Screening for ENU-Induced Mutations in Mice That Result in Aberrant Ethanol-Related Phenotypes

Behavioral Neuroscience

Volumn 121, Issue 4, 2007, Pages 665-678

  Hamre, Kristin M ^a   Goldowitz, Daniel ^a   Wilkinson, Sarah ^a   Matthews, Douglas B ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b University of Memphis

Author keywords

anxiolytic response; ataxia; ethanol consumption; locomotor activation; N ethyl nitrosourea

Indexed keywords

ALCOHOL; N ETHYL NITROSOUREA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; GENE MUTATION; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HYPOTHERMIA; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PEDIGREE; PHENOTYPE; TRANQUILIZING ACTIVITY;

ALCOHOLIC INTOXICATION; ANIMALS; BEHAVIOR, ANIMAL; DRINKING BEHAVIOR; FEMALE; LOCOMOTION; MALE; MAZE LEARNING; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; MUTAGENICITY TESTS; MUTATION; NITROSOUREA COMPOUNDS; PHENOTYPE; SPECIES SPECIFICITY; TIME FACTORS;

EID: 34548835528     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.121.4.665     Document Type: Article

References (63)

1. Balling R. ENU mutagenesis: Analyzing gene function in mice. Annual Review of Genomics and Human Genetics 2 (2001) 463-492
2. Belknap J.K., Crabbe J.C., and Young E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berlin) 112 (1993) 503-510
3. Boehm II S.L., Peden L., Chang R., Harris R.A., and Blednov Y.A. Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol. Alcoholism: Clinical and Experimental Research 27 (2003) 1033-1040
4. Boehm II S.L., Reed C.L., McKinnon C.S., and Phillips T.J. Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis. Psychopharmacology (Berlin) 161 (2002) 54-63
5. Bouwknecht J.A., van der Gugten J., Groenink L., Olivier B., and Paylor R. Effects of repeated testing in two inbred strains on flesinoxan dose-response curves in three mouse models for anxiety. European Journal of Pharmacology 494 (2004) 35-44
6. Brown S.D., and Balling R. Systematic approaches to mouse mutagenesis. Current Opinion in Genetics & Development 11 (2001) 268-273
7. Camarini R., and Hodge C.W. Ethanol preexposure increases ethanol self-administration in C57BL/6J and DBA/2J mice. Pharmacology, Biochemistry, and Behavior 79 (2004) 623-632
8. Connor J.P., Young R.M., Lawford B.R., Ritchie T.L., and Noble E.P. D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. European Psychiatry 17 (2002) 17-23
9. Corbetta S., Gualdoni S., Albertinazzi C., Paris S., Croci L., Consalez G.G., and de Curtis I. Generation and characterization of Rac3 knockout mice. Molecular and Cellular Biology 25 (2005) 5763-5776
10. Crabbe J.C., Belknap J.K., Mitchell S.R., and Crawshaw L.I. Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 269 (1994) 184-192
11. Crabbe J.C., Gallaher E.S., Phillips T.J., and Belknap J.K. Genetic determinants of sensitivity to ethanol in inbred mice. Behavioral Neuroscience 108 (1994) 186-195
12. Crabbe J.C., Johnson N.A., Gray D.K., Kosobud A., and Young E.R. Biphasic effects of ethanol on open field activity: Sensitivity and tolerance to C57BL/6N and DBA/2N mice. Journal of Comparative and Physiological Psychology 96 (1982) 440-451
13. Crabbe J.C., Metten P., Cameron A.J., and Wahlsten D. An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews 28 (2005) 785-802
14. Crabbe J.C., Phillips T.J., Buck K.J., Cunningham C.L., and Belknap J.K. Identifying genes for alcohol and drug sensitivity: Recent progress and future directions. Trends in Neuroscience 22 (1999) 173-179
15. Crabbe J.C., Wahlsten D., and Dudek B.C. Genetics of mouse behavior: Interactions with laboratory environment. Science 284 (1999, June 4) 1670-1672
16. Crawshaw L.I., Wallace H.L., Christensen R., and Crabbe J.C. Influence of ethanol on thermoregulation: Mapping quantitative trait loci. Physiological Genomics 7 (2001) 159-169
17. Crawshaw L.I., Wallace H.L., Crabbe J.C., Ramos C., Duerr J., and O'Connor C.S. Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice. American Journal of Physiology 273 (1997) R696-R702
