The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors

Biochemical Journal

Volumn 335, Issue 1, 1998, Pages 95-102

  Ariel, Naomi ^a   Ordentlich, Arie ^a   Barak, Dov ^a   Bino, Tamar ^a   Velan, Baruch ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AROMATIC COMPOUND; CARBAMIC ACID DERIVATIVE; CHOLINESTERASE INHIBITOR; HUPERZINE A; MUTANT PROTEIN; PHYSOSTIGMINE; PYRIDOSTIGMINE; TACRINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HUMAN; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TORPEDO CALIFORNICA;

TORPEDO CALIFORNICA;

EID: 0032190343     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3350095     Document Type: Article

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