Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8574-8586

  Blum, Andreas ^a   Böttcher, Jark ^a   Sammet, Benedikt ^a   Luksch, Torsten ^a   Heine, Andreas ^a   Klebe, Gerhard ^a   Diederich, Wibke E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Aspartic protease inhibitors; HIV 1 protease; Inhibitor design; Oligoamines

Indexed keywords

AMINE; AMPRENAVIR; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; BETA SECRETASE; BIS[2 (4 AMINOPHENYLSULFONYL N BENZYLAMINO)ETHYL]AMINE; BIS[2 (4 AMINOPHENYLSULFONYL N ISOBUTYLAMINO)ETHYL]AMINE; PEPSIN A; PROTEINASE; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; RENIN; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG RESEARCH; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME SUBSTRATE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROTEINASE INHIBITION; X RAY CRYSTALLOGRAPHY;

AMINES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CRYSTALLIZATION; DRUG DESIGN; HIV PROTEASE; PEPSIN A; PROTEASE INHIBITORS; RENIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 51449089910     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.012     Document Type: Article

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