58. Letwin, N. E., Kafkafi, N., Benjamini, Y., Mayo, C., Frank, B. C., Luu, T., Lee, N. H. & Elmer, G. I. 2006 Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations. J. Neurosci. 26, 5277-5287. (doi:10.1523/JNEUROSCI.4602-05.2006)
59. Lewohl, J. M., Wang, L., Miles, M. F., Zhang, L., Dodd, P. R. & Harris, R. A. 2000 Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol. Clin. Exp. Res. 24, 1873-1882. (doi:10.1111/j.1530-0277.2000.tb01993.x)
60. Li, C. Y., Mao, X. & Wei, L. 2008 Genes and (common) pathways underlying drug addiction. PLoS Comput. Biol. 4, e2. (doi:10.1371/journal.pcbi.0040002)
61. Liang, T. et al. 2003 α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc. Natl Acad. Sci. USA 100, 4690-4695. (doi:10.1073/pnas.0737182100)
62. Liao, G. et al. 2004 In silico genetics: identification of a functional element regulating H2-E α gene expression. Science 306, 690-695. (doi:10.1126/science.1100636)
63. Liu, J., Lewohl, J. M., Harris, R. A., Iyer, V. R., Dodd, P. R., Randall, P. K. & Mayfield, R. D. 2006 Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31, 1574-1582. (doi:10.1038/sj.npp. 1300947)
64. Logue, S. F., Swartz, R. J. & Wehner, J. M. 1998 Genetic correlation between performance on an appetitive-signaled nosepoke task and voluntary ethanol consumption. Alcohol. Clin. Exp. Res. 22, 1912-1920.
65. Lopez, M. F. & Becker, H. C. 2005 Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL /6J mice. Psychopharmacology (Berl.) 181, 688-696. (doi:10.1007/s00213-005-0026-3)
66. Lovinger, D. M. & Crabbe, J. C. 2005 Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nat. Neurosci. 8, 1471-1480. (doi:10.1038/nn1581)
67. Lowery, E. G., Sparrow, A. M., Breese, G. R., Knapp, D. J. & Thiele, T. E. 2008 The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice. Alcohol. Clin. Exp. Res. 32, 240-248.
68. Mahadev, K. & Vemuri, M. C. 1998 Effect of ethanol on chromatin and nonhistone nuclear proteins in rat brain. Neurochem. Res. 23, 1179-1184. (doi:10.1023/A:1020778018149)
69. Mardones, J. & Segovia-Riquelme, N. 1983 Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav. Toxicol. Teratol. 5, 171-178.
70. McClearn, G. E. 1979 Genetics and alcoholism simulacra. Alcohol. Clin. Exp. Res. 3, 255-258. (doi:10.1111/j.1530-0277.1979.tb05310.x)
71. McClearn, G. E. & Rodgers, D. A. 1959 Differences in alcohol preference among inbred strains of mice. Quart. J. Stud. Alcohol 20, 691-695.
72. Melo, J. A., Shendure, J., Pociask, K. & Silver, L. M. 1996 Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nat. Genet. 13, 147-153. (doi:10.1038/ng0696-147)
73. Metten, P. & Crabbe, J. C. 1996 Dependence and withdrawal. In Pharmacological effects of ethanol on the nervous system (eds R. A. Deitrich & V. G. Erwin), pp. 269-290. Boca Raton, FL: CRC Press.
74. Metten, P., Phillips, T. J., Crabbe, J. C., Tarantino, L. M., McClearn, G. E., Plomin, R., Erwin, V. G. & Belknap, J. K. 1998 High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mamm. Genome 9, 983-990. (doi:10.1007/s003359900911)
75. Moore, E. M., Serio, K. M., Goldfarb, K. J., Stepanovska, S., Linsenbardt, D. N. & Boehm, S. L. 2007 GABAergic modulation of binge-like ethanol intake in C57BL /6J mice. Pharmacol. Biochem. Behav. 88, 105-113. (doi:10.1016/j.pbb.2007.07.011)
76. Mott, R., Talbot, C. J., Turri, M. G., Collins, A. C. & Flint, J. 2000 A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl Acad. Sci. USA 97, 12 649-12 654. (doi:10.1073/pnas. 230304397)
77. Mulligan, M. K. et al. 2006 Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc. Natl Acad. Sci. USA 103, 6368-6373. (doi:10.1073/pnas.0510188103)
78. Murphy, J. M., Stewart, R. B., Bell, R. L., Badia-Elder, N. E., Carr, L. G., McBride, W. J., Lumeng, L. & Li, T. K. 2002 Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav. Genet. 32, 363-388. (doi:10.1023/A:1020266306135)
79. Newton, P. M. & Messing, R. O. 2007 Increased sensitivity to the aversive effects of ethanol in PKCε null mice revealed by place conditioning. Behav. Neurosci. 121, 439-442. (doi:10.1037/0735- 7044.121.2.439)
80. Ocaranza, P., Quintanilla, M. E., Tampier, L., Karahanian, E., Sapag, A. & Israel, Y. 2008 Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Alcohol. Clin. Exp. Res. 32, 52-57.
