Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-methylpyrrolidinyl] ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H 3 receptor antagonist with drug-like properties

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 165-175

  Esbenshade, Timothy A ^a   Fox, Gerard B ^a   Krueger, Kathleen M ^a   Miller, Thomas R ^a   Kang, Chae Hee ^a   Denny, Lynne I ^b   Witte, David G ^a   Yao, Betty B ^a   Pan, Liping ^a   Wetter, Jill ^a   Marsh, Kennan ^a   Bennani, Youssef L ^c   Cowart, Marion D ^a   Sullivan, James P ^a   Hancock, Arthur A ^a  

^a ABBOTT LABORATORIES   (United States)

^b PFIZER INC   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [2 (2 METHYLPYRROLIDINYL)ETHYL]BENZOFURAN 5 YL]BENZONITRILE; 5 (4 CYANOPHENYL) 2 [2 (2 METHYL 1 IMIDAZOLIDINYL)ETHYL]BENZOFURAN; A 349821; CIPRALISANT; CIPROXIFAN; CYCLIC AMP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; HISTAMINE H4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM MOBILIZATION; COGNITIVE DEFECT; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROSTIMULATION; GUINEA PIG; HISTAMINE RELEASE; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; MONKEY; NEUROLOGIC DISEASE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE; ANIMALS; BENZOFURANS; CALCIUM; CELL MEMBRANE; CEREBRAL CORTEX; CLONING, MOLECULAR; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; HISTAMINE ANTAGONISTS; HISTAMINE RELEASE; ILEUM; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROTRANSMITTER AGENTS; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3;

EID: 20144376337     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.078303     Document Type: Article

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