Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice

Neuropharmacology

Volumn 54, Issue 2, 2008, Pages 365-374

  Beckley, Ethan H ^b   Fretwell, Andrea M ^a   Tanchuck, Michelle A ^b   Gililland, Katherine R ^b   Crabbe, John C ^a,b   Finn, Deborah A ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Alcohol; Convulsions; GABAA receptors; Neurosteroid; Pentylenetetrazol; Selected lines

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ALCOHOL; PENTETRAZOLE;

ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENOTYPE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; WITHDRAWAL SYNDROME;

ANIMALS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CORTICOSTERONE; ESTRADIOL; ETHANOL; FEMALE; MICE; PREGNANOLONE; PROGESTERONE; RADIOIMMUNOASSAY; SEIZURES; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 38149133664     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.10.006     Document Type: Article

References (62)

1. Akwa Y., Purdy R.H., Koob G.F., and Britton K.T. The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behavioural Brain Research 106 (1999) 119-125
2. Alele P.E., and Devaud L.L. Sex differences in steroid modulation of ethanol withdrawal in male and female rats. Journal of Pharmacology and Experimental Therapeutics 320 (2007) 427-436
3. Barbaccia M.L., Affricano D., Trabucchi M., Purdy R.H., Colombo G., Agabio R., and Gessa G.L. Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats. European Journal of Pharmacology 384 (1999) R1-R2
4. A receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids?. Journal of Neuroscience 23 (2003) 10013-10020
5. A receptor. Nature Reviews Neuroscience 6 (2005) 565-575
6. A receptor. Brain Research 561 (1991) 157-161
7. Bitran D., Dugan M., Renda P., Ellis R., and Foley M. Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Research 850 (1999) 217-224
8. A receptors. Molecular Pharmacology 63 (2003) 53-64
9. Cagetti E., Pinna G., Guidotti A., Baicy K., and Olsen R.W. Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function. Neuropharmacology 46 (2004) 570-579
10. A receptor function. Journal of Neurochemistry 100 (2007) 279-294
11. Crabbe J.C., Kosobud A., Young E.R., Tam B.R., and McSwigan J.D. Bidirectional selection for susceptibility to ethanol withdrawal seizures in Mus musculus. Behavior Genetics 15 (1985) 521-536
12. Crabbe J.C., Phillips T.J., Kosobud A., and Belknap J.K. Estimation of genetic correlation: interpretation of experiments using selectively bred and inbred animals. Alcoholism: Clinical and Experimental Research 14 (1990) 141-151
13. Criswell H.E., and Breese G.R. A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary. Neuropsychopharmacology 30 (2005) 1407-1425
14. Dazzi L., Serra M., Seu E., Cherchi G., Pisu M.G., Purdy R.H., and Biggio G. Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride. Journal of Neurochemistry 83 (2002) 1103-1109
15. Devaud L.L., and Chadda R. Sex differences in the development of and recovery from ethanol dependence assessed by changes in seizure susceptibility. Alcoholism: Clinical and Experimental Research 25 (2001) 1689-1696
16. Devaud L.L., Purdy R.H., and Morrow A.L. The neurosteroid, 3α-hydroxy-5α-pregnan-20-one, protects against bicuculline seizures during ethanol withdrawal in rats. Alcoholism: Clinical and Experimental Research 19 (1995) 350-356
17. A receptors to neuroactive steroids in rats during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 278 (1996) 510-517
18. Engle E.T., and Rosasco J. The age of the albino mouse at normal sexual maturity. The Anatomical Record 36 (1927) 383-388
19. Finn D.A., and Crabbe J.C. Chronic ethanol differentially alters susceptibility to chemically induced convulsions in Withdrawal Seizure-Prone and Resistant-mice. Journal of Pharmacology and Experimental Therapeutics 288 (1999) 782-790
20. Finn D.A., Roberts A.J., Lotrich F., and Gallaher E.J. Genetic differences in behavioral sensitivity to a neuroactive steroid. Journal of Pharmacology and Experimental Therapeutics 280 (1997) 820-828
21. Finn D.A., Gallaher E.J., and Crabbe J.C. Differential change in neuroactive steroid sensitivity during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 292 (2000) 394-405
22. Finn D.A., Ford M.M., Wiren K.M., Roselli C.E., and Crabbe J.C. The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacology and Therapeutics 101 (2004) 91-112
23. Finn D.A., Sinnott R.S., Ford M.M., Long S.L., Tanchuck M.A., and Phillips T.J. Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6J mice. Neuroscience 123 (2004) 813-819
24. Finn D.A., Beadles-Bohling A.S., Tanchuck M.A., Gililland K.R., and Mark G.P. The hippocampus is an important brain site necessary for the anticonvulsant effect of allopregnanolone in WSP-1 mice. Alcoholism: Clinical and Experimental Research 29 (2005) 95A
25. Finn D.A., Douglass A.D., Beadles-Bohling A.S., Tanchuck M.A., Long S.L., and Crabbe J.C. Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal. Genes, Brain and Behavior 5 (2006) 53-63
26. Gabriel K.I., Cunningham C.L., and Finn D.A. Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology 176 (2004) 50-56
27. Gale K. Progression and generalization of seizure discharge: anatomical and neurochemical substrates. Epilepsia 29 (1988) S15-S34
28. Gorin-Meyer R.E., Wiren K.M., Tanchuck M.A., Long S.L., Yoneyama N., and Finn D.A. Sex differences in the effect of finasteride on acute ethanol withdrawal in C57BL/6J and DBA/2J mice. Neuroscience 146 (2007) 1302-1315