81. Olive, M. F., Mehmert, K. K., Messing, R. O. & Hodge, C. W. 2000 Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCε-deficient mice. Eur. J. Neurosci. 12, 4131-4140. (doi:10.1046/j.1460-9568.2000.00297.x)
82. Olive, M. F., Mehmert, K. K., Nannini, M. A., Camarini, R., Messing, R. O. & Hodge, C. W. 2001 Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-ε. Neuroscience 103, 171-179. (doi:10.1016/S0306-4522(00)00566-2)
83. Palmer, A. A. & Phillips, T. J. 2002 Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity. Alcohol. Clin. Exp. Res. 26, 1322-1329.
84. Pawlak, R., Melchor, J. P., Matys, T., Skrzypiec, A. E. & Strickland, S. 2005 Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proc. Natl Acad. Sci. USA 102, 443-448. (doi:10.1073/pnas.0406454102)
85. Peirce, J. L. et al. 2006 How replicable are mRNA expression QTL? Mamm. Genome 17, 643-656. (doi:10.1007/s00335-005-0187-8)
86. Petkov, P. M. et al. 2004 An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res. 14, 1806-1811. (doi:10.1101/gr.2825804)
87. Phillips, T. J. & Belknap, J. K. 2002 Complex-trait genetics: emergence of multivariate strategies. Nat. Rev. Neurosci. 3, 478-485.
88. Phillips, T. J. & Crabbe, J. C. 1991 Behavioral studies of genetic differences in alcohol action. In The genetic basis of alcohol and drug actions (eds J. C. Crabbe & R. A. Harris), pp. 25-104. New York, NY: Plenum Press.
89. Phillips, T. J., Crabbe, J. C., Metten, P. & Belknap, J. K. 1994 Localization of genes affecting alcohol drinking in mice. Alcohol. Clin. Exp. Res. 18, 931-941. (doi:10.1111/j.1530-0277.1994.tb00062.x)
90. Phillips, T. J., Belknap, J. K., Buck, K. J. & Cunningham, C. L. 1998 Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mamm. Genome 9, 936-941. (doi:10.1007/s003359900903)
91. Phillips, T. J., Broadbent, J., Burkhart-Kasch, S., Henderson, C., Wenger, C. D., McMullin, C., McKinnon, C. S. & Cunningham, C. L. 2005 Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. Behav. Neurosci. 119, 892-910. (doi:10.1037/0735-7044.119.4.892)
92. Qi, Z. H. et al. 2007 Protein kinase C ε regulates γ-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of γ2 subunits. J. Biol. Chem. 282, 33 052-33 063. (doi:10.1074/jbc.M707233200)
93. Quintanilla, M. E., Israel, Y., Sapag, A. & Tampier, L. 2006 The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. Addict. Biol. 11, 310-323. (doi:10.1111/j.1369-1600.2006. 00030.x)
94. Reilly, M. T., Fehr, C. & Buck, K. J. 2001 Alcohol and gene expression in the central nervous system. In Nutrient-gene interactions in health and disease (eds N. Moussa-Moustaid & C. D. Berdanier), pp. 131-162. Boca Raton, FL: CRC Press.
95. Renthal, W. et al. 2007 Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56, 517-529. (doi:10.1016/j.neuron.2007.09.032)
96. Rhodes, J. S., Best, K., Belknap, J. K., Finn, D. A. & Crabbe, J. C. 2005 Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol. Behav. 84, 53-63. (doi:10.1016/j.physbeh. 2004.10.007)
97. Rhodes, J. S., Ford, M. M., Yu, C.-H., Brown, L. L., Finn, D. A., Garland Jr, T. & Crabbe, J. C. 2007 Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav. 6, 1-18. (doi:10.1111/j.1601-183X.2006.00210.x)
98. 1) antagonist. Pharmacol. Biochem. Behav. 88, 497-510. (doi:10.1016/j.pbb.2007.10.008)
99. Rodriguez, L. A., Plomin, R., Blizard, D. A., Jones, B. C. & McClearn, G. E. 1994 Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BxD recombinant inbred strains. Alcohol. Clin. Exp. Res. 18, 1416-1422. (doi:10.1111/j.1530-0277.1994. tb01444.x)
100. Ryabinin, A. E., Yoneyama, N., Tanchuck, M. A., Mark, G. P. & Finn, D. A. 2008 Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption. Neuroscience 151, 780-790. (doi:10.1016/j.neuroscience.2007.11.014)
101. Scholz, H., Ramond, J., Singh, C. M. & Heberlein, U. 2000 Functional ethanol tolerance in Drosophila. Neuron 28, 261-271. (doi:10.1016/S0896-6273(00)00101-X)
102. Sharpe, A. L., Tsivkovskaia, N. O. & Ryabinin, A. E. 2005 Ataxia and c-Fos expression in mice drinking ethanol in a limited access session. Alcohol. Clin. Exp. Res. 29, 1419-1426. (doi:10.1097/01.alc. 0000174746.64499.83)
103. Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C. & Buck, K. J. 2004 Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 7, 699-700. (doi:10.1038/nn1271)
104. Shram, M. J., Bahroos, M., Beleskey, J. I., Tampakeras, M., Le, A. D. & Tomkins, D. M. 2004 Motor impairing effects of ethanol and diazepam in rats selectively bred for high and low ethanol consumption in a limited-access paradigm. Alcohol. Clin. Exp. Res. 28, 1814-1821. (doi:10.1097/01.ALC.0000148105.79934.14)
105. 1 receptors. Science 296, 931-933. (doi:10.1126/science. 1069836)
