Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia

Cell Death and Differentiation

Volumn 11, Issue 10, 2004, Pages 1102-1111

  Kerr, Lorraine E ^a   McGregor, A L ^a   Amet, L E A ^a   Asada, T ^a,d   Spratt, C ^a   Allsopp, T E ^a,b   Harmar, A J ^a   Shen, S ^a,c   Carlson, G ^a   Logan, N ^a   Kelly, J S ^a   Sharkey, J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Roger Land Building   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d ASTELLAS PHARMA INC   (Japan)

Author keywords

5 CSRTT; Apoptosis; Caspase 3; Ischaemia; Neurodegeneration; Stroke; Transgenic

Indexed keywords

CASPASE 3; PROCASPASE 3;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONTROL; GENE OVEREXPRESSION; GENETIC PREDISPOSITION; HOMEOSTASIS; MOUSE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPERFUSION INJURY; SURVIVAL; TASK PERFORMANCE; TRANSGENIC MOUSE; TRANSIENT ISCHEMIC ATTACK; WILD TYPE;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CASPASE 3; CASPASES; CELL SIZE; CELLS, CULTURED; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; MICE; MICE, TRANSGENIC; PHENOTYPE; TIME FACTORS; TRANSGENES;

MURINAE; MUS MUSCULUS;

EID: 5044241750     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401449     Document Type: Article

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