Characterization and application of a novel RNA aptamer against the mouse prion protein

Journal of Biochemistry

Volumn 139, Issue 3, 2006, Pages 383-390

  Sekiya, Satoru ^a,b   Noda, Ken ^c   Nishikawa, Fumiko ^b   Yokoyama, Takashi ^d   Kumar, Penmetcha K R ^b   Nishikawa, Satoshi ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c NATIONAL VETERINARY ASSAY LABORATORY   (Japan)

^d NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Blotting assay; In vitro selection; Prion; RNA aptamer

Indexed keywords

APTAMER; HEPARIN; MUTANT PROTEIN; PRION PROTEIN; RIBONUCLEASE; RNA;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOTINYLATION; BRAIN HOMOGENATE; CONTROLLED STUDY; IN VITRO SELECTION; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; RNA ISOLATION;

AMINO ACID SEQUENCE; ANIMALS; APTAMERS, NUCLEOTIDE; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRIONS; PROTEIN BINDING; RNA;

ANIMALIA;

EID: 33646352484     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj046     Document Type: Article

References (31)

1. Prusiner, S.B. (1982) Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144
2. Pan, K.M., Baldwin, M., Nguyen, J., Gasset, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R.J., and Cohen, F.E. (1993) Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 90, 10962-10966
3. Huang, Z., Gabriel, J.M., Baldwin, M.A., Fletterick, R.J., Prusiner, S.B., and Cohen, F.E. (1994) Proposed three-dimensional structure for the cellular prion protein. Proc. Natl. Acad. Sci. USA 91, 7139-7143
4. Cohen, F.E., Pan, K.M., Huang, Z., Baldwin, M., Fletterick, R.J., and Prusiner, S.B. (1994) Structural clues to prion replication. Science 264, 530-531
5. Scott, M., Foster, D., Mirenda, C., Serban, D., Coufal, F., Walchli, M., Torchia, M., Groth, D., Carlson, G., and DeArmond, S.J. (1989) Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell 59, 847-857
6. Saborio, G.P., Permanne, B., and Soto, C. (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810-813
7. Castilla, J., Saa, P., Hetz, C., and Soto, C. (2005) In vitro generation of infectious scrapie prions. Cell 121, 195-206
8. Gajdusek, D.C. (1991) The transmissible amyloidoses: genetical control of spontaneous generation of infectious amyloid proteins by nucleation of configurational change in host precursors: kuru-CJD-GSS-scrapie-BSE. Eur. J. Epidemiol 5, 567-577
9. Prusiner, S.B., McKinley, M.P., Groth, D.F., Bowman, K.A., Mock, N.I., Cochran, S.P., and Masiarz, F.R. (1981) Scrapie agent contains a hydrophobic protein. Proc. Natl. Acad. Sci. USA 78, 6675-6679
10. McKinley, M.P., Bolton, D.C., and Prusiner, S.B. (1983) A protease-resistant protein is a structural component of the scrapie prion. Cell 35, 57-62
11. Bolton, D.C., McKinley, M.P., and Prusiner, S.B. (1982) Identification of a protein that purifies with the scrapie prion. Science 218, 1309-1311
12. Yokoyama, T., Kimura, K.M., Ushiki, Y., Yamada, S., Morooka, A., Nakashiba, T., Sassa, T., and Itohara, S. (2001) In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J. Biol. Chem. 276, 11265-11271
13. Ellington, A.D. and Szostak, J.W. (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818-822
14. Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505-510
15. Tombelli, S., Minunni, M., and Mascini, M. (2005) Analytical applications of aptamers. Biosensors & Bioelectronics 20, 2424-2434
16. Jenison, R.D., Gill, S.C., Pardi, A., and Polisky, B. (1994) High-resolution molecular discrimination by RNA. Science 263, 1425-1429
17. Kikuchi, K., Umehara, T., Fukuda, K., Hwang, J., Kuno, A., Hasegawa, T., and Nishikawa, S. (2003) RNA aptamers targeted to domain II of hepatitis C virus IRES that bind to its apical loop region. J. Biochem. 133, 263-270
18. Zuker, M. (1989) Computer prediction of RNA structure. Methods Enzymol. 183, 202-287
19. Fukuda, K., Vishnuvardhan, D., Sekiya, S., Hwang, J., Kakiuchi, N., Taira, K., Shimotohno, K., Kumar, P.K.R., and Nishikawa, S. (2000) Isolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease. Eur. J. Biochem. 267, 3685-3694
20. Hwang, J., Fauzi, H., Fukuda, K., Sekiya, S., Kakiuchi, N., Shimotohno, K., Taira, K., Kusakabe, I., and Nishikawa, S. (2000) The RNA aptamer-binding site of hepatitis C virus NS3 protease. Biochem. Biophys. Res. Commun. 279, 557-562
21. Bagga, P.S. and Wilusz, J. (1999) Northwestern screening of expression libraries. Methods Mol. Biol. 118, 245-256
22. Cummins, L.L., Owens, S.R., Risen, L.M., Lesnik, E.A., Freier, S.M., McGee, D., Guinosso, C.J., and Cook, P.D. (1995) Characterization of fully 2′-modified oligonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res 23, 2019-2024
23. 165). J. Biol. Chem. 273, 20556-20567
24. Caughey, B., Brown, K., Raymond, G.J., Katzenstein, G.E., and Thresher, W. (1994) Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red. J. Virol. 68, 2135-2141
25. Warner, R.G., Hundt, C., Weiss, S., and Turnbull, J.E. (2002) Identification of the heparan sulfate binding sites in the cellular prion protein. J. Biol. Chem. 277, 18421-18430
26. Weiss, S., Proske, D., Neumann, M., Groschup, M.H., Kretzschmar, H.A., Famulok, M., and Winnacker, E.L. (1997) RNA aptamers specifically interact with the prion protein PrP. J. Virol. 71, 8790-8797
27. Proske, D., Gilch, S., Wopfner, F., Schatzl, H.M., Winnacker, E.L., and Famulok, M. (2002) Prion-protein-specific aptamer reduces PrPSc formation. Chembiochemistry 3, 717-725
28. Hay, B., Barry, R.A., Lieberburg, I., Prusiner, S.B., and Lingappa, V.R. (1987) Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein. Mol. Cell Biol. 2, 914-920
29. Sc)-specific epitope defined by a monoclonal antibody. Nature 390, 74-77
30. Nandi, P.K. (1997) Interaction of prion peptide HuPrP106-126 with nucleic acid. Arch. Virol. 142, 2537-2545
31. Nandi, P.K. and Nicole, J.C. (2004) Nucleic acid and prion protein interaction produces spherical amyloids which can function in vivo as coats of spongiform encephalopathy agent. J. Mol. Biol. 344, 827-837