106. Silver, L. M. 1995 Mouse genetics. New York, NY: Oxford University Press.
107. Sommer, W., Hyytia, P. & Kiianmaa, K. 2006 The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. Addict. Biol. 11, 289-309. (doi:10.1111/j.1369-1600. 2006.00037.x)
108. Sparta, D. R., Sparrow, A. M., Lowery, E. G., Fee, J. R., Knapp, D. J. & Thiele, T. E. 2008 Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures. Alcohol. Clin. Exp. Res. 32, 259-265.
109. Tabakoff, B., Saba, L., Kechris, K., Hu, W., Bhave, S. V., Finn, D. A., Grahame, N. J. & Hoffman, P. L. 2008 The genomic determinants of alcohol preference in mice. Mamm. Genome. [Epup ahead of print.] (doi:10.1007/s00335-008-9115-z)
110. Tarantino, L. M., McClearn, G. E., Rodriguez, L. A. & Plomin, R. 1998 Confirmation of quantitative trait loci for alcohol preference in mice. Alcohol. Clin. Exp. Res. 22, 1099-1105.
111. Thibault, C. et al. 2000 Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. Mol. Pharmacol. 58, 1593-1600.
112. Town, T., Schinka, J., Tan, J. & Mullan, M. 2000 The opioid receptor system and alcoholism: a genetic perspective. Eur. J. Pharmacol. 410, 243-248. (doi:10.1016/S0014-2999(00)00818-9)
113. Treutlein, J. et al. 2006 Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol. Psychiatry 11, 594-602. (doi:10.1038/sj.mp.4001813)
114. Turek, V. F., Tsivkovskaia, N. O., Hyytia, P., Harding, S., Le, A. D. & Ryabinin, A. E. 2005 Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. Psychopharmacology (Berl.) 181, 511-517. (doi:10.1007/s00213-005-0011-x)
115. Valdar, W. et al. 2006 Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat. Genet. 38, 879-887. (doi:10.1038/ng1840)
116. Wahlsten, D. & Crabbe, J. C. 2007 Behavioral testing. In The mouse in biomedical research, vol. 3 (eds J. G. Fox, C. Newcomer, A. Smith, S. Barhold, F. Quimby & M. Davisson). Normative biology, immunology and husbandry, pp. 513-534. 2nd edn. Amsterdam, The Netherlands: Elsevier.
117. Wahlsten, D., Bachmanov, A., Finn, D. A. & Crabbe, J. C. 2006 Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc. Natl Acad. Sci. USA 103, 16 364-16 369. (doi:10.1073/pnas.0605342103)
118. Walker, S. J. & Grant, K. A. 2006 Peripheral blood α-synuclein mRNA levels are elevated in cynomolgus monkeys that chronically self-administer ethanol. Alcohol 38, 1-4. (doi:10.1016/j.alcohol.2006.03.008)
119. Wang, Y., Krishnan, H. R., Ghezzi, A., Yin, J. C. & Atkinson, N. S. 2007 Drug-induced epigenetic changes produce drug tolerance. PLoS. Biol. 5, 2342-2353. (doi:10.1371/journal.pbio.0050265)
120. Wilhelm, J., Bayerlein, K., Hillemacher, T., Reulbach, U., Frieling, H., Kromolan, B., Degner, D., Kornhuber, J. & Bleich, S. 2006 Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism. J. Neural Transm. 113, 357-363. (doi:10.1007/s00702-005-0333-1)
121. Wilhelm, C. J., Reeves, J. M., Phillips, T. J. & Mitchell, S. H. 2007 Mouse lines selected for alcohol consumption differ on certain measures of impulsivity. Alcohol. Clin. Exp. Res. 31, 1839-1845. (doi:10.1111/j.1530-0277.2007.00508.x)
122. Xu, Y., Ehringer, M., Yang, F. & Sikela, J. M. 2001 Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. Alcohol. Clin. Exp. Res. 25, 810-818. (doi:10.1111/j.1530-0277.2001.tb02284.x)