Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: A proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted) piperidin-1-yl]butanes

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 18, 2001, Pages 2469-2473

  Finke, Paul E ^a   Meurer, Laura C ^a   Oates, Bryan ^a   Shah, Shrenik K ^a   Loebach, Jennifer L ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Castonguay, Laurie ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYLPIPERAZINE DERIVATIVE; 2 (3 CHLOROPHENYL) 1 [N (METHYL) N (PHENYLSULFONYL)AMINO] 4 (PIPERIDIN 1 YL)BUTANE DERIVATIVE; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; INDANONE DERIVATIVE; LACTAM DERIVATIVE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PHENYL GROUP; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; SPIRO COMPOUND; SULFIDE; SULFONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CHO CELL; CONTROLLED STUDY; DIASTEREOISOMER; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC 50; NONHUMAN; PHARMACOPHORE; PROTEIN EXPRESSION; REACTION ANALYSIS; RECEPTOR BLOCKING; STEREOCHEMISTRY; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; BUTANES; CELLS, CULTURED; CRICETINAE; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGE INFLAMMATORY PROTEIN-1; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEUTROPHILS; PIPERIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 17944379325     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00491-7     Document Type: Article

References (25)