18. Demarest K., McCaughran Jr. J., Mahjubi E., Cipp L., and Hitzemann R. Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Journal of Neuroscience 19 (1999) 549-561
19. Dere E., De Souza-Silva M.A., Spieler R.E., Lin J.S., Ohtsu H., Haas H.L., and Huston J.P. Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice. European Journal of Neuroscience 20 (2004) 1051-1058
20. Dick D.M., and Foroud T. Candidate genes for alcohol dependence: A review of genetic evidence from human studies. Alcoholism: Clinical and Experimental Research 27 (2003) 868-879
21. Dudek B.C., and Tritto T. Biometrical genetic analysis of ethanol's psychomotor stimulant effect. Alcoholism: Clinical and Experimental Research 18 (1994) 956-963
22. Enoch M.A., and Goldman D. The genetics of alcoholism and alcohol abuse. Current Psychiatry Reports 3 (2001) 144-151
23. Eriksson C.J., Fukunaga T., Sarkola T., Chen W.J., Chen C.C., Ju J.M., et al. Functional relevance of human adh polymorphism. Alcoholism: Clinical and Experimental Research 25 (2001) 157S-163S
24. Fee J.R., Sparta D.R., Knapp D.J., Breese G.R., Picker M.J., and Thiele T.E. Predictors of high ethanol consumption in RIIbeta knockout mice: Assessment of anxiety and ethanol-induced sedation. Alcoholism: Clinical and Experimental Research 28 (2004) 1459-1468
25. Fehr C., Rademacher B.L., and Buck K.J. Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry 27 (2003) 467-472
26. Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., and Buck K.J. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: Identification of Mpdz as a candidate gene. Journal of Neuroscience 22 (2002) 3730-3738
27. Foroud T., and Li T.K. Genetics of alcoholism: A review of recent studies in human and animal models. American Journal on Addictions 8 (1999) 261-278
28. Gill K., Desaulniers N., Desjardins P., and Lake K. Alcohol preference in AXB/BXA recombinant inbred mice: Gender differences and gender-specific quantitative trait loci. Mammalian Genome 9 (1998) 929-935
29. Goldowitz D., Frankel W.N., Takahashi J.S., Holtz-Vitaterna M., Bult C., Kibbe W.A., et al. Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Molecular Brain Research 132 (2004) 105-115
30. Grisel J.E., Metten P., Wenger C.D., Merrill C.M., and Crabbe J.C. Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism: Clinical and Experimental Research 26 (2002) 610-616
31. Hallikainen T., Hietala J., Kauhanen J., Pohjalainen T., Syvalahti E., Salonen J.T., and Tiihonen J. Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males. American Journal of Medical Genetics 119A (2003) 152-155
32. Hitzemann R., Cipp L., Demarest K., Mahjubi E., and McCaughran Jr. J. Genetics of ethanol-induced locomotor activation: Detection of QTLs in a C57BL/6J x DBA/2J F2 intercross. Mammalian Genome 9 (1998) 956-962
33. Justice M.J., Carpenter D.A., Favor J., Neuhauser-Klaus A., Hrabe de Angelis M., Soewarto D., et al. Effects of ENU dosage on mouse strains. Mammalian Genome 11 (2000) 484-488
34. Kapfhamer D., Valladares O., Sun Y., Nolan P.M., Rux J.J., Arnold S.E., et al. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nature Genetics 32 (2002) 290-295
35. Koyner J., Demarest K., McCaughran Jr. J., Cipp L., and Hitzemann R. Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross. Behavior Genetics 30 (2000) 159-170
36. Kralic J.E., Wheeler M., Renzi K., Ferguson C., O'Buckley T.K., Grobin A.C., et al. Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. Journal of Pharmacology and Experimental Therapeutics 305 (2003) 600-607
37. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berlin) 92 (1987) 180-185
38. Majchrowicz E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 43 (1975) 245-254
39. Majchrowicz E., and Hunt W.A. Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats. Psychopharmacology (Berlin) 50 (1976) 107-112
40. Marubio L.M., and Paylor R. Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors. Neuroscience 129 (2004) 575-582