29. A receptors in the acute and chronic effects of ethanol. Psychopharmacology 139 (1998) 2-19
30. A receptor expression: potential mechanisms. Neurochemistry International 37 (2000) 453-461
31. Hirani K., Khisti R.T., and Chopde C.T. Behavioral action of ethanol in Porsolt's forced swim test: modulation by 3alpha-hydroxy-5alpha-pregnan-20-one. Neuropharmacology 43 (2002) 1339-1350
32. Hirani K., Sharma A.N., Jain N.S., Ugale R.R., and Chopde C.T. Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 180 (2005) 267-278
33. Janis G.C., Devaud L.L., Mitsuyama H., and Morrow A.L. Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in male and female rats. Alcoholism: Clinical and Experimental Research 22 (1998) 2055-2061
34. Keith L.D., Winslow J.R., and Reynolds R.W. A general procedure for estimation of corticosteroid response in individual rats. Steroids 31 (1978) 523-531
35. Khisti R.T., VanDoren M.J., Matthews D.B., and Morrow A.L. Ethanol-induced elevation in 3α-hydroxy-5α-pregnan-20-one does not modulate motor incoordination in rats. Alcoholism: Clinical and Experimental Research 28 (2004) 1249-1256
36. Kokka N., Sapp D.W., Taylor A.M., and Olsen R.W. The kindling model of alcohol dependence: similar persistent reduction in seizure thresholds to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. Alcoholism: Clinical and Experimental Research 17 (1993) 525-531
37. Kosobud A.E., and Crabbe J.C. Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs. Brain Research 526 (1990) 8-16
38. A receptors: genomic and nongenomic mechanisms. Pharmacology and Therapeutics 101 (2004) 211-226
39. A receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. Journal of Pharmacology and Experimental Therapeutics 310 (2004) 1234-1245
40. Martin-Garcia E., and Pallares M. The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine. Brain Research 1062 (2005) 144-150
41. Martin-Garcia E., and Pallares M. Intrahippocampal nicotine and neurosteroid effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats. Behavioural Brain Research 164 (2005) 117-127
42. A receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex. Journal of Neurochemistry 70 (1998) 1160-1166
43. A receptor function and gene expression in the central nervous system. International Review of Neurobiology 38 (1995) 1-41
44. Morrow A.L., Janis G.C., VanDoren M.J., Matthews D.B., Samson H.H., Janak P.H., and Grant K.A. Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?. Alcoholism: Clinical and Experimental Research 23 (1999) 1933-1940
45. Murphy N.P., Sakoori K., and Okabe C. Lack of evidence of a role for the neurosteroid allopregnanolone in the ethanol-induced reward and c-fos expression in DBA/2 mice. Brain Research 1094 (2006) 107-118
46. Patchev V.K., Hassan A.H., Holsboer D.F., and Almeida O.F. The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Neuropsychopharmacology 15 (1996) 533-540
47. Paul S.M., and Purdy R.H. Neuroactive steroids. Federation of American Societies for Experimental Biology Journal 6 (1992) 2311-2322
48. Roach M., and Creaven P. A micro-method for the determination of acetaldehyde and ethanol in blood. Clinica Chimica Acta 21 (1968) 275-278
49. Roberts A.J., and Keith L.D. Corticosteroids enhance convulsion susceptibility via central mineralocorticoid receptors. Psychoneuroendocrinology 20 (1995) 891-902
50. Rivier C. Female rats release more corticosterone than males in response to alcohol: influence of circulating sex steroids and possible consequences for blood alcohol levels. Alcoholism: Clinical and Experimental Research 17 (1993) 854-859
51. Romeo E., Brancati A., De Lorenzo A., Fucci P., Furnari C., Pompili E., Sasso G.F., Spalletta G., Troisi A., and Pasini A. Marked decrease of plasma neuroactive steroids during alcohol withdrawal. Clinical Neuropharmacology 19 (1996) 366-369
52. Rupprecht R., and Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends in Neuroscience 22 (1999) 410-416
53. A receptor activity in rat hippocampus. Journal of Neuroscience 24 (2004) 6521-6530
54. Seymour A.M., Tanchuck M.A., Beadles-Bohling A.S., Metten P., Crabbe J.C., and Finn D.A. Behavioral sensitivity to allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice. Alcoholism: Clinical and Experimental Research 30 (2006) 26A
55. Tabachnick B.G., and Fidell L.S. Using Multivariate Statistics. fifth ed. (2007), Pearson Education, Boston, MA p. 212
56. Terdal E.S., and Crabbe J.C. Indexing withdrawal in mice: matching genotypes for exposure in studies using ethanol vapor inhalation. Alcoholism: Clinical and Experimental Research 18 (1994) 542-547
57. A receptors at inhibitory synapses. Nature Neuroscience 8 (2005) 889-897
58. Torres J.M., and Ortega E. Alcohol intoxication increases allopregnanolone levels in female adolescent humans. Neuropsychopharmacology 28 (2003) 1207-1209
59. Torres J.M., and Ortega E. Alcohol intoxication increases allopregnanolone levels in male adolescent humans. Psychopharmacology 172 (2004) 352-355
60. VanDoren M.J., Matthews D.B., Janis G.C., Grobin A.C., Devaud L.L., and Morrow A.L. Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. Journal of Neuroscience 20 (2000) 1982-1989
61. Veatch L.M., Wright T.M., and Randall C.L. Only male mice show sensitization of handling-induced convulsions across repeated ethanol withdrawal cycles. Alcoholism: Clinical and Experimental Research 31 (2007) 477-485
62. Wang C., Marz C.E., Morrow A.L., Wilson M.A., and Moore S.D. Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. Neuroscience Letters 415 (2007) 118-123