Structure-guided design of C2-symmetric HIV-1 protease inhibitors based on a pyrrolidine scaffold

Journal of Medicinal Chemistry

Volumn 51, Issue 7, 2008, Pages 2078-2087

  Blum, Andreas ^a   Böttcher, Jark ^a   Heine, Andreas ^a   Klebe, Gerhard ^a   Diederich, Wibke E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 BIS N SULFONAMIDE; PROTEINASE INHIBITOR; PYRROLIDINE DERIVATIVE; TARTARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; INFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41849085506     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701142s     Document Type: Article

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