Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice

Neuroscience

Volumn 104, Issue 4, 2001, Pages 947-955

  Hermann, D M ^b   Kilic, E ^b   Hata, R ^a   Hossmann, K A ^a   Mies, G ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

ATP bioluminescence; Caspase 3; Cerebral protein synthesis; Heat shock gene; Immediate early gene; p53 activated gene

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRAIN PROTEIN; DNA FRAGMENT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CONTROLLED STUDY; IN SITU HYBRIDIZATION; MALE; METABOLIC DISORDER; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PUTAMEN; REPERFUSION; REPRODUCIBILITY; SOMATOSENSORY CORTEX; SURVIVAL; TRANSIENT ISCHEMIC ATTACK;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; BRAIN ISCHEMIA; CASPASE 3; CASPASES; CELL DEATH; CEREBROVASCULAR CIRCULATION; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; LEUCINE; LUMINESCENT MEASUREMENTS; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; REPERFUSION INJURY; TIME FACTORS;

EID: 0035800010     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00125-7     Document Type: Article

References (28)

1. Oncogene jun encodes a sequence-specific transactivator similar to AP-1
2. Expression of interleukin-1β converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery
3. Recovery of monkey brain after prolonged ischemia. II. Protein synthesis and morphological alterations
4. Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro
5. Interleukin-1-beta-converting enzyme-related proteases (IRPS) and mammalian cell death - Dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
6. Cytokines and reperfusion in ischemic stroke
7. Activation of cpp32 protease in hippocampal neurons following ischemia and epilepsy
8. Expression of cell death-associated phospho c-Jun and p53-activated gene 608 in hippocampal neurons following global ischemia
9. Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice
10. Evolution of brain infarction after transient focal cerebral ischemia in mice
11. The c-Jun transcription factor - Bipotential mediator of neuronal death, survival and regeneration
12. Expression of c-jun, hsp72 and gfap following repeated unilateral common carotid artery occlusion in gerbils - Correlates of delayed ischemic injury
13. Expression of c-fos, junB, c-jun, MKP-1 and hsp72 following traumatic neocortical lesions in rats - Relation to spreading depression
14. Expression of redox-factor-1, p53-activated gene 608 and caspase-3 mRNAs following repeated unilateral common carotid artery occlusion in gerbils - Relationship to delayed cell injury and secondary failure of energy state
15. Glutamate-mediated injury in focal cerebral ischemia: The excitotoxin hypothesis revised
16. Periinfarct depolarizations
17. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70
18. A novel p53-inducible gene, pag608, encodes a zinc finger protein whose overexpression promotes apoptosis
19. A pictorial representation of endogenous brain ATP by a bioluminescent method
20. Comparison between freeze-blowing and funnel-freezing of rat brain for the measurement of cerebral glucose concentration in vivo
21. Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat
22. Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat
23. Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia
24. Localization of 70 kDa stress protein mRNA induction in gerbil brain after ischemia
25. Caspases as treatment targets in stroke and neurodegenerative disease
26. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus
27. Activation of p53 and its target genes p21 (WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning
28. Neuronal damage after repeated 5 minutes of ischemia in the gerbil is preceded by prolonged impairment of protein metabolism