Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates

Biochemistry

Volumn 35, Issue 33, 1996, Pages 10995-11004

  Hosea, Natilie A ^a   Radić, Zoran ^a   Tsigelny, Igor ^a   Berman, Harvey Alan ^b   Quinn, Daniel M ^c   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ORGANOPHOSPHATE; TRIFLUOROMETHYLACETOPHENONE; TRIMETHYLAMMNONIOTRIFLUOROMETHYLACETOPHENONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; EMBRYO; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

ACETYLCHOLINESTERASE; ANIMALS; ASPARTIC ACID; CATIONS; CELL LINE; CHOLINESTERASE INHIBITORS; DIFFUSION; ELECTROCHEMISTRY; HUMANS; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TORPEDO;

EID: 0029781839     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9611220     Document Type: Article

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