41. McClearn G.E., and Rodgers D.A. Differences in alcohol preference among inbred strains of mice. Quarterly Journal of Studies on Alcoholism 20 (1959) 691-695
42. McIlwain K.L., Merriweather M.Y., Yuva-Paylor L.A., and Paylor R. The use of behavioral test batteries: Effects of training history. Physiology & Behavior 73 (2001) 705-717
43. Melo J.A., Shendure J., Pociask K., and Silver L.M. Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nature Genetics 13 (1996) 147-153
44. Mishima K., Tanoue A., Tsuda M., Hasebe N., Fukue Y., Egashira N., et al. Characteristics of behavioral abnormalities in alpha1d-adrenoceptors deficient mice. Behavioural Brain Research 152 (2004) 365-373
45. Moore J.A., and Kakihana R. Ethanol-induced hypothermia in mice: Influence of genotype on development of tolerance. Life Sciences 23 (1978) 2331-2337
46. National Institutes of Health. Guide for the care and use of laboratory animals (DHEW Publication No. 86-23) (1986), U.S. Government Printing Office, Washington, DC
47. Nolan P.M., Peters J., Strivens M., Rogers D., Hagan J., Spurr N., et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nature Genetics 25 (2000) 440-443
48. O'Connor C.S., Crawshaw L.I., Kosobud A., Bedichek R.C., and Crabbe J.C. The effect of ethanol on behavioral temperature regulation in mice. Pharmacology, Biochemistry, and Behavior 33 (1989) 315-319
49. Pandey S.C., Carr L.G., Heilig M., Ilveskoski E., and Thiele T.E. Neuropeptide y and alcoholism: Genetic, molecular, and pharmacological evidence. Alcoholism: Clinical and Experimental Research 27 (2003) 149-154
50. Peirce J.L., Derr R., Shendure J., Kolata T., and Silver L.M. A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mammalian Genome 9 (1998) 942-948
51. Phillips T.J., and Dudek B.C. Locomotor activity responses to ethanol in selectively bred long- and short-sleep mice, two inbred mouse strains, and their F1 hybrids. Alcoholism: Clinical and Experimental Research 15 (1991) 255-261
52. Phillips T.J., Shen E.H., McKinnon C.S., Burkhart-Kasch S., Lessov C.N., and Palmer A.A. Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice. Alcoholism: Clinical and Experimental Research 26 (2002) 593-602
53. Rinchik E.M., and Carpenter D.A. N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations. Genetics 152 (1999) 373-383
54. Risinger F.O., Freeman P.A., Greengard P., and Fienberg A.A. Motivational effects of ethanol in DARPP-32 knockout mice. Journal of Neuroscience 21 (2001) 340-348
55. Rubinstein M., Phillips T.J., Bunzow J.R., Falzone T.L., Dziewczapolski G., Zhang G., et al. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90 (1997) 991-1001
56. Rustay N.R., Wahlsten D., and Crabbe J.C. Assessment of genetic susceptibility to ethanol intoxication in mice. Proceedings of the National Academy of Sciences of the United States of America 100 (2003) 2917-2922
57. Shirley R.L., Walter N.A., Reilly M.T., Fehr C., and Buck K.J. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nature Neuroscience 7 (2004) 699-700
58. Thiele T.E., and Badia-Elder N.E. A role for neuropeptide Y in alcohol intake control: Evidence from human and animal research. Physiology & Behavior 79 (2003) 95-101
59. Vitali R., and Clarke S. Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase. Behavioural Brain Research 153 (2004) 129-141
60. Vitaterna M.H., King D.P., Chang A.M., Kornhauser J.M., Lowrey P.L., McDonald J.D., et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264 (1994, April 29) 719-725
61. Wahlsten D., Metten P., Phillips T.J., Boehm II S.L., Burkhart-Kasch S., Dorow J., et al. Different data from different labs: Lessons from studies of gene-environment interaction. Journal of Neurobiology 54 (2003) 283-311
62. Winer B.J., Brown D.R., and Michels K.M. Statistical principles in experimental design. 3rd ed. (1991), McGraw Hill, Boston
63. Zhang B., Kirov S., and Snoddy J. WebGestalt: An integrated system for exploring gene sets in various biological contexts. Nucleic Acids Research 33 Web Server issue (2005) W741-W748