Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5101-5106

  Jitsuoka, Makoto ^a   Tsukahara, Daisuke ^a   Ito, Sayaka ^a   Tanaka, Takeshi ^a   Takenaga, Norihiro ^a   Tokita, Shigeru ^a   Sato, Nagaaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Brain permeability; Histamine H3 inverse agonist; PET tracer; Spiro isobenzofuranone

Indexed keywords

AMIDE; HISTAMINE H3 RECEPTOR ANTAGONIST; PIPERIDINE; SPIRO COMPOUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOFURANS; BRAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; HISTAMINE AGONISTS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, HISTAMINE H3; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51349160447     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.125     Document Type: Article

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